SEISMIC RESPONSE AND STORY-DRIFT OF REINFORCED CONCRETE FRAME WITH ECCENTRIC STEEL BRACE

通过对偏心支撑钢筋混凝土框架试验结果的分析以及性能设计和抗震设计位移控制的比较,对其抗震设计中的变形和性能进行研究。为满足性能设计和三水准抗震设计要求,偏心支撑框架结构的侧移限值应比纯框架结构更严格,而且使得支撑的受压屈曲控制在第一水准位移后,将有利于抗震性能的改善。由于偏心钢支撑的作用,偏心支撑框架结构中柱的剪力明显减小,侧向刚度增大,从而有效地避免了框架结构在地震中柱的剪切破坏和过大的侧移。偏心支撑框架结构的地震反应如最大侧移、最大速度、最大加速度明显降低,结果表明,K型支撑是理想的抗震布置方式。Depending on the experiment results analysis of the reinforced concrete frame eccentrically braced with steel(EBF structure) and drift limit comparison of performance-based design and three-stage seismic design,the deflection and behavior of EBF structure under seismic motion is discussed.From the point of three-stage principle of seismic design and performance-based design,the story-drift limit of EBF structure should be more strict than the pure frame.Because of the action of steel brace,the shear force of column in EBF structure is reduced and lateral stiffness of EBF structure is increased.The rupture of column and larger lateral deformation are avoided.It is also found that maximum deformation,acceleration,velocity and column shear of the EBF structure are obviously decreased comparing with the pure frame.The(K-type) brace is advantageous for the earthquake resistance.清华大学结构与振动教育部重点开放实验室资助项目(1997

MESOANALYSIS of CONCRETE BEHAVIOR DUE TO EFFECT of AGGREGATE GRADATION

为研究混凝土骨料级配对混凝土性能的影响,采用离散元法中颗粒-弹簧模型对不同骨料级配的混凝土性能进行了细观分析。将混凝土骨料随机分布在混凝土中,以骨料为刚性颗粒元、骨料之间的填充砂浆为弹簧元建立颗粒-弹簧模型,计算不同骨料级配下混凝土的应力-应变性能和破坏面。计算结果表明用这一模型计算的骨料级配变化对混凝土的影响与试验结果相吻合,这种颗粒-弹簧模型可以计算分析骨料级配变化对混凝土性能的影响。而且在平面问题中颗粒-弹簧模型的单元刚度矩阵为6x6,比传统有限元的存储量和计算量都小很多。For analyzing the influence of aggregate gradation on the concrete behavior,the grain-spring model of discrete element method is presented.Taking aggregates randomly distributed in the concrete as rigid grains and mortar between aggregates as springs,the grain-spring model is established in mesoscale.The stress-strain relationship and rupture surface of concrete having different aggregate gradation under compression are calculated.The calculated results are identical in many aspects with the results of experimentation.The results show that the grain-spring model in mesoscale can be used to analyze the influence of aggregate gradation on the macroscale behavior of concrete.And in the plane problem,the element stiffness matrix of the grain-spring model is 6×6.The quantity of storage and calculation is very smaller than that of the finite element method

Rearch on wire bending technique

传统的线材弯曲工艺在产品种类较多且交货时间较短的场合,越来越难以满足要求。本文利用数控技术和简单的折弯模具,提出了一种线材弯曲成形的方法。该方法通过在数控系统中对线材制品形状进行编程,在短时间内完成不同形状零件的加工。其强大的制造柔性,完全能够满足工业界日益增长的“即时制造“生产需要和产品的随时换代升级。The traditional wire bending technics is becoming difficult to meet the needs of the market which requires more types of products and shorter delivery time.The NC technology and simple standard bending dies were used in a new method of wire bending.Through programing in the NC system,parts in all sorts of shapes can be completed very quickly,which thoroughly satisfies the growing industrial requirement of "immediately create" production and that for the upgrade of products at any time.厦门市科技计划项目(3502Z20071099

用Taqman MGB探针研究中国人群TNF-α基因启动子区单核苷酸多态性

【目的】了解中国人群肿瘤坏死因子α（the tumour necrosis factor α，TNF-α）基因启动子区多态性。【方法】 随机选取20名深圳地区汉族健康体检者，采用两对引物PCR扩增TNF-α基因启动子区（-1389nt～＋125nt），对PCR产物进行序列分析，寻找单核苷酸多态性位点（single nueleofide polymorphisms，SNPs）。采用Taqman MGB探针建立了-857nt（C／T）位点的实时定量PCR（thereal-time PCR）分型方法，并对中国汉族、壮族、布依族，水族及苗族群体共l108份样本进行了基因分型。【结果】在启动子区（-1322nt～＋67at），发现6个SNP位点，即-885（A／G）、-863（C／A）、-646（G／A）、-648（G/A）、-568（G／C）和-857（C/T），其中位点-646nt（G→A）为新发现SNP。-885、-648及-568nt位点碱基虽然与Genbank不同，但测序的20个个体基因分型相同。中国人群-857nt（C／T）位点基因型频率分别为0．79（CC），0．19（CT）和0．02（TT），中国汉族、壮族、布依族，水族及苗族群体间无显著性差异。中国人群-857T等位基因频率为0．116，与文献报道的韩国人群相同，但比日本人群低。【结论】中国人群TNF-α基因启动子区单核苷酸多态性可能较保守。采用Taqman MGB探针实时定量PCR技术对SNPs进行基因分型简便、快速及准确，易于自动化，为大规模的疾病相关性研究提供了有效的工具

癌症患者的心身状况及心理干预

【: 目的】研究癌症患者的心身状况及心理干预对心身状况的影响。【方法】采用症状自评量表( SCL- 90) 、焦虑自评量表( SAS) 、抑郁自评量表( SDS) 评定癌症组(72 例)、肝炎对照组(30 例)及健康对照组(30 例)的 心身状况, 并随机将72 例癌症患者分为两组, 干预组(40 例)接受生物学治疗及心理干预, 对照组(30 例)只接 受生物学治疗, 治疗后用上述量表再评定一次。【结果】癌症组的SAS 标准分、SDS 抑郁指数及各项抑郁特异症 状评分、SCL-90 总分、阳性均分、躯体化、抑郁、焦虑因子分高于肝炎组和健康组( P< 0.01) ; 干预组SAS 标准 分、SDS 指数、SCL-90 总分、躯体化、抑郁、焦虑及敌对因子分干预后评定显著低于干预前( P< 0.01) , SAS 标准 分、SDS 指数、SCL-90 抑郁因子的减分值显著高于对照组( P< 0.01) 。【结论】癌症患者有明显的焦虑抑郁症状, 心身状况较差; 心理干预能有效改善癌症患者的焦虑抑郁情绪, 减轻心理症状

Experimental study on effect of Changrun Formula in regulating expression of AQP3 and AQP9 in colon mucosa of functional constipation rats

目的:观察肠润方对功能性便秘模型大鼠结肠黏膜AQP3、AQP9表达的影响,探究其调控AQP3、AQP9表达的分子机制。方法:60只SD大鼠随机分为空白组、模型组、阳性对照组(麻仁丸组)、肠润方组、肠润方联合P38MAPK抑制剂SB203580组。用复方地芬诺酯制造大鼠便秘模型,采用免疫组织化学及实时荧光定量PCR(q RT-PCR)检测大鼠便秘模型近端及远端结肠黏膜AQP3、AQP9的表达;Western Blot检测信号传导通路相关分子P38MAPK及P-P38MAPK的表达。结果:造模成功后,模型组近端结肠黏膜AQP3表达较空白组明显上升,而远端结肠黏膜AQP9表达较空白组明显下降(t值分别为3.148和7.069,P值均0.05)。肠润方联合P38MAPK抑制剂SB203580治疗后,近端结肠黏膜AQP3 m RNA水平显著上升(t=5.922,P0.05). The level of AQP3 m RNA in proximal colonic mucosa was significantly increased(t=5.922, P<0.01), and AQP9 m RNA was significantly decreased in distal colonic mucosa(t=4.038, P<0.01); The relative expression of P-P38/P38 protein was significantly decreased(t=19.419, P<0.01). Conclusion: The therapeutic action ofChangrun Formula on functional constipation rat models might through inhibiting the expression of AQP3 in proximal colon, and accelerating on expression of AQP9 in distal colon, and the regulating mechanism might relate with the inhibition on P38 MAPK and AKT phosphorylation.福建省自然科学基金项目(No.2012D043)~

Intratumoral Chemotherapy with an Implantable Collagen Film Impregnated with Epirubicin-loaded Polylactic Acid Microspheres Inhibits Tumor Growth in Hepatocellular Carcinoma Xenografts

[中文文摘]制备用于实体肿瘤局部治疗的植入型表阿霉素缓释药膜。采用复乳-溶剂挥发法制备聚乳酸载表阿霉素缓释微球,用交联复合法制备含载药微球的植入型胶原药膜;用扫描、透射电镜、共聚焦及粒度仪等考察微球和药膜的形貌、结构、粒径及体外释放;用H22肝癌荷瘤动物模型评价其体内抑瘤效果。结果:载药微球粒径分布均匀,外观圆整,平均粒径为5.81μm;微球的载药量4.39%,包裹率为37.2%;10h内载药微球在模拟体液中的累积释放率为35%;腹腔注射载药微球与瘤体局部植入胶原药膜对H22肝癌均有明显的抑瘤效果;微球注射与药膜植入两种不同给药方式对H22肝癌抑瘤效果也存在显著性差异(P<0.05)。植入型载表阿霉素缓释胶原膜具有良好的药物局部缓释特性,在肿瘤的术后局部治疗方面具有良好的临床应用前景。[英文文摘]Drug-releasing implants delivering chemotherapeutic agents can provide promising local therapy to patients with malignant disorders.The purpose of the present study was to develop implantable collagen film impregnated with epirubicin-loaded polylactic acid(PLA) microspheres(EPI-PM) for intratumoral administration in solid tumors.EPI-PM was prepared by double emulsion-solvent evaporation method,and the microspheres were further incorporated in biodegradable chemically cross-linked collagen to formulate implantable collagen film. The microspheres were characterized by scanning electron microscope , transmission electron microscope and laser confocus microscopy. In vitro release of epirubicin was examined by ultraviolet spectrophotometry. Transplantable murine hepatoma 22 (H22) model was used to evaluate the effects of EPI-PMor collagen film impregnated with EPI-PMon murine liver cancer.The results indicated that the epirubicin was well incorporated and dispersed homogeneously in PLA. The EPI-PM was uniformly spherical with average diameter of 5181μm, drug loading of 4139% , and embedding ratio of 3712%. The cumulative drug release rate of EPI2PM was 35 % in analog body fluid at the 10h. The tumor growth rate was significantly inhibited by intraperitonal injection of EPI2PMor intratumoral implantation of collagen film impregnated.国家重大科学研究计划项目(2006CB933300); 福建省自然科学基金(C0610045); 厦门市科技计划项目(3502Z20055007); 厦门市科技创新资金项目(3502Z20041029)

Tannin Content of Different Casuarina Species and Its Distribution Law

探讨了几种木麻黄单宁含量与种类、年龄、部位、生态环境的关系。结果表明:8种木麻黄小枝总多酚含量排序为:细枝木麻黄(CASuArInA CunnIngHAMInA)>山地木麻黄(C.JungHuHnIAnA)>山神木麻黄(C.COllIA)>短枝木麻黄(C.EQuISETIfOlIA)>鸡冠木麻黄(C.CrISTATA)>粗枝木麻黄(C.glAuCA)>肥木木麻黄(C.ObESA)>滨海木麻黄(AllOCASuArI-nA lITTOrAlIS);不同年龄木麻黄小枝总多酚含量随着年龄的增加而增大。短枝木麻黄和细枝木麻黄总多酚、可溶性单宁、蛋白质结合缩合单宁以及纤维素结合缩合单宁含量大体上以细根>树皮>小枝。随着离海岸带距离的增加,木麻黄小枝总多酚含量降低。木麻黄小枝蛋白质结合态缩合单宁含量非常低,而纤维素结合态缩合单宁含量较高,这可能与木麻黄鳞片叶退化为小枝,纤维素含量高有关。Tannin contents of different Casuarina species and tannin distribution rules of species,ages,position and ecological environment were studied.The results showed that the total phenol of branchlet of Casuarina was under the order as follows:Casuarina cunninghamina>C.junghuhniana>C.collia>C.equisetifolia>C.cristata>C.glauca>C.obesa>Allocasuarina littoralis.The total phenol contents of branchlets of different years old of Casuarina increased with ages.The total phenol,solubility tannins,protein binding condensing tannins,fibrin binding condensing tannins contents of short and thin Casuarina branchlets were under the following order wholly:thin root>bark>branchlet.With the increasing of the distance from coastal belt,the total phenol of branchlet declined.The protein binding condensing tannin of Casuarina branchlet was very low,whereas fibrin binding condenseing tannins content was highest.The reason could be the high fibrin content after Casuarina scale leaf degenerated to branchlet国家“十一五”科技支撑计划(2006BAD01A1605);福建省林业厅科研项目“木麻黄单宁生化活性与提取利用技术研究”资

结肠镜对急性不全肠梗阻的诊断及治疗作用探讨

目的　探讨结肠镜在急性不全肠梗阻患者中的诊断与治疗作用。方法　对我院 1994年 5月～ 2 0 0 3年 4月共 5 933例肠镜检查中的 12 2例 (占 2 .0 6 % )急性不全肠梗阻患者进行回顾性分析 ,就其发病年龄分布、梗阻病因及内镜下诊断进行分析探讨。结果　本组 12 2例急性不全肠梗阻的原因包括肠癌、息肉、粪块、炎症性肠病等多种 ,其中结直肠癌共 5 0例 ,发病率最高 ,占 4 0 .98% ,且以左半结肠癌为主。肠粪石梗阻在高龄患者中发病率仅次于结肠癌。全部患者的肠镜检查结果中无假阴性或假阳性。同时结肠镜可解除非肿瘤病变如粪石、肠粘连等所致的肠梗阻。结论　结肠镜检查对急性不全肠梗阻有重要的诊断价值并可对治疗起积极指导作用