The effect of CEND1 and its underlying mechanism in the pathogenesis of Alzheimer’s disease

阿尔茨海默病（Alzheimerdisease,AD）是一种以渐进性记忆力丧失和认知障碍为主要症状的神经退行性疾病，在此过程中会伴随神经元的大量死亡，该疾病严重影响人类健康。由于神经元的不可再生性，因此目前还没有有效的治愈AD的方法。因此研究AD致病过程中更早期的细胞紊乱变化，对于预防和干预神经元凋亡具有重要的意义。最近研究发现，AD病人大脑中分裂后期的神经元重新进入细胞周期，这些细胞周期重新激活的神经元并不能分裂而是开启了细胞凋亡的途径。我们称之为CellCycleRelatedNeuronalDeath(CRND)。而神经元细胞周期的紊乱是目前已知的关于AD最早期的细胞功能紊乱。研究了解在...Alzheimer disease (AD) is one kind of neurodegenerative diseases, which is characterized by memory loss, congenative disorder gradually and mass mortality of neurons during this process. This disease severly threats the human health. So far, AD can not be cured effectively because of the non-renewable of neurons. Therefore, the researches focusing on the change of earier cell disorders in AD patho...学位：理学硕士院系专业：药学院_化学生物学专业学号：3232011115329

Mechanism of Vesicle Formation of Surfactant

摘要 囊泡是由两个双亲分子定向单层尾对尾地结合成封闭单分子双层所构成的外壳，和壳内包藏的微水相构成。一般说来，具有大极性头基和双柔性链表面活性剂可以自发形成囊泡。由于大多数表面活性剂的分子都不具有这样的分子结构，为了要使一般表面活性剂能够自组装形成囊泡，则通常采用两种表面活性剂复配的方法，使两个头基结合在一起（如正、负离子头基相互吸引等）以满足自发形成囊泡的分子结构要求。目前大多数有关表面活性剂囊泡性质的研究都是采用两种表面活性剂复配的体系，并根据Israelachvili所提出的“聚集体临界堆积常数(P)公式”和透射电镜来研究囊泡体系的性质。而对于囊泡形成动力学以及囊泡形成的机理还研究...Abstract Vesicle is composed of crust which forms from closed unimolecule-bilayer that combined with monolayers of two amphiphilic molecules in tail-to-tail orientationally, and micro-hydrofacies that is contained within the crust. Generally speaking, the surfactant which has big polar head-group and two flexible chains can spontaneously form vesicles. Though most of surfactants don't have such m...学位：理学硕士院系专业：化学化工学院化学系_物理化学(含化学物理)学号：20042515

Kinetics of Vesicle Formation and Breakdown

利用停流装置研究了十二烷基硫酸钠(SDS)和十二烷基三甲基溴化铵(DTAB)复配形成囊泡的过程和囊泡破坏过程的动力学性质,并结合动态光散射技术和电子透射显微镜探索囊泡形成和囊泡破坏过程的机理.动态光散射和电子透射显微镜的研究结果表明囊泡的形成过程主要包括四个阶段:混合胶团→柔性的长棒状聚集体→"非平衡囊泡"→平衡囊泡,而与其对应的粒度分散度则呈现"单分散性→多分散性"的周期性变化规律.此外,动力学结果表明囊泡形成过程很长,但其活化能不大,这意味着囊泡形成过程的控制步骤可能不是活化能控制.而相对于囊泡的形成,囊泡的破坏过程是十分迅速的.A combination of stopped-flow,transmission electron microscopy and dynamic light-scattering techniques has been used to study the kinetics of vesicle formation and breakdown as well as the mechanism of vesicle formation and breakdown in DTAB/SDS aqueous solutions.The results show that the process of vesicle formation can be modeled as a sequence of distinct processes:mixed micelles→flexible stick-shaped aggregates→non-equilibrium vesicles→equilibrium vesicle system,and the evolution of particle dispersion degree appears to be a periodical change of "monodispersity→polydispersity".In addition,the kinetic analysis shows that the process of vesicle formation lasts for a long time.However,the activation energy of vesicle formation is not too high,which implies that the control procedure of the process is independent of activation energy.In contrast to the process of vesicle formation,vesicle breakup to mixed micelles appears to be a rapid process.厦门大学科技创新重点项目(No.XMKJCX20052001)资助项目

Studied the difference of genetic feature between tissue cultured and cultivated paddy rice of Jia He Zao Zan via microsatellite(SSR) markers

株高是水稻重要的农艺形状之一,植株过高将导致倒伏和减产,目前,很多新的技术究被用来鉴定,图位克隆与水稻株高相关的基因及机理的研究,本实验选择优质早籼稻佳禾早占种植苗和经过组培获得的矮化突变水稻为材料,为研究比较它们间的遗传物质上差异,根据康耐尔大学的资料设计了311对SSR引物对佳禾早占种植材料和组培材料进行分析,对两种材料进行PCR多态性扩增,结果发现两者间存在多态性的引物有88对,多态性比例达到30.3%。在矮杆材料中不但验证了已报道的11个与调控株高性状基因相连锁的标记连锁群,同时在第3号染色体和第9号染色体上还获得了两个以前基本未有报道的标记集中分布区域。结果说明,该培养基培育出的佳禾早占水稻后代所表现出的矮杆性状与亲本在遗传物质上确有明显差别。该结果有助于挖掘和定位新的矮杆基因,并有利于今后在水稻育种中进行水稻株高性状的控制,同时也为开展矮化性状机理的研究提供有利的实验材料。Plant height is one of the important agronomic traits of rice.Overhigh plant easily led to lodge and reduce output.Recently,great advances have been made in the identification,mapping,cloning and action mechanism of plant height genes in rice.This present paper selected the tissue cultured and cultivated paddy rice of Jia He Zao Zan(J.H.Z.Z) as experimental object,which were significant different on the height,the tissue cultured plant was only less than half height of the cultivated plant.In order to compare their differences of genetic and determine whether there are relationship between the dwarf gene and the dwarf character of tissue cultured plant,Polymorphism analysis was conducted between them by 311 pairs of rice SSR primers,designed by Cornell University,the result indicated that 88 pairs of primers had polymorphism between two kinds of materials,the ration in total primers was about 30.3%,the experimental result not only verified 11 multiple groups which regulate the height gene,but also obtained two group regions which control the dwarf character on chromosome 3 and chromosome 9,which have not been reported previously,these results will help to explore and determine the situation of new dwarf gene,and will be of benefit to act genetic manipulation of plant height of in rice breeding.These results also provided the evidence for studying the mechanism of dwarf.国家863项目(2002AA211091),(20001AA11091);; 厦门大学细胞生物学和肿瘤细胞工程教育部重点实验室开放基金资助(NO:2005108)资

Kinetics of vesicle formation and breakdown

A combination of stopped-flow, transmission electron microscopy and dynamic light-scattering techniques has been used to study the kinetics of vesicle formation and breakdown as well as the mechanism of vesicle formation and breakdown in DTAB/SDS aqueous solutions. The results show that the process of vesicle formation can be modeled as a sequence of distinct processes: mixed micelles --> flexible stick-shaped aggregates --> non-equilibrium vesicles --> equilibrium vesicle system, and the evolution of particle dispersion degree appears to be a periodical change of "monodispersity --> polydispersity". In addition, the kinetic analysis shows that the process of vesicle formation lasts for a long time. However, the activation energy of vesicle formation is not too high, which implies that the control procedure of the process is independent of activation energy. In contrast to the process of vesicle formation, vesicle breakup to mixed micelles appears to be a rapid process

The Relationship Between Primary School Students’ Growth Mindset, Academic Performance and Life Satisfaction: The Mediating Role of Academic Self-Efficacy

以5所公立小学的1161名四、五年级的小学生为研究对象,探讨成长型思维模式、学业自我效能感与小学生学业成绩以及生活满意度的关系。结果发现:(1)小学生的成长型思维模式与其学业自我效能感、学业成绩呈显著正相关,学业自我效能感与学业成绩、生活满意度呈显著正相关;(2)成长型思维模式显著正向预测学业自我效能感和学业成绩;(3)学业自我效能感可以显著正向预测生活满意度;(4)学业自我效能感在成长型思维模式与学生学业成绩之间起部分中介作用。</p

Are You Really Creative in Your Boss s Eyes?Effects of Subordinate s and Supervisor s Characteristics on Employee Creativity Evaluation

创造力评价决定了个体和组织能否慧眼识珠，精确识别出高质量的创意或高潜质的创造者，是促进创意转化、实现创新发展的最关键因素。作为创新领域的新兴议题，如何正确理解创造力评价的影响因素、降低创新评价偏差已成为学术界和务实领域亟待突破的瓶颈。本研究以创造者为评价对象，从人际交互层面探究主管对员工的创造力评价问题，两个现场的调查研究发现：(1) 员工的工作动机对创造力评价存在显著的调节作用，销售导向负向调节主管对其创造力的评分，在高的销售导向下，主管对员工创造力的评分更低，而客户导向表现出相反的调节模式，随着客户导向的增强，主管对员工创造力的评分更高；(2) 员工的工作绩效和主管的绩效趋近导向交互影响创造力评分的结果，员工的高绩效表现只有在主管的绩效导向也高的情况下，主管对其创造力的评分才高。</p