Fresh Insights into Disease Etiology and the Role of Microbial Pathogens.

Pathogens have been implicated in the initiation and/or promotion of systemic sclerosis (scleroderma, SSc); however, no evidence was found to substantiate the direct contribution to this disease in past years. Recently, significant advances have been made in understanding the role of the innate immune system in SSc pathogenesis, supporting the idea that pathogens might interact with host innate immune-regulatory responses in SSc. In light of these findings, we review the studies that identified the presence of pathogens in SSc, along with studies on pathogens implicated in driving the innate immune dysregulation in SSc. The goal of this review is to illustrate how these pathogens, specifically viruses, may play important role both as triggers of the innate immune system, and critical players in the development of SSc disease

Generalised Thurston-Bennequin invariants for real algebraic surface singularities

A generalised Thurston-Bennequin invariant for a Q-singularity of a real algebraic variety is defined as a linking form on the homologies of the real link of the singularity. The main goal of this paper is to present a method to calculate the linking form in terms of the very good resolution graph of a real normal unibranch surface singularity. For such singularities, the value of the linking form is the Thurston-Bennequin number of the real link of the singularity. As a special case of unibranch surface singularities, the behaviour of the linking form is investigated on the Brieskorn double points x^m+y^n\pm z^2=0.Comment: 22 pages, TeX, 12 figure

Spectral analysis of 50 GRBs detected by HETE-2

FREGATE, the gamma-ray detector of HETE-2 is entirely dedicated to the study of GRBs. Its main characteristic is its broad energy range, from 7 keV to 400 keV. This energy range can be further extended down to 2 keV using the data from the WXM, the X-ray detector of HETE-2. Such a large energy range allows to study in details the prompt emission of GRBs, determining with a high precision their spectral parameters. Moreover, because this energy range extends at low energies, the sample of GRBs detected by both FREGATE and WXM contains a significant fraction of X-Ray Rich GRBs and X-Ray Flashes. We present here the distributions of the spectral parameters mesured for the time integrated spectra of 50 GRBs. We put emphasis on the distribution of the low energy spectral index alpha. Because FREGATE and WXM detected all classes of GRBs, we also discuss the connection between GRBs, X-Ray Rich GRBs and X-Ray Flashes.Comment: 4 pages aipTEX, contribution to the 2003 GRB Conference, held at Santa Fe,N