促胰岛β细胞增生的黄酮类化合物的活体筛选

目的利用斑马鱼为模型进行黄酮类药物筛选,以期发现促进胰岛β细胞增生的药物。方法对生长5 d的斑马鱼胚胎进行黄酮类药物处理,并进行β细胞计数,筛选出能够促进β细胞数量增加的药物,并进一步分析其促进β细胞增加是源自于已有β细胞的复制或前体细胞的分化。结果淫羊藿素(Icaritin)能够增加胰岛β细胞的数量,并明显促进β细胞的复制。同时,我们发现有几个黄酮类化合物具有降血糖的作用。结论淫羊藿素能够明显促进β细胞的自我复制从而促进β细胞的增生。国家自然科学基金(No.81670709);;福建省自然科学基金(No.2017J01145);;中央高校基本科研业务费(No.20720170104、20720180044

Zooplanktonic diversity in the western Pacific

西太平洋区是全球海洋生物种源中心,许多类群的最高物种多样性都出现于该区域,因此,在该区开展种类多样性的研究不仅重要和必要,而且具有在跨国尺度上进行综合管理和相互合作的迫切性。本文在西太平洋的浮游动物样品鉴定分类、编目、文献资料整理和分析的基础上,记录和编入西太平洋10个浮游动物类群2,658种(含亚种),隶属于206科675属,其中水螅水母类99科251属697种,栉水母类12科22属59种,浮游软体动物14科35属86种,介形类8科89属416种,桡足类51科156属908种,糠虾类4科58属202种,磷虾类2科8属56种,十足类8科22属105种,毛颚类5科8属48种,被囊类5科26属81种。The western Pacific region has been operating as a centre for the origin of marine biodiversity: the richest diversity of many marine taxa was found in these waters.Therefore,biodiversity research and con-servation efforts in this area are necessary in order to promote the integrative and international management of this resource.The present work is a compilation of numbers of all the families,genera and species of ma-jor taxa of zooplankton known in the western Pacific Ocean(106°–150°E,0°–44°N).In all,2,658 zooplank-tonic species(including subspecies) belonging to 206 families and 675 genera have been recorded from taxonomic identifications and literature,99 families,251 genera and 697 species belong to the Medusozoa,12 families,22 genera and 59 species to the Ctenophora,14 families,35 genera and 86 species to the pelagic Molluscs(Pteropoda and Heteropoda),8 families,89 genera and 416 species to the Ostracoda,51 families,156 genera and 908 species to the Copepoda,4 families,58 genera and 202 species to the Mysidcea,2 fami-lies,8 genera and 56 species to the Euphausiacea,8 families,22 genera and 105 species to the Decapoda,5 families,8 genera and 48 species to the Chaetognatha,5 families,26 genera and 81 species to the Tunicata.908专项“中国海洋生物种类名录和图谱”(908-ZC-II-02)和908专项海洋生物样品库;科技部基础工作专项“我国和邻近西北太平洋海洋生物物种编目和分布图集编制”(2006FY220700

意味記憶からの情報検索 : 人間の記憶についての認知心理学的研究

This experiment measures retrieval time from semantic memory， and this paper explaines how a network representation of the propositions is created． Such representations reveal in graphical form the associative connections between concepts． The closer together the concepts in a propositional network are， the better cues they are for each other’s recall． The results of this experiment almost support the network of concepts assumed by Collins and Quillian（1969）in their experiment to compare reaction time in making true－false judgments about statements， but some do not． A hierarchy of concepts which they proposed can be rarely seen in this study．departmental bulletin pape

大熊猫粪便中线粒体基因库特点研究

为了解大熊猫（Ailuropoda melanoleuca）肠道脱落细胞中线粒体DNA（mtDNA）的异质性特点及其与年龄的关系，以92只不同年龄的大熊猫粪便为材料，通过扩增子高通量测序研究非编码的D-loop区、编码rRNA的16S rRNA区以及编码蛋白质的ND1和ND2区的异质性。结果显示：D-loop区存在3个异质性热点区段，突变碱基的数量远远高于其他3个编码区；D-loop区TS/TV小于16S rRNA和ND两个编码区，表明后两者较D-loop区受到更强烈的纯化选择；ND区第3位密码子的突变频率显著高于前两位，选择压力最低。此外，16SA3、ND1A6和ND2A7三个编码区的异质性可能与年龄相关。上述结果表明，大熊猫粪便DNA的异质性突变构成了一个多样性较高的线粒体基因库，突变在组织细胞水平上受到自然选择的作用。该线粒体基因库为揭示动物适应性进化机制、个体对环境的适应方式、个体适合度和动物与肠道微生物及环境的关系等提供一个全新的角度，也可能成为有潜力的大熊猫个体年龄预测标记