Transmission of H7N9 influenza virus in mice by different infective routes.

BackgroundOn 19 February 2013, the first patient infected with a novel influenza A H7N9 virus from an avian source showed symptoms of sickness. More than 349 laboratory-confirmed cases and 109 deaths have been reported in mainland China since then. Laboratory-confirmed, human-to-human H7N9 virus transmission has not been documented between individuals having close contact; however, this transmission route could not be excluded for three families. To control the spread of the avian influenza H7N9 virus, we must better understand its pathogenesis, transmissibility, and transmission routes in mammals. Studies have shown that this particular virus is transmitted by aerosols among ferrets.MethodsTo study potential transmission routes in animals with direct or close contact to other animals, we investigated these factors in a murine model.ResultsViable H7N9 avian influenza virus was detected in the upper and lower respiratory tracts, intestine, and brain of model mice. The virus was transmissible between mice in close contact, with a higher concentration of virus found in pharyngeal and ocular secretions, and feces. All these biological materials were contagious for naïve mice.ConclusionsOur results suggest that the possible transmission routes for the H7N9 influenza virus were through mucosal secretions and feces

The mouse and ferret models for studying the novel avian-origin human influenza A (H7N9) virus.

BackgroundThe current study was conducted to establish animal models (including mouse and ferret) for the novel avian-origin H7N9 influenza virus.FindingsA/Anhui/1/2013 (H7N9) virus was administered by intranasal instillation to groups of mice and ferrets, and animals developed typical clinical signs including body weight loss (mice and ferrets), ruffled fur (mice), sneezing (ferrets), and death (mice). Peak virus shedding from respiratory tract was observed on 2 days post inoculation (d.p.i.) for mice and 3-5 d.p.i. for ferrets. Virus could also be detected in brain, liver, spleen, kidney, and intestine from inoculated mice, and in heart, liver, and olfactory bulb from inoculated ferrets. The inoculation of H7N9 could elicit seroconversion titers up to 1280 in ferrets and 160 in mice. Leukopenia, significantly reduced lymphocytes but increased neutrophils were also observed in mouse and ferret models.ConclusionsThe mouse and ferret model enables detailed studies of the pathogenesis of this illness and lay the foundation for drug or vaccine evaluation

Higgs boson pair production process e+e−→ZHHe^+e^-\to ZHH in the littlest Higgs model at the ILC

The physics prospect at future linear $e^{+}e^{-}$ colliders for the study of the Higgs triple self-coupling via the process of $e^{+}e^{-}\to ZHH$ is investigated. In this paper, we calculate the contribution of the new particles predicted by the littlest Higgs model to the cross sections of this process in the future high energy $e^{+}e^{-}$ collider($ILC$). The results show that, in the favorable parameter spaces preferred by the electroweak precision, the deviation of the total cross sections from its $SM$ value varies from a few percent to tens percent, which may be detected at the future $ILC$ experiments with $\sqrt{s}$=500GeV.Comment: 13 pages,4 figure

InstructHumans: Editing Animated 3D Human Textures with Instructions

We present InstructHumans, a novel framework for instruction-driven 3D human texture editing. Existing text-based editing methods use Score Distillation Sampling (SDS) to distill guidance from generative models. This work shows that naively using such scores is harmful to editing as they destroy consistency with the source avatar. Instead, we propose an alternate SDS for Editing (SDS-E) that selectively incorporates subterms of SDS across diffusion timesteps. We further enhance SDS-E with spatial smoothness regularization and gradient-based viewpoint sampling to achieve high-quality edits with sharp and high-fidelity detailing. InstructHumans significantly outperforms existing 3D editing methods, consistent with the initial avatar while faithful to the textual instructions. Project page: https://jyzhu.top/instruct-humans .Comment: Project Page: https://jyzhu.top/instruct-human

UV-Based 3D Hand-Object Reconstruction with Grasp Optimization

We propose a novel framework for 3D hand shape reconstruction and hand-object grasp optimization from a single RGB image. The representation of hand-object contact regions is critical for accurate reconstructions. Instead of approximating the contact regions with sparse points, as in previous works, we propose a dense representation in the form of a UV coordinate map. Furthermore, we introduce inference-time optimization to fine-tune the grasp and improve interactions between the hand and the object. Our pipeline increases hand shape reconstruction accuracy and produces a vibrant hand texture. Experiments on datasets such as Ho3D, FreiHAND, and DexYCB reveal that our proposed method outperforms the state-of-the-art.Comment: BMVC 2022 Spotligh

Improving Deep Regression with Ordinal Entropy

In computer vision, it is often observed that formulating regression problems as a classification task often yields better performance. We investigate this curious phenomenon and provide a derivation to show that classification, with the cross-entropy loss, outperforms regression with a mean squared error loss in its ability to learn high-entropy feature representations. Based on the analysis, we propose an ordinal entropy loss to encourage higher-entropy feature spaces while maintaining ordinal relationships to improve the performance of regression tasks. Experiments on synthetic and real-world regression tasks demonstrate the importance and benefits of increasing entropy for regression.Comment: Accepted to ICLR 2023. Project page: https://github.com/needylove/OrdinalEntrop