3 research outputs found

    一例补体抑制剂治疗欠佳的再生障碍性贫血-阵发性睡眠性血红蛋白尿患者的多学科诊疗分析

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    一例青年男性患者诊断再生障碍性贫血伴阵发性睡眠性血红蛋白尿(paroxysmal nocturnal hemoglobinuria,PNH),经免疫抑制剂治疗后仅部分缓解。近1年贫血加重、输血依赖,考虑PNH活动性溶血所致,更换依库珠单抗治疗后贫血仍持续加重。详细询问病史发现患者慢性牙周感染,近1个月牙周疼痛溢脓伴发热。多学科讨论考虑慢性牙源性感染激活补体系统是PNH溶血加重的主要原因,急性感染影响了依库珠单抗的疗效。经多学科会诊制定治疗方案,给予静脉抗生素联合牙周冲洗、拔牙控制牙源性感染,同时继续按期输注依库珠单抗,患者临床症状好转,血红蛋白迅速上升,脱离血制品输注。该病例为通过多学科协作诊疗解决罕见病在新药物治疗中遇到的困难提供了经验参考

    粘土矿物对蓝细菌化石形成的作用及机制

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    蓝细菌是地球上最早出现的生物之一,其化石记录可追溯至~35亿年前。浅海环境是蓝细菌化石等地球早期微生物化石形成的一个重要埋藏学窗口。有研究表明,微生物胞外有机物能够结合金属离子,使其表面矿化并形成低结晶度的自生粘土矿物,从而促进微生物化石的形成及保存(Fein等,2002;Gauger等,2016)。然而Brasier等(2015)发现,地球早期微生物化石中的粘土矿物(伊利石或者蛭石)具有较高

    Prediction of Energy Resolution in the JUNO Experiment

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    International audienceThis paper presents the energy resolution study in the JUNO experiment, incorporating the latest knowledge acquired during the detector construction phase. The determination of neutrino mass ordering in JUNO requires an exceptional energy resolution better than 3% at 1 MeV. To achieve this ambitious goal, significant efforts have been undertaken in the design and production of the key components of the JUNO detector. Various factors affecting the detection of inverse beta decay signals have an impact on the energy resolution, extending beyond the statistical fluctuations of the detected number of photons, such as the properties of liquid scintillator, performance of photomultiplier tubes, and the energy reconstruction algorithm. To account for these effects, a full JUNO simulation and reconstruction approach is employed. This enables the modeling of all relevant effects and the evaluation of associated inputs to accurately estimate the energy resolution. The study reveals an energy resolution of 2.95% at 1 MeV. Furthermore, the study assesses the contribution of major effects to the overall energy resolution budget. This analysis serves as a reference for interpreting future measurements of energy resolution during JUNO data taking. Moreover, it provides a guideline in comprehending the energy resolution characteristics of liquid scintillator-based detectors
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