川桑葚中鞣酸的提取及纯化工艺研究

对脱除多糖的桑葚干燥粉末先用N,N—二甲基甲酰胺提取鞣酸,再用石油醚和正丁酸甲酯萃取3次后获得鞣酸粗品。鞣酸粗品经酸沉、醇沉和重结晶3种方法纯化,采用单因素试验与正交试验优选鞣酸提取工艺和纯化工艺。结果发现:最佳提取工艺条件为N,N-二甲基甲酰胺与川桑葚质量比12∶1、石油醚与正丁酸甲酯体积比3∶1、提取温度40℃、提取时间8 h;最佳纯化工艺条件为酸沉时间16 h、醇沉时间4 h、重结晶温度50℃

当归补血无糖颗粒成型工艺研究

目的:研究当归补血无糖颗粒的生产工艺。方法:探究不同辅料的配比配方对当归补血无糖颗粒的吸湿性、溶化性、成型率的变化影响;以颗粒的休止角、相对湿度为指标对药物颗粒成型进行考察评价,筛选出合理生产工艺条件。结果:实验结果表明,选择“浸膏∶甘露醇∶微晶纤维素(3∶0.1875∶0.063)”方案辅料配比最为合理,崩解剂选择5%羧甲基淀粉钠,可在30 min内完全崩解;矫味剂选择加入0.1%的甜蜜素口感适中,适合糖尿病人;休止角平均值为30.3°,临界相对湿度约为80%制得无糖颗粒抗湿能力强,满足生产装量差异的要求。结论:该生产工艺制备的当归补血汤无糖颗粒符合质量要求,扩大了当归补血汤的临床使用范围

中华医学会会议论文集

目的精神分裂症患者存在前瞻记忆(prospective memory,PM)缺陷。虽有少量研究提示精神分裂症的PM缺陷可能源自于PM的第三阶段(意向激活)缺陷,但目前尚未发现直接针对意向激活(包括线索识别及意向提取成分)的实验研究。本研究试图阐明线索识别及意向激活成分在精神分裂症PM缺陷中的性质及作用。方法共有30例早期精神病(FEP)患者及30名健康志愿者入组,分别测定了线索识别、意向提取、工作&nbsp;</p

中国神经科学学会会议论文集

目的:精神分裂症患者存在前瞻记忆(prospective memory,PM)缺陷。虽有少量研究提示精神分裂症的PM缺陷可能源自于PM的第三阶段(意向激活)缺陷,但目前尚未发现直接针对意向激活(包括线索识别及意向提取成分)的实验研究。本研究试图阐明线索识别及意向激活成分在精神分裂症PM缺陷中的性质及作用。方法:共有30例早期精神病(FEP)患者及30名健康志愿者入组,分别测定了线索识别、意向提取、&nbsp;</p

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies