The New Ice Age: Addressing the Deficiencies in Arkansas\u27s Posthumously Conceived Children Statute

The ability to conceive a child using the preserved genetic material, or gametes, of a deceased person presents a number of legal issues for inheritance, estate planning, Social Security, and parental rights. New medical advancements in assisted reproductive technology (ART) enable individuals to conceive children after their death, complicating the conventional methods of determining heirship of the decedent under state intestacy laws. The purpose of intestacy law is to determine the succession of a decedent that dies without a will, or intestate, with the goal of carrying out the donative intent of the decedent. Intestacy law has failed to keep pace with these technological advancements, which has left the legal status of posthumously conceived children (PCC) uncertain in many states

On the Lattice Corrections to the Free Energy of Kink-Bearing Nonlinear One-Dimensional Scalar Systems

A ri proof of the effective potential (lattice corrections included) deduced by Trullinger and Sasaki is given. Using asymptotic methods from the theory of differential equations depending on a large parameter, the lattice corrections to the kink and kink-kink contributions to the free energy are calculated. The results are in complete agreement with a first order correction to the energy of the static kink.Comment: 12 pages,plainte

On a class of rational and mixed soliton-rational solutions of Toda lattice

A class of rational solutions of Toda lattice satisfying certain Backlund transformations and a class of mixed rational-soliton solutions (quasisolitons) in wronskian formare obtained using the method of Ablowitz and Satsuma. Also an extended class of rational solutions are found using an appropriate recursion relation. They are also solutions of Boussinesq equation and it is conjectured that there is a larger class of common solutions of both equations.Comment: 10 pages, Late

Statistical approach of the modulational instability of the discrete self-trapping equation

The discrete self-trapping equation (DST) represents an useful model for several properties of one-dimensional nonlinear molecular crystals. The modulational instability of DST equation is discussed from a statistical point of view, considering the oscillator amplitude as a random variable. A kinetic equation for the two-point correlation function is written down, and its linear stability is studied. Both a Gaussian and a Lorentzian form for the initial unperturbed wave spectrum are discussed. Comparison with the continuum limit (NLS equation) is done.Comment: 10 page

Why Do Hedge Funds Stop Reporting Their Performance?

It is well known that the voluntary reporting of hedge funds may cause biases in estimates of their investment returns. But wide disagreements exist in explaining why hedge funds stop reporting to the datagathering services. Academic studies have suggested that poor or failing funds stop reporting while industry analysts suggest that better performing funds cease reporting because they no longer need to attract new capital. Using the TASS dataset, we find that hedge funds’ returns are significantly worse at the end of their reporting live. We then use survival time analysis techniques to examine the funds’ time to failure and changes in the hazard rate (i.e., the probability of failure) over time. We also estimate the effects of funds’ performance, size, and other characteristics on the hazard rate. Consistent with the finding on funds’ returns at the end of their reporting lives, we find that better performing and larger hedge funds have lower hazard rates.

The forced adoption of a fast-track appraisal process for a breast cancer treatment in UK

Trastuzumab (Herceptin ®, Roche) is approved in UK for the treatment of the metastatic breast cancer since 2001. As of 2005, concomitantly with the publication of 3 studies that showed it produces a 50% reduction of the recurrence rates of breast cancer, trastuzumab started to be prescribed in the earlt adjuvant treatrnent of this disease. Und June 2006, trastuzumab did not have both: 1) regulatory approval and 2) NICE [National Institute for Health and Clinical Excellence] recommendation for the use in early stages of breast cancer. During the period until June 2006, the trastuzumab use in those patients was not reimbursed and because the cost of trastuzumab is equal with the yearly UK average income, most of patients could not self fund their treatrnent. Before the publication of the final NICE guidance, the new data of trastuzumab in early breast cancer raised enormous patient and professional interest and expectations. A great volume of public and professional pressure was generated to transcend a system by which Primary Care Trusts can reimburse a treatment only after a formal guidance was issued. This paper draw on a case study depicting and analyzing the process by which regulatory approval and NICE recommendations were achieved in a record time and how trastuzumab became a standard treatment on early adjuvant breast cancer. According to the data we gathered in this work we were witnessing one of the fastest processes of adoption of a health care technology since the creation of NICE, in 1999. This study addresses the following research question: How and why does the adoption pattern of trastuzumab differ from the rational decision-making model of the reimbursement process in UK? [Author, p. 4]]]> Breast Neoplasms ; Antibodies, Monoclonal ; Antineoplastic Agents ; Drug Approval ; Drug Evaluation https://serval.unil.ch/resource/serval:BIB_CE0F0DE7396F.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_CE0F0DE7396F4 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_CE0F0DE7396F4 info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf oai:serval.unil.ch:BIB_CE0FBCDAC626 2022-05-07T01:27:18Z openaire documents <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_CE0FBCDAC626 Elezioni del Gran Consiglio 2019: flussi elettorali e profili dei partiti Pilotti, Andrea Mazzoleni, Oscar info:eu-repo/semantics/other misc 2020 <![CDATA[Quali flussi elettorali si sono riscontrati alle ultime elezioni del parlamento ticinese dell’aprile 2019? Come è cambiata la base elettorale dei principali partiti ticinesi? A queste domande tenta di rispondere l’Osservatorio della vita politica regionale dell’Università di Losanna, sulla base di due indagini svolte presso un campione rappresentativo di cittadini nei giorni successivi alle elezioni cantonali del 2015 e del 2019. L’analisi dei flussi elettorali, ossia la quota degli spostamenti avvenuti nel sostegno delle varie liste elettorali, mostra che i quattro partiti che tendenzialmente hanno perso schede rispetto al 2015 (PLR, Lega, PPD e PS), lo devono anzitutto alla minore capacità di intercettare nuovi elettori (astensionisti o cittadini che hanno da poco acquisito il diritto di voto). UDC e Verdi, ossia i partiti che conquistano nuovi sostegni, confermano invece la loro capacità, come già nel 2015, di attrarre nuovi elettori e di raccogliere l’appoggio di elettori dei partiti maggiori. Nel 2019, quasi la metà della forza elettorale dell’UDC è dovuta a votanti che quattro anni prima avevano sostenuto PLR e LEGA, con un aumento netto di attrattività nei confronti soprattutto dei votanti PLR rispetto al 2015. È da notare inoltre l’elevata quota di votanti provenienti dalla LEGA che nel 2019 opta per la scheda senza intestazione di partito. Il successo dei Verdi è invece dovuto soprattutto alla capacità di convincere una quota importante di coloro che avevano votato PS nel 2015 a cambiare lista. Nel 2019, quasi un terzo dell’elettorato dei Verdi è composto da ex elettori ed elettrici del PS. L’analisi del profilo dei principali partiti mostra che nel 2019 il voto femminile ha svolto un ruolo più importante rispetto al recente passato. Del voto delle donne hanno beneficiato soprattutto PS e PPD, meno LEGA e UDC ma anche i Verdi. Questi ultimi confermano invece una quota più importante rispetto agli altri partiti di giovani votanti. Il PLR è il solo partito che non ha visto cambiamenti nella composizione di genere del proprio elettorato raccogliendo, come nel 2015, un sostegno suddiviso in misura equilibrata tra uomini e donne. Il PS e l’UDC hanno potuto contare sull’aumento più marcato del voto dell’elettorato più anziano (66 anni e più). I titolari di un apprendistato o di un diploma di una scuola professionale continuano a costituire una parte importante dell’elettorato della LEGA, mentre i Verdi confermano una forte presenza della formazione universitaria. La scheda senza intestazione, ossia la facoltà di sostenere solo candidati e non direttamente un partito, è stata la seconda “lista” più votata (19,74%). L’aumento significativo (+2,43 punti percentuali) coincide, dal punto di vista socio-demografico, con un suo uso più ampio da parte dell’elettorato femminile, di votanti in età compresa tra i 18 e i 45 anni e di chi svolge un lavoro domestico non retribuito. La scheda senza intestazione risulta un mezzo sempre più usato dalle categorie di cittadini che, in generale, tendono a figurare fra gli astensionisti e meno coinvolti dalla politica