祖霊神話の表現 : 台湾原住民族の芸術 : 歴史・伝統・宗教・儀礼・習俗・装飾からの考察

東京藝術大学平成21年

Solvent-induced Intramolecular Charge Transfer in D-σ-A Dyads and Triads with Narrow HOMO-LUMO Gaps: A Theoretical Investigation

由强电子给体与强电子受体基团通过饱和s桥键连而成的D-s-A型二对物及A-s-D-s-A型三对物分子化合物，极易受环境因素的诱导发生分子内的电荷/电子转移（ICT），而表现出双稳态。该特性为分子水平上设计和制作多功能的有机分子材料提供了极大可能性，已成为新型分子器件的研究热点。针对这类可能具有双稳态特性的桥连二对物与三对物分子，本文基于现有的理论溶剂模型，采用量子化学计算，系统地研究了一系列基于TTF（TTF=trathiafulvalene）为电子给体的D-s-A型二对物及A-s-D-s-A型三对物分子的电子结构性质，以及溶剂对这类化合物电子态及相关性质的影响。具体结果总结如下：一、对于强电...The molecular D-s-A dyads and A-s-D-s-A triads, containing a strong electron-donor (D) and an electron-acceptor (A) linked by a saturated covalent , have narrow HOMO-LUMO gaps and readily undergo intramolecular charge/ transfer (ICT) upon various external stimulations and exhibit bistability as well as fascinating phenomena, e.g., solvatochromism. Accordingly, they are promising building blocks o...学位：理学博士院系专业：化学化工学院化学系_物理化学学号：1912005140307

デザイン コミュニケーション ノ ジッセン ト ソノ コンセプト

第2部 コミュニケーションデザイン論集論文・実践報

Power Allocation Algorithm Minimizing Outage Probability in Cognitive Radio Relay Network

为提升认知无线中继网络的中断性能,通过分析系统中断概率及用户功率分配情况,提出一种最小化中断概率的功率分配算法。给出在主用户干扰约束和总功率约束; 条件下最小化中断概率的数学优化方程组,根据用户的最大发射功率与干扰电平阈值的受限关系,分别考虑分配功率不超过干扰电平阈值、中继节点功率受限于干扰; 电平阈值以及所有节点受限于干扰电平阈值这3种情况,对应提出3种最佳功率分配方案,并基于KKT条件求解最优值。实验结果表明,该功率分配算法与基于频; 谱共享以及基于机会主义中继选择的中断概率分析方法相比,性能增益提升显著,并且在总功率、干扰电平变化的条件下,所采用的功率分配方案提升系统中断性能; 效果较好。To improve the outage performance of cognitive radio relay network,this; paper proposes a power allocation algorithm minimizing outage; probability by analyzing the system outage probability and user power; allocation conditions. It presents the mathematical optimization; equations minimizing outage probability of under master user; interference constraint and total power constraint. Then, according to; the relationship between the user's maximum transmit power and; interference level threshold,it proposes three optimal power allocation; schemes respectively to deal with three types of cases,including the; distribution of power not exceeding the interference level threshold,the; relay node power limited by the interference level threshold,and all; nodes limited by the interference level threshold. Finally,the optimal; value is solved based on Karush-Kuhn-Tucker(KKT) conditions.; Experimental results show that compared with similar power allocation; methods,the proposed algorithm has obvious performance gain promotion.; And the effectiveness of the adopted power allocation schemes is proved; the most effective in enhancing the system outage performance when the; total power or the interference level is changing.国家自然科学基金; 闽南师范大学教学研究基

思行善政、教书育人——通识教育课在新工科建设中的教改研究与创新实践

深化教育教学改革、创新思政教育工作,将知识技能传授、素质能力培养与学生理想、价值、道德、信念有机结合,是中国特色社会主义新时代对\"新工科\"人才培养工作提出的全新挑战。通识教育作为\"课程思政\"建设的排头兵,肩负着打开局面、示范指引的重要作用。通过对通识教育课程思政的教改研究与创新实践,有助于推动高等院校形成\"三全育人\"新氛围,开创\"新工科\"人才培养新方式,树立\"思行善政、教书育人\"新模式,为打造以实践能力养成和社会主义核心价值观形成为核心的创新性人才的培养奠定基础

Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2

大多数真核生物的体细胞是二倍体，即仅含有两组染色体，分别遗传自父本和母本。而一些特定组织如心脏、肝脏等就含有多倍体细胞，特别是肝脏组织含有较高比例的四、八倍体等多倍体细胞。肝脏是人体的重要解毒器官，同时酒精、肝炎病毒等毒性物质或毒性代谢物容易诱发肝细胞的基因突变，多倍体被认为有利于提供代偿性的正常基因来维持肝脏稳态。然而肝脏受损后，多倍体细胞将会受胁迫进行增殖，再生修复受损的肝组织。因此研究机体调控多倍体细胞产生及多倍体细胞进行细胞分裂的调控机理对于理解肝癌的发病机理和肝癌的治疗至关重要。Hippo信号通路在调节组织成体干细胞的分化和增殖，调控器官再生与尺寸大小中具有重要作用。深入研究发现, Hippo信号通路下游效应分子YAP通过AKT-SKP2信号促进二倍体细胞向多倍体转化及多倍体细胞的生长增殖。本项研究阐明了Hippo缺失及YAP激活促进多倍体细胞产生及增殖作为肝癌发生发展中的一个重要机制，为肝癌诊疗提供了新的策略。 周大旺，博士，厦门大学生命科学学院教授、副院长、国家杰出青年基金获得者。【Abstract】Polyploidy can lead to aneuploidy and tumorigenesis. Here, we report that the Hippo pathway effector Yap promotes the diploid-polyploid conversion and polyploid cell growth through the Akt-Skp2 axis. Yap strongly induces the acetyltransferase p300-mediated acetylation of the E3 ligase Skp2 via Akt signaling. Acetylated Skp2 is exclusively localized to the cytosol, which causes hyper-accumulation of the cyclin-dependent kinase inhibitor p27, leading to mitotic arrest and subsequently cell polyploidy. In addition, the pro-apoptotic factors FoxO1/3 are overly degraded by acetylated Skp2, resulting in polyploid cell division, genomic instability, and oncogenesis. importantly, the depletion or inactivation of Akt or Skp2 abrogated Hippo signal deficiency-induced liver tumorigenesis, indicating their epistatic interaction. Thus, we conclude that Hippo-Yap signaling suppresses cell polyploidy and oncogenesis through Skp2.该研究工作获得了国家自然科学基金委、国家重点基础研究发展计划(973)项目、青年千人计划和中央高校基本科研基金的资助。 The Yap (S127A) transgenic mice were kindly provided by Dr. Fernando Camargo from Harvard Medical School, Boston, MA. D.Z. and L.C. were supported by the National Natural Science Foundation of China (31625010,U1505224, and J1310027 to D.Z.; 81422018, U1405225, and 81372617 to L.C.; 81472229 to L.H.), the National Basic Research Program (973) of China (2015CB910502 to L.C.), the Fundamental Research Funds for the Central Universities of China-Xiamen University (20720140551 to L.C. and 2013121034 and 20720140537 to D.Z.)

オンラインによる「JICA水産分野留学生向け共通プログラム : 日本の開発経験」第1回の実施

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