On Some Classes of Special Complex Finsler Metrics

本文主要目的是尝试给出有效的方法以构造复Finsler几何中性质较好的度量，如(弱)复Berwald度量，(弱)Kähler-Finsler度量，具有常数全纯曲率的度量.为此我们研究了四类特殊的复Finsler度量，即酉不变复Finsler度量，酉不变度量的变形度量，广义复（α，β）度量和强凸的复Finsler度量.主要内容如下: 第一章介绍了本文的研究背景和所得到的主要结果. 第二章研究了酉不变复Finsler度量.我们首先得到了复Finsler度量是酉不变度量的刻画和酉不变复Finsler度量是弱复Berwald度量的刻画，进而给出了酉不变弱复Berwald度量具有常数全纯曲...This thesis attempts to provide effective approaches for constructing metrics with elegant properties in complex Finsler geometry, such as (weakly) complex Berwald metrics, (weakly) Kähler-Finsler metrics, metrics of constant holomorphic curvature. For this purpose, we mainly investigate four classes of special metrics, namely, unitary invariant complex Finsler metrics, modified metrics arisi...学位：理学博士院系专业：数学科学学院_基础数学学号：1902013015415

滋补肝肾解肌通络法治疗视频终端视疲劳的临床观察

目的:观察滋补肝肾解肌通络法治疗视频终端视疲劳的临床疗效。方法:将符合纳入标准的视频终端视疲劳患者53例106只眼,随机分为对照组(26例52只眼)和治疗组(27例54只眼)。对照组用七叶洋地黄双苷滴眼液滴眼;治疗组在七叶洋地黄双苷滴眼液滴眼的基础上,采用自拟滋补肝肾解肌通络中药方口服,以10天为1个疗程,连续治疗2个疗程。比较两组视疲劳症状评分、坚持近距离用眼时间、泪膜破裂时间、泪液分泌、调节灵敏度,治疗后评价临床疗效。结果:治疗组27例54只眼,显效19只眼,有效26只眼,无效9只眼,总有效率83.3%;对照组26例52只眼,显效13只眼,有效16只眼,无效23只眼,总有效率55.8%。治疗组疗效优于对照组。两组患者治疗后视疲劳症状评分、泪膜破裂时间均较本组治疗前显著改善,组间比较无差异。两组患者治疗后坚持近距离用眼时间,泪液分泌,调节灵敏度均较本组治疗前显著改善,且治疗组明显高于对照组。结论:相对于七叶洋地黄双苷滴眼液,给予视频终端视疲劳患者滋补肝肾解肌通络中药治疗,有效率更高,更有利于改善患者视疲劳。2018年四川省省级科研院所科技成果转化资金项目“医院制剂杞黄明目颗粒的开发”(项目编号2018YSZH0008

Clinical observation on treatment of children amblyopia by Peibuganshen Huoxuetongluo method

目的观察培补肝肾活血通络法治疗儿童弱视的临床疗效。方法将符合纳入标准的儿童弱视患者74例134只眼,随机分为对照组（36例65只眼）和治疗组（38例69只眼）。对照组用1%阿托品眼膏点眼后验光配镜,同时采用遮盖方法及精细作业治疗;治疗组在戴镜、遮盖及精细作业的基础上,采用自拟培补肝肾活血通络方口服,以1个月为1个疗程,连续治疗3个疗程。比较两组视力和视力改善的起效时间,治疗后评价临床疗效。结果治疗组38例69只眼,基本痊愈23只眼,进步36只眼,无效10只眼,总有效率85.5%;对照组36例65只眼,基本痊愈13只眼,进步20只眼,无效32只眼,总有效率50.8%。治疗组疗效优于对照组（Mann-Whitney U检验,Z=-3.684,P〈0.001）。两组患者治疗后视力均明显改善（P〈0.05）;治疗后治疗组视力明显高于对照组（P〈0.05）。治疗组视力改善的起效时间短于对照组（P〈0.05）。结论培补肝肾活血通络法治疗儿童弱视的有效率明显高于常规基础治疗,且起效快,有临床应用价值。OBJECTIVE To observe the clinical effects of Peibuganshen Huoxuetongluo method on children amblyopia. METHODS Seventy-four children amblyopia cases（134 eyes） met the inclusion criteria were randomly divided into control group of 36 patients（65 eyes） and treatment group of 38 patients（69 eyes）. The patients in con-trol group were treated with 1% atropine and optometry glasses as well as cover up therapy and eyesight exercise; in addition to above mentioned methods, subjects in treatment group were given Peibuganshen Huoxuetongluo decoc-tion orally. Both groups were treated continuously for 3 courses of 3 months. The eyesight and effect onset time were compared between the two groups. After treatment, clinical curative effect was evaluated. RESULTS Among 38 cases（69 eyes） in treatment group, 23 eyes were recovered, 36 improved, 10 had no effects and the total effective rate was 85.5%; among 36 cases（65 eyes） in control group, 13 eyes were recovered, 20 improved, 32 had no effects and the total effective rate was 50.8%. The efficacy of treatment group was remarkably superior to the control group（Mann-Whitney U test, Z =-3.684, P〈0.001）. The eyesight of the treatment group after treatment was remarkably higher than that of the control group（P〈0.05）. The onset time of eyesight of the treatment group was shorter than that of the control group, and the differences had statistical significance（P〈0.05）. CONCLUSIONS Treating children amblyopia with Peibuganshen Huoxuetongluo method showed higher effective rate and shorter onset time in contrast to the routine basic therapy, thus it was of value in clinical application.四川省中医药管理局科研项目（2014-B-026

文昌信仰与孝道文化的完善

宋元时期 ,儒家孝道文化越来越显露出自身的矛盾和难题 ,迫切需要新的思想文化的灌输和改造。道教孝道文化尤其是文昌帝君的出现 ,在吸收儒家孝道思想基因和解决儒家孝道难题的基础上 ,从宗教神学的立场出发 ,解决了忠与孝的两难、如何辩孝以及行孝的言行一致等一系列问题 ,从宗教心理和行为上建立了神佑鬼惩的监督手段等 ,表现出独特的宗教特色以及中国本土的文化特性 ,为中国孝道文化的完善做出了重要贡献

The Development Trend of Women's Floor Exercise and Problems and Countermeasures in China during the London Olympic Games Period——From the Difficulty Value and Complete Quality Perspective

目的:难度价值和完成质量是体操比赛中获取胜利的两大法宝,本研究从此两方面视角对伦敦奥运周期世界女子自由体操的发展现状及其变化规律进行回顾和梳理,找出我国女子自由体操存在的主要问题和差距,并提出缩小差距的应对策略和建议,以期提高我国女子自由体操的技术水平,为备战2016年奥运会作出一定的贡献。方法:研究主要运用文献资料、录像资料、专家访谈等资料搜集方法和视频观察、主题分析等资料分析方法。结论:提高成套动作的难度价值和动作完成质量是伦敦奥运周期女子自由体操的发展现状;女子自由体操已经成为我国女子体操队的弱项,在难度组别、难度分、空翻动作类型、成套动作的完成质量等六个方面落后国外优秀运动员;以重视体能、提高抗压能力、全面发展空翻动作类型和创新动作、提高动作完成质量、培养个人风格为切入点和突破口,是提高我国女子自由体操水平的有效途径。Objective: The difficulty value and complete quality is two magic weapons to obtain victory in the gymnastics competition.The paper reviewed current situation of the development and changes of world women's floor exercise during the London Olympic Games period from the above-mentioned two perspectives,found out the main problems and gaps,and pointed out the coping strategies and recommendations of narrowing gaps.The main goal is to raise the technical level of our country's floor exercise and to have positive significance for China's preparation for the 2016 Olympic Games.Methods: The paper mainly adopts the methods of document literature,video observation,expert interview and theme analysis.Conclusions: Improving difficulty value and complete quality is the current situation in London Olympics period.Women's floor exercise has become the weakness of China,and we have fell behind with the foreign excellent athletes on six aspects such as the difficulty of group,difficulty credit,somersault movement types,quality of complete set movements and so on.The effective ways to raise the technical level of China's floor exercise are paying attention to physical fitness,improving compression ability,all-round development of somersault movement type and innovative action,improving the complete quality,cultivating personal style

雷帕霉素衍生物对胰岛的毒性研究

目的探讨雷帕霉素及其衍生物依维莫司、地磷莫司、佐他莫司对胰岛的毒性作用。方法采用小鼠胰岛素瘤细胞(MIN6)作为体外研究胰岛细胞的对象,分别在含有依维莫司、地磷莫司、佐他莫司的培养基中孵育MIN6细胞48小时,通过Brdu检测细胞增殖、CCK8检测细胞活力、PI检测细胞周期、流式细胞术检测细胞凋亡以及ELISA检测细胞分泌胰岛素功能,观察3种雷帕霉素衍生物对MIN6细胞的影响。结果我们发现3种雷帕霉素衍生物均会对MIN6细胞的增殖和活力产生抑制作用。在细胞周期和凋亡实验中,与阴性对照组比较,3种衍生物对MIN6细胞的影响呈现抑制G1期向S期转变的趋势和促进细胞凋亡的趋势,但差异没有统计学意义。另外,3种衍生物与雷帕霉素一样,均可减少MIN6细胞分泌胰岛素,差异具有统计学意义。结论雷帕霉素及其衍生物依维莫司、地磷莫司、佐他莫司均对胰岛产生一定毒性。国家自然科学基金项目(31271038,81302546

Synthesis of Ruthena-polycyclic Complexes by Ruthenium-Vinylcarbene Complex

研究了配位不饱和的钌杂S-顺丁二烯化合物[ru(CHC(PPH3)CH(2-Py))Cl2PPH3]bf4(1)与水、甲醇、苯胺和2-巯基吡啶等亲核试剂的[4+1]关环反应,合成了一系列有趣的钌杂多环化合物[ru(CHC(PPH3)CHr(2-Py))Cl(PPH3)2]bf4[r=OH(2),OME(3),和nHPH(4)]与[ru(CHC(PPH3)CH(S(2-Py))(2-Py))PPH3(S(2-Py)]bf4(5).此外,将配位不饱和的钌配合物1与三苯基膦配体反应,制备了类似于氮杂金属萘的配位饱和化合物[ru(CHC(PPH3)CH(2-Py))Cl2(PPH3)2]bf4(6).6与Hbf4反应可生成金属杂环结构类似的分子内含三氯桥的双钌核配合物[{ru(CHC(PPH3)CH(2-Py))PPH3}2(μ-Cl)3](bf4)3(7).以上产物均通过核磁(nMr)与元素分析进行了表征,并解析了部分产物的X射线单晶结构.Treatment of ruthenium-vinylcarbene complex [Ru(CHC(PPh3)CH(2-Py))Cl2 PPh3 ]BF4(1) and PPh3 with nucleophilic reagents H2 O,CH3 OH,NH2 Ph,or 2-mercaptopyridine led to the ruthena-polycyclic complexes [Ru(CHC(PPh3)CHR(2-Py))Cl(PPh3)2 ]BF4 [R = OH(2),R = OCH3(3),R = NHPh(4)] or [Ru(CHC(PPh3)CH(S(2-Py))(2-Py))PPh3(S(2-Py)]BF4(5).They are stable under air at solid state.CH3 OH in the reaction is not only the reagent but also the solvent and the reaction must be heated at 60 ℃ for 6 h.All the other reactions were carried out at room temperature in CH2Cl2.The crystals of 4 and 5 were grown from CH2 Cl2 and CHCl3 solutions layered with diethyl ether,respectively.The structures 4 and 5 were determined by X-ray crystallography.The crystal size of 4 is a=1.29145(3) nm,b=1.37687(5) nm,c= 1.86914(4) nm,α=92.114(2)°,β=106.271(2)°,γ=96.333(3)° and the size of 5 is a=1.15333(18) nm,b=1.20072(19) nm,c=1.9081(3) nm,α=88.466(3)°,β=87.918(3)°,γ=79.521(3)°.In addition,refluxing 1 with PPh3 in CHCl3 for 6 h to produce red solid [Ru(CHC(PPh3)CH(2-Py))Cl2(PPh3)2 ]BF4(6).The reaction of complex 6 with HBF4 at room temperature for 3 h afforded the(μ-Cl)3-bridged bisruthenium-vinylcarbene complex [{Ru(CHC(PPh3)CH(2-Py))PPh3 }2(μ-Cl)3 ](BF4)3(7) in 87% yield.The crystal of 6 was grown from CH3 COCH3 solution layered with diethyl ether,and the crystal of 7 was grown from CHCl3 solution layered with diethyl ether.The structures of 6 and 7 were also determined by X-ray crystallography.The crystal size of 6 and 7 are a=1.13777(3) nm,b=1.56466(7) nm,c=1.79541(7) nm,α=75.822(3)°,β=79.502(2)°,γ= 79.259(3)°,a=1.68830(3) nm,b=2.33421(4) nm,c=2.48603(4) nm,α=90°,β=96.5530(10)°,γ=90°,respectively.The CCDC number for 3,5,6,and 7 are 945539(3),945538(5),945541(6),and 945542(7).All these complexes were fully characterized by elemental analysis and NMR spectroscopy.国家重点基础研究发展计划(No.2012CB821600); 国家自然科学基金(Nos.20925208;21174115;21272193); 长江学者和创新团队发展计划资助~

突发事件中医疗救援队伍的全方位心理支持措施

突发事件是指包含自然灾害、公共卫生事件等在内的造成严重社会危害，需要应急应对的事件。医疗救援队伍是突发事件的主力救援队伍，他们在进行救援任务的同时，由于救援环境不适应，防护物资不足、过度工作等原因，身心都承受着巨大的压力，常出现恐惧、紧张、焦虑、悲观、自责，甚至出现急性应激障碍。若得不到及时有效的心理支持，在事件结束后仍会遗留如创伤后应激障碍等长期的心理问题。全方位的心理支持包括救援全程的心理测量，救援前的队伍组建和详尽的心理支持干预培训，救援期间的自我放松、基本的生活和安全保障、药物治疗、在线心理援助和救援后的撤离应激源、重建生活方式等

siRNA对VEGFR2的表达抑制及对HL60细胞和人内皮细胞的影响

【目的】为探索治疗白血病的新思路研究了小干扰RNA（siRNA）对肿瘤细胞株HL60和人血管内皮细胞（EC）株EA·hy926血管内皮细胞生长因子受体2（VEGFR2）基因表达的抑制作用。【方法】制备并筛选VEGFR2基因的最有效siRNA，并据此设计shRNA寡核苷酸链，构建pENTR^TM／U6干扰表达载体。瞬时转染细胞．采用MTF法、RT-PCR法及Western blot测定VEGFR2表达抑制情况。【结果】VEGFR2 siRNAa、b、c抑制HL60细胞效率分别为77．5％、45．0％、80．9％，以siRNAc最高，利用其shRNA和pENTR^TM／U6构建的入门克隆转染HL60，抑制细胞效率达99．1％；此入门克隆对VEGF＆基因mRNA和蛋白的表达抑制在HL60和EA·hy926细胞均显著。【结论】在体外shRNA表达载体可有效抑制HL60细胞VEGFR2自分泌和旁分泌，有效抑制白血病细胞生长

乙肝病毒表面抗原基因在花生中的遗传转化及免疫原性检测

首次用花生半胚作为外植体,与农杆菌EHA105(含质粒p1301HBs)共培养5d,再生培养基中通过加入潮霉素进行抗性筛选,得到抗潮霉素的芽,经芽的伸长、诱导生根获得转化植株。经PCR、PCR-Southern杂交、Southern点杂交等分子检测,证实目的基因已整合到花生基因组中,ELISA检测证实了在花生中表达的HBsAg具有较好的活性。经初步定量,花生小芽的蛋白初提液中可溶性蛋白含量1.044g/L,HBsAg小蛋白的含量约占总可溶性蛋白的0.032%,每克转化植株小芽鲜重含HBsAg小蛋白约2.4×10-7g。转基因花生植株初提重组蛋白经HPLC纯化、浓缩后,注射初免一次的小鼠,有明显的特异性抗体产生。口服饲喂已免疫但抗体下降至0.025(HBsAbELISAD值)Balb/c小鼠,发现有较强的抗体回升,达3.54,表明转基因花生疫苗可以加强口服免疫