98 research outputs found

    Imaging TNFR1 and Integrin αvβ3 Positive Breast Carcinoma with a Novel Flurine-18 labeled Heterodimer peptide probe

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    第一部分正电子成像探针[18F]AlF-NOTA-WH701用于乳腺癌的显像 目的:已有相关文献证实肿瘤坏死因子受体1(TNFR1)在包含乳腺癌在内的多种肿瘤细胞上均有表达,之前我们通过噬菌体肽库展示技术筛选出能够特异性靶向TNFR1受体的功能性短肽(Thr-Ala-Gln-Ser-Ala-Tyr),并命名为WH701,通过利用放射性核素标记,拟得到特异性靶向TNFR1受体的正电子探针。 方法:我们利用固相法合成NOTA-WH701,并采用AlF的方法通过[18F]标记得到[18F]AlF-NOTA-WH701,在MCF-7人乳腺癌肿瘤细胞中,检测TNFR1受体的表达情况,并检测[18F]...Chapter 1 Imaging TNFR1 Positive breast carcinoma with a Novel Flurine-18 Labeled Peptide Probe Purpose: We have screened a novel ligand targeting TNFR1 which named WH701 by using technology of phage-displayed peptide libraries. WH701 conjugated by NOTA-NHS. NOTA-WH701 was radiolabeled with 18F using NOTA-AlF chelation reaction. After this, we evaluated the diagnostic property of [18F]AlF-NOTA-WH...学位:医学硕士院系专业:医学院_影像医学与核医学学号:2452014115351

    Research On Waveguide Sensors Based On Localized Surface Plasmon Resonance Effect

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    由于贵金属粒子局域表面等离子体共振(LocalizedSurfacePlasmonResonance,LSPR)特性在传感领域的潜在应用价值,它已经成为近年来光电子传感领域的研究热点。基于LSPR效应的传感器具有制备成本低廉、高灵敏度、快速响应等优点,在生物医学、药物检测、食品安全、环境检测等领域可以发挥重要的作用。本论文在总结前人研究的基础上,将光电子技术、生物医学技术、纳米科学技术交叉融合,同时发挥聚合物良好的力学性能、光学性能,提出制备基于金纳米球颗粒的LSPR效应的聚合物光波导传感器,它具有低成本、高集成度和便携化的特点,并能够与不同结构、种类的波导器件构成集成光子传感芯片。 本论文...Due to the potential application value of the localized surface plasmon resonanc ( Localized Surface Plasmon Resonance, LSPR ) effect of precious metals particles in the sensing field, it has become a hotspot in the field of photoelectron sensing in recent years. The sensors based on LSPR effect have the advantages of low preparation cost, high sensitivity and quick response, which can play an im...学位:工程硕士院系专业:信息科学与技术学院_工程硕士(电子与通信工程)学号:2312014115311

    中国南北朝時代における法華信仰の造像

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    Tohoku University博士(文学)thesi

    麦積山石窟における両小龕モチーフの宗教的背景 ー 一四八窟を中心に ー

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    中国南北朝時代における法華信仰の造像

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    博士学位論文の要旨及び審査結果の要旨 (Summary of Thesis(DR))othe

    Characteristics of Polymer Waveguide Sensor Based on Local Surface Plasmon Resonance

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    以SU-8光刻胶作为波导芯层材料,设计了基于金纳米粒子的局域表面等离子体共振(LSPR)波导传感器。根据Mie理论,建立了金纳米粒子的消光模型,理论分析了纳米粒子半径、待测物折射率等因素对局域表面等离子体共振曲线的影响。分析表明:当待测液体折射率增大时,LSPR共振峰的位置发生红移。随着金纳米粒子半径的逐渐增大,传感器灵敏度增加。共振吸收峰逐渐由单峰变为双峰,其中一个峰位于520 nm波长附近,主要由表面等离子体吸收造成;另一个峰随金纳米粒子半径的增大而逐渐红移,主要由表面等离子体散射造成。A SU-8 polymer waveguide sensor based on local surface plasmonresonance( LSPR) was designed. The extinction model of Au nanoparticles was established. Influence of Au nanoparticle'radius and refractive index of analyte on LSPR curve was analysized. The theoretical analysis results show that the resonance wavelengths of LSPR sensor move to longwave direction when the refractive index of the analyte increases. With the increasing of Au nanoparticles' radius,the sensitivity increases and the resonance absorption peak gradually changes from one peak to two peaks. One of the peaks locates near 520 nm wavelength,mainly caused by surface plasmon absorption. Another peak which is caused by surface plasmon scattering,moves to longwave direction gradually with the increasing of Au nanoparticles' radius.厦门大学校长基金(20720150086);; 国家自然科学基金(61107023);; 教育部博士点专项科研基金(20110121120020)资助项

    黄绿光发光二极管光衰性能研究

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    AlGaInP是GaAs基LED有源区主要材料,广泛应用于黄绿光至红光波段的LED。但在短波段尤其是黄绿光波段(565~575 nm),因其材料组成较接近间接带隙,其发光效率和稳定性存在问题。目前黄绿光功率衰减以俄歇复合损耗、非复合辐射中心损耗、载流子损耗为主。所以研究相同生长温度不同阱垒厚度、量子阱相同厚度不同生长温度、P型掺杂层掺杂浓度对发光光衰的影响。发现较薄的MQW阱垒厚度、较高的MQW生长温度及P-space后端P型层前端插入一层20 nm厚度,1.7×1018 cm-3浓度的高掺杂层三种方案可以改善黄绿光发光二极管光衰性能。天津市科技支撑、新材料重大专项项目(17YFZCGX00330,18ZXCLGX00080
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