Study on Corrosion Resistance of Zr-0.8Sn-1Nb-0.3Fe Alloy after Kr~+ Ion Irradiation

采用高压釜腐蚀实验研究了2种不同制备工艺下的Zr-0.8Sn-1Nb-0.3Fe合金(1#,2#)经360℃、5~25; dpa的Kr~+辐照后、在400℃/10.3 MPa过热蒸汽中的耐腐蚀性能,用透射电子显微镜(TEM)、扫描电镜(SEM)、; X射线衍射仪(XRD)分析合金腐蚀后氧化膜显微组织结构。结果表明,100; d腐蚀后,合金的腐蚀增重随着辐照剂量的增加而增加,由于1#合金中的第二相比2#合金更为细小、弥散,相同辐照剂量下,前者的腐蚀增重较低。腐蚀转折前; ,从蒸汽腐蚀侧到锆合金基体,氧化膜中的氧含量逐渐降低,靠近蒸汽侧的氧化膜主要由等轴晶形态的单斜ZrO_2组成,而基体界面处的氧化膜主要为柱状晶形; 态的四方ZrO_2和六方Zr_3O;腐蚀转折后,基体界面处的氧化膜呈"花菜"状生长,"花菜"尺寸大小与氧化膜生长速率的高低及不均匀生长趋势的大小; 呈对应关系。The corrosion resistance of Zr-0.8Sn-1Nb-0.3Fe alloys prepared by two; different processes was investigated in 400℃/18.6MPa superheated steam; by static autoclave after irradiated by 360℃ with Kr~+-irradiation of; 5~25 dpa. The microstructures of oxidation film after corrosion were; analyzed by TEM, SEM, and XRD. The results showed that the corrosion; weight-gain increased with the irradiation dose, while the weight-gain; of 1# alloy with smaller and more dispersive SPPs than 2# alloy was; lower under the same irradiation dose. Before corrosion turning, the; oxygen content in the oxidation film decreased from the steam-side to; the zirconium matrix. The oxidation film beside the steam-side was; mainly composed by equiaxied monoclinic ZrO_2 crystal, while near the; film/matrix interface by columnar quartet ZrO_2 crystal and hexagonal; Zr_3O crystal. After transition of corrosion weight, the film near the; interface grew like cauliflowers, and the size of cauliflowers were; corresponded to the growth rate and uneven growth trend of oxidation; film

Classification method of diabetes based on integration of characteristic classifier

目的:结合医用电子鼻技术,探讨糖尿病患者及其口腔呼气的气味图谱特征。方法:选择180例糖尿病患者和100例健康者,用医用电子鼻采集280例口腔呼气的气味图谱,采用基于数据特征划分的方法,用支持向量机和随机森林集成模型对糖尿病患者进行分类预测。结果:1线性核函数的支持向量机(SVM1)分类结果不是很理想,低于多项式核(SVM2)、径向基函数核(SVM3)和随机森林(RF)3种分类器,说明分类超平面显然是非线性的;2集成分类器对糖尿病患者和健康者的气味图谱特征的识别准确率可达88.04%。结论:基于特征划分的分类器集成方法预测性能明显好于单一分类器,为使用医用电子鼻进行糖尿病诊断分析提供了一种有效手段。Objective: To discuss the proi le features of oral odor of diabetic patients based on medical electronic nose technology. Methods: 180 patients of diabetes and 100 healthy people were selected, and the proi le features of oral odor of 280 volunteers were collected by using medical electronic nose. The classii cation forecasting was carried out on diabetic patients by using support vector machine(SVM) and random forest integration model based on partitioning method of data characteristics. Results: 1The classii cation result of SVM1 was not very good, which was lower than that of SVM2, SVM3 and RF, and the result showed that the classii cation hyperplane is nonlinear. 2The accurate rate of recognition of integrated classii er on diabetic patients and healthy people is 88.04%. Conclusion: The forecasting performance of classii er integration method based on feature division is superior to that of single classii er signii cantly, which provided an ef ective means for the diagnostic analysis of diabetes based on medical electronic nose.国家自然科学基金项目(No.81373552);; 福建省教育厅A类项目(No.JA14212);; 福建工程学院科研启动项目(No.GY-Z12079)~

Neighboring / Adjacent Coupling Relationship Between Urbanization and Farmland Safety Based on the Decoupling Theory

当前我国快速城市化推进对半城市化、农村等近程区域分布的耕地产生直接、强烈的影响,也对耕地安全造成强大的胁迫效应。为此,构建城市化-耕地安全综合评; 价指标体系,分别计算城市化指数和耕地安全胁迫指数,并基于脱钩理论方法对城市化水平与耕地安全水平的近程耦合关系进行量化分析。以江苏省连云港市为例,; 定量分析20002014年间其城市化水平与耕地安全的脱钩-耦合关系及耕地安全对城市化进程的响应程度。结果表明,; 20002014年间,连云港市城市化指数持续增高,耕地安全胁迫指数波动降低;; 20002007年为强脱钩、弱脱钩、扩张负脱钩及扩张脱钩的波动状态;; 20082014年呈更加强烈的波动状态,包括20082012年的强脱钩和2013年的扩张负脱钩状态,这反映出区域发展规划、土地利用规划和城市总体; 规划的实施对这一典型近程耦合系统产生了较大影响。研究期内连云港市城市化水平大幅提高,耕地安全所受胁迫程度不断降低,两者虽总体呈强脱钩关系,但仍需; 注意近程耦合结果波动性较大所揭示的不确定性问题,需要谨慎权衡城市化相关政策对耕地安全的影响。与过去的宏观、单一指标模型相比,基于近程耦合关系提出; 的多指标脱钩-耦合模型更具综合性,能更加全面、精细化分析快速城市化进程与耕地安全保护之间的复杂关系,为半城市化地区景观安全格局评估提供支撑,为城; 市化与耕地保护之间的协调发展提供决策支持。The current rapid development of urbanization in China has directly and; seriously affected farmlands distribution in its para-urbanized; neighboring /adjacent regions,and also posed severe stresses on safety; of these land. It is,therefore,essential to build up a comprehensive; urbanization and farmland safety assessment indicator system,work out; quantitatively urbanization index and farmland safety stress index,and; analyze quantitatively neighboring coupling relations between; urbanization and arable land safety based on the decoupling theory and; method. A case study was conducted of Lianyungang City of Jiangsu; Province to explore quantitatively coupling-decoupling relationship; between urbanization and farmland safety and response of farmland safety; to the progress of urbanization during the period from 2000 to 2014.; Results show that during the study period,urbanization index of; Lianyungang City increased steadily,while farmland safety stress index; fluctuated with a declining trend. Their relationship displayed a wavy; trend from 2000 to 2007,i.e. strong decoupling-weak decoupling-expanding; negative decoupling-expanding connection and a strong fluctuation curve; from 2008 to 2014,including strong decoupling during 2008-2012 and; expanding negative decoupling in 2013,which reflects strong impacts of; the implementation of the regional development,land use and city overall; programs on this typical neighboring / adjacent coupling system. During; the study period,Lianyungang City made a huge and steady progress in; urbanization, while reducing fluctuation of its stress on farmland; safety. Though the two posed a strong decoupling relationship,the; problem of uncertainty reflected in the huge fluctuation of the result; of the neighboring /adjacent decoupling calls for high attention,and the; influence urbanization had on farmland safety needs to be weighed; prudently. Compared to the macroscopic single indicator models used in; the past,the multi-index decoupling-coupling model built for the; neighboring coupling relationship is more comprehensive and capable of; analyzing the complex relationship between rapid urbanization and; protection of farmland safety in a more holistic and finer way.; Furthermore,it may provide theoretical support to landscape safety; assessment of para-urbanizd regions and to decision-making on harmonized; development of both urbanization and protection of farmland.国家自然科学基金; 厦门大学大学生创新创业训练计划; 中国科学院大学生创新实践训练计

Application of Ionic Liquids in Extraction and Separation

室温离子液体是由正负离子组成的室温为液体的熔融盐,因其具有极低的蒸汽压、可设计性和特殊的选择溶解能力等独特的性质,使得其在萃取分离有机物及金属离子、液相微萃取和汽油柴油中脱硫及碱性氮化物等领域都有着广泛应用。综述了离子液体在萃取分离上的应用进展。Ionic substances with melting points close to room temperature were referred as room-temperature ionic liquids,which showed lots of unique properties,e.g.environmentally benign,nonvolatile,designable and were good solvents for a wide range of both organic and inorganic materials.Ionic liquids are widely used in extraction and separation processes,e.g.extraction and separation of metal ions and organic compounds,headspace liquid-phase micro extraction,removal of basic nitrogen compound from distilled diesel and desulphurization of gasoline.In this paper,the recent application of ionic liquids in extraction and separation were reviewed.教育部科学技术研究基金重点资助项目(207108

福建省实验动物学学科发展研究报告

1实验动物科学概述1.1实验动物科学的概念实验动物科学(lAbOrATOry AnIMAl SCIEnCES)是以实验动物资源研究、质量控制和利用实验动物进行科学实验的一门综合性学科。在《学科分类与代码标准》(gb/T13745-1992)中,与实验动物科学有关的学科分别是“实验动物学“、“医学实验动物学“、“比较病理学“等

铁皮石斛多糖通过上皮-间质转化抗肝纤维化

目的探讨铁皮石斛多糖（DOP）对CCl4 诱导肝纤维化（HF）的影响及其作用机制。方法将56 只雄性SD 大鼠随机分为七组：正常组（NG）、模型组（MG）、秋水仙碱组（CG， 0.1mg/ kg）、扶正化瘀组（FG， 0.45g/kg）、低剂量DOP 组（LDG， 0.05 g/kg）、中剂量DOP 组（MDG， 0.1 g/kg）和高剂量DOP 组（HDG，0.2 g/kg），每组8 只。采用皮下注射40% CCl4 橄榄油混合液制备HF 大鼠模型，每3 d 注射1次，共10周。造模第6周结束后，各药物组分别给予秋水仙碱、扶正化瘀和DOP 溶液灌胃处理，NG 和MG 大鼠给予等量0.9 % 生理盐水处理，每天1次，连续4周。各组大鼠肝组织病理学采用苏木精-伊红（HE）、Masson 染色、天狼星红（Sirius red）染色检测；肝功能和肝纤四项指标采用血液生化法检测；肝组织中α-SMA、Col-I、E-cadherin、ZEB1 基因和蛋白的表达分别采用RT-qPCR 法和Western Blot 法检测。结果HE、Masson、Sirius red 染色结果显示MG 大鼠肝脏组织出现典型的HF 病理特征，LDG、MDG 和HDG 大鼠HF 均出现不同程度改善。肝功能检测结果显示，LDG、MDG、HDG 大鼠的血清AST、TBIL、AKP 水平与MG 相比均显著降低（P < 0.05或 < 0.01），血清ALT 水平除LDG 外均显著降低（P < 0.05或 < 0.01）。肝纤四项指标检测结果显示，LDG、MDG、HDG 大鼠的血清HA、LN、PC-Ⅲ、COL-Ⅳ 含量与MG 比较均明显下降（P < 0.05或 < 0.01）。基因、蛋白检测结果显示，LDG、MDG、HDG 大鼠肝组织中α-SMA、COL-I、ZEB1 的相对表达量明显降低（P < 0.05或 < 0.01），而E-cadherin 的相对表达量升高（P < 0.05或 < 0.01）。此外，HA、α-SMA、COL-I、ZEB1、E-cadherin 的表达均存在一定的DOP 剂量依赖性。结论DOP 可通过抑制大鼠肝组织的上皮-间质转化减轻CCl4 诱导的HF 程度

庚型肝炎病毒基因在大肠杆菌中表达的初步研究

利用原核表达载体 pRSET或 (和 )pGEX在大肠杆菌内表达了覆盖庚型肝炎病毒 (HGV)C NS3和NS5区的多段基因。CE1、E2、NS3、NS5及NS3 NS5嵌合基因等的 8段基因均有高效表达 ,各重组蛋白产量与菌体总蛋白之比在 10 %～ 35 %之间。对以上重组蛋白进行免疫学筛选 ,证实其中 7个重组蛋白均具免疫学活性 ,在一定程度上确定了重组HGV抗原表位的分布 ,为HGV的血清学和免疫学诊断试剂的研究奠定了坚实基

从中国非甲-庚型肝炎病人中克隆到TT病毒样DNA序列

从中国非甲－庚型肝炎病人中克隆到ＴＴ病毒样ＤＮＡ序列张军１杨海杰１苏智军２张奕返２林长青１黄鹤１郭庆１王颖１曾定１夏宁邵１（１厦门大学肿瘤细胞工程国家专业实验室厦门３６１００５２福建省泉州市第一医院泉州３６２０００）肝炎是严重危害我国人民身体健康的疾..

CCCCC pentadentate chelates with planar Möbius aromaticity and unique properties

本课题充分发挥了厦门大学多学科协同研究优势，通讯作者为夏海平教授（合成、表征）、刘刚教授（生物医学应用）和吕鑫教授（理论计算）。合成实验和结构表征由朱从青（第一作者，目前在麻省理工学院、2005年诺贝尔化学奖得主Richard Schrock教授课题组从事博士后研究）完成；生物医学应用由杨彩霞（共同第一作者）、林凎、杨宇惠、王晓勇合作完成；理论计算由朱军、王永恒、朱从青完成。美国NIH的陈小元教授参与了生物医学应用的讨论。该研究工作得到国家自然科学基金委、科技部项目的支持。The coordinating atoms in polydentate chelates are primarily heteroatoms. We present the first examples of pentadentate chelates with all binding atoms of the chelating agent being carbon atoms, denoted as CCCCC chelates. Having up to five metal-carbon bonds in the equatorial plane has not been previously observed in transition metal chemistry. Density functional theory calculations showed that the planar metallacycle has extended Craig-Möbius aromaticity arising from 12-center–12-electron dπ-pπ π-conjugation. These planar chelates have broad absorption in the ultraviolet-visible–near-infrared region and, thus, notable photothermal performance upon irradiation by an 808-nm laser, indicating that these chelates have potential applications in photothermal therapy. The combination of facile synthesis, high stability, and broad absorption of these complexes could make the polydentate carbon chain a novel building block in coordination chemistry.the National Basic Research Program of China (nos. 2012CB821600 and 2014CB744503) , the National Science Foundation of China (nos. 21332002, 81422023, 51273165, 21490573, and 21573179)

第十八届美国理论与应用力学大会总结

1会议概况2018年6月5—9日,第18届美国理论与应用力学大会(18th U.S. National Congress of Theoretical and Applied Mechanics, USNCTAM2018)在美国芝加哥召开.本次大会由美国力学国家委员会和中国力学学会联合主办,旨在探讨和交流近四年世界范围内在理论和应用力学领域的基础研究、创新技术的最新进展,吸引了来自世界各地的近千名专家学