545 research outputs found

    Mechanism Study on Gab2-mediated Hepatocarcinogenesis

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    肝细胞癌(HCC)是全球最常见和最致命的恶性肿瘤之一,HCC大概占原发性肝癌的85%-90%。据统计,全球范围内每年有一半肝癌病人(250,000/500,000)死于肝细胞癌。其主要原因可归结为没有有效的治疗方法、病人容易产生放化疗抵抗以及高度复发性。虽然目前针对诱发肝癌发生的信号机理研究发现了许多重要的治疗肝癌的靶点分子,但是临床上有显著治疗效果,并可解决肝癌高复发难题的药物却显得捉襟见肘。因此急需找到一种能够整合细胞内多种效应分子的轴蛋白,并以此蛋白为靶点开发靶向治疗药物,从而达到改善目前治疗肝癌效率低下的目的。 Gab2作为船坞蛋白受到细胞外刺激因子的激活,能够铆钉在细胞膜上招募细胞...Hepatocellular carcinoma (HCC) is one of the most common and deadliest malignancies worldwide. HCC accounts for 85%-90% of primary liver cancers with 500,000 new cases as well as 250,000 deaths of HCC all over the world every year. The main factors for the high mortality rate of HCC patients are due to the lack of effective treatments, the increasing resistance to conventional radiotherapy and che...学位:理学博士院系专业:药学院_化学生物学学号:3232013015430

    The Competitive Research & Development Strategies of HD Interactive TV in Guangdong Municipal Broadcast and TV system

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    本文通过对高清互动电视的发展历程和内涵外延的特性研究,分析了技术变革带来了服务模式、盈利模式和竞争模式的变化。从高清互动电视的市场宏观环境和竞争环境入手,对广电高清互动电视进行了SWOT分析。同时,以A市广电的业务发展和业务收入作为分析案例,提出了A市高清互动电视的发展对策,通过竞争策略、品牌策略、内容策略和销售策略,保障高清互动电视的快速渗透,确保其在市场中的领先地位。 本文共分五个方面进行阐述。第一部分为研究综述,概要介绍研究背景、研究目的和意义以及国内相关研究的进展。第二部分为高清互动电视概述,简要介绍高清互动电视的发展进程、高清互动电视的内涵和外延,分析其对服务内容、盈利模式、竞争模...With the rapid development of digital technology, communications technology and video technology, it requires video services more autonomous, personalized, and diversified. And the triple play policy has made an unprecedented challenge to the original broadcasting monopoly. After analyzed macro environment and the competitive environment of broadcasting high-definition interactive television, the ...学位:工商管理硕士院系专业:管理学院高级经理教育中心(EMBA项目)_高级管理人员工商管理硕士(EMBA)学号:X201115626

    Research and Application of Commercial Bank Performance Management System

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    在经济全球化进程加快,市场竞争日益激励的21世纪,企业的竞争将是基于核心能力的竞争。人力资源作为蕴含在企业竞争优势中的一种难以模仿的、特定的资源,成为决定企业竞争成败的关键因素。绩效管理是企业人力资源管理中的核心问题,对提升商业银行竞争能力、塑造商业银行的核心竞争力方面发挥着越来越大的作用。绩效管理是将企业的战略目标分解到各个业务单元,并且分解到每个人,因此,只有对每个员工的绩效进行管理、改进和提高,才能提高企业整体的绩效,企业的生产力和价值才能随之提高,企业的竞争优势也就由此而获得。 目前A银行绩效考核仍采用传统的人工考核、人工汇总统计的考核工作模式,且绝大部份岗位特别是普通员工的考核只能...The competitiveness of enterprises will be competitive based on core competence in the 21st century with acceleration of economic globalization and increasingly competitive market. Human resources which is a competitive advantage difficult to imitate, is to maintain a source of competitive advantage and become a deciding factor in competition. Performance management is the core of human resources ...学位:工程硕士院系专业:软件学院_工程硕士(软件工程)学号:X200823016

    The Study on Classifiers of Eastern Hubei Dialect

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    本文综合调查了鄂东地区的红安、麻城、黄州、浠水、英山、罗田、蕲春、黄梅8个地区的方言量词使用情况。通过田野调查的方法,描写、比较分析鄂东地区方言量词的共同点和异同点。在此基础上,本文还把鄂东方言量词与共同语及周边的西南官话和赣方言进行比较,旨在探寻鄂东地区方言与普通话、西南官话和赣语的联系。 全文共分四章。第一章绪论部分介绍本文的选题依据、意图以及目前学术界对汉语方言量词的研究情况,同时还简要介绍鄂东方言的语音系统。 第二章是文章的主体部分,共分为两大模块。第一个模块是把鄂东8个地区的方言量词与普通话进行比较。目的有两个,一是描写鄂东方言量词面貌,二是寻找鄂东方言量词和普通话之间的联系和区...This research makes a dialectal research on Hong’ an ,Macheng, Xishui, Luotian, Yingshan, Qichun, Huangmei, Huangzhou, which are located on the east of Hubei province. The aim of research is to describe , compare and analyze the dialectal classifiers of the above 8 eastern Hubei districts. In this case, the features and differences between the different dialect can be discovered by deep comparison...学位:文学硕士院系专业:人文学院中文系_汉语言文字学学号:1022009115194

    在岸与离岸人民币汇率价差的影响因素研究

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    2015年的\"8. 11\"汇改后,在岸与离岸人民币汇率呈双向波动,汇率价差不断拉大已成常态。因此,对在岸与离岸人民币汇率价差的研究具有十分重要的现实意义。结合理论分析与实证研究,探讨人民币在岸与离岸汇率价差的波动特征,运用VAR模型对汇率价差的影响因素以及传导路径进行实证研究。结果表明:离岸人民币资金存量对汇率价差具有显著的负面影响,在岸与离岸的利率价差与汇率价差呈正向相关,全球投资者风险偏好的变动会导致汇率价差的反向变动,汇率价差对四个因素都进行了冲击传导。最后提出了推进离岸市场建设、增强市场流动性等政策建议。教育部人文社会科学基金规划项目“人民币汇率联动与人民币定价权研究”(16YJA790051)的阶段性研究成

    知识型企业高绩效本质研究

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    知识型企业以知识作为创造价值的主要资本,拥有高素质的人才群体,且以创新作为企业发展的理想动力。知识型企业高绩效主要依赖知识管理的有效运行,通过对知识获取、知识传递、知识创新和知识应用等活动的协调实施,实现对企业知识资源的充分开发和利用,以达到高绩效的目的

    关于厦门市发展观光农业的思考

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    一、观光农业概念的引入农业生产是经济的再生产过程与自然的再生产过程的交织,农业生产兼经济功能与生态功能于一体,从人类发展的历史来看,生态功能在人类社会发展的早期并不具备经济学上的意义,因为它象阳光、空气、水等自然资源一样,是自然界本身提供的。而从经济..

    Fluorescence Studies of the Excimer Formation Induced by Cationic Surfactant Below the Critical Micelle Concentration

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    [中文文摘]研究了阳离子表面活性剂CTAB在临界胶束浓度(CMC) 前对1 - 芘丁酸(PBA) 和1 - 萘乙酸(NAA) 荧光光谱的影响, 观测到PBA和NAA激基缔合物的发光. 实验证明: CMC前CTAB 能够诱导PBA, NAA激基缔合物的形成. 这一结果为设计阴离子表面活性剂的荧光检测新方法提供了理论基础.[英文文摘]The effect of cationic surfactant CTAB on the fluorescece of 1-pyrenebutyric acid and 1-Naphthylacetic acid was studied below the CMC of CTAB.The excimer emission of PBA and NAA was observed.It was concluded that the cationic surfactant,CTAB at concentration below its CMC could induce the formation of PBA and NAA excimer.This result forms the basis for the sensing assay of anionic surfactant by fluorescence spectroscopy.国家自然科学基金(29675018);福建省自然科学基金(D991002)

    The YAG laser texturing technology and application with controllable disorder distribution

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    The special morphology of spots isolated from each other could lead the laser texturing (LT) sheet to better stamping and coating properties, compared with shot Blast texturing (SBT) sheet and Electro-discharge Texturing (EDT) sheet. While the spots with regular distribution caused the laser texturing sheet appearing fringes easily. There were three methods to achieve YAG laser texturing disorder distribution spots, including controlling disorder delay, controlling disorder deflection, and controlling disorder image carving, which could reach the disorder spots texturing effect of EDT, and resolve the fringes problem of laser texturing. JM-3000 YAG laser texturing equipment was composed by mechanical system, laser system, controlling system, the outside optical system, frequency convertion cooling system and protection gas system, which achieved the disorder spots distribution of YAG laser texturing
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