Experimental Study on Performance of Zero-emission Heat Pump System for Exhaust Gas after Drying Process in Pharmaceutical Industry

This study develops a zero-emission heat pump system consists of heat pipes, water coils, and heat pumps for exhaust gas to mitigate the incomplete treatment, disgusting smell, and unrecoverable heat of exhaust gas after the drying process in the pharmaceutical industry. The quality of gas recycling and reuse is guaranteed by closed-loop dehumidification, waste gas treatment, and heating, thereby achieving near-zero emissions and recovery of waste heat. The experimental results of the system performance show that when the average temperature of the supply air is 65.1 °C, the relative humidity of the supply air is 21.1%, the air volumetric flow rate is 12 000 m3/h, the coefficient of performance of the heat pump unit is 4.7, and the specific moisture extraction rate of the system is 8.5 kg/(kW?h). The composition of the circulating gas shows that 73.2% of the volatile organic compounds are absorbed, and no non-condensable, flammable, or explosive gases are accumulated in the system during each production period

A novel algicidal properties of fermentation products from Pseudomonas sp. Ps3 strain on the toxic red tide dinoflagellate species

The viability of both China’s offshore fishing operations and the global marine fishing industry is threatened by the occurrence of red tides caused by Gymnodinium catenatum and Karenia mikimotoi. Effective control of these dinoflagellate-mediated red tides has become a pressing issue that requires immediate attention. In this study, High-efficiency marine alginolytic bacteria were isolated and underwent molecular biological identification to confirm their algicidal properties. Based on a combination of morphological, physiological, biochemical, and sequencing results, Strain Ps3 was identified as belonging to the species Pseudomonas sp. We examine the effects of algicidal bacteria on the red tide species G. catenatum and K. mikimotoi within an indoor experimental setting. Then gas chromatography– mass spectrometry (GC–MS) was used to analyze the structure of the algolytic active substances. This investigation demonstrated that with exposure to the algae-lysis experiment, the Ps3 strain has the best algae-lysis effect, with G. catenatum and K. mikimotoi reaching 83.0 and 78.3%. Our results from the sterile fermentation broth experiment showed that the inhibitory effect on the two red tide algae was positively correlated with the concentration of the treatment. At a treatment concentration of 2.0% (v/v), the 48 h lysis rates of G. catenatum and K. mikimotoi due to exposure to the Ps3 bacterial fermentation broth were 95.2 and 86.7%, respectively. The results of this study suggest that the algaecide may be a rapid and effective method to control dinoflagellate blooms, as evidenced by the observed changes in cellular morphology in all cases. In the ethyl acetate phase of Ps3 fermentation broth, the cyclic (leucine-leucine) dipeptide was the most abundant. The findings of this study contribute to our understanding of red tide prevention and control and provide a theoretical foundation for further research in this field

Development and validation of a nomogram for predicting the incidence of infectious events in patients with idiopathic inflammatory myopathies

BackgroundInfection is a leading cause of mortality in idiopathic inflammatory myopathies (IIMs). This study aimed to develop a nomogram for predicting severe infection risk in IIM patients.MethodsPatients with IIMs admitted to Zhongshan Hospital, Fudan University, from January 2015 to January 2022 were enrolled. They were randomly divided into derivation (70%) and validation (30%) sets. Univariate and multivariate Cox regression identified independent risk factors for severe infection, and the Akaike information criterion (AIC) was applied for model selection. A nomogram was constructed to predict severe infection risks at 6 months, 1 year, and 3 years. Predictive accuracy and discriminative ability were evaluated using the concordance index (C-index), calibration curves, and the area under the receiver operating characteristic curve (AUC). Decision curve analysis (DCA) assessed clinical utility. Kaplan-Meier (K-M) curves were used to analyze survival differences between high- and low-risk groups stratified by nomogram scores.ResultsAmong 263 IIM patients, 81 experienced 106 severe infection events, with lower respiratory tract infections being the most common (47.2%). Independent risk factors included age at onset (HR 1.024, 95% CI 1.002-1.046, p=0.036), lactate dehydrogenase (HR 1.002, 95% CI 0.999-1.005, p=0.078), HRCT score (HR 1.004, 95% CI 1.001-1.006, p=0.002), and lymphocyte count (HR 0.48, 95% CI 0.23-0.99, p=0.048). The nomogram demonstrated strong predictive performance, with AUCs of 0.84, 0.83, and 0.78 for 6 months, 1 year, and 3 years in the derivation set, and 0.91, 0.77, and 0.64 in the validation set. Calibration curves showed good agreement between predicted and observed risks, while DCA demonstrated significant net benefit over individual predictors. Kaplan-Meier curves revealed significant differences in the cumulative risk of severe infection between high- and low-risk groups. Further validation in DM and ASS subgroups demonstrated that the nomogram effectively predicted severe infections, with AUCs of 0.86, 0.81, and 0.73 for DM and 0.86, 0.83, and 0.74 for ASS at 6 months, 1 year, and 3 years, respectively.ConclusionWe have developed a new nomogram to predict severe infection risk in IIM patients at 6 months, 1 year, and 3 years. This model aids clinicians and patients in formulating treatment and follow-up strategies

Oil-gelling properties of soy lecithin fractions

The ethanol soluble, phospolipid and glycolipid fractions of soy lecithin could act as oleogelators, while the ethanol insoluble fraction failed.</jats:p