Effects of Shiitake mushroom (Lentinus edodes) supplementation into quail diets on performance, blood serum parameters and intestine microbial populations : Effects of Shiitake Mushroom (Lentinus edodes) Supplementations into Quail Diets

This study was conducted to investigate the effects of shiitake mushroom (Lentinus edodes) (SM) supplementations into quail diets on live weight (LW), live weight gain (LWG), feed consumption (FC), feed conversion ratio (FCR), blood serum biochemical parameters (total cholesterol, total protein, triglyceride, glucose) and intestine bacteria populations. A total of 120 Japanese quail (Coturnix coturnix Japonica) were used in present experiments. Quail were separated into 4 groups (control and 3 treatment groups). Control group was fed with a basic ration and treatments groups were fed with 0.5, 1 and 2% shiitake mushroom-supplemented diets. Shiitake mushroom supplementations significantly influenced live weights (P<0.05). Differences in live weight gains, feed consumptions, feed conversion ratios, blood serum parameters and intestine bacteria populations of the treatment groups were not found to be significant (P>0.05). SM supplementations influenced live weight gains and feed conversion ratios in the 4th week of the experiments (P>0.05). SM supplementations also influenced blood serum glucose levels (P<0.05)

Multi-Task Edge Prediction in Temporally-Dynamic Video Graphs

Graph neural networks have shown to learn effective node representations, enabling node-, link-, and graph-level inference. Conventional graph networks assume static relations between nodes, while relations between entities in a video often evolve over time, with nodes entering and exiting dynamically. In such temporally-dynamic graphs, a core problem is inferring the future state of spatio-temporal edges, which can constitute multiple types of relations. To address this problem, we propose MTD-GNN, a graph network for predicting temporally-dynamic edges for multiple types of relations. We propose a factorized spatio-temporal graph attention layer to learn dynamic node representations and present a multi-task edge prediction loss that models multiple relations simultaneously. The proposed architecture operates on top of scene graphs that we obtain from videos through object detection and spatio-temporal linking. Experimental evaluations on ActionGenome and CLEVRER show that modeling multiple relations in our temporally-dynamic graph network can be mutually beneficial, outperforming existing static and spatio-temporal graph neural networks, as well as state-of-the-art predicate classification methods. Code is available at https://github.com/ozzyou/MTD-GNN

Multi-Task Edge Prediction in Temporally-Dynamic Video Graphs

Graph neural networks have shown to learn effective node representations, enabling node-, link-, and graph-level inference. Conventional graph networks assume static relations between nodes, while relations between entities in a video often evolve over time, with nodes entering and exiting dynamically. In such temporally-dynamic graphs, a core problem is inferring the future state of spatio-temporal edges, which can constitute multiple types of relations. To address this problem, we propose MTD-GNN, a graph network for predicting temporally-dynamic edges for multiple types of relations. We propose a factorized spatio-temporal graph attention layer to learn dynamic node representations and present a multi-task edge prediction loss that models multiple relations simultaneously. The proposed architecture operates on top of scene graphs that we obtain from videos through object detection and spatio-temporal linking. Experimental evaluations on ActionGenome and CLEVRER show that modeling multiple relations in our temporally-dynamic graph network can be mutually beneficial, outperforming existing static and spatio-temporal graph neural networks, as well as state-of-the-art predicate classification methods. Code is available at https://github.com/ozzyou/MTD-GNN

Synthesis and biological evaluation of platinum complexes of highly functionalized aroylaminocarbo-N-thioyl prolinate containing tetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione moieties

Platinum complexes, derived from two families of bidentate funcionalized aroylaminocarbo-N-thyoyl prolinates, are prepared using mild conditions from prolinates, which are available via 1,3-dipolar cycloadditions. The resulting four coordinated neutral square-planar platinum(II) complexes are very stable and are fully characterized. Their structures are determined by spectroscopic and analytical methods and one of them by single crystal X-ray diffraction analysis. In this pattern, the platinum exhibits distorted square planar geometry, with cis-bond angles ranging from 89.42(2) and 94.37(6)° and trans-bond angles of 176.19(6) and 177.08(6)°, respectively. Anti(myco)bacterial and antifungal studies of all these new compounds are carried out under standardized protocols.This work is a part of Samet Belveren's ongoing PhD thesis granted by Mersin University (Project no. BAP-SBE TEB(SB) 2017-2-TP3-2564). We gratefully acknowledge financial support from Mersin University and the Spanish Ministerio de Economía y Competitividad (MINECO) (projects CTQ2013-43446-P and CTQ2014-51912-REDC), the Spanish Ministerio de Economía, Industria y Competitividad, Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER, EU) (projects CTQ2016-76782-P and CTQ2016-81797-REDC), the Generalitat Valenciana (PROMETEOII/2014/017), University of Alicante and Mersin University (Project. MEU-2017-COL-01007-M150D)

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

Protective effectiveness of anise against testicular ischemia and reperfusion injury: An experimental study in rats

Testicular torsion is a frequently encountered clinical condition that requires urgent treatment. The aim of this study is to investigate the efficacy of Anise (Pimpinella anisum L.) in treating the pathological condition due to ischemia and reperfusion injury by using biochemical, histopathological and immunohistochemical methods. A total of 6 groups were formed with 8 male Wistar Albino rats in each group. Group 1 (n=8): control group, Group 2 (n=8): Anise aqueous solution was given orally 5 ml/kg by gavage for 30 days. Group 3 (n=8): Ischemia and Reperfusion (I/R) group, bilateral testicles were rotated 270° and reperfused after 30 minutes of ischemia. Group 4 (n=8): I/R+ Anise group, Group 5 (n=8): Anise+ I/R group and Group 6 (n=8): Anise+ I/R+ Anise group. The results of the Anise group and the Control group were similar. However, the damage in the I/R group was considerably more severe than in any of the other study groups. While it was observed that spermatogenic cells started to regenerate in the I/R+Anise group, edema and congestion were observed in the Anise+I/R group. In the Anise+I/R+Anise group, all histological findings and biochemical parameters were similar to those of the control group. It was observed that anise had protective effects in ischemia and reperfusion injury in rat testicles

Synthesis of highly functionalized 2-(pyrrolidin-1-yl)thiazole frameworks with interesting antibacterial and antimycobacterial activity

A versatile, facile and concise approach to access to highly substituted functionalized 2-(pyrrolidin-1-yl)thiazole ring system is accomplished. The efficient protocol proceeds by the reaction of corresponding racemic or enantiomerically enriched pyrrolidines and readily available benzoylisothiocyanate in acetonitrile followed by sequential reaction of readily available alpha-bromo ketones in acetone. The selectivity and good yield in the desired product is another important advantage of this reaction protocol. In a few cases, the resulting N-benzoylthiourea intermediate cyclizes spontaneously before reacting with the benzophenone component. Finally, a wide study of the biological scope of this new bisheterocyclic molecules is reported.This work is a part of Samet Belveren's ongoing PhD thesis granted by Mersin University (Project no. BAP-SBE TEB(SB) 2017-2-TP3-2564). The authors thank Mersin University (Turkey) and the University of Alicante for support. We also thank the Scientific and Technological Research Council of Turkey (TÜBİTAK), the Spanish Ministerio de Economía y Competitividad (MINECO) (projects CTQ2013-43446-P and CTQ2014-51912-REDC), the Spanish Ministerio de Economía, Industria y Competitividad, Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER, EU) (projects CTQ2016-76782-P, and CTQ2016-81797-REDC), the Generalitat Valenciana (PROMETEOII/2014/017), (Consolider Ingenio 2010, CSD2007-00006) for research financing

From Bioactive Pyrrolidino[3,4-c]pyrrolidines to more Bioactive Pyrrolidino[3,4-b]pyrrolidines via Ring-Opening/Ring-Closing Promoted by Sodium Methoxide

The process involving a rearrangement of pyrrolidino[3,4-c]pyrrolidine to another pyrrolidino[3,4-b]pyrrolidine using sodium methoxide as base is fully studied. The effects of the substituents are analyzed during the ring-opening/ring-closing sequence. Computational studies are also performed to explain the importance of susbstituents and quaternary carbons, especially when the (3-indolyl)methyl is present in the starting material. Finally, all the samples are evaluated as potential candidates for antibacterial and antimycobacterial activities.We are grateful for support from Mersin University [Project no: MEU-2017-COL-01007-M150D and BAP-SBE AKB (SB) 2012-8 YL and BAP 2015- AP2-1342]. We gratefully acknowledge financial support from the Spanish Ministerio de Economía y Competitividad (MINECO) (projects CTQ2013-43446-P and CTQ2014-51912-REDC), the Spanish Ministerio de Economía, Industria y Competitividad, Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER, EU) (projects CTQ2016-76782-P and CTQ2016-81797-REDC), the Generalitat Valenciana (PROMETEOII/2014/017), the Gobierno Vasco/Eusko Jaurlaritza (GV/EJ, grant IT673-13), and the University of Alicante. O.L. gratefully acknowledges UPV/EHU for her postdoctoral grant. O.L. and A.d.C. gratefully thank SGI/IZO-SGIker and DIPC for generous allocation of computational resources

Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

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