Clinical effects of goshajinkigan for male infertility

本剤は八味地黄丸にゴシツ, シャゼンシを加味した漢方薬である.その粉末5.0 g/日を男性不妊症患者中, 無力精子症3例, 乏精子症27例の計30症例に3ヵ月以上投与し, 検討した.1)精子運動率に対して53%の症例に有効性を認めた.2)精子数は33%に有効な増加を認め, ことに精子濃度10×106/ml以上の症例に有効であった.3)妊娠成立は30例中1症例のみであった.4)血清LH, FSH, 及び精液中prostaglandin E値には本剤投与前後において有意の変動は認められなかったNo study has been reported of the effects of Goshajinkigan on male infertility. Thirty infertile male patients were orally given Goshajinkigan at a daily dose of 5.0 g for three months or more. Sixteen of these patients showed significant improvement in sperm motility. Ten cases showed effective increase in sperm count. Only one patients became pregnant during the period of administration of this drug. Laboratory examination showed no significant change in serum LH, serum FSH or prostaglandin E in seminal fluid. These results suggest that administration of TSUMURA-Goshajinkigan is effective as therapy for male infertility, but how this drug may be involved in promoting fertility should be investigated in future

A Case of Leiomyosarcoma of Prostate: Multimodality Therapy Suppressed Disease Progression for Long Term

A 67-year-old man presented with macroscopic hematuria. Transrectal prostatic needle biopsy was performed because of elevated prostate specific antigen (PSA) (3.85 ng/ml) and palpation of hard nodules at the prostate. Pathological diagnosis was leiomysarcoma. Computed tomography revealed several pulmonary metastases. Radical cysto-prostatectomy and construction of ileal conduct were performed. Adjuvant radiotherapy (50 Gy) was also performed. During follow-up, the size of the pulmonary metastases increased, and we decided to start systemic chemotherapy 7 months after surgery. The chemotherapy consisted of gemcitabine (900 mg/m2 on day1 and day 8), and docetaxel (100 mg/m2 on day 8). After eight courses, there was 20% reduction in the size of some pulmonary metastases. He remained alive 21 months after diagnosis

Changes of hemoglobin values during the menstrual periods throughout the year in female collegiate EKIDEN runners

To investigate the changes of hemoglobin values during the monthly menstrual periods throughout the year in female collegiate Ekiden runners having normal menstruation. Four picked female collegiate long-distance runners and five ordinary women with no athletic experience as controls were the objects of this study. The following annually changing parameters were measured: daily body composition and hemoglobin level (Hb level; measured by ASTRIM FIT [Sysmex Corp., Japan]). All data were average values selected from five days of before and after monthly menstrual periods. The values of all parameters obtained during monthly menstrual periods of each subject were adopted for the analysis. Both runners group and control group indicated significant lower Hb values in menstrual periods than the values before and after the menstrual periods (p<0.05, respectively). And furthermore, the Hb value of runners group in menstrual periods (11.8±0.9 g/dL: lower than the reference value regulated by World Health Organization) was especially lower than the value of control group (13.5±0.9 g/dL). It was suggested from the results that female Ekiden runners should be careful with health management and adjustment of the daily practice for long-distance running particularly during each menstrual period正常な月経を有する大学女子駅伝選手における年間を通じた月経周期時のヘモグロビン値の変動について検討することを目的とした。被検者は，駅伝を専門とする長距離女子選手4名と，運動経験のない一般女性5名であった。ヘモグロビン（Hb）の測定は，毎日の起床時と就寝前に実施した。Hbの測定には簡易的ヘモグロビンモニタリング測定装置（シスメックス社製）を用いた。尚，各被検者の月経期及び月経前後のデータは，毎月の月経開始から終了までと，その前後のそれぞれ5日間の平均値を採用した。長距離選手群及び一般女性群の両群で，月経前後に比べて月経期が有意に低いHb値を示した（それぞれp<0.05）。さらに，月経期（11.8±0.9 g/dL：世界保健機関によって規制された基準値より低い）の長距離選手群のHb値は，一般女性群（13.5±0.9 g/dL）よりも特に低かった。以上の結果より，女性は月経期間中，特に長距離選手においては健康管理及び日常練習の調整に注意する必要があることが示唆された

フローサイトメトリーによる酵母生菌数の迅速測定

東京水産大学食品生産学科東京水産大学食品生産学科東京水産大学食品生産学科東京水産大学食品生産学科東京水産大学食品生産学