An algorithm for chip surface defect detection based on sequential similarity and light source automatic adjustment

为了解决当前缺陷检查算法在保护罩反光环境下易导致采集芯片连接器图像光照不均,使其缺陷检测精度较低,无法精确定位出浅插与破损的不足,设计了基于序贯相似性检测匹配与光源自动调节的芯片连接器表面缺陷检测识别算法。首先,基于序贯相似性检测匹配,定位出连接器位置,提取出连接器不良常发区域;然后设计了光源自动调节机制,视觉软件通过光源数字控制器SDK与网线触发光源关闭或调暗,消除保护罩反光对图像质量的影响;最后采用线检测,统计缺陷区域二值图特征,完成缺陷检查。实验数据显示,与当前缺陷检查技术相比,在面对保护罩反光严重环境下的芯片连接器缺陷检查时,该算法具有更高的检查精度。Since the current defect detection algorithm used in the protection cover reflective environment is easy to result in the nonuniform illumination of the acquired image of the chip connector, make its defect detection precision low, and is unable to locate the shallow insert and damage, an algorithm for chip connector＇s surface defect detection based on the sequential simi- larity detecting marching and light source automatic adjustment was designed. On the basis of the sequential similarity detection matching, the position of the connector is located to extract the often occurring nonuniform illumination area of the connector. The light source automatic adjustment mechanism was designed. The visual software triggers the light source＇s turnoff or dim- ming through the light source digital controller SDK and cable to eliminate the effect of light reflected by the protection cover on image quality. The line detection is used to count the features of the binary image of the defect area to detect the defect. The ex- perimental data shows that, in comparison with the current defect detecting technology, the algorithm proposed in this paper has higher detecting precision while detecting the defect of the chip connector in the protection cover reflective environment.福建省教育厅科研课题资助项目（JAT160832

Fenofibrate ameliorates experimental autoimmune myocarditis and possible mechanism of modulating Th17 related cytokines

研究背景：心血管疾病（cardiovasculardisease）是引起社会整体发病率和死亡率居高不下的主要病因。心肌炎（Myocarditis）是一种异质性的心肌炎症疾病，多数心肌炎患者可发展为以进行性心衰为主要特征的扩张型心肌病（DilatedCardiomyopathy，DCM），预后较差。因此对心肌炎发生发展过程的研究，并利用其特点进行针对性治疗显得尤为重要。目前为止，心肌炎的发病机制尚不明确，有研究发现，自身免疫反应在心肌炎及DCM的发生发展中扮演极其重要的角色。本实验以自身免疫性心肌炎为基础展开研究。 在经典的辅助性T细胞亚群Th1/Th2研究过程中，发现了一种新型的分化发育和功...Background: Cardiovascular disease as the major cause of death have enormously elevate social morbidity and mortality. Myocarditis is one of a kind heterogeneity cardiovascular inflammatory disease,which mostly wind up with dilated cardiomyopathy as the dynamic changes of disease feathered by progressed congestive heart failure,finally lead to a poor prognosis due to undetermined mechanism. In ord...学位：医学硕士院系专业：医学院_内科学学号：2452010115327

The Study of Inbound Logistics and Path planning of Y Company Based on Milk-run

在汽车制造业中，汽车零部件入厂物流是物流系统良性运作的最关键部分。通过学习国外物流管理模式，我国在汽车零部件物流管理方面也开始借鉴“即时供货”和“零库存”等理念。这种精益化的物流运作必然要求小批量、多频次的配送作业，增加了供应商的运输配送成本和库存成本，整个供应链的成本并没有得到有效的降低。 据此，国外将Milk-run运输模式应用到汽车生产行业，提高入厂物流运行效率，降低汽车零部件供应商和主机厂的库存量，从而降低入厂供应链物流的综合成本。近年来，国内应用Milk-run的企业也在增多。上海通用实行Milk-run，成功地实现了运输成本降三成。但整体来看，Milk-run在国内应用的范围较小...In the auto industry, auto parts logistics is the key component of well operation. By learning from advanced international logistical management mode, the concept of instant supply and zero-stock were introduced into our auto-parts logistical. Small batch and frequently delivery are often needed in this kind of logistics process which increases the cost of transportation and storage. The cost of t...学位：工程硕士院系专业：管理学院_物流工程学号：1772010115108

カチオン性高分子による負に帯電したコロイド粒子の凝集機構

この博士論文は内容の要約のみの公開（または一部非公開）になっています筑波大学 (University of Tsukuba)201

カチオン性高分子による負に帯電したコロイド粒子の凝集機構

筑波大学University of Tsukuba博士（農学）Doctor of Philosophy in Agricultural Science2014【要旨】thesi

Influencing Factors’ Analysis of Business Cycle Synchronization between China and Its Major Trading Partners

随着经济全球化的日益深化，世界经济通过贸易、投资、产业等渠道密切联系。一国经济周期波动通过这些渠道对他国经济周期波动产生影响，出现了世界经济周期的协动性。本文通过研究经过H-P滤波剔除趋势项后的中国与主要贸易伙伴的实际GDP波动项变化及建立VAR模型两个角度发现，随着时间的推移，中国与其主要贸易伙伴经济周期协动性呈现逐渐增强的趋势。有多种因素影响中国经济周期协动性，本文通过选取与中国贸易联系较为紧密的22个国家（地区），构建GMM面板数据回归模型，分别研究了双边贸易强度、双边产业内贸易强度、双边直接投资强度和产业结构相似度4个因素对经济周期协动性的影响。 研究表明，在1992-2011年间，...With the deepening of economic globalization, global economy becomes increasingly connected via various channels like trade, investment and industry and so on. The business cycle of one country impacts the business cycle of other countries through these channels, hence the world business cycle synchronization. The paper finds that as time goes by, business cycle synchronization between China and i...学位：经济学硕士院系专业：经济学院_国际贸易学学号：1572011115183

厦门环岛文化艺术创意产业发展及对策研究

《厦门环岛文化艺术创意产业现状以及发展对策研究》立足于厦门文化创意产业,在调研分析的基础上以研究厦门环岛文化艺术创意产业的现状及发展对策为切入点,着眼于整个厦门的文化创意产业发展,提出具有一定参考价值的关于厦门文化创意产业的调研报告,并对厦门环岛文化艺术创意带进行模拟规划,提供政府咨询

Structure, Energetics and Vibrational Frequency Shifts of Water Molecules Confined Inside Single-walled Carbon Nanotubes:A DFT Study

利用密度泛函理论中的杂化泛函M06-2X研究了受限于不同管径单壁碳纳米管(SWCnT)内水分子团簇(H2O)n=3~6的结构、能量以及振动频率.结果显示由于SWCnT的限域效应,水分子团簇的几何构型与在真空相比发生了巨大变化,如受限(H2O)6能形成单链锯齿型水分子构型.随着管直径的增大,纳米管与水之间的相互作用逐渐减弱,但水分子之间的氢键相互作用能变化不大.对比受限和真空下水分子O—H振动频率发现,绝大部分O—H的振动频率由于碳纳米管与水的相互作用而发生了红移.AIM理论分析显示O—H振动频率的红移应归因于其电子密度的减小.这也表明碳纳米管绝非简单的几何限制效应,而是与水分子之间存在弱电子相互作用,主要包括H…π氢键作用和O…π轨道作用,从而导致水分子的小部分电荷转移到了SWCnT上.The study of confined water molecules has attracted much attention because of their fascinating properties.In the present work, small water clusters(H2O)n=3~6 encapsulated in different diameter of single-walled carbon nanotubes(SWCNT) were investigated using density functional theory(DFT).The DFT-based M06-2X method along with mixed basis sets(6-311+G(d, p)//6-31+G(d)) was employed in all calculations for structure, interaction energy, charge transfer and vibrational frequency.The results indicate that as compared to water molecules in vacuum, the geometries of confined water molecules changed significantly due to the confinement effect of carbon nanotubes, for example, the(H2O)6 cluster can form chain-like configuration via hydrogen bond.The tube-water interaction energy decreased with the increase of the nanotubes diameter, while the hydrogen bond energy between water molecules changes slightly.Vibrational analysis reveals the red shift of the majority of the O—H stretching modes inside SWCNT compared to vacuum vibrational frequencies due to the tube-water interaction.The Bader's theory of atoms in molecule(AIM theory) has been used to characterize the tube-water interactions.Electron density ρ that reflects the strength of a bond has been used to explain the phenomenon of the red shift.The AIM analysis suggests that the red shift of O—H vibrational frequencies for confined water molecules should be attributed to the decrease of the electron density ρ.This fact demonstrates that the tube-water interaction is not a simple effect of geometry confinement, but weak electronic interaction between the molecular orbital of the confined water molecules and the delocalized π electrons from carbon nanotube.It mainly includes the H…π hydrogen bond interaction and O…π orbital interaction, resulting in a slight charge transfer from water molecules to SWCNT.Therefore, when constructing carbon nanotube devices, one should not ignore the existence of water molecules.We hope that our results can provide a guidance to the understanding of the behavior of water molecules encapsulated inside nanoscale environment.国家重点基础研究发展计划(No.2012CB214901); 国家自然科学基金(No.51274197)资助~

基于均匀设计的祛湿化瘀方防治脂肪肝不同作用环节的主效应中药剖析

目的:以对实验性脂肪肝有显著防治作用的祛湿化瘀方为切入点,探索中药复方多途径、多环节药理作用的相应物质基础的研究方法。方法:采用CCl4复合高脂低蛋白饮食诱导的大鼠脂肪肝模型,运用"均匀设计法",根据复方中的5味中药(茵陈、栀子、虎杖、田基黄、姜黄),选用U11(1110)表进行组方设计所得10种组合进行干预,分别以肝甘油三酯(triglyceride,TG)、血清丙氨酸氨基转移酶(alanine aminotransferase,ALT)、丙二醛(malonyl-dialdehyde,MDA)为不同病理环节的考察指标,根据回归方程获得针对上述不同指标所提示的最佳效应中药或某种配伍组合,并根据其提示的效应中药或组合,重新分组实验进行验证。结果回归方程显示,降低肝脏TG的最佳效应组合是茵陈0.07g、田基黄0.05g、栀子0.17g、姜黄0.03g,降低ALT的最佳效应组合是茵陈0.33g、虎杖0.25g、田基黄0.25g、姜黄0.17g。而针对MDA未获得回归方程。验证实验证实了上述"筛选"结果的可靠性。结论:①均匀设计是可靠的剖析某一病理环节主效应中药或配伍组合的分析方法;②在整体实验水平,针对某一指标环节的最佳效应中药仍以中药配伍组合方式出现,也说明了中药配伍复方针对复杂病理变化的科学性

Effects of Serum Medicated with Duhuo Jisheng Decoction on the Induced Degeneration of Articular Chondrocytes in Vitro Culture Based upon “caveolin-p38MAPK” Signal Pathway

目的:观察独活寄生汤含药血清对兔退变软骨细胞“CAVEOlIn-P38MAPk“信号通路的调控作用,探讨独活寄生汤治疗骨关节炎的作用机制。方法:将20只3月龄新西兰兔随机分为生理盐水组(空白血清组)和独活寄生汤组(含药血清组),每组10只。分别在24 H、36 H、48 H不同采血时间点采集独活寄生汤含药血清和空白血清,将5%、10%、15%、20%不同浓度两种血清作用于体外培养第2代软骨细胞,确定含药血清最佳干预条件;建立体外退变软骨细胞模型,分别给予独活寄生汤含药血清(含药血清组)和空白血清(空白血清组)干预36 H,收集软骨细胞,运用WESTErn blOT法检测血清干预后退变软骨细胞CAVEOlIn-1、P38、P-P38蛋白表达,rT-PCr法检测血清干预后退变软骨细胞白细胞介素(Il)-1β、肿瘤坏死因子(Tnf)-α、基质金属蛋白酶(MMP)-3、MMP-13、CAVEOlIn-1 M rnA表达。结果:浓度为15%的36 H采血时间点含药血清的促增殖作用最明显;退变软骨细胞中存在“CAVEOlIn-P38MAPk“信号通路的激活,独活寄生汤含药血清可抑制CAVEOlIn-1、P-P38蛋白表达及Il-1β、Tnf-α、MMP-3、MMP-13、CAVEOlIn-1 M rnA的表达,差异有统计学意义(P<0.05)。结论:独活寄生汤能通过抑制“CAVEOlIn-P38MAPk“信号通路的激活及其下游效应分子,从而有效抑制软骨细胞凋亡。Objective:To observe the effects of serum medicated with Duhuo Jisheng Decoction on the induced degeneration of articular chondrocytes in vitro culture based upon "caveolin-p38MAPK" signal pathway and probe the mechanism of Duhuo Jisheng Decoction in the treatment of osteoarthritis.Methods:20 March old New Zealand rabbits were randomly divided into normal saline group(blank serum group)and Duhuo Jisheng Decoction group(drug containing serum group),10 rats in each group.The second generation of cartilage cells was cultured in vitro using different time points of sample collection such as 24 h,36 h and 48 h,serums medicated with 5%,10%,15% and 20% concentrations of Duhuo Jisheng Decoction and blank serums.The best intervention time of medicated serum was determined,which was then used to deal with the degenerating chondrocytes.The degenerated cartilage cell models in vitro were established,which were intervened by the serum medicated with Duhuo Jisheng Decoction(drug containing serum group)and the blank serum(blank serumgroup)after 36 h,collecting chondrocytes.The Western Blot method was used to detect the expression of degenerated cartilage cells caveolin-1 and p-p38 protein after serum intervention.The RT-PCR method was usedto detect the expression of degenerated cartilage cells IL-1β,TNF-α,MMP-3,MMP-13 and caveolin-1 m RNA after serum intervention.Results:The concentration of 15% and 36 h sampling time point serum on the proliferation;the activation of "caveolin-p38MAPK" signaling pathway in the degeneration of cartilage cell,Duhuo Jisheng decoction containing serum can inhibit the expression of caveolin-1,p-p38 protein expression and IL-1β,TNF-α, MMP-3,MMP-13,caveolin-1,m RNA,the difference was statistically significant(P < 0.05).Conclusion:Duhuo Jisheng decoction can inhibit the "caveolin-p38MAPK" signal pathway and its downstream effector molecules, which can effectively inhibit the apoptosis of cartilage cells.国家自然科学基金资助项目(81302986); 福建省卫生厅青年科研课题资助计划项目(2012-2-69); 福建省自然科学基金(2013J01389); 福州市卫生系统科技计划(2013-S-wq6