Study on Solid-State Polycondensation and Properties of Poly(Lactic Acid-co-Glycolic Acid)

聚乳酸乙醇酸（PLGA）是一类重要的生物可降解材料。PLGA的制备方法主要有开环聚合法和直接熔融缩聚法两种。但是，开环聚合法条件苛刻，且所用的锡类催化剂具有细胞毒性。因此，使用低毒催化剂或在无催化剂条件下，直接熔融聚合制备生物医学工程材料要求的PLGA是目前研究的热点。 本文以乳酸(LA)、乙醇酸(GA)为原料，在无催化剂的条件下熔融聚合合成聚乳酸乙醇酸（PLGA）低聚物，采用红外、核磁共振、XRD、DSC、特性黏数等对产物进行表征，探讨聚合条件、单体投料比对聚合物分子量和结晶性能的影响。结果表明，在150℃下，反应20h后，PLGA的粘均分子量为2.82×104；在160℃下继续反应36...Poly (lactic acid-co-glycolic acid) (PLGA) is one of the most important biodegradable polyester materials. PLGA is mainly synthesized through two ways, ring-opening polymerization and direct melt polymerization. But the application of ring-opening polymerization is limited due to harsh conditions and the use of tin catalysts which show cell toxicity. Therefore, it is a hotspot that research on syn...学位：工学硕士院系专业：材料学院_材料物理与化学学号：2072010115007

金属烤瓷全冠修复中排龈术对牙周健康的影响

【目的】研究前牙金属烤瓷全冠修复后, 牙龈、牙周组织的变化以及排龈术应用对它们的影响。【方法】追踪观察 1994～ 1995 年间排龈组与不排龈组金属烤瓷全冠修复的患牙的牙龈、牙周组织状况, 进行资料的统计分析。【结果】金属烤 瓷修复后牙周组织的主要变化为:颈缘变色、慢性单纯性牙龈炎和牙周炎。排龈组与不排龈组的牙周疾病发生率有显著性差 异, 排龈组明显少于未排龈组。【结论】前牙金属烤瓷全冠修复时排龈技术的应用对修复后牙周组织有影响, 合理、正确地使 用排龈材料和技术可有效地预防牙周组织疾病的发生

Investigation on The Circadian Action Factor of RGB White LEDs

采用司辰节律因子模型,通过计算三基色白光LED光源在不同工作电流下的司辰节律因子,对可调色温的三基色白光LED光源进行非视觉效应研究。为了获取与自然光非视觉效应类似的LED白光,建立了司辰节律因子和相关色温分别相对于工作电流的关系模型,从而已知自然光的司辰节律因子和相关色温,就可以确定三基色LED的工作电流。通过测试一天内不同时刻的自然光光谱,根据上述模型推算出了三基色LED的工作电流。在所推算的三基色电流下,测试了白光LED光谱参数并计算了相应的司辰节律因子。与自然光司辰节律因子的对比结果表明,理论值和实验值的误差在1.1%以内,证实该方法具有可行性。本文所呈现的方法对于利用三基色白光LED模拟自然光具有一定的指导意义。The circadian action factor( CAF) model was adopted to study the non-visual biological effects for the three-primary color-tunable white LEDs by calculating CAFs at various driving currents. In order to obtain the white light similar to the natural light according to non-visual biological effects,the models of CAF versus current and CCT versus current were generated. Therefore,the driving currents of three-primary LEDs could be determined after the CAF and the CCT of the natural light were known. Based on aforementioned models,and after the natural light at different times in a day was tested,the driving currents of three-primary LEDs were deduced. Then,driven by these currents,white LEDs were tested and their CAFs were calculated. A comparison between calculated values and experimental counterparts shows that the difference lies within 1. 1%,suggesting the feasibility of this approach. This work appears meaningful for mimicking the natural light by using three-primary white LEDs.科技部国际合作项目(2015DFG62190);; 国家自然科学基金(61504112);; 福建省产学合作重大专项(2013H6024);; 福建省自然科学基金(2016R0091);; 科技部港澳台科技合作专项(2015DFT10120)资助项

结核分枝杆菌相关γ-干扰素体外释放试验在结核病诊断中的应用价值

目的探讨结核分枝杆菌相关γ-干扰素体外释放试验(Tb-IgrA)在结核病诊断中的应用价值。方法用国产Tb-IgrA试剂定量检测268例结核病患者和104例体检健康者外周血结核特异性γ-干扰素的含量,同时与澳大利亚QfT-gIT试剂和结核菌素纯化蛋白质衍生物(PPd)皮试进行平行比较分析。结果国产Tb-IgrA试剂、QfT-gIT试剂和PPd皮试3种方法的敏感性分别为90.7%、88.1%和75.4%,特异性分别为76.9%、80.8%和54.8%,阳性预测值分别为91.0%、92.2%和81.1%,阴性预测值分别为76.2%、72.4%和46.3%,准确性分别为86.8%、86.0%和69.6%。三种方法对肺结核与肺外结核的检测效果无显著差异。结论 Tb-IgrA法对诊断结核病有较高的敏感性和准确性,在结核病防控中有较好的应用价值。国家十一五“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项资助项目(2008ZX10003-004

紫杉醇简化预处理方案治疗晚期恶性肿瘤18例次临床报告

目的　为了简化紫杉醇静脉化疗预处理方案 ,提高工作效率。方法　化疗方案 :18例次均采用紫杉醇+顺铂方案 ;紫杉醇预处理方案 :于应用紫杉醇前 30分钟给予地塞米松 2 0 m g静脉点滴 ,同时给予西米替丁 30 0 mg静脉推注 ,苯海拉明 5 0 mg肌肉注射。结果　 1例膀胱浸润性移行细胞癌达到 CR,2例肺鳞状细胞癌达到 PR,1例肺腺癌 PD,1例鼻咽低分化鳞癌 PD,2例乳腺癌 PD;1例乳腺癌患者是术后辅助化疗 ,不能评价疗效。毒副反应 :(1)骨髓抑制 : 度 2例次 , 度 1例次 ,发生率 16 %。 (2 )脱发 :有 16例次出现 ,发生率 89%。 (3)关节和肌肉酸痛 :有2例次发生 ,发生率 11%。 (4)周围神经病变 :2例次出现肢端麻木。全组未出现 1例过敏反应。结论　建议在给予紫杉醇静脉化疗时 ,从第三周期起常规采用简化预处理方案 ,这样可简化患者服药次数 ,简化工作程序 ,提高工作效

奥沙利铂/亚叶酸/氟尿嘧啶双周静脉给药(mFOLFOX6方案)治疗晚期胃癌22例

目的探讨奥沙利铂、亚叶酸、氟尿嘧啶双周静脉给药(mFOLFOX6方案)治疗晚期胃癌的疗效和毒性。方法22例具有可测量病灶的胃腺癌患者纳入本研究。患者接受奥沙利铂85 mg/m2(2 h静脉滴注),亚叶酸350 mg(2 h静脉滴注),氟尿嘧啶0.4 g/m2(2~4 min静脉推注)、氟尿嘧啶2.4 g/m2(46 h持续静脉滴注),每2周重复,6周为1个疗程。结果22例中有20例可评估疗效,所有患者均可评估毒性。病人每6周评估疗效。在20例可评估疗效的病例中,部分缓解7例(35.0%),稳定8例(40.0%),疾病进展5例(25.0%)。中位进展时间5.0个月,中位生存时间9.6个月。3、4级中性粒细胞减少3例(13.6%),发热性粒细胞减少1例(4.5%);3、4级贫血1例(4.5%);3、4级腹泻2例(9.1%);3、4级口腔黏膜炎2例(9.1%);1、2级外周神经损害9例(40.9%)。无治疗相关死亡。结论奥沙利铂、亚叶酸、氟尿嘧啶双周方案治疗晚期胃癌在客观有效率、中位疾病进展时间、中位生存期等方面与其他联合化疗方案相近,不良反应显著减轻

Effects of systemic and interventional chemotherapy with CPT-11 + xeloda for the liver metastasis from colorectal carcinoma

目的:评价开普拓+希罗达方案(XELILI方案)介入及全身化疗治疗大肠癌肝转移的疗效及毒副作用。方法:病理确诊的大肠癌患者50例,其中45例为根治术后FOLFOX4方案化疗后出现肝转移,5例为初治者。术前常规检查除外治疗禁忌症并CT扫描测量肝转移灶大小,予以开普拓+希罗达方案介入栓塞化疗序贯全身化疗,开普拓用量:180mg/m2,碘化油10ml～20ml,希罗达2000mg/m2,分两次口服,连服14天,休息7天,21天一周期。2周期后复查血常规、肝肾功能、腹部CT,判断疗效及是否进一步介入治疗,若肝转移灶及原发灶CR,继续静脉点滴开普拓,口服希罗达化疗至6个周期;PR者经皮肝穿瘤内注射盐酸;PD者改含贝伐单抗方案化疗。结果:CR8例,PR25例,SD10例,PD7例,总有效率为66%(34/50),主要毒副反应为栓塞后综合征、急性胆碱能综合症及骨髓抑制,5例出现轻中度肝功能损害,4例迟发性腹泻。随访3年,疾病进展时间为7个月,中位生存期为25个月。结论:开普拓+希罗达方案介入结合全身治疗大肠癌肝转移是安全、有效的,但两者配合的标准方案尚待研究。 【英文摘要】 Objective:To evaluate the therapeutic effects of systemic and interventional chemotherapy with CPT-11 +xeloda(XELILI regimen) for the liver metastasis from colorectal carcinoma.Methods:Among the 50 cases with pathologically diagnosed colorectal carcinoma,there were 45 cases found liver metastasis after curative surgical operation tveating with FOLFOX4 chemotherapy regimen treatment,and 5 cases undergone no prior chemotherapy.All patients were treated with XELILI regimen by intravenous injection and transhep..

不完全性脊髓损伤患者主要照顾者负性情绪与创伤后成长的纵向研究

目的探讨不完全性脊髓损伤患者主要照顾者在其治疗不同时期负性情绪与创伤后成长的纵向变化及二者之间的关系。方法以不完全性脊髓损伤患者主要照顾者76例作为研究对象,采用心境和焦虑症状问卷、创伤后成长量表在术前、术后进行问卷调查。结果心境和焦虑症状总分术后三个月(50.34±3.46)与术前(57.23±9.06)、术后一周(56.89±9.03)相比有显著差异,术后一个月心境和焦虑症状总分(52.30±9.05)与术后一周(56.89±9.03)相比有显著差异,差异有统计学意义(P<0.05);术后三个月创伤后成长总分(62.43±11.03)与术前(56.72±12.75)、术后一周(58.71±14.63)相比有显著差异,术后一个月创伤后成长总分(60.12±14.48)与术后一周(58.71±14.63)相比有显著差异,差异有统计学意义(P<0.05)。结论负性情绪各维度与创伤后成长相关。负性情绪各维度与创伤后成长总分、新的可能性、个人力量、自我转变相关

Light Distribution Design and Simulation of LED for High Uniformity Illumination of Desk Lamp

针对台灯照明的高均匀性要求,设计一个自由曲面透镜对lEd光源进行二次光学配光。根据非成像光学理论,在已知入射光强分布与所需配光效果的前提下,建立关于透镜自由曲面面型的偏微分方程,并采用相应的数值解法,得到自由曲面面型数据。通过在建模软件rHInOCErOS中建立光学透镜的模型,并在TrACEPrO中进行光学仿真,得出仿真结果,验证此设计方法的可行性。According to high uniformity requirements of desk lamp lighting, a free curved surface lens is de-signed to perform the secondary light distribution of light emitting diode(LED) light source.Based on the theory ofnon-imaging optics, at the condition of known incident light intensity distribution and required light distribution effect,partial differential equations related to the shape of free curved surface are established.And corresponding numericalvalue algorithm is adopted to obtain the data of the shape of free curved surface.The models of optical lens are builtthrough simulation software Rhinoceros.And optical simulation is performed in Tracepro.The simulation results areobtained to verify the feasibility of the design method.福建省重大科技项目资助(2006H0092

LED Lighting Design of Underground Parking Lots Based on DILAUX

目前由于汽车的广泛普及,对城市的地下车库照明提出了更多的要求,但随着新一代照明光源lEd照明技术进一步的发展与完善,使得地下车库照明有了更节能、更环保、更经济的可能。在dIlAuX中建模57x33.3M2的中型地下车库,并利用dIlAuX计算软件对地下车库的lEd照明进行模拟、计算、优化,不断的调整灯具位置以及灯具间隔来到达最佳的照明效果,通过实景分析来探讨lEd在地下车库照明领域应用的可行性及其应用前景,并为地下车库照明提供一种设计上的借鉴。More requirements for the light system of civil underground parking lot lighting are concerned since cars are wildly-used nowadays.And it becomes possible to make the light system of underground parking lot more energy-saving,more environmental friendly and more economic as the new generation of LED technology gets more and more developed and improved.DILAUX is a kind of lighting calculation software,and it is used to model an underground parking lot with a medium 57 × 33.3m2and some simulations,calculations,and optimization on the LED light of the parking lot are also done by DILAUX.Therefore,constantly adjust locations and intervals of the lighting fixtures to achieve the optimal results.Furthermore,the feasibilities and application prospects of LED lighting applications in the underground parking lot field can also be explored through the real analysis.Overall,it shows an example to design the light system for civil underground parking lots.国家自然科学基金(61301009); 福建省重大科技项目资助(2006H0092); 福建省自然科学基金计划资助项目(2013J01252