Design and Implementation of a Criminal Commutation and Parole System

随着信息大爆炸时代的到来，社会各行各业也吹响信息化的号角，政府机关部门也不例外。信息化、自动化为工作带来的便利显而易见，利用信息技术更好的开展工作，提高工作效率，使工作更加便捷已经成为一种趋势。伴随着信息技术的发展与进步，我们进入了一个全新的时代——信息化时代。信息化、科技化逐渐深入各个领域，改变了传统的工作模式，让我们享受到了技术的发展带来的便利，也为我们打开了数字化办公之门。监狱是我国最重要的刑罚机关，肩负着教育改造服刑人员，降低再次犯罪率，维护社会的安全与稳定的重任。随着刑法修正案的出台，使更多的人关注监狱的减刑假释工作，这也对监狱工作提出了更高的要求。减刑假释是监狱工作的重要环节之一，...With the advent of the era of information explosion, the social from all walks of life also blew the horn of informatization, government departments, is no exception. Informatization, automation brings the convenience for work it is obvious that the use of information technology to work better, improve work efficiency, make the job more convenient has become a trend. With the development of inform...学位：工程硕士院系专业：软件学院_工程硕士(软件工程)学号：X201323191

两岸市场化媒介中的林书豪形象——以《南方都市报》与《苹果日报》台湾版为例

笔者选取两岸市场化媒介代表,南方都市报及苹果日报台湾版作为样本,采用内容分析的方法试图研究两岸市场化媒介关于林书豪的报道呈现出怎样的差异,这种差异塑造了怎样不同的林书豪媒介形象

A multimechanistic antibody targeting receptor-binding sites potently cross-protects against influenza B viruses

流感病毒HA是研制流感药物和流感疫苗的重要靶标，但HA具有高度变异性，如何在高变异HA中找到不变之处，即高度保守表位，是研制流感特效药物和广谱疫苗的关键。近年来国外报道的流感HA广谱中和单抗的识别位点均在较为保守的HA茎部区，而针对流感病毒与细胞受体结合部位的HA头部区尤其是RBS区，一直未能发现广谱中和抗体。夏宁邵教授团队通过探索多种免疫策略和筛选策略，成功筛选出一株广谱中和单抗12G6，识别一个位于HA头部RBS上的全新保守性表位。体外实验显示12G6人源化改造的C12G6抗体能高效中和1940-2016年间世界各地历年流行的代表三个遗传变异亚系的18个乙型流感病毒代表株对细胞的感染，并能保护小鼠致死性感染，治疗效果显著优于已报道的代表性抗体以及抗流感药物；C12G6与“达菲”联合用药具有明显的协同效果。此外，雪貂感染模型的预防和治疗效果进一步证实了C12G6作为抗体药物的治疗潜能。研究还显示该表位是病毒感染复制的关键表位，该位点的突变会造成病毒毒力显著下降。最后，研究揭示了C12G6通过五种不同的抗病毒作用机制发挥作用，提示其高效的抗病毒活性得益于多机制协同效应，这也是目前国内外第一次发现一个流感抗体能通过如此全面的抗病毒机制发挥作用。 该发现为研制能抵抗各种变异株的乙型流感特效治疗药物和通用疫苗带来新希望。 该研究工作依托分子疫苗学和分子诊断学国家重点实验室（厦门大学）、国家传染病诊断试剂与疫苗工程技术研究中心、厦门大学养生堂生物药物联合实验室完成。陈毅歆副教授、夏宁邵教授为该研究论文的共同通讯作者。在读博士研究生沈晨光、陈俊煜、李睿、王国松和硕士研究生张梦娅等为共同第一作者。【Abstract】Influenza B virus causes considerable disease burden worldwide annually, highlighting the limitations of current influenza vaccines and antiviral drugs. In recent years, broadly neutralizing antibodies (bnAbs) against hemagglutinin (HA) have emerged as a new approach for combating influenza. We describe the generation and characterization of a chimeric monoclonal antibody, C12G6, that cross-neutralizes representative viruses spanning the 76 years of influenza B antigenic evolution since 1940, including viruses belonging to the Yamagata, Victoria, and earlier lineages. Notably, C12G6 exhibits broad cross-lineage hemagglutination inhibition activity against influenza B viruses and has higher potency and breadth of neutralization when compared to four previously reported influenza B bnAbs. In vivo, C12G6 confers stronger cross-protection against Yamagata and Victoria lineages of influenza B viruses in mice and ferrets than other bnAbs or the anti-influenza drug oseltamivir and has an additive antiviral effect when administered in combination with oseltamivir. Epitope mapping indicated that C12G6 targets a conserved epitope that overlaps with the receptor binding site in the HA region of influenza B virus, indicating why it neutralizes virus so potently. Mechanistic analyses revealed that C12G6 inhibits influenza B viruses via multiple mechanisms, including preventing viral entry, egress, and HA-mediated membrane fusion and triggering antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity responses. C12G6 is therefore a promising candidate for the development of prophylactics or therapeutics against influenza B infection and may inform the design of a truly universal influenza vaccine.This research was supported by grants from the National Natural Science Foundation of China (31670934 and 81371817), the Ministry of Science and Technology of the People’s Republic of China (2011ZX09102-009-12 and 2012DFH30020), the Research Grants Council of the Hong Kong Special Administrative Region (7629/13M, 17103214, and 17154516), and a sponsored research agreement from Sanofi Pasteur. 研究工作得到了香港大学新发传染病国家重点实验室和赛诺菲巴斯德公司的技术支持和帮助，获得国家自然科学基金、新药创制国家科技重大专项、科技部对港科技合作项目等课题资助

高校科技发明成果转化与变现能力评估研究

我国经济目前正在转向高质量发展阶段，科技创新能力是经济健康发展的驱动力。国家在高校中投入了大量的资金和人力扶持科研产业，但最终进行有效转化的科研成果却远低于期望。为探究我国高校科技发明成果转化与变现的问题，本文采用因子分析法与聚类分析法，对于高校的科技成果转化与变现能力进行评价，寻求合理的解决措施。</jats:p

Improvement of facial nerve function by thunder-fire moxibustion combined with acupoint massage in a patient with facial paralysis of wind-cold pattern (雷火灸配合手法穴位按摩改善1例风寒证面瘫患者面神经功能的护理体会)

This paper summarized the treatment effect of thunder-fire moxibustion combined with acupoint massage on the rehabilitation of facial nerve function in a patient with facial paralysis of wind-cold pattern. Based on the syndrome differentiation, a combination of traditional Chinese Medicine external techniques including thunder-fire moxibustion and acupoint massage was carried out to relieve the clinical symptoms and improve the recovery of facial nerve function of the patient with facial paralysis of wind-cold pattern. (本文总结1例采用雷火灸配合手法穴位按摩改善风寒证面瘫患者面神经功能的护理经验。在常规护理的基础上, 根据患者辨证采取雷火灸配合手法穴位按摩, 通过中医外治法精准作用于病灶, 增强经络的感知传导, 改善面神经活动能力, 进而促进患者面瘫的康复。

T2* mapping评估克罗恩病炎症活动性的应用研究

目的】探讨T2 * mapping对评估克罗恩病（CD）炎症活动性的应用价值。【方法】98例CD患者行MR肠道造影及 T2*WI扫描。在T2 * mapping上测量病变肠壁的T2 * 值，以MR活动性指数（MaRIA）为CD炎症活动性的参考标准，分析T2 * 值 与CD活动性的关系。【结果】160个肠段中，缓解期CD（MaRIA < 7）26段，轻度活动期CD（7 ≤ MaRIA < 11）23段，中-重度活 动期（MaRIA≥11）111段。三组CD肠壁的T2*值差异有统计学意义（均P < 0.05）。160个肠段的T2*值与MaRIA具有较好的 相关性（r = 0.743，P < 0.05）。ROC曲线分析显示T2 * 值在鉴别缓解期和活动期CD（AUC = 0.877）以及鉴别缓解期-轻度活 动期和中-重度活动期CD（AUC = 0.848）均具有较高的诊断准确性，其中T2 * 值选择阈值为20 ms时诊断轻度和中-重度活动 期CD的敏感性为74.5%，特异性为84%。【结论】T2 * mapping的定量指标T2 * 值与CD活动性有较好的相关性，可准确诊断CD 的炎症活动性

Nursing of a patient with stage II pressure sore after stroke treated by Chinese herbal medicine external application (中药涂药法治疗1例中风后II期压疮患者的护理体会)

This article summarized the treatment and nursing experience of a patient with stage II pressure sore after stroke. The main nursing measures of TCM included nursing evaluation, basic nursing and wine rhubarb drug external application. TCM nursing by syndrome differentiation is effective in would healing and pain relief in patient with stage II pressure sore after stroke. (本文总结了1例中风后II期压疮患者的治疗及护理经验。护理措施包括护理评估、基础护理、中药酒大黄涂药治疗, 通过辨证施护, 以充分改善患者压疮症状, 减轻患者痛苦。

Research on present situation of the hierarchical medical system in nursing work of emerging infectious diseases (分级诊疗制度在突发性传染病护理工作中的应用现况探讨)

Emerging infectious disease is characterized by sudden and rapid spread, and failure to curb its development in the first place would pose a serious threat to social stability and human health. The hierarchical medical system can realize rapid triage, better separate infectious patients, suspected patients and non-infectious patients, and optimize diagnosis, treatment and nursing work. Taking COVID-19 epidemic as an example, this paper will discuss the present situation of the hierarchical medical system in control and nursing management of sudden infectious diseases, summarize the problems existing in current graded diagnosis and treatment system of China, and propose proposals to promote the development and improvement of the hierarchical medical system. (突发性传染病具有发生突然、传播速度快等特点, 若不能在第一时间采取措施遏制其发展, 将会对社会稳定和人类健康构成严重威胁。分级诊疗制度可以实现快速分诊, 将传染性患者、疑似患者、非传染性患者分开, 优化诊疗、护理工作流程。本研究以新型冠状病毒肺炎疫情为例, 总结分级诊疗制度在突发性传染病护理工作中研究进展, 分析我国目前分级诊疗制度存在的问题, 并提出促进分级诊疗制度发展和完善的刍议。

Fabrication and Impedance Performance of Gradient LaNi0.6Fe0.4O3-&delta;-Gd0.2Ce0.8O2 Composite Cathodes for Intermediate Temperature Solid Oxide Fuel Cell

应用丝网印刷和共烧结制备LaNi0.6Fe0.4O3-&delta;(LNF)-Gd0.2Ce0.8O2(GDC)梯度复合阴极/Gd0.2Ce0.8O2/Sc0.1Zr0.9O1.95(ScSZ)/Gd0.2Ce0.8O2/LaNi0.6Fe0.4O3-&delta;(LNF)-Gd0.2Ce0.8O2(GDC)，组成梯度复合阴极对称电池. 实验表明，在750 oC工作温度下单层70%LNF-30%GDC（文中均指质量百分比）复合阴极的极化电阻为0.581 &Omega;&middot;cm2，而三层60%LNF-40%GDC/70%LNF-30%GDC/100%LNF复合阴极的极化电阻最小（0.452 &Omega;&middot;cm2）. 由于阴极组成在ScSZ电解质和LNF阴极之间呈梯度变化，因此获得了最佳的阴极/电解质界面，大大加快了三相界面或气体/阴极/电解质三相接触点反应区的扩散，其电荷传递电阻Rct和浓差极化电阻Rd均减小，因而具有最低的阴极极化电阻值.A LNF-GDC composite cathode with a gradual change in the composition between ScSZ electrolyte and LNF cathode was fabricated to reduce the cathode polarization resistance (Rp). The gradual change in composition between ScSZ electrolyte and LNF cathode shows the decreases in the charge transfer resistance (Rct) and gas phase diffusion resistance (Rd). The results revealed that the Rp value, measuring 0.452 &Omega;&middot;cm2 at 750 &deg;C, was the lowest for LNF-GDC composite cathodes with three layers and gradient changes in composition between ScSZ and LNF (Cathode C),, whereas the Rp value of 70%LNF-30%GDC composite cathodes with one layer (Cathode A) was 0.581 &Omega;&middot;cm2. The reduction in Rp for the LNF-GDC composite cathodes with three layers and gradient changes in composition between ScSZ and LNF may be related to the fact that the microstructure of the cathode/electrolyte interfaces is significantly improved, resulting in the increase in the area of triple phase boundaries (TPBs), which enhanced the surface exchange of oxygen. This implied that the gradient LNF-GDC composite cathodes showed excellent performance in terms of its electrochemical properties.国家自然科学基金项目(No. 51201098)资助作者联系地址：上海交通大学 机械与动力工程学院，燃料电池研究所，上海 200240Author's Address: Institute of Fuel Cell, School of Mechanical Engineering, Shanghai Jiaotong University, Shanghai 200240, China通讯作者E-mail：[email protected]