小儿腹腔镜在青春期及青春期前重型地中海贫血患儿生育力保存中的应用及可行性分析

目的分析青春期及青春期前重度β-地中海贫血（TM）患儿生育力保存行小儿腹腔镜的术中及术后情况，进一步探讨小儿腹腔镜在生育力保存手术中的应用前景。方法对13例青春期及青春期前拟行造血干细胞移植的 TM 患者通过小儿腹腔镜获取卵巢组织行卵巢组织冷冻（OTC）合并卵子体外成熟（IVM）行生育力保存的病例进行分析，探索小儿腹腔镜在生育力保存手术中的安全性及可行性。结果13名患儿的手术方式均为腹腔镜下单侧卵巢切除，平均手术时长（58.31±20.25） min，术中平均出血（2.46±1.13） mL，13例手术术后均无并发症，平均住院日为（3.62±1.33） d。13例患儿均成功获得卵巢组织可供冷冻，平均冷冻卵巢组织7.77±2.31片；其中11名患儿同时获得成熟卵母细胞可供冷冻，平均冷冻卵母细胞4.92±4.27枚。结论小儿腹腔镜获取卵巢组织是安全有效的生育力保存术式，可在青春期及青春期前血液疾病患者中大力推广

Prediction of Energy Resolution in the JUNO Experiment

International audienceThis paper presents the energy resolution study in the JUNO experiment, incorporating the latest knowledge acquired during the detector construction phase. The determination of neutrino mass ordering in JUNO requires an exceptional energy resolution better than 3% at 1 MeV. To achieve this ambitious goal, significant efforts have been undertaken in the design and production of the key components of the JUNO detector. Various factors affecting the detection of inverse beta decay signals have an impact on the energy resolution, extending beyond the statistical fluctuations of the detected number of photons, such as the properties of liquid scintillator, performance of photomultiplier tubes, and the energy reconstruction algorithm. To account for these effects, a full JUNO simulation and reconstruction approach is employed. This enables the modeling of all relevant effects and the evaluation of associated inputs to accurately estimate the energy resolution. The study reveals an energy resolution of 2.95% at 1 MeV. Furthermore, the study assesses the contribution of major effects to the overall energy resolution budget. This analysis serves as a reference for interpreting future measurements of energy resolution during JUNO data taking. Moreover, it provides a guideline in comprehending the energy resolution characteristics of liquid scintillator-based detectors