中药合剂治疗慢性胃炎的临床疗效观察

目的观察五磨饮子合半夏泻心汤加减治疗慢性胃炎患者的临床疗效及中医证候的影响。方法将60例患者随机分为2组,对照组30例,予枸橼酸莫沙必利片治疗。治疗组30例,予五磨饮子合半夏泻心汤加减治疗,2组治疗疗程均为4周,治疗结束后第1个月随访,分别在治疗前、治疗第4周、治疗结束后1个月记录患者的中医证候积分。结果治疗组中医证候疗效总有效率为93.33%,优于对照组73.33%,差异有统计学意义(P<0.05),治疗组治疗4周中医证候积分(6.34±6.46)分,对照组(10.75±6.97)分,2组比较差异有统计学意义(P<0.01);治疗组治疗结束后1个月中医证候积分(6.15±6.03)分,对照组(10.57±7.12)分,2组比较差异有统计学意义(P<0.01)。结论五磨饮子合半夏泻心汤加减治疗慢性胃炎疗效肯定

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目的：探讨胃苏颗粒联合西药治疗老年胃食管反流病（GERD）的临床疗效。方法：回顾性分析2015年3月~2016年10月在厦门大学附属第一医院杏林分院接受治疗的GERD老年患者的临床资料。根据其治疗方式分为对照组和观察组,其中对照组给予常规西药治疗,观察组给予胃苏颗粒联合西药治疗。治疗4周后,观察两组患者的治疗效果,比较两组患者治疗前后反流检查计分（RFS）、压痛程度、炎症细胞因子水平、临床症状体征改善情况和不良反应发生率的差异。结果：治疗后观察组总有效率显著高于对照组,RFS、VAS评分及血清IL-18、IL-6、hsCRP水平显著低于对照组,反酸、烧心和腹痛等积分显著低于对照组（P〈0.05）。两组患者腹泻、肝肾功能受损等不良反应发生率差异无统计学意义。结论：胃苏颗粒联合西药对老年GERD患者有良好的疗效,可缓解症状,降低血清炎症细胞因子水平

Thermodynamics and kinetics of D-glyceric acid adsorption on ion exchange resin

D-甘油酸是一种重要的甘油衍生物,具有解酒护肝的功能。关于D-甘油酸生产方法的研究已有不少,但对其分离方法及分离机理的研究却鲜见报道。通过静态吸附实验,研究了D-甘油酸在201×7阴离子交换树脂上的等温热力学和动力学特性。结果表明,D-甘油酸在201×7阴离子交换树脂上的最大平衡吸附容量随p H的增加而降低,其吸附等温线符合Freundlich模型。在293~308 K下,吸附焓变为14.77 k J·mol-1,表明该吸附过程为吸热过程。升高温度有利于提高吸附速率,但对最大平衡吸附容量影响不大。同时,采用动边界模型描述D-甘油酸在该树脂上的交换行为,分别考察了料液浓度、树脂粒径和温度对交换过程的影响。交换过程的吸附速率随D-甘油酸浓度和温度的增加而增大,但随树脂粒径的增大而减小。研究表明该离子交换过程的速率控制步骤为颗粒扩散过程,交换过程的反应速率常数k0为1.22×10-3,反应级数a为0.631,表观活化能Ea为14.90 k J·mol-1,并得到了动力学总方程。D-glyceric acid, one of the promising glycerol derivatives, has various biological functions such as accelerating ethanol and acetaldehyde oxidation. Plenty studies on the synthesis but few studies on downstream processes to recover D-glyceric acid were available. A static equilibrium adsorption was performed to study isothermal thermodynamics and kinetics of D-glyceric acid adsorption onto 201×7 strong basic anion exchange resin. The results showed that the adsorption process followed the Freundlich isothermal model at different p H and temperature conditions, which the maximum adsorption capacity decreased with increasing initial p H. The change of adsorption enthalpy was 14.77 k J·mol-1 at 293—308 K, suggesting an endo-thermic adsorption process. Raising temperature improved adsorption rate with limited influence on equilibrium adsorption capacity. The Dynamic Boundary Model was used to investigate adsorption kinetics with a focus on effects of D-glyceric acid concentration, resin particle diameter and adsorption temperature. The results suggested the particle diffusion was rate-limiting step of the adsorption process. The adsorption rate increased with the increase of D-glyceric acid concentration and temperature, but decreased with the increase of resin particle diameter. The general kinetics equation was obtained with the rate constant of exchange(k0), reaction order(a) and the apparent activation energy of reaction(Ea) as following k0=1.22×10-3, a=0.631, Ea=14.90 k J·mol-1.福建省高校产学合作项目(2015N5006);; 福建省教育厅中青年教师教育科研项目(JA15393);; 泉州师范学院青年博士预研基金项目(2015QBKJ04)~

莆田市旅游形象建设探究

该文在对莆田市旅游形象进行问卷调查的基础上,就如何从莆田市的旅游资源和地方文化出发,塑造莆田市鲜明的旅游形象进行探讨,并通过旅游活动开发、宣传促销等有针对性的传播策略来强化莆田“妈祖故里莆商情,湖光山色荔枝城“的旅游形象。“海滨旅游地形象策划研究”项目;项目来源:省教育厅(B)类;项目编号:JB06082;校内编号:J1-53

LED Color Analysis

主要对蓝光、绿光、白光lEd的色度特性进行分析,首先通过单色仪,分别测得蓝光、绿光、白光lEd的相对光谱功率分布并以色度学理论为基础,计算出光源主波长、色纯度、色温和显色指数.计算结果表明:蓝光lEd和绿光lEd主波长随标准光源的不同变化不大,色纯度比较高,分别在0.64和0.87左右,一般显色指数为-29和-14,显色性很差,不适合用来做照明光源.白光lEd主波长随标准光源的不同变化较大,色纯度相当低,接近0,一般显色指数为82,显色性很好,完全符合照明光源的要求.In order to study the color characteristics of light-emitting diode,the characteristics of blue,green and white LED colors are analyzed.Firstly,the spectral power distribution of blue,green,white LED is respectively measured by using the monochromator,and then on the basis of the theory chroma,the main light source wavelength,color purity,color temperature and color rendering index are calculated.The results show that blue LED and green LED dominant wavelengths change little with different standard light sources,and the color purities are relatively high,at 0.64 and 0.87,respectively,the general color-rendering is very poor for the index of-29 and-14,so these blue and green LED are not suitable to be used as lighting source.White LED dominant wavelength largely change with different standard light sources,and color purity is relatively low,near 0,color rendering is good for the general color-rendering index of 82, so white LED is in full conformance with the lighting requirements

Determination of bisphenol A in environmental water samples by stir bar sorptive extraction based on molecularly imprinted polymer

以双酚A(bPA)为单体,利用整体材料“原位“聚合技术制备以分子印迹聚合物为涂层的吸附萃取搅拌棒(MIP-SbSE),然后与高效液相色谱(HPlC)-二极管阵列检测器联用,探讨其对环境水样bPA的选择萃取性能。优化萃取过程中吸附和解吸时间、解吸液种类以及基底PH值和离子强度对目标化合物的选择吸附性能。在最佳条件下,MIP-SbSE可对模板分子进行有效的选择吸附,线性范围为1.0~200μg/l,检出限(S/n=3)和定量限(S/n=10)分别为0.28μg/l和0.94μg/l。在实际水样分析中,具有良好的加标回收率,其值为96.0%~108.7%。研究结果表明,所建立的方法具有简便、灵敏和环境友好等特点。A new stir bar sorptive extraction (SBSE) based on molecularly imprinted polymer (MIP) with bisphenol A as template was prepared.Based on it,a simple,selective and sensitive method for the determination of bisphenol A (BPA) was developed combined with high performance liquid chromatography (HPLC) with diode array detection.To achieve the optimum extraction performance,several main parameters,including extraction and desorption time,the nature of desorption solvent,pH value and contents of inorganic salt in the sample matrix,were investigated.The optimized parameters for the extraction of BPA from water matrix with the MIP-SBSE are as follows: extraction and desorption time were 120 min and 10 min,respectively; the pH value of matrix was 10.0; using acetonitrile (including 1% acetic acid) as desorption solvent; no salt was added in the matrix.Under the optimized experimental conditions,the method showed good linearity between 1.0-200 μg/L.The detection limit (S/N=3) and quantification limit (S/N=10) of the proposed method for the BPA was 0.28 μg/L and 0.94 μg/L,respectively.The proposed method was successfully applied to the determination of the target compound in water samples.The recoveries of spiked target compound in real samples ranged from 96.0%-108.7%.The results indicated that the developed method possessed the advantages such as high sensitivity,simplicity,low cost and environmental friendliness.国家自然科学基金项目(No.20805039);福建省青年科技人才创新项目(No.2006F3117

Optimization Electrode of GaN-Based Light-Emitting Diode

针对以蓝宝石为衬底的GaN基发光二极管出现的电流扩展不均的问题,采用有限元方法建立了GaN基发光二极管的三维网络模型,并对四种常见结构的器件进行数值模拟,发现影响二极管电流的因素不仅与发光二极管电极的位置有关,而且依赖于器件的结构参数。以电流扩展不均为指标确定出这四种器件中最佳的电极位置分布,同时对最佳电极位置分布的器件进行了结构参数优化,结果表明当p型金属层方块电阻与n型GaN的方块电阻接近时,电流扩展均匀性最好,且p-GaN的接触电阻和厚度越小,电流扩展越不均匀。A 3D networks model of GaN-based LED on sapphire substrate was built by finite element analysis to simulate the non-uniformity current spreading.Analog modeling was done on the four normal device structures,it was found that the factors effected the current of LED were the position of electrode and the parameters of device structure.Considering the practical structures of GaN-based LED,four LED designs were modeled and the optimal electrode distribution was obtained,meanwhile the structure parameters were optimized.It reveals that the smaller contact resistances and the thickness of p-GaN are,the more non-uniformity of current distribution is.国家自然科学基金(60276029);; 国家863计划(2004AA311020和2006AA032409);; 福建省科技项目和基金(2006H0092,A0210006,2005HZ1018

Experimental study on characteristics of stress wave propagation in mesoscale and complex rock mass by microseismic monitoring

采用全数字型多通道微震监测系统,对深部复杂采空区岩体和上部露天台阶絮渣岩体分别进行了现场爆破应力波传播特性试验,利用P波触发时间和传播距离组成的离散点进行线性拟合,得出应力波传播速度,结果显示深部复杂采空区岩体和上部絮渣岩体明显出现两个层状速度模型。利用应力波振幅和传播距离组成的离散点进行曲线拟合,并对应力波信号进行频谱分析和滤波处理,研究应力波的衰减特性。试验结果表明,应力波振幅随传播距离的增加而减小,且在数值上呈乘幂衰减;应力波衰减系数和应力波频率成正比,数值上呈三次多项式关系,高频成分应力波衰减更加明显。利用试验数据,分别计算出深部复杂采空区岩体和上部絮渣岩体的平均品质因子,计算结果分别为4.055和2.478,两者远小于一般原岩的岩体品质因子,说明复杂采空区和絮渣的存在对应力波的传播有很大影响。By using the digital multi-channel microseismic monitoring system, the characteristics of blast stress wave propagation in deep complex and mined-out area and upper fractured rock mass are tested.The wave velocity is acquired by the curve fitting method, which uses the P wave triggering time and propagation distance.The results show that the wave velocities in deep complex and mined-out rock mass and upper coagula rock mass are obviously different.Fitted the curve by using the stress wave amplitude and propagation distance, it is found that the stress wave amplitude decreases in the form of power when the propagation distance increases.By using the signal spectrum analysis and filtering, the attenuation coefficient and frequency are in cubic polynomial relations, and the attenuation of the high-frequency wave is more obvious.The average quality factors in deep complex and mined-out area and upper fractured rock mass, are calculated and they are 4.055 and 2.478, far less than those of the original rock mass, indicating that the mined-out area and fracture have great influence on the stress wave propagation

Two Epothilones from Sorangium cellulosum Strain So0157-2

目的:对粘细菌SOrAngIuM CEllulOSuM SO0157-2的化学成分进行研究。方法:通过色谱层析对提取物进行分离纯化,并通过波谱解析(一维、二维的核磁共振谱和质谱)确定了化合物的结构。结果:分别鉴定为SECO-EPOTHIlOnEA(1)和1-METHyl-SECO-EPOTHIlOnEA(2)。结论:化合物1和2都是首次从该菌株中分离得到。其中1是首次分离得到的新天然产物。AIM:To study the chemical constituents of Sorangium cellulosum So0157-2.METHODS:The chemical constituents were isolated and purified by column chromatography,and their structures were identified by spectroscopic analyses including 1D-,2D-NMR data and MS analyses.RESULTS:Two epothilones were purified and identified as seco-epothilone A(1) and 1-methyl-seco-epothilone A(2).CONCLUSION:1 and 2 were obtained from this strain for the first time,and 1 was a new natural product.supportedbyKeyProgramofInternationalCooperation;MinistryofScienceandTechnologyofChina(No.2007DFA30970);the863ProgramofChina(No.20060102Z1083)---

雌性大鼠性早熟对糖脂代谢的影响

目的探究雌性大鼠性早熟对糖代谢和脂代谢的影响。方法将60只两天龄的雌性大鼠随机分为性早熟组和正常组两组，分别在5天龄时给予达那唑（300 μg/只）或溶剂大豆油进行皮下注射，从21天龄起每天观察大鼠的阴道开口状况。建模成功的两组按照阴道开口顺序分别于阴道开口后3 d、7周龄和12周龄进行处死，处死前空腹12 h。方法测量麻醉后的体重和鼻肛长，通过酶联免疫吸附试验测量葡萄糖、胰岛素、血脂、雌二醇、瘦素和脂联素的浓度，病理切片观察肾周脂肪、子宫和卵巢的变化。结果通过正常组和早熟组两组3个时间点对比，早熟组在阴道开口3 d时体质量和鼻肛长小于正常组，但是不影响后续生长发育，7周龄和12周龄时两组体质量和鼻肛长差异无统计学意义。两组的胰岛素浓度对比在阴道开口后3天内有统计学意义（P = 0.001），早熟组存在高胰岛素血症，且早熟组此时的肾周脂肪细胞增多，在7和12周龄差异无统计学意义，两组3个时间点的雌二醇、瘦素和脂联素浓度差异均无统计学意义，两组卵巢和子宫与体质量的比重差异无统计学意义。结论通过两组大鼠的对比，性早熟使机体提前跨越发育的时间窗，不能适应内环境的骤变，产生的一系列变化只是暂时性且可逆性，至成年期会恢复