Clustered Distribution of Natural Product Leads of Drugs in the Chemical Space as Influenced by the Privileged Target-Sites

10.1038/srep09325Scientific Reports

The Proximal Operator of the Piece-wise Exponential Function and Its Application in Compressed Sensing

This paper characterizes the proximal operator of the piece-wise exponential function $1\!-\!e^{-|x|/\sigma}$ with a given shape parameter $\sigma\!>\!0$, which is a popular nonconvex surrogate of $\ell_0$-norm in support vector machines, zero-one programming problems, and compressed sensing, etc. Although Malek-Mohammadi et al. [IEEE Transactions on Signal Processing, 64(21):5657--5671, 2016] once worked on this problem, the expressions they derived were regrettably inaccurate. In a sense, it was lacking a case. Using the Lambert W function and an extensive study of the piece-wise exponential function, we have rectified the formulation of the proximal operator of the piece-wise exponential function in light of their work. We have also undertaken a thorough analysis of this operator. Finally, as an application in compressed sensing, an iterative shrinkage and thresholding algorithm (ISTA) for the piece-wise exponential function regularization problem is developed and fully investigated. A comparative study of ISTA with nine popular non-convex penalties in compressed sensing demonstrates the advantage of the piece-wise exponential penalty

Rethink left-behind experience: new categories and its relationship with aggression

Left-behind experience refers to the experience of children staying behind in their hometown under the care of only one parent or their relatives while one or both of their parents leave to work in other places. College students with left-behind experience showed higher aggression levels. To further explore the relationship between left-behind experience and aggression, the current study categorized left-behind experience using latent class analysis and explored its relationship with aggression. One thousand twenty-eight Chinese college students with left-behind experience were recruited, and their aggression levels were assessed. The results showed that there were four categories of left-behind experience: “starting from preschool, frequent contact” (35.5%), “less than 10 years in duration, limited contact” (27.0%), “starting from preschool, over 10 years in duration, limited contact” (10.9%), and “starting from school age, frequent contact” (26.6%). Overall, college students who reported frequent contact with their parents during the left-behind period showed lower levels of aggression than others did. Females were less aggressive than males in the “starting from preschool, frequent contact” left-behind situation, while males were less aggressive than females in the “starting from school age, frequent contact” situation. These findings indicate that frequent contact with leaving parents contributes to decreasing aggression of college students with left-behind experience. Meanwhile, gender is an important factor in this relationship

国际二语自我调节学习研究二十年回顾： 基于文献计量与范围综述的融通方法 Self-regulated Learning in Second Language Education: A Synthesized Method of Bibliometrics and Scoping Review

The present study conducted a synthesized review of the literature on SRL in L2 settings over the past two decades. Drawing upon the Web of Science Core Collection database, this study initially employed bibliometrics to conduct a visualization analysis of 195 research papers on SRL in L2 contexts from 2005 to 2023. This analysis systematically examined the publication trends, research hotspots, and core authors. Then, using a scoping review approach, this study scrutinized 63 core empirical articles to further explore theoretical frameworks, research contexts, research scopes, and methodologies. The key findings are summarized as follows: (1) Research on SRL in L2 settings has developed into an essential topic with prolific studies on a range of themes; (2) Theoretical challenges arise from the ambiguous definition of SRL and terminological inconsistencies. The preponderance of sociocognitive theory in the literature restricts a multifaceted examination of SRL in L2 settings; (3) Most studies focus on tertiary-level participants, neglecting learners from diverse cultural backgrounds and age groups; (4) The bulk of empirical research focuses on L2 writing, with limited exploration of other language skills like reading, vocabulary, listening, and speaking among others; (5) Cross-sectional design is widely used with quantitative methods for data collection, while experimental or longitudinal studies are in urgent need. Recommendations for future studies are proposed, including extending theoretical frameworks to encompass sociocultural theory, language ecology, or complex dynamic systems theory， with a hope in broadening the research topics, such as exploring SRL of L2 across various linguistic proficiencies and sociocultural/educational backgrounds, or conducting longitudinal studies using various research methods to trace the development of SRL

Predicting Continuous Locomotion Modes via Multidimensional Feature Learning from sEMG

Walking-assistive devices require adaptive control methods to ensure smooth transitions between various modes of locomotion. For this purpose, detecting human locomotion modes (e.g., level walking or stair ascent) in advance is crucial for improving the intelligence and transparency of such robotic systems. This study proposes Deep-STF, a unified end-to-end deep learning model designed for integrated feature extraction in spatial, temporal, and frequency dimensions from surface electromyography (sEMG) signals. Our model enables accurate and robust continuous prediction of nine locomotion modes and 15 transitions at varying prediction time intervals, ranging from 100 to 500 ms. In addition, we introduced the concept of 'stable prediction time' as a distinct metric to quantify prediction efficiency. This term refers to the duration during which consistent and accurate predictions of mode transitions are made, measured from the time of the fifth correct prediction to the occurrence of the critical event leading to the task transition. This distinction between stable prediction time and prediction time is vital as it underscores our focus on the precision and reliability of mode transition predictions. Experimental results showcased Deep-STP's cutting-edge prediction performance across diverse locomotion modes and transitions, relying solely on sEMG data. When forecasting 100 ms ahead, Deep-STF surpassed CNN and other machine learning techniques, achieving an outstanding average prediction accuracy of 96.48%. Even with an extended 500 ms prediction horizon, accuracy only marginally decreased to 93.00%. The averaged stable prediction times for detecting next upcoming transitions spanned from 28.15 to 372.21 ms across the 100-500 ms time advances.Comment: 10 pages,7 figure

ARGO: An Auto-Tuning Runtime System for Scalable GNN Training on Multi-Core Processor

As Graph Neural Networks (GNNs) become popular, libraries like PyTorch-Geometric (PyG) and Deep Graph Library (DGL) are proposed; these libraries have emerged as the de facto standard for implementing GNNs because they provide graph-oriented APIs and are purposefully designed to manage the inherent sparsity and irregularity in graph structures. However, these libraries show poor scalability on multi-core processors, which under-utilizes the available platform resources and limits the performance. This is because GNN training is a resource-intensive workload with high volume of irregular data accessing, and existing libraries fail to utilize the memory bandwidth efficiently. To address this challenge, we propose ARGO, a novel runtime system for GNN training that offers scalable performance. ARGO exploits multi-processing and core-binding techniques to improve platform resource utilization. We further develop an auto-tuner that searches for the optimal configuration for multi-processing and core-binding. The auto-tuner works automatically, making it completely transparent from the user. Furthermore, the auto-tuner allows ARGO to adapt to various platforms, GNN models, datasets, etc. We evaluate ARGO on two representative GNN models and four widely-used datasets on two platforms. With the proposed autotuner, ARGO is able to select a near-optimal configuration by exploring only 5% of the design space. ARGO speeds up state-of-the-art GNN libraries by up to 5.06x and 4.54x on a four-socket Ice Lake machine with 112 cores and a two-socket Sapphire Rapids machine with 64 cores, respectively. Finally, ARGO can seamlessly integrate into widely-used GNN libraries (e.g., DGL, PyG) with few lines of code and speed up GNN training.Comment: To appear in IEEE International Parallel and Distributed Processing Symposium (IPDPS) 202

Fisher discriminant analysis of multimodal ultrasound in diagnosis of cervical metastatic lymph nodes in papillary thyroid cancer

Background/Aims The purpose of this study was to develop a diagnostic model utilizing multimodal ultrasound parameters to aid in the detection of cervical lymph node metastasis in papillary thyroid cancer (PTC) patients. Methods The study included 84 suspicious lymph nodes from 69 PTC patients, all of whom underwent fine needle aspiration with pathological results. Data from conventional grayscale ultrasound, shear wave elastography (SWE), and superb microvascular imaging were analyzed. Key ultrasound features were compared between benign and metastatic groups to create a diagnostic model using Fisher’s stepwise discriminant analysis. The model’s effectiveness was assessed with self-testing, cross-validation, and receiver operating characteristic curve analysis. Results Four features, namely lymphatic hilum (X1), cortical hyperechogenicity (X2), vascular pattern (X4), and SWEmean (X7), were integral to the discriminant analysis, resulting in the equation: Y1 = −3.461 + 2.423X1 + 0.321X2 + 1.620X4 + 0.109X7, Y2 = −8.053 + 0.414X1 + 2.600X2 + 2.504X4 + 0.192X7. If Y1 < Y2, the LN would be diagnosed as metastatic lymph nodes. The model demonstrated an area under the curve of 0.833, with a sensitivity of 83.33% and specificity of 83.33%. Conclusions The multimodal ultrasound diagnostic model, established through Fisher’s stepwise discriminant analysis, proved effective in identifying metastatic lymph nodes in PTC patients