International tax Competition Coordination in the Context of Globalization

在经济全球化时代，各国之间的竞争日益加剧，税收作为竞争的手段之一，为越来越多的国家所利用，由此导致国际税收竞争愈演愈烈。国际税收竞争有力地促进国际经济的发展，但同时有害国际税收竞争带来的危害也不容忽视，有害国际税收竞争问题引起了国际社会的关注。规范国际税收竞争，抑制有害国际税收竞争成了迫切需要解决的问题。 本文系统地分析了国际税收竞争的概念，概括了当前国际税收竞争的一些特征，剖析了国际税收竞争协调模式的优点和缺点，最后就中国如何参与国际税收竞争协调提出了自己的意见。全文除前言和结语外，共分为三章。 第一章首先对国际税收竞争的概念进行了界定，在此基础上分析了国际税收竞争产生和发展的原因，概括...In the era of globalization, competition between different countries becomes increasingly fierce. A growing number of countries make use of tax to compete with each other, which makes international tax competition fiercer and fiercer. The international tax competition promotes economy development dramatically, however，at the same time, people begin to pay attention to the bad results caused by har...学位：法学硕士院系专业：法学院法律系_国际法学(含国际公法、国际私法、国际经济法)学号：20040808

Grp78/Bip介导戊型肝炎病毒衣壳蛋白对宿主细胞的吸附

目的探讨Grp78/Bip在戊型肝炎病毒(HEV)衣壳蛋白进入宿主细胞过程中的作用。方法采用pull-down和免疫共沉淀技术进一步验证p239与Grp78/Bip的相互作用;采用激光共聚焦显微镜技术检测p239与细胞膜表面Grp78/Bip共定位情况;采用原核表达纯化的Grp78/Bip蛋白封闭p239的Grp78/Bip结合位点,检测其阻断p239吸附细胞的效果。结果p239与Grp78/Bip可以直接结合,而且这种结合是可逆的生理性结合;p239与Grp78/Bip在细胞膜上存在部分共定位;Grp78/Bip能部分阻断p239对肝细胞的吸附。结论Grp78/Bip参与并介导HEV衣壳蛋白对宿主细胞的吸附

重组戊型肝炎病毒衣壳蛋白p239特异性吸附、侵入HepG2细胞并阻断野病毒对肝细胞的感染

By using Western blot and immunofluorescence assays,the recombinant HEV capsid protein p239 was found specifically attached to the HepG2 cell surface and entered to the cytoplasm with the increase of incubation temperature.Pre-mixture of wild-type HEV with p239 blocked the infectivity of the virus on primary cultured human hepatocytes and HepG2 cells,indicating that p239 and HEV competed the same targeting site on these cells.These data provide evidence that p239 has a similar cell surface structure with wild-type HEV

Chemical constituents of bear bile

目的:系统研究中国传统名贵中药熊胆中的化学成分。方法:利用大孔树脂,SEPHAdEX lH-20,OdS及正相硅胶柱等色谱手段进行分离,通过多种波谱学数据分析进行单体化合物的结构鉴定。结果:从熊胆中分离得到9个单体化合物,经结构鉴定分别为4′,7-二羟基异黄酮(1),4′,7-二羟基-6-甲氧基异黄酮(2),4′,5,7-三羟基异黄酮(3),4′-甲氧基-7-羟基异黄酮(4),牛磺熊去氧胆酸(5),牛磺鹅去氧胆酸(6),熊去氧胆酸(7),鹅去氧胆酸(8),胆固醇(9)。结论:化合物1~4为首次从熊胆中分离,也是从熊科动物中首次分离得到。Objecctive: To study the chemical constituents of bear bile.Method: The compounds were isolated by repeated column HP20 macroporous adsorption resin,Sephadex LH-20,ODS and silica gel as packing materials.The structures were identified on the basis of extensive spectroscopic data analysis and by comparison of their spectral data reported.Result: Nine compounds were identified as 4′,7-dihydroxyisoflavone(1),4′,7-dihydroxy-6-methoxyisoflavone(2),4′,6,7-trihydroxyisoflavone(3),4′-methoxy-7-hydroxyisoflavone(4),tauroursodeoxycholic acid(5),taurochenodeoxycholic acid(6),ursodeoxycholic acid(7),chenodeoxycholic acid(8),cholesterol(9).Conclusion: Compounds 1-4 were separated from bear bile for the first time.厦门市科技计划项目(3502Z20083005