过氧化物酶体增殖物活化受体γ与血管钙化

流行病学资料显示,血管钙化与慢性肾脏病(chronic kidney disease,CKD),尤其是维持性透析患者心血管疾病的患病率和病死率密切相关。过氧化物酶体增殖物活化受体γ(peroxisome proliferator-activated receptor gamma,PPARγ)是许多生理和疾病的重要调节因子。近来有研究表明PPARγ通过调节间充质干细胞和造血干细胞在体内骨量稳态中起着双重调节作用,而CKD患者血管钙化往

慢性肾脏病患者甲状腺功能与心血管疾病相关性的研究进展

慢性肾脏病(chromc kidney disease,CKD)是当前全球面临的严重公共卫生问题之一,尽管针对CKD的治疗手段不断进展,终末期肾脏疾病(end-stage renal disease,ESRD)患者的病死率仍居高不下,给临床工作者带来了极大的挑战。在CKD早期,心血管疾病(cardiovascular diseases,CVD)即发生,且随着病情的进展日渐加重,而CVD是尿毒症患者的首位死亡原因。早期发现ESRD患者CVD的危险因素,及时采取有效干预措施,对减少维持性血液透析(ma

Acute kidney injury after liver transplantation:recent view and future forecast

Objective Acute kidney injury（AKI） is a common complication after liver transplantation（LT）,which affects the short-term and long-term prognosis of liver transplant patients.The occurrence of postoperative AKI after LT is multifactorial,and lacks uniformity and wide variation of AKI definitions.Traditional indicators to assess renal function have limitations under end-stage liver disease（ESLD） conditions,so novel biomarkers need to be combined.Various pharmacological and non-pharmacological measures have been studied to prevent and treat AKI after liver transplantation,but its effectiveness still needs to be confirmed by further studies.This review will discuss the diagnosis and risk factors of AKI after liver transplantation,summarize the existing effective prevention and treatment strategies to meet the challenge of this difficult problem

慢性肾脏病-矿物质骨代谢紊乱新型生物标志物的研究进展

慢性肾脏病（chronic kidney disease,CKD）是指肾小球滤过率-1·（1.73 m2）-1或者有尿异常、影像学或者组织学异常超过3个月,根据KDIGO指南,CKD分为CKD 15期[1]。2012年我国人群CKD发病率已达10.8%[2]。在糖尿病伴有高血压的人群中,CKD的发病率为59.6%[3]。慢性肾脏病-矿物质骨代谢紊乱（chronic kidney disease-mineral and bone disorder,CKD-MBD）是CKD的常见并发症。根据2009年KDIGO指南CKD-MBD定义为:一种系统性的矿物质和骨代谢异常,具有以下一个或多个特征:钙、磷、甲状旁腺素（parathyroid hormone,PTH）

Preparation and Application of Phenobarbital Electrochemical Sensor Based on

以马来松香丙烯酸乙二醇酯(EGMRA)为交联剂,甲基丙烯酸为功能单体,在玻碳电极表面电聚合了一种对苯巴比妥分子具有专一性识别的聚合膜。在最佳实验条件下,采用循环伏安法(CV)、差分脉冲伏安法(DPV)及电化学交流阻抗法(EIS)对印迹传感器的性能进行研究。实验结果表明:该印迹传感器对苯巴比妥具有快速响应、专一性识别和高灵敏度的特点,且苯巴比妥的浓度在8.0×10-7~1.0×10-4mol/L范围内与DPV电流信号呈良好的线性关系,相关系数(r)为0.998 3。检出限(S/N=3)为5.4×10-8mol/L。将此印迹传感器应用于实际样品中苯巴比妥的检测,加标回收率为95.7%~105.0%。Abstract: A specific molecularly imprinted polymer(MIP) film for the determination of phenobarbital (PB) was electropolymerized on a glassy carbon electrode using methacrylic acid as functional monomer and ethylene glycol maleic rosinate acrylate(EGMＲA) as cross-linking agent． The optimum experimental conditions were explored． Under the optimum experimental conditions，the response performances of the sensor for phenobarbital recognition were investigated by cyclic voltammetry(CV)， differential pulse voltammetry(DPV) and electrochemical impedance spectroscopy(EIS)． The results showed that the molecularly imprinted film exhibits a quick response，good sensitivity and selectivity to the template molecule phenobarbital． A good linear relationship between DPV current signals and phenobarbital concentration in the range of 8. 0 × 10 － 7 － 1. 0 × 10 － 4 mol /L was obtained，with a correlation coefficient( r) of 0. 998 3 and a detection limit( S /N = 3) of 5. 4 × 10 － 8 mol /L． The prepared sensor was successfully applied in the determination of phenobarbital in practical samples with recoveries of 95. 7% － 105. 0%．广西自然科学重点基金(2013GXNSFDA019006);广西教育厅科研项目(2013YB068);广西研究生教育创新计划资助项目(YCSZ2014120);广西民族大学重点科研项目(2012MDZD040

智能足疗按摩及保洁服务机器人

本发明公开了一种智能足疗按摩及保洁服务机器人，其包括集成设置的自主移动平台单元、智能座椅平台单元和机器人主体单元，所述智能座椅平台单元和机器人主体单元均安装在所述自主移动平台单元上。所述智能座椅平台单元包括座椅底板、座椅靠背和至少一种座椅调节模块。所述机器人主体单元包括保洁执行模块，用户足底数据采集存储器，按摩执行模块，电源模块和电控模块等。所述自主移动平台单元包括平台基体，移动轮，外部环境监测感知传感器等。本发明的智能足疗按摩及保洁服务机器人兼具保健、保洁服务等功能，且还可被赋予一系列智能化功能，因此具有广泛的服务应用价值与广阔的市场前景