A Study on the Supervision Process of Fujian Marine Safety Administration about Seafarer’s Training

近五年来，福建海事局辖区船员培训产业蓬勃发展，各类船员培训机构无论在培训项目和培训规模方面都得到迅速发展，与此同时，为保证船员培训教育产业“又快又好”发展，向社会输送素质高，数量多的合格船员，福建海事局不断加大船员培训的监督管理力度，将船员培训机构培训资质现场核验、船员培训开班报备审批、船员培训日常监督检查、船员考试评估监督管理、船员证件制作与发放等五项工作作为船员培训监管的核心活动，并分别按照各自的业务流程加以实施。自上述五项核心监管活动开展以来，无论是海事部门，还是船员培训机构都增加了繁重的工作，但是并没有取得预期的效果，船员培训产业中滋生了许多问题。 为此，本文对福建海事局船员培训运作...In recently five years, seafarer’s training industry got vigorously developed in the area under Fujian Maritime Safety Administration’s control, which expressed in training programs and training scale aspects. Meanwhile, in order to output more qualified seafarers, Fujian Maritime Safety Administration took the training qualification checking, training activity opening approval, training activity ...学位：工商管理硕士院系专业：管理学院工商管理教育中心（MBA中心）_工商管理硕士(MBA)学号：1792008115120

Facile Synthesis of 2H-Pyrroles: Combination of Gold Catalysis and Lewis Acid Catalysis

报道了利用金催化与铜催化相结合合成5-氨基-2H-吡咯的方法.首先通过均相金催化异恶唑与炔酰胺反应生成α-亚胺金卡宾中间体,再经[3+2]环加成反应合成并分离出5-氨基-3H-吡咯,然后通过铜催化的去酰基化和基团迁移反应来实现3H-吡咯向2H-吡咯的转化.该方法不但操作简单、反应条件温和、官能团兼容性良好,而且还能进行克量级放大.这项研究为合成具有重要生物活性的5-氨基-2H-吡咯化合物提供了广谱实用的合成方法.A two-step synthesis of 5-amino 2H-pyrroles using gold and copper catalysis was presented. Firstly, 5-amino 3H-pyrroles were synthesized by gold-catalyzed formal [3+2] cycloaddition between ynamides and isoxazoles via α-imino gold carbene intermediate. The following Lewis acid-triggered decarbonylation and group migration results in the formation of 5-amino 2H-pyrroles. Other notable features of this method include the simple procedure, the mild reaction conditions and compatibility with a broad range of functional groups. Thus, this protocol provides a practical and general solution for the synthesis of 5-amino 2H-pyrroles. Accordingly, isoxazole 2(2.0 equiv., 0.6 mmol) and Ph3 PAu NTf2(5 mol%) were added to a suspension of the ynamide 1(1.0 equiv., 0.3 mmol) in DCM(3.0 m L) at room temperature. The reaction mixture was then stirred at r.t. and the progress of the reaction was monitored by TLC. The reaction typically took 2 h. Upon completion, the mixture was quenched with pyridine, concentrated and purified by chromatography on silica gel, using an eluent of petroleum ether/ethyl acetate(5/1, V/V), to afford 3H-pyrrole 3. Then, 3H-pyrrole 3 and Cu(OTf)2(10 mol%) were dissolved in DCM(3 m L) and stirred at room temperature for 6 h. The residue was purified by column chromatography on silica gel, using an eluent of petroleum ether/ethyl acetate(3/1, V/V), to afford the desired 2H-pyrrole 4. Under this condition, a variety of differently substituted ynamides 1 and isoxazoles 2 work well to provide the corresponding 2H-pyrroles 4a~4l in moderate to good overall yields. But N-(4-methoxybenzyl)-N-(phenylethynyl)methanesulfonamide 1a reacts with 4-(3-bromophenyl)-3,5-dimethylisoxazole 2d poorly under this condition, affording product 4h in only 33% yield. These results indicate that this method has certain universality, but the reaction is influenced by the substituents to some extent. Notably, the scalability and preparative utility of the developed methodology was exemplified by the fact that the desired product 4a was obtained without a significant loss in yield when the reaction was scaled up to 5 mmol. Also a plausible mechanism is proposed and we tend to believe that the reaction is featured by an α-imino gold carbene intermediate.国家自然科学基金(No.21272191);; 福建省杰出青年科学基金(No.2015J06003);; 国家基础科学人才培养基金(No.J1310024)资助~

审美的现代探索历程与精神反思——读《现代西方审美主义思潮与文学》

顾梅珑新著《现代西方审美主义思潮与文学》紧扣审美主义思潮与社会文化的关系,从宏观和微观两个层面细致梳理了它充满矛盾与悖论的发展轨迹,在全面把握审美主义特质的基础上,多方面探索了审美现代性对启蒙现代性的纠偏作用以及它在文学层面的种种表现。专著贯穿着强烈的问题意识,浸润于文学个案分析、审美主义本身的困境阐释,在对时代背景和社会现实的观照中,不仅展示出审美思潮文学中的表现,还为现实人生提供了建构性参考。著者将严谨的学术思考与深厚的人文情怀密切结合,在对审美主义思潮的探索与展望中为现代人的审美困境寻找出路,体现出当代优秀学者的社会责任感和使命感

Efficient and Practical Synthesis of α-Amino Amides through Gold-Catalyzed Intermolecular Oxidation of Ynamides

α-氨基酰胺作为一类重要的羰基化合物广泛存在于众多天然的和非天然的生物活性分子之中.本工作实现了芳胺nH对在水相体系中通过金催化的分子间氧化炔烃途径产生的α-羰基金卡宾的插入反应.这种通过非重氮方式产生α-羰基金属卡宾的策略为有效合成多种官能团化的α-氨基酰胺化合物提供了一种通用且实用的方法.α-Amino amides constitute an important category of carbonyl compounds which exist in a large number of bioactive natural and non natural molecules.In this paper, an efficient intermolecular reaction of gold carbene intermediates, generated through gold-catalyzed intermolecular oxidation of alkynes, with primary anilines has been realized in aqueous media.Importantly, this non-diazo approach provides a general and practical solution for the synthesis of various functionalized α-amino amides.国家自然科学基金(Nos.21102119;21272191); 教育部创新团队资助项目~

锌介导的炔酰胺串联氧化/卤化反应合成α-卤代酰胺

α-卤代酰胺是一类十分重要的羰基化合物,广泛存在于众多天然产物和生物活性分子之中.本工作实现了通过卤化锌同时作为催化剂和卤素源的炔酰胺串联氧化/卤化反应,从而避免使用其他的外加卤化试剂.该反应可以中等到良好的产率得到一系列合成上非常有用的α-卤代酰胺化合物

Gold-catalyzed efficient synthesis of azepan-4-ones via a two-step [5+2] annulation

A surprisingly efficient synthesis of azepan-4-ones via a two-step [5 + 2] annulation is developed. This reaction involves a key gold catalysis and shows generally high regioselectivities and good to excellent diastereoselectivities

Credit risk assessment of enterprise basing on neural network

企业信用等级评估是金融领域重要的问题 ,论文采用人工神经网络模型研究企业信用等级的评估问题 .按照企业样本在信用等级的分布状况来抽样 ,然后 ,根据企业样本性质的不同 ,将其分为制造业和非制造业两大类 .利用偏相关分析方法建立了企业信用评级的指标体系 .此外 ,还介绍了几种企业信用评级常用的评估模型 ,并将神经网络评估模型的性能和其他的信用评估模型作了比较 ,实验结果表明神经网络模型具有更好的预测准确性Credit rating of the enterprise is very important problem in the financial field. In this article, we researched this problem using artificial neural network model. We got the samples basing on the distribution of credit rating of the all samples. And then, we divided the samples of the enterprises into two sets, one is manufacture and the other is non manufacture, we also developed an indicators′ system using partial correlation method. Furthermore, we introduced many credit assessment models in common use and compared the result of our model with that of some of them. The result from the experiment shows that our model is more applicable and suitable

Palladium-catalyzed highly regio- and stereoselective addition of organoboronic acids to allenes in the presence of AcOH

The Pd-0-catalyzed regio- and stereoselective addition of organoboronic acids to allenes leads to stereodefined tri- or tetrasubstituted alkenes. Furthermore, this method shows high substitutent-loading capability and tolerance of various substitutents. A hydropalladation-Suzuki coupling mechanism, which may account for the regio- and stereoselectivity, is proposed

Research on the Clinical Pathway PDCA Continuous Improvement System Based on the Theory of Feedback Closed-loop Control System

运用控制论方法，将控制理论领域反馈的闭环控制法、管理学的PDCA循环等方法运用于信息系统的整合建设，建立电子病历一电子医嘱一临床路径一医院管理信息系统的“全闭环”临床路径执行和反馈体系，建立了疾病诊疗规范制定、临床操作服务、过程质量监管三位一体的医疗服务安全质量监测与持续改进闭环体系，临床路径信息管理平台对加强医疗服务安全动态监管，促进科学化、精细化、专业化管理，改善服务水平，提高效率具有不可或缺的重要作用。With the method of control theory, the feedback closed loop control method in the field of control theory, PDCA circulation of management and other methods are applied to the integrative construction of information system. The ＂closed loop＂ clinical pathway implementation and feedback system of electronic medical records-electronic medical advice-clinical pathway- hospital management information system is established. The medical service safety quality monitoring and continuous improvement closed-loop system integrating disease diagnosis and treatment specification formulation, clinical operation service and process quality supervision is set up. The clinical path information management platform has an indispensable important role on strengthening the dynamic supervision of medical service security, promoting scientific, refined and professional management, and improving the service level and eficiency.国家自然科学基金面上项目一大数据驱动的抗菌药物使用与管理决策优化研究（编号：71672160