Mechanisms of neuroprotection by curcumin in acute epileptic rat

目的：通过腹腔注射大剂量戊四氮建立急性大鼠癫痫模型，运用姜黄素进行干预，观察姜黄素对癫痫大鼠行为的影响和神经元的保护作用及其机制研究。 方法：实验选用健康雄性SD大鼠48只，完全随机分为:姜黄素组、对照组、模型组、实验组，每组12只大鼠，造模前进行相应的预干预，然后通过腹腔注射戊四氮建立急性癫痫动物模型。观察造模后各组大鼠行为学表现；尼氏染色、HE染色观察各组大脑病理变化；Tunnel染色观察各组大脑皮质神经元的凋亡情况；免疫组织化学方法观察姜黄素对海马组织或皮质部分LC3-Ⅱ、Beclin1表达的影响。 结果：相对于模型组，实验组腹腔注射姜黄素可明显延长发作潜伏期；病理学显示，实验组相对...Objective：To discuss the antiepileptic and neuroprotective effects of curcumin in epilepsy modeled by PTZ intraperitoneal injection. Medthods: The 48 SD male rats were randomly divided into four groups: curcumin group,control group, model group and curcumin intervention group,12 rats in each group.To establishe acute animal model of epilepsy by PTZ intraperitoneal injection ,we observed the behav...学位：医学硕士院系专业：医学院_外科学学号：2452014115355

The Research of the Establishment of TC All-around Automobile Service Center

随着国内汽车销售服务行业竞争日益激烈，4S店依靠汽车销售取得高额利润的可能性已经越来越低，但厦门TC集团却通过构建全方位汽车服务中心取得了良好的效益。 本文以TC全方位汽车服务中心为研究对像，结合汽车4S经营现状和特点，参考罗杰.G.施罗德服务模型的研究思路，按照战略制定、服务产品设计、服务提供系统设计、效果评价的顺序，采用定量与定性分析相结合的方法和实证调查分析方法对TC全方位服务中心的构建进行分析和研究。研究主要内容包括TC全方位服务中心构建的业务背景、构建目标、服务选择、服务选址、构建效果评价和改进建议。 通过分析和总结，作者认为服务创新、服务组织适应服务战略是TC全方位汽车服务中心...Although there is less possibility for Automobile 4S shop to earn exorbitant profits through sales only under fiercer and fiercer competition, the Xiamen TC Group have a good practice through setting up all-around automobile service center. The article makes a research about the TC all-around automobile service center, and the research is also combined with the current situation and features of a...学位：工商管理硕士院系专业：管理学院工商管理教育中心（MBA中心）_工商管理硕士(MBA)学号：1792008115119

邑,城在乡土中——中国城镇化的自我逻辑

当今,在我国的城镇化建设中的潜在性认知分类,是城市与乡土的分离和对峙。这样的认知深受西方\"城乡\"关系的影响。一方面,从中仍可瞥见西方\"大传统/小传统\"(城/乡)的辙迹;[1]另一方面又暗含着\"城市话语\"的权力底色。在这样的模型中,明显已经与我国传统的城邑形制渐行渐远,与自己的传统不符合,需要引起反思与反省。历史地看,我国自古便不存在这样的认知和逻辑,而\"邑\"是一个值得进行知识考古的概念

Photosynthetic capacity of three common species of macroalgae and the application in coral aquarium

利用水下饱和脉冲调制叶绿素荧光仪(dIVIng-PAM)测定了珊瑚养殖水处理中3种常见大型海藻石莼(ulVA lACTuCA)、条浒苔(EnTErOMOrPHA ClATHrATA)和羽状蕨藻(CAulErPA MEXICAnA)光能转化效率(fV/fM),快速光曲线(rlC)相关参数和非光化学淬灭(nPQ)。结果表明:石莼和条浒苔的fV/fM分别为0.808±0.004和0.816±0.009,显著高于羽状蕨藻。最大相对电子传递速率rETrMAX(17.52±2.92和19.59±4.43μMOl E·M-2·S-1)、半饱和光强Ik(53.41±8.18和59.71±13.52μMOl PHOTOnS·M-2·S-1)也明显高于羽状蕨藻(rETrMAX和Ik分别为13.72±5.41μMOl E·M-2·S-1和32.67±14.06μMOl PHOTOnS·M-2·S-1),表明石莼和条浒苔有着比羽状蕨藻更高的光合能力和对强光的耐受能力,光保护能力更强;羽状蕨藻较高的rlC初始斜率α表明其在弱光下拥有更强的光捕获能力,弱光下光合效率更高;随光照的增强(0~373μMOl PHOTOnS·M-2·S-1),羽状蕨藻nPQ的增幅有限(0~0.2),最大值仅为条浒苔和石莼的38.1%和62.5%,表明这种藻类更容易受到强光的抑制。因此,在珊瑚养殖的水处理中,可以根据不同的光照选择适宜的藻种或藻种组合并根据光梯度进行布局,反之也可以根据藻种来选择合适的光源,以达到最佳的处理效率。This study investigated the difference of photosynthetic capacity in three macroalgae species( Ulva lactuca,Enteromorpha clathrata,and Caulerpa mexicana) commonly used for nutrient removal in coral aquariums.The photochemical efficiency( Fv/Fm),parameters relevant to rapid light curve( RLC) and non-photochemical quenching( NPQ) in the macroalgae were measured by underwater saturation pulse modulated chlorophyll fluorometer( Diving-PAM).The results showed that Fv/Fmwas 0.808 ± 0.004 for U.lactuca and 0.816 ± 0.009 for E.clathrata,which were higher than that for C.mexicana.Higher maximum relative electron transfer rates( rETRmax)( 17.52 ±2.92 and 19.59 ±4.43 μmol e·m- 2·s- 1) and half-starved value of light intensities( Ik)( 53.41 ±8.18 and 59.71 ±13.52 μmol photons·m- 2·s- 1) were observed in U.lactuca and E.clathrata than that in C.mexicana( 13.72 ± 5.41 μmol e·m- 2·s- 1for rETRmaxand 32.67 ± 14.06 μmol photons·m- 2·s- 1for Ik),indicating that U.lactuca and E.clathrata have stronger photosynthetic capacities,photo-protection capacities and tolerance to higher intense light than C.mexicana.A significantly lower RLC initial slope α in C.mexicana implied that this algal species has a higher photosynthetic capacity under weak light condition.With increasing the light intensity( 0- 373 μmol photons·m- 2·s- 1),however,C.mexicana had a limited increase of NPQ( 0- 0.2),the maximum of which was equivalent to 38.1% of that in U.lactuca and 62.5% of that in E.clathrata.These results indicate that the photosynthesis of E.clathrata may be more easily limited by intense light.Our study suggests that the selection of algal species for nutrient removal in a coral aquarium should be adapted to the light intensity.Single species or the combination of different species of macroalgae can be selected according to the illumination of the coral aquarium in order to maximize the efficiency of nutrient removal.国家海洋局第三海洋研究所基本科研业务项目(海三科2011033); 厦门海洋研究开发院共建项目; 海洋公益性行业科研项目(201105012)资

撕开包裹——让她走出来——评《流亡》中的黄曼曼

左翼青年作家洪灵菲的《流亡》在1928年由现代书局出版,在当时反响颇大。其描绘的是革命青年在大革命失败后为了逃避国民党的追捕而流亡东南亚诸国的经历。在爱情与革命的纠缠中,男权意识和性别歧视有意无意地将女主人公置于边缘地带,时隐时现。本文试图从细读文本出发,将她从阴影中牵引出来,给她一个全貌。撕开包裹,让她走出历史的迷雾,与“他“并驾齐驱

简论独立董事独立性之若干问题

独立董事制度的核心在于独立董事的独立性,独立性可以说是独立董事制度能否真正发挥作用之重要因素,也可以说是独立董事制度能否成功之基础,亦即如果独立董事不能真正独立,那么独立董事制度的存在就失去了原本的意义。本文尝试以独立董事有关之法律法规为视角探讨独立董事的独立性问题

Analysis of Constraint Conditions of China's New Round of Tax Reform

税收是一个古老的经济范畴，是国家调节社会经济最重要的杠杆之一。税收制度是一国政治、经济、文化等因素的综合反映，只有和经济发展相适应的税收制度才能更好地发挥作用。随着社会经济环境和国际经济形势的不断变化，原有税制的弊端凸现。税制改革呼声越来越高，然而税制改革的实际进程却很缓慢，既有国内经济运行状况和国际经济趋势的约束，也有国内政治、社会、文化等方面的限制。本文立足于我国税制现状，从税收原则角度，公共政策理论角度以及税收文化角度分析我国新一轮税制改革的约束条件，提出了新一轮税制改革的现实选择以及几点配套措施。本文包括五章：第一章《导言》包括选题背景，文献综述以及本文结构。第二章《从税收原则角度分析...Tax is a summary of the oldest areas of economy. It is one of the most important levers for the state to regulate social economy. Tax system is the comprehensive reflection of a country's politics, economy culture, etc. Only the tax system which adapts to the development of economy can work better. Along with the social and economic environment and the ever-changing international economic situatio...学位：经济学硕士院系专业：经济学院财政金融系_财政学(含税收学)学号：20044101

HISTOLOGICAL STUDIES ON THE DEVELOPMENT OF EURYTREMA COELOMATICUM IN THE SNAILS BRADYBAENA SIMILARIS FERUSSAC

目的　为了解腔阔盘吸虫在贝类宿主体内发育的组织学情况。方法　用腔阔盘吸虫 (Eurytremacoelomaticum)虫卵人工感染同型阔纹锅牛BradybaenasimilarisFerussac后在不同时间里固定蜗牛 ,经石蜡包埋 ,连续切片、苏木精伊红复染 ,观察腔阔盘吸虫在蜗牛体内的发育变化。结果与结论　感染后 5～ 12天为早期母胞蚴阶段 ,感染 15天母胞蚴体内开始出现子胞蚴的胚球 ,2 9天的母胞蚴增大明显 ,胚球数目增多 ;40天的母胞蚴布满肠壁周围 ,胚球两端拉长 ;47天的母胞蚴体内的子胞蚴胚球增大明显 ,已出现内外囊壁的分化 ,内囊壁包围着胚细胞组成的中心区域 ;感染 91天的子胞蚴体内出现尾蚴胚体 ;118天的子胞蚴体内的尾蚴已经成熟 ,子胞蚴移向呼吸腔Aim This paper reported the histological development of Eurytrema coelomaticum in the snails Bradybaena similaris Ferussac.Method Snails were infected experimentally by feeding Eurytrema coelomaticum eggs,5～6 snails were fixed in Bouin's fluid at intervals of 3～6 days postinfection,the entire animal was dehydrated in thanol-toluol series,embedded in paraffin,serially sectioned at 10μm,and stained with Enlirch's hematoxylin-eosin.Results and Conclusion the germinal cells in the mother sporocyst stretched and scattered in 5～12days postinfection snails,and the number of germninal cells increased.In the 15 days postinfection snails,germinal cells created a large space around themselves and germinal balls were presented in mother sporocyst,each become a daughter sporocyst.At 29 days postinfection mother sporocyst enlarged obviously,the mumber of germinal balls increased.At 40 days postinfection,mother sporocyst scattered all over the intestine wall.The germinal balls lengthened at the both sides.By 47 days postinfection,the germinal balls in mother sporocyst enlarged significantly,daughter sporocyst balls present internal and external cyst walls,the internal cyst wall surrounded the central area that the germ cells aggregate.After 3 months postinfection,daughter sporocyst present the cercarial embroys.At 118 days postinfection,the cercariae in daughter sporocyst were mature and daughter sporocyst moved to pulmonary cavity

在兴趣中学习,在快乐中成长——浅谈分子生物学实验课教学实践的改革与创新

分子生物学实验是现代生物学实验课程的一个组成部分,是当前生物学领域发展最快的一个学科,新的分子生物学技术层出不穷,该学科是生物学最活跃的领域。分子生物学实验课是面向本科生开设的一门实验课程。为了很好地进行这门课的教学,我们采取了模拟科研的教学形式,让理论和实践相结合,用理论来指导实践,用实验来验证和加深理论认识,用实践来培养学生的基本理论、基本知识、基本技能。同时在教学中贯穿着素质教育,培养学生的动手能力、创造能力、创新意识。这样起到了既教书又育人的目的

Observation on Mesocoelium ovatum Juvenile,Adult and Egg by Scanning Electron Microscope

报道了用扫描电镜观察卵形半肠吸虫成虫、童虫、虫卵的体表超微结构，成虫、童虫体表布满单生棘和皱折，虫卵表面光滑具卵盖.The author reports the surface structure of Mesocoelium ovatum juvenile and mature adult as well as egg by scanning electron microscope observaton for the first time .The appearance of juveniles looks very like the mature adults.They both are covered with folds and spines,though their sizes and some inner structures are different under the light microscope.The juveniles have the sex organs but no egg in the uterus.It is shown that the maturation of surface structure may not be related with the development time.The body surface of juveniles and adults are provided with transverse folds and vertical folds,which only are present at the anterior end and posterior end.The shape and arrangement of the tegumental spines of worms at different maturation are basically uniform,belonging to the single spaced-pattern with pointed grow backword projecting.Several dome-shape papillae are observed around the rim of the oral sucker and acetabulum.They are tentatively identified as sensory organs.The surface of eggshell of M.ovatum including the operculum is generally smooth,and the operculum is thick and prominent