Effect of ZnO on Cu/ZnO/Al_2O_3 catalysts for methanol synthesis

[中文文摘]用高速碰撞共沉淀法制备m(CuO) /m(ZnO) /m(Al2 O3 )比分别为 60 /3 0 /1 0和 3 0 /60 /1 0的 1 #和 2 #催化剂 ,结果表明高ZnO的 2 #催化剂活性较好 ,分散度较大。XPS测试表明 2 #催化剂表面ZnO吸附的中间体 (CHx 或CHxO)较多且表面的Cu+1浓度较高 ,从而促进CO加氢合成甲醇的活性。[英文文摘]Cu/ZnO/Al_2O_3 catalysts with ratios of 60/30/10 and 30/60/10 have been prepared by high speed collision coprecipitation method. The performance of the catalyst with the higher ZnO content shows the higher activity in methanol synthesis. The characterization results indicated that the catalyst with the higher ZnO content has higher dispersion. On the surface of the higher ZnO content catalyst, there was more Cu+1 and more intermediate (CH_x and CH_xO) adsorpted. It is beneficial for the CO hydrogenating to produce methanol

シクロデキストリン ニヨル ディオスゲニン ノセイブツガク テキ リヨウノウ ノ カイゼン

会議

Utilization of reconstructed cultured human skin models as an alternative skin for permeation studies of chemical compounds

Two reconstructed human skin models, EpiskinSM and EpiDermTM, have been approved as alternative membranes for skin corrosive/irritation experiments due to their close correlation with animal skin. Such reconstructed human skin models were evaluated as alternative membranes for skin permeation experiments. Seven drugs with different lipophilicities and almost the same molecular weight were used as test penetrants. Relationships were investigated between permeability coefficients (P values) of the seven drugs through six kinds of reconstructed cultured human skin models and human skin. A fairly good relationship in P values was observed between TESTSKINTM LSE-high (LSE-high) or EpiDermTM and human skin, suggesting that these reconstructed human skin models could be used as alternative membranes for skin permeation experiments. However, the partition parameter, KL, and diffusion parameter, DL-2 in these reconstructed human skin models were different to those of human skin. Especially, KL values in reconstructed human skin models were very different to those in human skin, even for LSE-high and EpiDermTM. Therefore, suitable reconstructed human skin models should be carefully selected on a case by case basis.Original Articl

间歇式轴向压应力对组织工程骨种子细胞的黏附增殖与成骨分化促进作用的研究

目的探究间歇式轴向压应力对组织工程骨种子细胞黏附、增殖与成骨分化能力的影响。方法构建表达绿色荧光蛋白的兔骨髓间充质干细胞(rBMSCs)作为示踪种子细胞,运用旋转细胞培养仪将松质骨支架和种子细胞共培养7 d获得组织工程骨(TEB),实验组在第7～14天施加大小10 N、频率1 Hz、4 h/d的间歇式轴向压应力刺激,对照组常规培养,14 d后胰酶消化法获取两组种子细胞并比较其黏附、增殖和成骨分化能力。采用两组独立样本t检验进行统计学分析。结果 (1)流式细胞术显示rBMSCs被成功提取分离。(2)倒置荧光显微镜及扫描电镜显示TEB中种子细胞与支架相容性良好。(3)活体荧光成像系统及扫描电镜显示应力刺激组种子细胞的生长状况要优于非应力刺激组,前者平均荧光密度及细胞数/500倍视野均大于后者,差异均具有统计学意义(平均荧光密度:(3.75±0.34)×108 vs(2.91±0.22)×108,t=2.90,P=0.04;细胞数/500倍视野:30.50±4.43 vs 21.00±5.13,t=3.14,P=0.01)。(4)细胞黏附实验显示,应力刺激组种子细胞的75﹪细胞贴壁时间短于非应力刺激组,两组时间分别为(3.00±0.41) h、(13.33±1.70)h,差异具有统计学意义(t=8.20,P <0.01),前者的最终细胞贴壁率高于后者(99.97﹪±0.34﹪vs 85.83﹪±1.18﹪),差异具有统计学意义(t=11.31,P <0.01)。(5) CCK-8检测显示,在培养第48～96 h,应力刺激组种子细胞的增殖能力优于非应力刺激组,将两者的450 nm吸光度值在第48小时(0.49±0.02、0.40±0.02)、72 h(0.76±0.07、0.64±0.04)和96 h(1.58±0.07、1.34±0.13)分别进行比较,差异均具有统计学意义(t=5.15、2.57、2.86,P均<0.01)。(6)在成骨诱导14 d后,应力刺激组种子细胞的ALP和Ca结节染色阳性率要强于非应力刺激组:两组ALP染色阳性率分别为26.73﹪±4.56﹪、16.68﹪±3.89﹪,差异具有统计学意义(t=3.33,P=0.03);两组Ca结节染色阳性率分别为41.81﹪±3.56﹪、27.40﹪±2.35﹪,差异具有统计学意义(t=3.68,P=0.02)。结论间歇性轴向压应力可促进组织工程骨种子细胞的黏附、增殖与成骨分化

カンゴシ ノ ゾクセイ ニ ヨル ショクム ストレス ト サポート ニンチ ノ サイ

研究報

Developing On-site,Quick Screening Platform for Artificial Pigments in Food Using Surface-enhanced Raman Spectroscopy

已有研究表明食品加工过程中添加的人工合成色素不仅不能提供营养物质,而且可能是导致小儿多动症的来源之一,影响儿童智力发育.基于表面增强拉曼光谱(SERS)原理和便携式拉曼光谱仪,提出了一种非定向的现场快速筛查方法.该方法只需对疑似含有人工合成色素的固体或液体状食品样品进行简单前处理,即可进行SERS检测.样品前处理和检测的总时长不超过15 min,检出质量浓度在1 mg/L水平,可有效满足政府职能部门的现场执法需求.除具有快速、方便、灵敏度高等特点之外,该检测方法的最大优势在于实现了未知样品的现场非定向测试:在同一种前处理过程和检测方法下,可对食品中常添加的亮蓝、胭脂红、日落黄、柠檬黄、苋菜红和诱惑红6种人工合成色素进行快速鉴定和半定量分析.As widely used additives in food processing,artificial pigments have no any nutrition but are potential sources of hyper-activity and affect the intellectual development of children.On the basis of surface-enhanced Raman spectroscopy( SERS) and portable Raman instrument,we developed a non-targeting,on-site and quick screening platform for artificial pigments in food matrix. SERS measurement could be carried out after the food matrix( either in solid or liquid states) being simply pretreated for 15 min.The detectable concentration is as low as 1 mg / L,a level meeting the demand of the on-site enforcement by the government.Besides the advantages of quick,easy-on-going,and high sensitivity,the most distinguished point of SERS is the non-targeting qualitative on-site detection for the typical pigment additives,including brilliant blue,carmine,sunset yellow,lemon yellow,amaranth and allura red,et al.,while both the pretreatment procedure and the SERS detection remain the same.国家自然科学基金(21473140);; 福建省高校产学合作项目(2016Y4012);; 中央高校基本科研业务费专项(2072016011

沙格列汀治疗2型糖尿病病人致心衰风险的荟萃分析

目的:系统评价2型糖尿病病人用沙格列汀治疗与心衰风险的相关性。方法:检索中文科技期刊全文数据库(维普)、万方数据-数字化期刊群、中国期刊全文数据库(中国知网)、PubMed和Cochrane library建库至2017年12月的相关文献。按Cochrane系统评价法筛选沙格列汀致心衰的所有随机、对照临床试验(RCT),将纳入的文献进行数据提取和质量评价后,应用RevMan 5.3软件进行meta分析。结果:共纳入11篇文献,meta分析结果显示:沙格列汀致心衰的风险高于对照组,差异有统计学意义[RR=1.20,95%CI(1.02,1.42),P=0.03]。进一步研究发现,5mg/d沙格列汀单药或联合治疗致心衰的风险高于对照组,差异有统计学意义[RR=1.24,95%CI(1.05,1.46),P=0.01];2.5、10mg/d沙格列汀无论单药或联合治疗致心衰的风险与对照组比较均无显著性差异[2.5mg/d沙格列汀RR=0.69,95%CI(0.31,1.55),P=0.37;10mg/d沙格列汀RR=0.18,95%CI(0.02,1.67),P=0.13]。结论:使用5mg/d沙格列汀治疗可增加心衰风险,而其他剂量的沙格列汀均未发现增加心衰的风险。沙格列汀治疗2型糖尿病的远期安全性需进行更多大样本、高质量、长期随访的RCT加以验证

Effects of Soil Salinity on the Quality of Carrot

采用土壤盆栽试验,设置6个盐度水平(0、500、1000、1500、2000、2500 Mg/kg),研究胡萝卜种植过程中盐度对其叶绿素、维生素C、可溶性糖、可溶性蛋白质及硝酸盐含量的影响。结果表明,种植胡萝卜的土壤盐度控制在500 Mg/kg,可以提高胡萝卜的品质,减少盐分对土壤的损伤。具体表现为,500 Mg/kg盐度处理对胡萝卜叶绿素含量无显著影响,而高盐度使胡萝卜叶绿素总含量降低;500~1000 Mg/kg盐度可增加胡萝卜维生素C和可溶性蛋白质含量;可溶性总糖含量以500 Mg/kg处理的降低幅度最小,500~2000 Mg/kg处理使胡萝卜硝酸盐含量呈降低趋势,但高盐度(2500 Mg/kg)则会增加其硝酸盐含量。A soil pot experiment with different levels of saltnity(0,500,1500,2000,2500 mg/kg) were carried out to study the effects of salinity on the quality of carrot.The results showed that controlling certain salinity 500 mg/kg,could improve the quality of carrot.Because the salinity of 500 mg/kg had no effect on the chlorophyll content of carrot,and high salinity caused total chlorophyll content decreased,low salinity was conducive to the promotion of carrot synthesis of vitamin C and soluble protein,soluble sugar content of carrot was decreased by the increasing of salinity levels,Nitrate content in carrots increased at the high salinity(2500 mg/kg) treatment.厦门市科学技术局项目(3502Z20071098

A Study on Life and Health of Old-old Elderly lived in an Area of Heavy Snowfall

目的:本研究の目的は,豪雪地帯に暮らす後期高齢者の生活機能に焦点をあてることで,彼らの健康力・生活力を積極的に評価する側面に観点をおき,後期高齢者の生産的能力を支援する介護予防対策について提案することである.中間報告では,身心活動性を中心に報告する.研究方法:対象地域はJ市(高齢化率19.4)とK市(同26.5)であり,対象は満75歳以上の在住者でインタビューに回答することを承認された本人とし,調査票を用いた構成的面接法により個別に実施した.用いた指標は,老研式活動能力指標,転倒アセスメント,体力スケール,老人用うつスケール短縮版であり,分析はSPSS 11.0で行った.結果:全調査対象者は171人(平均年齢80.5歳),男性64人(37.4%),女性107人(62.6%)であった.性別家族構成には有意差がみられ,約85%は介護保険を申請しておらず,4つの指標とも85歳以上で顕著な低下がみられた.聴力低下も著しく85歳以上の55%にみられ,痛みのある者も全体で54%,冬期間には64%となり,女性に多くみられた.身体の変形のある者は6割弱であった.考察:本調査対象者の85%以上は,被介護者にならない程度に自立した集団といえるが,85歳以上では身心活動能力に顕著な低下あるいはリスクが観察された.一方,高齢者夫婦が存命の家族構成では,身心活動能力が高い傾向にあることも明らかにされた.聴力や痛みの自立度に与える影響の大きさも示され,健康診査時の補聴器の導入や痛み,変形に関する時系列の評価の必要性が示唆された.departmental bulletin pape