３種類のGentiana属生薬「竜胆」、「秦艽」及び「ゲンチアナ」の含有成分とそれらの抗炎症活性に関する比較研究

富山大学・富医薬博甲第171号・何毓敏・2015/05/20富山大

A Study on Self-organizing Evolution of Media ——Take the Evolution of Internet as Example

从最初的口口相传到如今的印刷媒体、电子媒体和网络媒体协同发展的复杂格局，媒介经历了漫长的演化过程，这里我们不可避免地遇到两个问题：媒体演化是否有规律可循；如果有，其规律又是什么。本研究主要探讨的就是媒介演化的规律问题。本文认为：媒介演化是一个自组织的过程。新媒介的产生和演进，是在与环境的互动下，无需特定外力，系统自发生成、发展、规束并逆转的过程和结果。每一种新媒介的产生都会经历这样一个过程，同时新旧媒介之间差异化共存，无需外界的特定指令，系统自发从无序走向有序、从低级有序走向高级有序。 本文把媒介看成一个复杂系统，并以互联网为例，主要采用文献分析的方法探讨了互联网的一系列自组织现象：自生成、...Media are playing an increasingly important part in social communications. However, we don＇t have much knowledge about media as we think. The purpose of this thesis is inquiring into the self-organizing phenomenon presenting to media and trying to chase down the inner factors and mechanism. Media are self-organized system and their essence are self-organization. The evolution of media are the proc...学位：文学硕士院系专业：新闻传播学院新闻学系_新闻学学号：1052006115020

Study on Agglomeration’s Effect to Regional Tax Competition in China

梯度的经济发展策略使得我国区域经济发展的差异扩大，区域经济发展的不均衡和不恰当的分权路径加剧了我国区域间的税收竞争。经过分析，发现我国区域税收负担呈现东部高、西部次之、中部最低的现象。东部地区虽然税负最高，但仍是我国吸引资本最多的地区；相反，中西部地区整体税负低于东部地区，但其经济发展状况远落后于东部地区。随着世界经济的发展，产业集聚对地区经济的影响越显重要，西方学者通过研究发现政府能够对产业集聚产生的集聚租金征税，使得产业集聚地区的税收负担高于不曾发生产业集聚的地区，同时不会影响产业集聚地区对资本的吸引能力。研究产业集聚对我国区域税收竞争的影响，对于我国日后制定税收政策、协调区域税收竞争，均...The economy disparity between regions which was widened by the gradient economy development strategy intensifies the tax competition among regions in China with the fiscal decentralization reform. As it shown, the tax gap between regions is obvious: eastern area enjoys the highest tax burden, next to western area, and tax burden is the lowest in middle area. Although the eastern area enjoys the hi...学位：经济学硕士院系专业：经济学院财政系_财政学(含税收学)学号：2005130082

The transition of Native Customs in the non-treaty ports:A case study of YangZhou Native Customs

滨下武志先生的《中国近代经济史研究——清末海关财政与开港市场圈》中文本的面世，为笔者提供了学习和借鉴的机会。常关制度、厘金制度的连续性是一个重要的课题。学术界研究常关的角度主要有两种：一种是单纯常关的视角，对明清以来常关前身——钞（榷）关的研究。另一种则是，单纯海关史的研究，从近代洋关立场研究常关。学术界此种二分法研究常关，使得洋关成立而促使中国关税制度的变化（清朝常关制度的变化）方面的研究进展甚微。常关研究“清末——民国常关最终被裁撤”时期，这段时间至今尚是一片空白。本文借鉴先前学者常关个案研究的分析模式，转而对扬州常关进行剖析。就扬州关的设置与发展，从其独立自主行使主权到与洋关并存的竞争，...Research on China's modern economic history - the late Qing Dynasty in Chinese Maritime Customs and the financial markets and open circle, published by Hamashita Takeshi, gives me a good opportunity for reference since the Chinese version is available. Study on the institutions of Native Customs Service and the consistency of Likin System becomes a hot issue to explore the mechanism how the tariff...学位：历史学硕士院系专业：人文学院历史学系_中国近现代史学号：1032006115013

NGF与TrkA受体在儿童膀胱过度活动症中的研究进展

神经生长因子（NGF）因其在神经细胞的存活、生长以及分化过程中发挥重要作用而得到广泛研究。它分布于机体的各处，根据所结合受体发挥不同的病理生理作用。原肌球蛋白相关激酶A（TrkA）是其高亲和力受体，诸多研究表明NGF在与其结合后，根据其下游不同的信号转导通路而发挥不同作用。NGF与其结合后还对体内发生的其他信号转导通路有交叉影响作用。本文从不同的疾病症状对NGF与TrkA结合后的信号转导通路进行综述，从而探讨NGF/TrkA信号通路在儿童膀胱过度活动症的作用

Chronic hypoxia enhances aggressiveness of MCF-7 breast cancer cells through EMT

目的：探讨慢性缺氧应激对人乳腺癌MCF-7细胞恶性生物学行为的影响及可能机制。方法：将人乳腺癌MCF-7细胞分为缺氧组（1%O2、5%CO2和94%N2）和正常对照组（常氧）进行培养。利用MTT法、CCK-8实验、细胞直接计数法及细胞侵袭和迁移实验对MCF-7细胞活力、增殖及侵袭和迁移能力进行检测;用软琼脂集落形成实验及Matrigel 3D培养技术检测MCF-7细胞非锚定生长能力及极性改变情况;利用MCF-7细胞构建裸鼠皮下种植瘤模型,检测慢性缺氧应激对体内肿瘤生长及肺转移的影响;利用倒置显微镜观察MCF-7细胞形态改变;Western blot检测低氧诱导因子1（hypoxia-inducible factor-1,HIF-1）和磷酸化的糖原合成酶激酶3β（glycogen synthase kinase-3β,GSK-3β）在缺氧环境下表达水平的改变,以及E-钙黏连蛋白（E-cadherin）、N-钙黏连蛋白（Ncadherin）、波形蛋白（vimentin）、基质金属蛋白酶3（matrix metalloproteinase-3,MMP-3）、MMP-9等上皮-间充质转化（epithelial-mesenchymal transition,EMT）相关蛋白的表达水平。结果：与正常对照组相比较,慢性缺氧组MCF-7细胞活力、增殖能力及侵袭迁移能力增强,细胞非锚定生长能力提高且在3D培养系统更容易发生极性改变,呈现侵袭样生长,体内生长及转移能力增强;除了HIF-1被缺氧诱导表达升高外,GSK-3β呈现活化趋势,且上皮样标志物E-cadherin蛋白表达水平明显下降,而间充质样标志物N-cadherin、vimentin、MMP-3和MMP-9蛋白表达水平明显升高。结论：慢性缺氧应激促进了乳腺癌细胞恶性生物学行为,且其机制可能与EMT有关。AIM：To investigate the effects of chronic hypoxia on the aggressiveness of MCF-7, a human breast cancer cell line , and the underlying mechanisms .METHODS： MCF-7 cells were cultured under hypoxia （ 1% O2 , 5%CO2 and 94%N2 ） or control （95%O2 and 5%CO2 ） condition.The viability, proliferation, and invasion and migration abilities of the MCF-7 cells were determined by MTT assay , CCK-8 assay, cell counting, and cell invasion and migration assays.Anchorage-independent growth and the alteration of cellular polarization of the MCF-7 cells were tested by soft agar colony formation assay and Matrigel-3D culture assay, respectively.The effects of chronic hypoxia on the growth and metas-tasis of MCF-7 cells in vivo were investigated by xenograft in nude mice .The morphological changes of the MCF-7 cells were observed under an inverted microscope .Hypoxia-induced alterations in the levels of hypoxia inducible factor-1 （ HIF-1 ） and phosphorylated glycogen synthase kinase-3β（ p-GSK-3β） as well as epithelial-mesenchymal transition （ EMT） mol-ecules, such as E-cadherin, N-cadherin, vimentin, matrix metalloproteinase （ MMP）-3 and MMP-9, were determined by Western blot .RESULTS：Chronic hypoxia significantly increased the viability , proliferation , and invasion and migration abilities of MCF-7 cells in vitro, enhanced the anchorage-independent growth , facilitated cellular polarization alteration in Matrigel-3D culture, and promoted cancer metastasis in vivo.Hypoxia up-regulated HIF-1, activated GSK-3β, down-regu-lated E-cadherin and increased the protein levels of N-cadherin, vimentin, MMP-3 and MMP-9.CONCLUSION：Chronic hypoxia enhances the aggressiveness of breast cancer cells probably through EMT .中国博士后科学基金第59批面上资助项目（No.2016M592037）;安徽省自然科学基金资助项目（No.1608085MH187

First-principles study of the structure of methanethiolate on Ag(111)

We have systematically investigated the adsorption of methanethiolate (CH3S) on the Ag(111) surface employing density-functional theory. Various adsorption geometries have been considered and the energetically most favorable structure of CH3S/Ag(111) was identified. Though the calculated structural parameters for the layer spacing of the adsorbate relative to the nearest Ag layer and the S-Ag bond lengths are reasonable consistent with the experimental results, difference exists about the height corrugation in the S layer. Our results show that the buckling of the S layer observed in experiment might not represent the true atomic positions

Atomic structure of Si nanowires on Ag(110): A density-functional theory study

We have systematically investigated the adsorption of Si on the Ag(110) surface employing density-functional theory. Various adsorption geometries have been considered for Si coverages up to 2.0 monolayers. Our results show that the Si-Ag bonds are slightly more favorable than the Si-Si bonds at low Si coverage and an attractive interaction between the Si adatoms is also identified. From the calculated results, we identify the most possible atomic structures of Si nanowires on the Ag(110) surface and propose a reasonable mechanism for the growth of Si nanowires on the Ag(110) surface

基于“民族-国家”形象建构视域下的体育强国建设

体育作为世界共通的语言,在塑造国家形象、提升国际地位方面起到了重要作用。体育强国建设从某种程度上来说就是国家软实力的建构,它涉及民族国家形象方面影响力和号召力的认知与重塑。文章从体育强国建设的历程、相关认识、现实困境和应然取向等几方面进行分析,指出在建设体育强国的过程中需要面对民众思想观念、民众接受度、国际体育贡献低、西方文化霸权主义造成负面影响等几方面问题。在建设体育强国的过程中,应转变当前体育价值观、创新体制,培育新的金牌增长点,大力发展中国体育文化和提高国际体育话语权。国家社会科学基金项目(16BTY021);;福建省哲学社会科学重点项目(FJ2015A009