Study on Ultrafast Localized Two-Dimensional MR Spectroscopy Based on Spatially Encoded Technique

核磁共振定域谱（MRS）是获得活体内生化参数定量信息和诊断信息的唯一非侵入技术。一维1HMRS谱峰分辨率受到化学位移范围和J偶合裂峰的限制。2DMRS通过将严重重叠的一维谱峰散开在二维平面上，改善了谱峰重叠现象，极大提高了谱的分辨率。然而，长时间的二维采样严重影响它的广泛应用。基于空间编码的超快速采样技术只需单次扫描即可获得一组二维谱数据，极大地缩短了实验时间。将空间编码单扫描方法与2DMRS相结合，不仅解决了采样时间长的问题，还能部分克服磁场的不均匀性。本论文利用空间编码超快速2DNMR谱技术和定域谱的相关特性，提出了两种超快速定域谱序列。主要成果如下： 一、阐述了几种常见的单体素定位法和...Localized magnetic resonance spectroscopy (MRS) is the only non-invasive technique for acquiring in vivo biochemical and diagnostic information. The spectral resolution of one-dimensional (1D) 1H MRS is often low due to narrow chemical shift range and spin-spin splitting of J-coupled resonances. Localized 2D MRS was introduced to greatly alleviate this problem through spreading resonances on a 2D ...学位：理学硕士院系专业：物理与机电工程学院物理学系_无线电物理学号：1982009115255

Dipolar Field Effects in CRAZED and COSY Experiments

文章简单描述了高极化核自旋体系中分子间多量子相干(IMQC)有关的实验现象,详细讨论了在不同温度和不同梯度场强度下CrAzEd和COSy(gCOSy)实验中的偶极场效应,实验结果表明梯度场、偶极场、分子自扩散等各种因素都会影响IMQC信号。The relevant experiment phenomena of intermolecular multiple-quantum coherence(iMQC) in highly polarized spin systems were briefly described in this paper.Dipolar effects in CRAZED and COSY(gCOSY) experiments at different temperature,different gradient strength were also discussed in detail.Experimental results suggest that factors including gradient,dipolar field,and molecular diffusion can affect iMQC signal.中央高校基本科研业务费项目(2010121010

Two-Dimensional Localized Magnetic Resonance Spectroscopy and its In Vivo Application

核磁共振定域谱(MrS)是获得活体生化定量信息和诊断信息的无损检测技术,是核磁共振成像强有力的补充技术,可为临床诊断和疾病预测提供重要的信息.然而,活体1d1H MrS通常存在代谢物谱峰拥挤、分辨率较低和归属难等问题.引入2d MrS可在较大程度上解决1H MrS谱峰重叠和谱峰归属难的问题.该文简述和分析了几种典型的2d MrS新方法及其优缺点,并讨论了它们在脑部、肌肉、乳腺、前列腺等活体组织中的应用.虽然2dMrS存在着实验时间较长的局限,但最新研究表明其具有一些独特的优势及较好的发展前景.Localized magnetic resonance spectroscopy(MRS) is a non-invasive technique for acquiring in vivo biochemical and diagnostic information,acting as a powerful complement to MRI.It can provide important information for clinical diagnosis and disease prediction.However,1D in vivo 1H MRS has the problems of peak crowding,low spectral resolution and difficult peak identification.The two-dimensional(2D) MRS has been introduced to address these problems to a large extent.In this review,we analyzed the advantages and disadvantages of several typical 2D MRS methods.Their in vivo applications in brain,muscle,breast and prostates were also discussed.Although 2D MRS has the limitation of long experimental time,it still holds some unique advantages and presents a promising prospect according to the latest research.国家自然科学基金资助项目(10974164);中央高校基本科研业务费资助项目(2010121010