科技大数据增值丰富化方法研究与工具研发

【目的】解决科技大数据数据源分散、质量不高、内容单薄等问题。【方法】采用数据清洗、实体对齐、实体字段融合、冲突检测等增值计算方法, 设计开发一套科技大数据增值丰富化的工具。【结果】通过本文研发的丰富化工具, 在人员、机构、会议、期刊实体及实体关系层面实现实体数据对齐, 实体字段内容增加5-10倍, 实体分析维度提升2-3倍。【局限】增值数据的及时性、规范性需要结合服务需求在实际应用中不断优化提升。【结论】研究成果提升了科技大数据知识发现平台以及相关情报智能分析系统的数据服务维度及深度。</p

Study on the Development prospects of Guizhou province coal Prearation of ethylent glycol

本文运用战略管理的理论，着重分析了世界和中国煤化工企业的产能、产量及未来发展情况、中国煤化工产品国际竞争力、以及贵州省煤化工产业的发展策略和乙二醇产业的发展前景。研究了全球煤化工产业发展的情况、贵州省煤化工乙二醇产业的发展战略，在贵州建设煤制乙二醇技术应用和研发基地、大力打造煤制乙二醇企业集群，争取国家按照建设循环经济产业园区的思路，将煤制乙二醇化工产业战略重点放在贵州，在贵州陆续投资建设大型乙二醇后加工处理企业以及乙二醇创新技术应用、乙二醇工业装备制造等大中小型化工工业项目，发展一批新的煤制乙二醇工业行业，支持、帮助贵州的化工企业和科研机构、大专院校主动参与国内外先进煤制乙二醇工艺、乙二醇聚...This paper applies the theory of strategic management, analyzes the world and China coal chemical industry production capacity, production and development situation, the international competitiveness of Chinese products, coal chemical industry and coal chemical industry in Guizhou province development strategy and the ethylene glycol industry development prospects; research on the development stra...学位：工商管理硕士院系专业：管理学院高级经理教育中心（EMBA项目）_高级管理人员工商管理硕士(EMBA)学号：X201115605

Antitumor effect of hydroxy camptothecin-loaded amphiphilic block copolymer nanoparticles

目的研究羟基喜树碱双嵌段共聚物纳米粒（MePEG．PLGA．HCPT．NPs）的抗肿瘤作用。方法选择人肝癌细胞株Bel-7402为体外模型，采用MTT法观察体外肝癌细胞的生长和增殖抑制情况，评价MePEG-PLGA-HCPT-NPs对肝癌细胞的毒性作用；采用激光共聚焦荧光显微镜技术观察其对肝癌细胞摄取药物的影响；采用小鼠H22肝癌细胞实体瘤模型进行体内抑瘤实验观察荷瘤动物的生长情况，测定肿瘤生长抑制率。结果MePEG—PLGA-HCPT．NPs能抑制肝癌细胞的生长增殖，且随羟基喜树碱浓度的升高而增强；激光共聚焦荧光照片显示载药纳米粒能有效地被Bel．7402细胞摄取；MePEG-PLGA-HCPT-NPs对小鼠的H22实体瘤生长具有明显的抑制作用，低、中、高剂量组的生长抑瘤率分别为37．62％、50．31％和70．25％，与对照组相比差异均有统计学意义（P〈0．05）。结论MePEG-PLGA-HCPT-NPs具有较强的体外、体内抗肿瘤作用。与羟基喜树碱注射剂相比，MePEG-PLGA-HCPT-NPs的抑瘤率更高，且与剂量有关，并对肿瘤生长的抑制更为持久。AIM To study the antitumor effect of hydroxy camptothecin（HCPT）-loaded amphiphilic block copolymer nanoparticles（MePEG-PLGA-HCPT-NPs）. METHODS The human hepatoma cell lines Bel-7402 in vitro were selected as model, the cell growth and viability inhibited by MePEG-PLGA-HCPT-NPs were observed and the antitumor cytotoxicity was evaluated by MTT assay. Cellular uptake of HCPT was observed by Confocal fluores- cence microscopy（CLSM）. Hepatocellular carcinoma cell H22 was subcutaneously injected into mice and MePEG- PLGA-HCPT-NPs was administered to the tumor-bearing mice. The growth of tumor was measured, and the inhibi- tory rate of tumor growth was calculated. RESULTS Hepatoma cell growth and viability were inhibited by Me- PEG-PLGA-HCPT-NPs, the inhibition was enhanced with increasing concentrations. CLSM photos indicated that MePEG-PLGA-HCPT nanoparticles enhanced the intracellular uptake of HCPT in Bel-7402 ceils. Marked inhibitory effect of MePEG-PLGA-HCPT-NPs on the transplanted hepatocellular carcinoma H22 was observed in the tumor- bearing mice. The inhibitory rates were 37.62% , 50.31% and 70.25% in the groups treated with low, medium and high dosage of MePEG-PLGA-HCPT-NPs, respectively （P 〈 0. 05 vs control group）. CONCLUSION Me- PEG-PLGA-HCPT-NPs has marked inhibitory effects on tumor growth in vitro and in vivo. The inhibitory effect of MePEG-PLGA-HCPT-NPs is obvious and dose-dependent and higher than that of HCPT injection.福建省医学创新课题项目（编号2014-CXB-35）;厦门市科技计划指导性项目（编号3502220159001

透析法制备载羟基喜树碱-聚乳酸纳米粒及其理化性质研究

采用直接透析法制备载羟基喜树碱-聚乳酸(HCPT-PLA)纳米粒并研究其理化性质、体外释放和细胞毒性.以HCPT-PLA纳米粒的载药率为评价标准,通过正交设计考察PLA浓度、HCPT与PLA的质量比和不同截留分子质量透析袋对其指标的影响.利用Malvern nano-zs粒度测定仪、XRD、DSC和激光共聚焦显微镜(CLSM)对HCPT-PLA纳米粒的理化性质进行表征.薄膜透析法考察体外释药特性;MTT试验检测细胞毒作用.在优化条件下制备的载药纳米粒为实心球形,平均粒径为226.8 nm,多分散系数为0.270,载药率为7.49%.HCPT是以晶体状态均匀分布于PLA纳米粒中.药物体外释药符合Higuchi方程Q=2.000 6X1/2-2.593 4,r=0.989 2.MTT试验显示HCPT-PLA纳米粒呈现明显细胞毒作用.透析法制备HCPT-PLA纳米粒,粒径小且分布均匀,具有较好的缓释特性;细胞毒性试验表明HCPT-PLA纳米粒具有较强的抑瘤作用且抑瘤效果优于HCPT

夜间低温对红树幼苗光合特性的影响

以温室栽培秋茄（Ｋａｎｄｅｌｉａｃａｎｄｅｌ）和木榄（Ｂｒｕｇｕｉｅｒａｇｙｍｎｏｒｒｈｉｚａ）幼苗为材料，每日傍晚１９：００至次日８：００进行１３ｈ５℃和１０℃夜间低温处理，白天将材料移至温室．室温恢复１ｈ和４ｈ，分别测定功能叶的净光合速率、气孔导率、蒸腾速率和叶绿素含量．结果表明：夜间低温明显降低秋茄和木榄幼苗的净光合速率，５℃处理抑制程度大于１０℃．白天常温恢复时间增长，净光合速率回升．１０℃处理１～５ｄ，秋茄和木榄幼苗叶净光合速率的抑制程度逐渐下降，其中秋茄幼苗叶的净光合速率恢复能力强于木榄．低温处理过程中，秋茄和木榄叶净光合速率与气孔导率和蒸腾速率均呈线性关系，表明红树叶光合碳获得的减少与叶片水分丢失同时进行，气孔导率是控制光合碳合成和蒸腾水分丢失动态平衡的主要因

暴露测年样品中26Al和10Be分离及其加速器质谱测定

在已有实验流程基础上,建立并优化了石英样品中Be和Al提取、纯化等实验流程,设计的流程条件实验包括实验试剂、器皿和离子交换柱选择、离子交换树脂分离Be和Al时酸浓度选择等。结果表明,选择钢铁研究总院研制的~9Be标准溶液作为~(10)Be样品制备的载体;使用一次性实验器皿;选用4 cm规格的离子交换柱;用0.05 mol/L草酸和0.75 mol/L盐酸混合溶液洗脱吸附于阴离子树脂上的Al,可有效提取、纯化样品中的Be和Al。加速器质谱(AMS)测量结果显示,13组化学空白的~(10)Be/~9Be和~(26)Al/~(27)Al比值平均值分别为7.48×10~(-15)和1.96×10~(-15),与国内已有宇宙成因核素实验室的结果(5×10~(-15)~8×10~(-15))具有可比性。电感耦合等离子体发射光谱(ICP-AES)的测量结果表明,Be、Al回收率分别达90%和60%。基于新建立的实验流程分析了祁连山北侧金佛寺的一个岩石样品,获得了~(10)Be和~(26)Al的暴露年代分别为(10.7±1.0)ka和(10.0±1.2)ka,与前人研究结果一致

A Study on the Integration of MI and RBI into Maintenance Management Systems

[[abstract]]長期以來製程工廠在安全維護上，重點多放在壓力容器等設備的本體上，檢查規劃與執行亦然。不過，經驗顯示，事故通常發生在系統最脆弱的部位，而這些部位通常不是設備本體。因此，近年各國檢查規範開始接受並導入系統性檢查的觀念。然而，在執行實務上，因系統性檢查之項目、數量、方法、週期和判定標準等有待建立準則，要落實並不容易，且各國因檢查機構與權限的設定因國情與文化不同，而有顯著的差別，例如美國給予授權檢查員很大的裁量權來決定檢查結果，日本與我國則比較重視專責機構的運作，故為提升製程工廠安全防護，導入系統安全檢查機制，有必要進行設備維護管理、設備完整性與風險基檢查結合機制與技術之探討。 本報告以美國 OSHA PSM 之 MI 項目及日本保安檢查為輔，從業界之設備完整性現況調查為起點。一方面研究產業的維修管理模式，另一方面以國內石化業的設備管理模式為基準，對設備分類與分級作法開始整理，並針對常用的失效分析技術如失效模式與效應分析(FMEA)及風險基礎檢查(RBI)等，整理評估方法，並建立應用案例。最後，調查石化業常用的維修管理系統(CMMS)，發展適合我國業者導入的設備完整性作法，最後將成果以實務手冊呈現。研究建議石化相關公會、協會及學術界，有系統引進國外如 API 相關標準、技術等技術規範，政府支援辦理相關課程、研討會及技術說明會等，並在監督檢查上建立系統性檢查機制，從方法與制度上建立落實誘因，促進雇主一起參與執行。另建議事業單位於平時即進行相關之數據資料蒐集，並完整確實保存與分析，不但能強化設備之安全管理，對於往後之設備相關檢查作業透過數據管理，亦更有說服力。[[abstract]]Pressure vessels have long been the focus of safety maintenance in manufacturing plants, and inspection regulations also focus on pressure vessels and their components. Experience shows, however, that accidents frequently occur at the weakest points in a system, and that these points are often in piping, tubes, and other locations. The recent trend in inspection planning has been moving toward the concept of systemic inspection, with increased emphasis on overall plant safety. What makes systemic inspection difficult is that it is not easy to determine the number of inspections to be made, let alone the methods of inspection, number of check points, and judgment criteria. Inspection agencies and the extent of their authority vary among different countries. In the United States, for example, authorized inspectors have a great amount of discretionary power over the inspection and certification process. In Japan and Taiwan, by contrast, the inspection process is controlled largely by the authorized inspection agencies. Also in Taiwan, industries want the items and extent of inspection to be as thorough and clearly defined as possible. Using the Mechanical Integrity (MI)-related items in the Process Safety Management (PSM) system of America’s OSHA as a platform, we set out to gather technical information and data on Japanese safety inspection regulations as well as from other sources. We started with sample plant investigations aimed at gaining an understanding of how industry establishes MI regulations and at comparing maintenance management systems. At the same time, we studied several useful technologies and practices. Computerization-related tasks included equipment classification, ranking, and damage coding. Failure analysis methodologies have long been difficult for plant engineers to handle, so in this report we provide a concise introduction to and implementation procedures for failure mode and effect analysis (FMEA) and risk based inspection (RBI), together with sample problems. Key functionalities of computerized maintenance management systems (CMMS) that are necessary for the assurance of mechanical integrity are also addressed. Finally, the overall results were compiled and presented in a handbook of guidelines. Topics covered in the study included: A comparison of pressure vessel regulations in America, Japan, and Taiwan; A summary of maintenance management practices of typical petrochemical plants in Taiwan; Application of CMMS; Introduction to failure and risk analysis of processing equipment; and Investigation of maintenance practices of five sample chemical plants