The Role and Mechanism of RARα in the Development of Gastric Carcinoma

尽管胃癌的发病率在下降，但其死亡率仍位于全球第二位。由于缺乏有效的早期诊断方法，大多数胃癌病人在确诊时已到了晚期阶段。因此亟需寻找新的胃癌诊断与治疗的分子靶点。许多研究表明视黄酸受体在肿瘤的进程中起着重要的作用，然而，RARα与肿瘤的关系尚不清楚。本论文以胃癌为研究对象，阐明RARα在胃癌发生发展中的作用及其分子机制。 本论文主要通过Q-PCR、Westernblot、IHC/ICC等方法研究胃癌组织和细胞中RARα的表达情况及其临床意义。利用MTT、细胞集落形成、裸鼠皮下异种成瘤、流式细胞术、Transwell以及药物敏感性等实验研究RARα对胃癌细胞生长、迁移侵袭以及耐药性的影响。通过研...Despite of the descending incidence of gastric carcinoma (GC) , it remains the second mortality of cancer in the worldwide. Due to lack of effective and reliable tools for early detection, most patients typically have late stages of disease by the time of diagnosis. Therefore, it is urgent to find new molecular target in the diagnosis and treatment of GC. Many studies have shown that retinoic acid...学位：医学硕士院系专业：医学院_免疫学学号：2452013115345

Research development of retinoic acid receptor α in tumor

视黄酸受体(rAr)家族成员包括rAr与视黄酸X受体两大类,它们由3种不同的基因α、β、γ编码,由此形成不同的受体亚型。与其他受体一样,rArα参与调控细胞分化、增殖、凋亡以及胚胎发育、视觉形成、骨骼形成、新陈代谢、造血等许多关键的生命活动过程,并且rArα的异常表达具有肿瘤相关性和组织差异性。现就rArα在肿瘤中的研究情况进行综述。Retinoic acid receptor(RAR) family member including RAR and retinoid X receptor two categories, which consists of three different genes α, β, γ, thereby forming different receptor subtypes.Like with other receptors, RARαinvolves in the regulation of cell differentiation, proliferation, apoptosis, and embryonic development, visual formation,bone formation, metabolism, blood and many other key life activities.Meanwhile, there are the high correlation and tissue differentiation between abnormal expression of RARα and tumor.Here is to make a review on RARα and tumor.国家自然科学基金面上项目(81572394); 福建省卫生系统中青年骨干人才培养项目(2015-ZQN-ZD31); 福建省自然科学基金计划项目(2015J01560

A legume and application thereof

本发明涉及改良盐碱地的技术，具体的说是一种根瘤菌及其应用。根瘤菌(Ensifer sp.)YIC4027，已于2015年6月19日保藏于中国微生物菌种保藏管理委员会普通微生物中心(简称CGMCC，地址为：北京市朝阳区北辰西路1号院3号)，其保藏编号为CGMCC No.CGMCC 10994。本发明菌株生长速度快，耐盐碱，能够与田菁有效共生固氮，在温室和大田环境下显著促进田菁的生长，显著提高植株地上、地下部分的产量，提高了田菁的产量和品质；有利于种植田菁改良盐碱及其他贫瘠土地，减少化肥使用，减少化肥造成的环境污染，最终达到改良盐碱及贫瘠土壤，促进生态恢复和保护生态环境的目的

一种根瘤菌及其应用

本发明涉及改良盐碱地的技术，具体的说是一种根瘤菌及其应用。根瘤菌(Ensifer?sp.)YIC4027，已于2015年6月19日保藏于中国微生物菌种保藏管理委员会普通微生物中心(简称CGMCC，地址为：北京市朝阳区北辰西路1号院3号)，其保藏编号为CGMCC?No.CGMCC?10994。本发明菌株生长速度快，耐盐碱，能够与田菁有效共生固氮，在温室和大田环境下显著促进田菁的生长，显著提高植株地上、地下部分的产量，提高了田菁的产量和品质；有利于种植田菁改良盐碱及其他贫瘠土地，减少化肥使用，减少化肥造成的环境污染，最终达到改良盐碱及贫瘠土壤，促进生态恢复和保护生态环境的目的

Effect of efficient inoculants on coastal saline soil phytorehabilitation by Sesbania cannabina in the Yellow River Delta

A plot experiment was conducted to monitor the effects of dual-inoculation of efficient Sesbania rhizobia and arbuscular mycorrhizal fungi on the salt reducing effect and soil nutrition in moderate saline-alkali soil of the Yellow River Delta hinterland to explore the application prospects for microbe-plant associations during saline- alkali soil rehabilitation. The results showed that the up-ground biomass increased by 28.6% and below-ground biomass increased 51.3% in dual-inoculating planted soil > Sesbania planted soil > unplanted soil. The soil salt content of Sesbania planted soil was maintained at 0.9-2.0, which was 67%-79% lower compared to unplanted soil. The salt content in dual inoculating planted soil was 20%-25% lower than that in planted soil. The dual inoculation treatment increased available nitrogen, phosphorus, and potassium in soil greater than the Sesbania planted soil. These results indicate that dual-inoculation of efficient Sesbania rhizobia and arbuscular mycorrhizal fungi improved the ability of green manure crops to fertilize and rehabilitate saline-alkali soil

Rhizosphere growth promoting bacteria and application thereof

本发明涉及农业微生物领域，具体地说是一种降解苹果自毒物质根皮苷的根瘤菌及其应用。根瘤菌(Rhizobium pusense)YIC4105，已于2017年11月02日保藏于中国微生物菌种保藏管理委员会普通微生物中心(CGMCC)，保藏号为CGMCC No.14852。本发明菌株分离自黄河三角洲自然分布的田菁根际土壤，经人工分离、纯化得到；该菌株具有较强的降解根皮苷的能力；能够在苹果根际稳定定殖；利用该菌株能有效防因根皮苷积累引起的苹果幼苗连作障碍；具有开发成促进农作物生长的微生物接种剂或微生物菌肥的良好前景