便携拉曼检测集成装置与芯片式卡盒相结合用于食品添加剂的快速检测

针对食品安全体系拉曼光谱检测的自动化前处理问题,研制了一台便携拉曼检测集成装置,能与芯片式卡盒相结合以实现食品添加剂的前处理及检测。集成装置主要包括触控屏、控制板、通讯模块、蠕动泵及小型拉曼光谱仪。蠕动泵对芯片式卡盒所需的溶剂进行程序驱动,自动完成检测前的前处理工作;小型拉曼光谱仪对前处理收集液进行检测;控制板对蠕动泵及拉曼光谱仪的参数进行设定监控;通讯模块则可把检测数据传输到WIFI设备或云数据中心,并接受指令。将集成装置应用于糖果中食用色素的检测,结果表明日落黄与柠檬黄的检测限均可达到10 mg/L。该装置体积小、检测过程快,适合用于食品安全体系的现场快速检测。国家自然科学基金(NO.U1505243);;福建省自然科学基金(NO.2015J01064);;福建省高校青年自然基金重点项目(NO.JZ160404);;国家重大科学仪器设备开发专项(2011YQ030124)资

SUMS99方案治疗儿童急性淋巴细胞白血病的长期疗效

【目的】回顾和探讨56例儿童急性淋巴细胞白血病（acute lymphoblastic leukemia,ALL）分型治疗的疗效和预后因素。【方法】回顾分析1999～2002年收治的56例儿童ALL,按中山医科大学99（SUMS99）方案的分型标准,标危型ALL（standard risk-ALL,SR-ALL）33例,中危型（middle risk-ALL,IR-ALL）12例,高危型ALL（high risk-ALL,HR-ALL）11例;所有患者按SUMS99方案进行治疗。【结果】56例患者4周内完全缓解（complete remission,CR）率SR-ALL组和IR-ALL为100%,而HR-ALL组为72.73%（8/11）,6周才CR者3例。SR-ALL组早期缓解时间为（17.1±6.4）d,IR-ALL组早期缓解时间为（24.5±5.6）d,HR-ALL组早期缓解时间为（29.9±6.3）d。本组共死亡13例,死亡率为23.0%,其中死于骨髓复发者9例,死于感染者4例。本组目前无病存活共43例,其中SR-ALL组为90.9%（30/33）,IR-ALL组为83.3%（10/12）,HR-AL组为27.3%（3/11）.SR- ALL组平均生存时间为75．2个月，IR—ALL组平均生存时间为56．8个月，HR-ALL组平均生存时间为25．3个月。2例HR一ALL患者进行组织相容性抗原全相合外周血干细胞移植，目前均无病存活。【结论】分型治疗儿童急性淋巴细胞白血病是达到高生存率和改善生存质量的重要手段，但本方案仍然未能解决HR-ALL的疗效，选择合适供者进行异基因造血干细胞移植可能是今后改善HR-ALL预后的方向

类泛素蛋白及其中文命名

泛素家族包括泛素及类泛素蛋白,约20种成员蛋白.近年来,泛素家族领域取得了迅猛发展,并已与生物学及医学研究的各个领域相互交叉.泛素家族介导的蛋白质降解和细胞自噬机制的发现分别于2004和2016年获得诺贝尔奖.但是,类泛素蛋白并没有统一规范的中文译名. 2018年4月9日在苏州召开的《泛素家族介导的蛋白质降解和细胞自噬》专著的编委会上,部分作者讨论了类泛素蛋白的中文命名问题,并在随后的\"泛素家族、自噬与疾病\"(Ubiquitinfamily,autophagy anddiseases)苏州会议上提出了类泛素蛋白中文翻译草案,此草案在参加该会议的国内学者及海外华人学者间取得了高度共识.冷泉港亚洲\"泛素家族、自噬与疾病\"苏州会议是由美国冷泉港实验室主办、两年一度、面向全球的英文会议.该会议在海内外华人学者中具有广泛影响,因此,参会华人学者的意见具有一定的代表性.本文介绍了10个类别的类泛素蛋白的中文命名,系统总结了它们的结构特点,并比较了参与各种类泛素化修饰的酶和它们的生物学功能.文章由45名从事该领域研究的专家合作撰写,其中包括中国工程院院士1名,相关学者4名,长江学者3名,国家杰出青年科学基金获得者18名和美国知名高校华人教授4名.他们绝大多数是参加编写即将由科学出版社出版的专著《泛素家族介导的蛋白质降解和细胞自噬》的专家

不同阻力訓練方式與混合運動型態對於衰弱高齡者日常功能能力影響之文獻回顧

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The Sino- Lao Transnational ethnic groups and the inter- ethnic relations among them

文章论述并分析了老挝民族识别与划分的理论和实践。通过对中老两国不同的民族识别和划分标准进行对比, 认为中老跨国民族或族群若按中国的划分标准为11 个, 若按老挝的标准为16个。根据作者的识别和划分, 文章进一步论述了中老跨国民族的历史和现实族群关系。最后, 作者还就中老跨国民族及其族群关系的相关理论和实践问题进行了论述

An Exploratory Study on the Analysis of Building Intercom Industry and the Incumbent Responses to IP-based Products

室內對講機存在於每戶家庭中，扮演著不可或缺的角色。然而，不具備絢麗 外表、時尚科技應用的室內對講機，造成我們對他的忽視。近年來智慧居家服務平台的推出，導致室內對講機開始有了前所未有的改變。新一代的IP室內對講機結合了居家控制、網路應用服務與對講功能，讓家庭住戶可透過室內對講機進行燈光、音樂、瓦斯、窗簾等情境控制，而IP對講機也成為與網路世界的連結點，可透過這窗口使用相關網路應用服務，如：進行遠距醫療、獲取相關生活資訊等等。隨著科技進步所帶來的轉變，使得相關企業的聚光燈又再度聚焦在對講機身上。 本研究將透過質性研究方法，探討現階段台灣對講機產業的結構變化。由於國內在室內對講機產業的相關研究不多，本研究主要透過新聞、安防雜誌…等管道蒐集次集資料，並輔以對傳統對講機廠商的訪問，加深本研究的深度，並維持資料來源的客觀性。 本研究發現，傳統對講機產業的既有廠商對IP對講機的進入，因其本身核心事業與擁有的技術能力的不同，而有不同的認知與因應作為，而生產IP對講機所需要的技術能力，為原有對講機廠商進入IP對講機市場的主要障礙。透過本研究，可了解當對講機產業面臨轉型時，原有的領導廠商如何審視IP對講機的出現，IP對講機帶來的是危機還是轉機? 廠商是否要冒著對產品主導地位下降的風險與其他廠商進行策略聯盟發展IP對講機? 或是固有原有的核心事業並將IP對講機視作曇花一現的產品? 而新競爭者是如何憑藉本身所擁有的關鍵資源、技術進入對講機市場?Building intercom has been widely adopted by almost every household in Taiwan. Although this kind of product doesn’t have fashion design and astonished technology like iPhone, we still can’t live without it. However, the newly emerged IP-based home service platform has started to change the structure of building intercom industry. As a new generation of building intercom product, IP-based building intercom contains home automation, internet service, and intercom system, among others. Family use IP-based building intercom not only for communication purposes but also for controlling light, music, curtain, and even to set up different kinds of scenario to enjoy their life. And internet service provider can provide health care, traffic information…etc. via the IP-based building intercom. Overall, the IP-based building intercom seems re-energize the industry momentum. The purpose of the present study is to investigate the extent of industry change of the existing building intercom market and the tendency of responding to the new entry from the incumbents. As there are few research on the building intercom industry, we undertook qualitative research approach to this inquiry. We utilize secondary information from news and magazines of security industry and field interview to draw our inductive conclusions. Based on our research, we find that the differential responses of incumbents in the traditional building intercom industry are contingent upon the extent of their core businesses and technological capabilities. We conclude with the identification of entry and entry barriers as well as incumbent’s respond strategy. Is the IP-based building intercom an opportunity or crisis for the incumbents? Do the incumbents develop the IP-based building intercom at the risk of losing their dominant power or just focus on their core businesses? And how the entry break into the building intercom industry via their key resource and key technology

Comparison of 2 Interferon-Gamma Assays and Roche Cobas Amplicor Mycobacterium Tuberculosis Assay for Rapid Diagnosis of Tuberculosis among Patients with Suspected Tuberculosis in Taiwan

BACKGROUND AND PURPOSE: Two commercial interferon-gamma (IFN -gamma) assays, which are commonly used for diagnosing latent tuberculosis (TB), are also useful for diagnosis of active TB. In this study, the IFN-gamma assays and polymerase chain reaction (PCR) for diagnosis of TB were compared. METHODS: A prospective comparison of the performance of 2 commercial IFN-gamma assays - QuantiFERON- TB Gold (QFT-G) and T-SPOT.TB ( T SPOT) - and PCR using the Roche Cobas Amplicor Mycobacterium tuberculosis (RCA-TB) assay for the rapid diagnosis of TB was conducted from January 2007 to December 2007 at a university-affiliated hospital in Taiwan. RESULTS: Of 187 patients enrolled in the study, results from both T SPOT and QFT-G were available for 154, including 109 patients with active TB and 45 with no TB. The sensitivity of T SPOT (89.0%) was higher than that of QFT-G (71.4%). RCA-TB had the highest sensitivity ( 90.2%) and specificity (100%), but was usually performed in patients with positive acid-fast bacilli smear test. In patients with extrapulmonary TB, T SPOT had a high diagnostic value (sensitivity, 81.3%). A significant discordance between the 2 IFN-gamma assays was also noted. IFN-gamma assays provided a more rapid diagnosis for tuberculosis than the conventional culture method (mean +/- standard deviation, 8.23 +/- 12.86 days; p < 0.001). CONCLUSIONS: Use of IFN-gamma may shorten the time to diagnosis of TB, especially for smear-negative patients and those with extrapulmonary disease