非酒精性脂肪性肝病无创性诊断方程的构建

目的利用与非酒精性脂肪性肝病(NAFLD)相关的常用临床及实验室指标,构建无创性诊断方程,并评估该方程对NAFLD的预测及诊断价值。方法选取2016年11月-2017年11月西安医学院第一附属医院诊断为NAFLD患者127例和健康对照者30例,记录研究对象的性别、年龄、BMI、病史、ALT、AST、GGT、尿素氮(BUN)、尿酸(UA)、血肌酐(Cr)、TC、TG、HDL、LDL、糖化血红蛋白(HBA1c)、游离脂肪酸(FFA)、空腹血糖(FPG)、空腹胰岛素(FINS)、PLT、超声检查结果和Fibro Scan的检查结果等数据。计量资料组间比较采用t检验,相关性使用Pearson相关性分析,回归方程的构建使用多元线性回归方程模型,构建受试者工作特征曲线(ROC曲线),计算回归方程的敏感度和特异度。结果与脂肪肝相关的指标包括BMI(r=0.308,P=0.005)、ALT(r=0.379,P<0.001)、AST(r=0.318,P=0.004)、GGT(r=0.293,P=0.009)、UA(r=0.244,P=0.033)、FFA(r=0.249,P=0.030);对Fibroscan的受控衰减参数(CAP)相关指标进行多重回归分析,CAP的回归模型具有统计学意义(F=11.113,P<0.001),其校正决定系数R2=0.274,说明回归引起的变异在总变异中所占的比率为27.4%,对CAP影响最大的指标是ALT(β=0.358,P=0.001),其次是BMI(β=0.258,P=0.012<0.05),构建的回归方程为CAP=113.163+0.252×ALT+6.316×BMI,诊断方程的ROC曲线下面积为0.927,灵敏度为87.68%,特异度为90.00%,cut-off值为277.67,P<0.001,具有较高的诊断效能。结论与目前已有的诊断方程相比,此方程的ROC曲线下面积、特异度、灵敏度均较佳,计算方法最为简单,实用性及可操作性强,有利于便捷筛查出早期NAFLD,提高自我干预意识,进一步降低NAFLD的全球危害和疾病进程。可以作为一个诊断NAFLD的方程,供临床参考及推广。陕西省普通高等学校优势学科建设项目(陕教位[2014]3号文件

The Morphology of the Primary Dental Arch of Chinese Children in Shijiazhuang-City Part-I: Research concerning the size of the primary tooth crown, primary dental arch and the condition of primary occlusion

The purpose of this study was to investigate the size of the primary tooth crowns, primary dental arches, standard values and frequency distribution of primary occlusion in Chinese children. With the cooperation of a kindergarten in Shijiazhuang-city, China, the dental plasters from 55 children (36 boys and 19 girls, age range from 3-6 years old) with normal primary occlusion were collected. Because of different growth rates of the children, these children were divided into two groups, one comprising children less than 5 years old and the other of 5 years old or older. According to the method that the Japanese Society of Pediatric Dentistry reported, the data were statistically analyzed and compared to Japanese children. The results were summarized as follows: 1. Except lower primary lateral incisors, the values of the mesio-distal width of primary crowns of each tooth were significantly larger for boys than for girls in all tooth types. Also the Chinese children were inclined to show smaller mesio-distal tooth crown width than those of the Japanese children in all types of teeth. 2. Compared with the Japanese children, the Chinese children were inclined to show smaller primary dental arch length both in the maxilla and the mandible. But in the senior group, the Chinese girls were inclined to show smaller primary dental arch width than their Japanese female counterparts. On the contrary, the Chinese children tended to show larger dimensioned primary dental arch height than those of the Japanese children. 3. Though spaces between teeth (primate and growth spaces) were found in the Chinese children, the frequency was lower than that of the Japanese children. 4. The frequency of terminal plans in the Chinese children was 41.8% in the vertical type, 6.4% in the distal-step type and 51.8% in the mesial step type. 5. The primary canines occlusal relationship in the Chinese children was 63.1% in type I, 13.6% in type II and 23.7 in type III

Effects of Compound Galangai Oils and Cyperus Oils on Serum Gastrointestinal Hormones in Gastrelcosis Mice Model

目的:探讨良附油对胃溃疡小鼠模型血清胃肠激素的影响。方法:ICR小鼠随机分成9组:正常对照组,模型组,良附丸组(2g.kg-1),消旋山莨菪碱片组(0.005g.kg-1),良附油高、中、低剂量组(8、4、2mL.kg-1),高良姜油组(8mL.kg-1),香附油组(8mL.kg-1)。预防给药6天后,采用利血平致胃溃疡小鼠模型,ELISA酶联免疫法测定小鼠血清胃动素(MOT)、生长抑素(SS)、P物质(SP)、血管活性肠肽(VIP)的含量。结果:与模型组相比:①各治疗组均能降低利血平致胃溃疡小鼠模型溃疡指数及提高溃疡抑制率(P<0.01)。②良附油高、中剂量组,高良姜油组、香附油组、良附丸组、消旋山莨菪碱片组均能降低胃溃疡小鼠模型血清MOT,SP含量(P<0.01,P<0.05),升高血清SS、VIP含量(P<0.01,P<0.05),良附油组呈明显的量-效关系。结论:良附油抗胃溃疡作用可能与其降低血清MOT,SP的含量,升高血清SS,VIP的含量有关;且高剂量组调节胃肠激素的作用相当于良附丸及消旋山莨菪碱片组。Objective：To explore effects of Compound Galangai Oils and Cyperus Oils（CGOCO） on serum gastrointestinal hormones of gastrelcosis mice model.Methods：ICR mice were randomly divided into 9 groups：control group,modle group,liangfu pills group（2g·kg-1）,racanisodimine group（0.005g·kg-1）,CGOCO high dosage group,CGOCO middle dosage group,CGOCO low dosage group,galangai oils group（GO）,cyperus oils group（CO）.The gastrelcosis mice model was induced by reserpine,which was then given drugs for 6 days.The content of motilin（MOT）,somatostatin（SS）,substance P（SP）,vasoactive in testinal peptide（VIP） in serum were determined by ELISA.Results：Compared with the model group：① All the treatment groups could decreased ulcer index and increased ulcer inhibition rate（P0.01）.②CGOCO,GO,CO,liangfu pills,racanisodimine group obviously decreased the content of MOT,SP in serum（P0.01,P0.05）,significantly increased the content of SS,VIP in serum（P0.01,P0.05）.And with the obvious dose-effect in CGOCO group.Conclusion：CGOCO treats gastrelcosis by reducing the content of MOT and SP,increaseing the content of SS and VIP in serum,and adjust the role of gastrointestinal hormones are equivalent to those of Liangfu pills and Racanisodimine

Effects of valtrate on anxiety models in rats and its possible mechanisms

[目的]研究高良姜油抗胃溃疡(GU)的作用及其机制。[方法]ICR小鼠随机分成7组,分别为:正常对照组,模型组,奥美拉唑组(0.014 g/kg),良附丸组(2 g/kg),高良姜油高、中、低剂量(8、42、ml/kg)组,预防给药6d后,采用利血平致GU小鼠模型,收集小鼠胃液,测定胃液量、总酸度、胃蛋白酶活性及血清一氧化氮(NO)、超氧化物歧化酶(SOD)及丙二醛(MDA)水平。[结果]与模型组相比,高良姜油高、中剂量组,良附丸组,奥美拉唑组均能抑制利血平致GU小鼠模型胃液量、总酸度及胃蛋白酶活性,且能增加血清NO水平和SOD活性,降低MDA水平;但中剂量组胃蛋白酶活性变化无统计学意义。[结论]高良姜油抗GU作用机制可能与其抑酸、抗氧化、增强保护因子有关;高良姜油高剂量抗氧化与增加血清NO水平的作用与良附丸相当

Effect of oils in alpinia officinarum hance on serum NO, SOD, MDA in gastrelcosis mice model

目的:研究高良姜油对胃溃疡小鼠模型血清一氧化氮(NO)、超氧化物歧化酶(SOD)及丙二醛(MDA)的影响。方法:ICR小鼠随机分成8组:正常组、模型组、山莨菪碱片组(0.005g/kg)、奥美拉唑组(0.014g/kg)、良附丸组(2g/kg),高良姜油高、中、低剂量组(8、4、2mL/kg),预防给药6d后,采用利血平致胃溃疡小鼠模型,测定小鼠血清NO含量、SOD活性及MDA含量。结果:与模型组相比,高良姜油的高、中剂量组、良附丸组、奥美拉唑组、山莨菪碱组均能增加利血平致胃溃疡小鼠模型血清NO含量和SOD活性,降低MDA含量(P<0.05,P<0.01)。结论:高良姜油抗胃溃疡作用机制可能与其抗氧化、舒张血管作用有关。Objective： To explore effects of Oils in alpinia officinarum hance （OAOH）on NO, SOD, MDA of gastrelcosis mice model .Method： ICR mice were randomly divided into 8 groups：control group, modle group, racanisodimine group （ 0.005g/kg ） , Omeprazole group（0.014g/kg）,liangfu pills group （ 2g/kg ） , OAOH high dosage group, OAOH middle dosage group, OAOH low dosage group （ 8, 4, 2mL/kg ） . The gastrelcosis mice model was induced by reserpine,which was then given drugs for 6 days. Nitric oxide（NO） content,superoxide dismutase（SOD） activity and malondialdehyde（MDA） content in mice serum were determined.Result： Compared with the model group： OAOH （H,M）, liangfu pills, Omeprazole group ,racanisodimine group obviously ncreased the content of NO and active of SOD in serum, decreased the content of MDA in serum （ P〈0.05, P〈0.01 ） . Conclusion： OAOH treats gastrelcosis by eliminating free radical and improving local blood circulation of the ulcer

INFLUENCE OF SUPPORT SPRING ON NATURAL FREQUENCY AND LIMIT VELOCITY OF CURVED PIPE CONVEYING FLUID

基于Hamilton变分原理,导出具有弹性支撑的1/4圆形输液曲管的变分—积分方程.采用多个函数组合的方法,选取满足边界条件的试函数,利用Galerkin直接法求出系统的固有频率和极限流速的近似解析公式.数值结果表明,弹簧对固有频率和极限流速都有显著影响.根据数值结果,用最小二乘法给出固有频率和极限流速与弹簧刚度的关系公

Effect of oils in alpinia officinarum hance on serum NO, SOD, MDA in gastrelcosis mice model

目的：研究高良姜油对胃溃疡小鼠模型血清一氧化氮（NO）、超氧化物歧化酶（SOD）及丙二醛（MDA）的影响。方法：ICR小鼠随机分成8组：正常组、模型组、山莨菪碱片组（0.005g/kg）、奥美拉唑组（0.014g/kg）、良附丸组（2g/kg）,高良姜油高、中、低剂量组（8、4、2mL/kg）,预防给药6d后,采用利血平致胃溃疡小鼠模型,测定小鼠血清NO含量、SOD活性及MDA含量。结果：与模型组相比,高良姜油的高、中剂量组、良附丸组、奥美拉唑组、山莨菪碱组均能增加利血平致胃溃疡小鼠模型血清NO含量和SOD活性,降低MDA含量（P〈0.05,P〈0.01）。结论：高良姜油抗胃溃疡作用机制可能与其抗氧化、舒张血管作用有关

Effects of Oils in Alpinia officinarum Hance on Serum Motilin,Somatostatin,Substance P,Vasoactive Intestinal Peptide in Gastrelcosis Mice Model

目的:观察高良姜油对胃溃疡小鼠模型血清胃肠激素的影响。方法:ICR小鼠随机分成7组:正常对照组、模型组、良附丸组(2 g.kg-1)、消旋山莨菪碱片组(0.005 g.kg-1)、高良姜油低、中、高剂量组(2,4,8 mL.kg-1)。预防给药6 d后,采用利血平致胃溃疡小鼠模型,ELISA酶联免疫法测定小鼠血清胃动素(MOT)、生长抑素(SS)、P物质(SP)、血管活性肠肽(VIP)的含量。结果:与模型组相比:①各治疗组均能降低利血平致胃溃疡小鼠模型溃疡指数及提高溃疡抑制率(P<0.01)。②高良姜油高、中剂量组,良附丸组、消旋山莨菪碱片组均能降低胃溃疡小鼠模型血清MOT,SP含量(P<0.01,P<0.05),升高血清SS含量(P<0.01,P<0.05);高良姜油高剂量组能升高血清VIP含量(P<0.01),但中剂量组血清VIP含量变化无统计学意义。结论:高良姜油抗溃疡作用可能与其降低血清MOT,SP的含量,升高血清SS,VIP的含量有关。Objective：To observe effects of oils in Alpinia officinarum Hance（OAOH） on serum gastrointes-tinal hormones in gastrelcosis mice model.Method：ICR mice were randomly divided into 7 groups：control group,model group,liangfu pills group（2 g.kg-1） racanisodimine group（0.005 g.kg-1）,OAOH low dose group,OAOH middle dose group,OAOH high dose group（2,4,8 mL.kg-1）.The gastrelcosis mice model was induced by reser-pine,which was then given drugs for 6 days.The content of motilin（MOT）,somatostatin（SS）,substance P（SP）,va-soactive in testinal peptide（VIP） in serum were determined by ELISA.Result：Compared with the model group：① All the treatment decreased ulcer index and increased ulcer inhibition rate（P 0.01）.②OAOH,liangfu pills,group racanisodimine obviously decreased MOT,SP in serum（P 0.01,P 0.05）,significantly increased SS in serum（P 0.01,P 0.05）;High dose OAOH increased VIP content in serum（P 0.01）.Conclusion：OAOH treats gas-trelcosis by reducing the content of MOT and SP,increaseing the content of SS and VIP in serum

The Effect of Dialect on Social Decision Making and Emotion--Evidence from Electrophysiology

方言是心理学本土化研究的新方向，本研究旨在考察语言类型（方言、普通话）对群体和个体社会决策的影响。实验1通过改编的公共物品博弈范式，发现方言条件下信任与合作水平、主观评定积极情绪和心率的变化值更大，皮肤电无显著变化；普通话条件下信任在主观消极情绪评定和合作行为间发挥着完全中介作用。实验2利用改编的最后通牒博弈范式，发现不公平的￥2-￥8分配方案下方言条件的接受率显著高于普通话条件，提议越公平接受率越高。结果表明方言会影响人们认知、情绪和决策行为，研究为语言和决策领域的探索提供了新思路