教育领域人力资源开发的有效性和均衡性研究

依据劳动经济学和国情实际, 中国的人力资源是指16 岁法定年龄以上、具有智力劳动和体力劳动能力人口的总 称 。21 世纪初, 中国基于全球性产业竞争需要和小康社会 发展目标, 制定了建设人力资源强国的战略。在当前及未 来人力资源开发战略中, 作为教育体系组成部分的高等教 育、职业教育是重要实施途径。教育领域的人力资源开发 活动, 是教育社会功能和个体功能两方面的具体体现, 应兼 顾社会发展和个人发展两方面需求

中国区域高等教育发展的“规划”与“自组织”——全球化时代社会人力资源开发的视角

中国区域高等教育发展目前存在偏重规模速度的弊端,未来适应中国融入全球化发展的背景,区域高等教育要为本地社会人力资源的有效开发和均衡开发服务,实现这一目标的方式是建立开放的区域社会化学习体系,以及采用“规划”与“自组织”相结合的教育开发策略。教育部“985 工程” 二期创新研究基地资助项目( A2005101)教育

福州市2010年甲型H1N1流感病毒分离株血凝素基因分子进化分析

目的了解福州市2010年甲型Hl N1流感病毒HA基因的突变和分子进化。方法采用RT-PCR技术扩增流感病毒A/Fuzhou/2/2010(H1N1)血凝素HA基因,测定核苷酸序列,用Clus-talX 1.83软件进行序列比对,用Bi-oedit软件的Clusta W程序进行序列同源性分析,用Mega 5.0软件以邻位相连算法(NJ)构建系统进化树。结果福州市2010年甲型Hl N1流感分离株A/Fuzhou/2/2010(H1N1)与福州市2009年首例甲型Hl N1流感病毒株HA基因同源性为98.9%,与疫苗参考株A/California/07/2009 HA基因同源性为98.5%;HA1区段有11个位点发生改变。结论福州市2010年甲型Hl N1流感病毒血凝素虽然个别氨基酸位点发生了突变,但在抗原决定簇位点的氨基酸并没有发生变化,未出现具有显著意义的抗原漂移

Physiological Properties and Cultivation in Photobioreactor of Undariapinnatiflda clone

裙带菜(Undariapinnatifida)作为海洋中的初级生产者,将成为21世纪人类食物、药物和化工原料的重要来源.裙带菜的传统养殖技术效率低、特别是良种化程度低已制约了其发展.基于裙带菜无性繁殖系的生理特性,将光生物反应器等生化工程技术用于其培养和扩增,是实现良种化、规模化和产业化的关键.该文以裙带菜无性繁殖系的雌、雄配子体和幼孢子体为实验研究对象,实验证明裙带菜具有蓝光效应,即蓝光能促进配子体的生长、发育、光合放氧和无机碳利用能力,配子体所吸收400~500nm光量子数决定其发育率的高低,超过800μmolcm<'-2>时,发育率达到100%;蓝光也明显促进了幼孢子体光合色素合成和光合作用能力.利用光生物反应器培养的裙带菜配子体,能健康生长并发育为幼孢子体,通过室内育苗和海上养殖,成为商品.上述实验结果将为裙带菜无性繁殖系育苗法的产业化提供理论依据和技术支持

Regulation of testicular cell junction dynamics

Spermatogenesis is an important cellular process in which mature haploid spermatozoa are produced from diploid spermatogonia and finally released from the seminiferous epithelium into the tubular lumen. This process involves extensive and timely restructuring of cell junctions at the Sertoli-Sertoli cell interface where the blood-testis barrier (BTB) and basal ectoplasmic specialization (ES) are located and at the Sertoli-germ cell interface where apical ES is present. The restructuring of cell junctions is involved in facilitating the translocation of spermatocytes across the BTB into adluminal compartment of the seminiferous epithelium as well as the detachment of mature elongated spermatids from the epithelium for release. Turnover of the BTB and Sertoli-mature spermatid contact (apical ES) can be interrupted by environmental toxicant such as cadmium (Cd) and is tightly regulated by cytokines such as transforming growth factor betas (TGF-βs). However, the molecular mechanisms involved in the regulation of testicular cell junction dynamics have not been completely explored. This dissertation focused on examining the mechanisms on how Cd and TGF-β3 regulate junction proteins, nectin-2 and JAM-B respectively. Nectin-2 is found at the basal and apical ES for the formation of the BTB and Sertoli-spermatid adhesion. Results of this study have demonstrated that CdCl2 reduces nectin-2 mRNA and protein levels and causes the loss of nectin-2 at the cell-cell interface. Inhibitor and shRNA knockdown have shown that CdCl2 speeds up nectin-2 protein degradation through clathrin-mediated endocytosis. Immunofluorescence staining and endocytosis assays further confirmed that nectin-2 internalization is promoted upon Cd treatment. In addition, Cd causes nectin-2 gene repression by reducing the bioavailability of endogenous transcription factors as well as impeding the binding of positive regulators to the promoter region. Collectively, these results have unraveled a novel and direct regulatory mechanism of Cd-mediated male reproductive dysfunction and explain why testis is more susceptible to Cd toxicity than other tissues. Junctional adhesion molecule-B (JAM-B) is found between Sertoli cells at the BTB as well as between Sertoli and germ cells at the apical ES in the testis. It was found that TGF-β3 downregulates JAM-B mRNA and protein levels, and reduces the bioavailability of JAM-B at the site of cell-cell contact. TGF-β3 promotes JAM-B protein degradation via ubiquitin-proteasome pathway with the activation of Smad signaling cascade. Besides, TGF-β3 destabilizes JAM-B mRNA transcript via ERK1/2 and p54 JNK activation. These results have unraveled the mechanisms by which TGF-β3 exerts negative regulatory effects on JAM-B expression that is crucial for the BTB integrity and Sertoli-germ cell interaction. Taken together, the findings reported herein demonstrate that testicular cell junction proteins are regulated by environmental toxicant and cytokine at the transcriptional, post-transcriptional and post-translational levels. Data presented herein strengthen the understanding on how testicular cell junction dynamic is regulated and shed new insights for prevention of Cd-induced male infertility.published_or_final_versionBiological SciencesDoctoralDoctor of Philosoph

The Living Heritage and Media Enhancement of Southern-Fujian Nursery Rhymes from the Perspective of Socio-cultural Mindset

童谣是基于儿童知识学习需求和心理发育特征创作并传承的韵文体裁,具备超越时空限制的文化传承功能。闽南童谣是横跨海峡两岸、连接海外华人华侨,为闽南文化圈共享的文化文本,也是受到重视和保护的非物质文化遗产。闽南童谣的传播、变异定型是考察闽南文化在海外华人群体及台湾民间传播、发展的脉络和向心、离心趋向重要的研究线索。现有闽南童谣的数字媒介产品已呈现出影像化、流行化的活态传承新机遇。在闽南语传播面临的不利条件下,用动画手段为闽南童谣提供叙事语境来促成理解和自发模仿的传播手段,在现有措施的基础上重视影像媒介产品开发,对闽南童谣内向型的保护传承与外向型的沟通传播都具有重要的价值。</p

Trend of Regional Higher Education Development——from Socialization Learning System on China-centred Approach

本文从21世纪初的新“中国中心观”出发,剖析了中国融入全球化发展的背景,指出发展本质是全球背景下中国的发展,中国背景下各区域的发展,并最终落实到区域背景下家庭及个人的发展上。因此,中国区域高等教育需要着眼于人力资源的高效、合理、持续开发和利用,形成多元社会观和人本观,服务于产业发展和文化创新,目标是全球竞争取胜和实现小康社会,而实现这一目标最合理的教育发展模式应该是开放式的区域社会化学习。Based on the new China-centred Approach in 21st century, this article analyses the background of China being combined with globalization development, and points out that the essential of Chinese development is constructed on the development of different regions and different Chinese people from different families in China. Chinese regional higher education need carry out human resources development efficiently, serve industry and culture development. The best mode of regional higher education is socialization learning system therefore.教育部“985”工程“中国特色高等教育体系”项目研究成果之