Associations of Fetuin B with Metabolic Syndrome

研究背景 代谢综合征是一组复杂的代谢紊乱症候群，指人体蛋白质、脂肪、碳水化合物等物质发生代谢紊乱的病理状态。其基本特点包括：糖代谢紊乱；高凝血、低纤溶血症；脂代谢紊乱；高血压；肥胖或超重；血管内皮功能障碍；高尿酸血症；微量白蛋白尿；高同型半胱氨酸血症等。目前代谢综合征的发病机制并不明确，大多认为由遗传因素与环境因素共同决定，其中中心性肥胖是代谢综合征的关键始动因素，胰岛素抵抗是发病的中心环节，慢性轻度炎症促进代谢综合征的发展。代谢综合征与心血管死亡率增加密切相关，这使本病的预后更加严重。根据美国第三次全国健康和营养调查，20岁以上美国人口代谢综合征患病率约为24%，我国尚缺乏相关大规模流行病...Background Metabolic syndrome is a group of complex metabolic disorders syndromes, refers to the protein, fat, carbohydrates in the pathological state of metabolic disorders. It has many essential characteristics including glucose metabolism disorders, high coagulation and low fibrinolysis, lipid metabolism disorders, hypertension, obesity or overweight, vascular endothelial dysfunction, hyperuri...学位：医学硕士院系专业：公共卫生学院_流行病与卫生统计学学号：3262014115056

Immigrant Community and Transnational Education: A Study of Chinese Schools Founded by Philippines Overseas Chinese from Jinjiang in Modern Period

华侨教育长期以来都是史学界关注的焦点和研究的热点。本文选取晚清民国时期晋江籍菲律宾华侨于晋江与菲律宾两地跨国创办的华侨学校为研究对象，通过对两地办学背景、侨校教育体制模式的选择与运用及新式华侨教育体制对中国传统教育体制转型影响的分析，了解广大华侨在民族文化认同的基础上所形成的华侨跨国教育对于华侨居留地与祖籍地侨乡之间区域文化网络特色形成的重要意义。 本文首先从华侨移民史入手，了解晋江与菲律宾之间的渊源关系，分析华侨教育于19世纪末20世纪初于晋江与菲律宾兴起的社会政治经济原因，并以两地侨校的典型：小吕宋华侨中西学堂和泉州培元中学为例，通过对两校具体运作的介绍，诠释两地学校在教学内容与教育取向...Overseas Chinese Education has long been a hot topic in history study. This dissertation surveys the overseas Chinese school in Jinjiang and Philippines established by Jinjiang overseas from Philippines in republic era. By focusing on the founding background, the selection and function of the education institution, as well as the influence exerted by new-style overseas Chinese education system on ...学位：历史学硕士院系专业：人文学院历史学系_专门史学号：1032006115011

Hepatitis B virus X protein and endoplasmic reticulum stress

乙型肝炎病毒(hepatitis B virus,HBV)感染与持续性肝损伤和原发性肝细胞癌(hepatocellular carcinoma,HCC)关系密切.我国是HBV感染的高流行区,给人群带来的健康威胁和损害是关注的热点问题.HBV感染是HCC的主要病原学因素之一,但其诱导肿瘤形成潜在的分子机制依然存在争议.其中HBV的X蛋白(HBV X protein,HBx)在HBV致肝细胞损伤、诱导肝细胞恶性转化、与环境因素暴露协同诱导肝致癌作用等过程中所起的作用都是研究的焦点.HBx作为多功能调控蛋白调控大量细胞信号转导通路,包括内质网(endoplasmic reticulum,ER)应激反应,值得关注的是近几年已有文献报道HBx表达对肝细胞ER应激的诱导作用,但对调控的分子机制的认识还不明确.因此,本文综述了HBx影响肝细胞ER应激的研究进展,为HBV感染诱导肝损伤和疾病的分子机制提供线索.Persistent hepatitis B virus(HBV) infection is closely related to chronic hepatitis,cirrhosis and liver cancer.China is a country with a high prevalence of HBV infection,where the infection rate is up to 60%-70%,bringing great threat and harm to public health.What's worse is that HBV infection is the main etiology factor of primary hepatocellular carcinoma(HCC).However,the underlying mechanisms of virus-induced tumor formation remain controversial.Numerous studies indicate that HBV X protein(HBx) plays a prominent role in HBV-induced liver cell damage,hepatitis,liver fibrosis and malignant transformation,and is related to liver cancer induced by environmental exposure factors.As a multifunctional regulatory protein,HBx regulates a variety of cell signal transduction pathways,including the endoplasmic reticulum(ER) stress response.ER stress refers to the dysfunction of the ER,and misfolded or unfolded proteins gather in the ER.It is noteworthy that the expression of HBx can induce or effect ER stress,although the molecular mechanism remains unclear.This review summarizes the role of HBx in ER stress pathways,providing clues for the liver injury induced by HBV infection.国家自然科学基金资助项目,Nos.81172705,81472997,81573181 973;; 计划前期研究专项基金资助项目,No.2014CB560710;; 福建省自然科学基金资助项目,Nos.2014J01372,2015J01344~

罗格列酮对压力超负荷大鼠血流动力学及心肌肥厚的影响

【目的】探讨过氧化物酶体增殖物激活受体γ（PPAR-γ）配体罗格列酮对压力超负荷大鼠血流动力学及心肌肥厚的影响。【方法】30只SD大鼠随机分为假手术组（n=9）和压力超负荷模型组（n=21），应用腹主动脉缩窄的方法制作压力超负荷模型，将制作模型后24h仍存活的16只大鼠随机分为压力超负荷（PO）组（n=7）和罗格列酮（PO＋Ros）组（n=9）。罗格列酮组给予罗格列酮3mg／（kg·d）共8周。8周后测定血流动力学；称量心脏质量；放射免疫分析方法测量血浆肾素活性、血管紧张素Ⅱ和醛固酮。【结果】与PO组相比，PO＋Ros组动脉血压降低（P〈0．05）；＋dp/dtmax升高（P〈0．05）；心脏质量指数和左室质量指数降低（P〈0．05）；血浆肾素活性、血管紧张素Ⅱ、醛固酮和胰岛素及血糖水平无明显差异（P〉0．05）。【结论】PPAR-γ配体改善压力超负荷性心肌肥厚和左室舒缩功能，降低动脉血压，其效应与血浆肾素血管紧张素系统无明显关系

静脉留置针对血管物理刺激与静脉炎关系的实验研究

目的 :探讨留置针对血管物理刺激与静脉炎的关系。方法 :采用自身对照法 ,分别在家犬颈外静脉、右前臂头静脉、左前臂头静脉留置 2 0G、2 2G、2 4G套管针 ,并模拟输液 ,3d后取局部血管送病理检查 ,光镜下观察血管及周围组织变化。结果 :同型号静脉留置针中 ,颈外静脉发生炎性反应程度较轻 (u =9.5 4,P <0 .0 0 1) ,不同型号留置针在同血管中 ,2 4G引起的炎性反应程度较轻 (u =2 .39,P <0 .0 5 )。结论 :留置针直径与血管直径比例同静脉炎发生率有关。临床护士使用静脉留置针时 ,在不影响病人治疗情况下 ,尽量选择最小型号留置针 ,以减少留置针对血管的物理刺激 ,降低静脉炎的发生几

静脉留置针封管方式与静脉炎关系的实验研究

目的　探讨封管方式对留置针所致静脉炎发生几率的影响。方法　采用自身对照法 ,分为常规组和改良组 ,比较经留置针对家犬输入刺激性药物后 2种封管方式与静脉炎性病理改变的关系。结果　改良封管法致静脉炎性反应率大大低于常规封管法 ,2组差异有极显著性 (P <0 .0 0 1 )。结论　输入高渗液或刺激性药物后先静滴生理盐水 2 0ml,再用肝素盐水封管 ,可显著降低静脉炎的发生几率 ,延长套管针留置时

角膜塑形镜控制青少年低中高度近视发展的效果

【目的】探讨过夜配戴角膜塑形镜（OK镜）治疗青少年轻度、中度及高度近视的效果差异。【方法】前瞻性病 例研究。收集 54 例（107 眼）青少年近视患者，平均年龄（11.6 ± 2.4）岁，按患者戴镜前等效球镜度分为低度近视组（51 眼，-0.75 ~ -3.00 D）、中度近视组（36眼，-3.25 ~ -5.00 D）及高度近视组（20眼，-5.25 ~ -9.00 D）。观察配戴前1天及配戴1 年后3组内及组间等效球镜度、中央角膜厚度、角膜曲率、前房深度和眼轴变化。【结果】轻度近视组、中度近视组及高度近 视组基线平均等效球镜度（D）分别为-2.15 ± 0.63、-4.20 ± 0.54 和-6.63 ± 1.18；三组基线眼轴（mm）分别为 24.50 ± 0.66、 25.16 ± 0.65及26.35 ± 0.87。三组患者基线中央角膜厚度、前房深度、中央角膜K值、平K值及陡K值差异均无统计学意 义。戴镜1年后3组眼轴增长值（mm）分别为0.22 ± 0.27、0.09 ± 0.22和0.02 ± 0.22；其中低度近视组与中度近视组、高度近 视组相比，组间眼轴增长值差异有统计学意义（P值分别为0.04、0.008），中度近视组与高度近视组两组间眼轴增长值差异 无统计学意义（P值为0.35）。三组戴镜1年后等效球镜度显著下降，3组内差异均有统计学差异（P均< 0.0001），低度近视组 与中度、高度近视组间差异具有统计学意义（P均< 0.0001）。1年前后3组中央角膜K值、平K值、陡K值均明显变平坦，组 内差异比较均有统计学差异（P均< 0.0001）。中央角膜厚度、前房深度及角膜直径1年前后差异无统计学意义。【结论】中 高度近视者采用角膜塑形镜控制近视的作用较低度近视更优。角膜曲率改变的量可能是影响OK镜近视治疗效果的主要 因素之一

Occurrence and Distribution of Organotin Compounds in Thais clavigera from Xiamen Coast

采用戊基化格式衍生法,gC-fPd分析了厦门港周边海域9个小岛屿分布的疣荔枝螺(THAIS ClAVIgErA)体内3种丁基锡化合物(buTylTInS)和3种苯基锡化合物(PHEnylTInS)的存在形态与分布特征.结果表明,丁基锡化合物总浓度(ΣbTS)为0.3~70.6ng.g-1,平均值为28.8ng.g-1,以一丁基锡化合物(MbT)为主.苯基锡化合物总浓度(ΣPHTS)为nd~18.8ng.g-1,平均值为7.9ng.g-1,以三苯基锡化合物为主.厦门港周边海域以丁基锡化合物为主要污染物,占到总有机锡化合物(ΣOTS)的74.3%~96.8%.疣荔枝螺体内(ΣbTS)和(ΣPHTS)呈现从厦门港内到港外逐渐降低的趋势.疣荔枝螺体内TbT和TPHT的浓度显示良好的相关关系(r2=0.7109,P<0.01),说明TPHT和TbT来源趋同,即来源于船舶防污涂料,或水产养殖污染源.与我国东南沿海港口相比,厦门海域疣荔枝螺体内丁基锡化合物的污染处于一个较低水平但比2002年有所加重.Occurrence and distribution of 6 organotin compounds including butyltin and phenyltin species were detected in Thais clavigera which were collected from 9 coastal areas sites around Xiamen Coast,by pentylized derivatization,GC-FPD.Results indicated that all Thais clavigera samples were contaminated with organotin compounds.The concentrations in Thais clavigera soft bodies varied from 0.3 to 70.6 ng.g -1 with a mean value of 28.8 ng.g -1 for butyltin compounds,and from nd to 18.8 ng.g -1 with a mean value of 7.9 ng.g -1 for phenyltin compounds,respectively.MBT and TPhT were high levels in butyltin compounds and phentyltin compounds,respectively.In addition,butyltin compounds were the dominant contaminates in all samples with high percentage from 74.3% to 96.8%.There was a significant correlation between TBT and TPhT (R2 = 0.710 9,p < 0.01).This result showed that both TBT and TPhT came from antifouling paints for ships or for mariculture nets.Compared with those data reported from the other regions around southeast coast of China,present study reveals that contaminated level of organotin compounds in Thais clavigera are relatively lower in Xiamen Coast.But it is higher than those in 2002.国家自然科学基金项目(40476048;20777060

Template Synthesis and UV-Vis Absorption Spectra of the Nanowire Arrays of Cadmium Chalcogenides

以多孔氧化铝为模板 ,用交流电分别通过含有相应的CdCl2 、ZnCl2 、单质S、Se等的二甲亚砜 (DMSO)溶液 ,沉积CdS、CdSe以及CdxZn1-xS半导体纳米线阵列并研究其紫外可见吸收光谱 .实验结果表明 ,当半导体纳米线的直径小于 2 5nm时 ,其吸收边相对于体相的吸收边产生蓝移 ,而且蓝移的幅度随着半导体纳米线直径的减小而增加 ,显示了明显的量子限域效应 .XU Shi_min, XUE Kuan_hong , KONG Jing_lin, SUN Dong_mei, FENG Yu_ying, LU Hai_yan (Dept. of Chem., Nanjing Normal Univ., Nanjing 210097, China) WANG Guang_hou (National Laboratory of Solid State Microstructures, Nanjing Univ., Nanjing 210093, China)The porous alumina membrane formed in the anodic oxidation of highly pure aluminum foil has attracted a great deal of attention in recent years [1] . It can be served as a desired template to prepare nanometer scale materials [2] due to its unique structure of discrete and cylindrical nanopores, paralleled one another, with the homogeneous size and distribution [3] . Chalcogenide semiconductors have promising prospect in the applications of photovoltaic [4] and photoconducting devices [5] and have been extensively exploited for many years. Olbright and his co_workers studied experimentally and theoretically the optical nonlinearties of CdS xSe 1-x _doped glass [6] ; Britt and Ferekides reported that the conversion efficiency in a solar cell of thin_film CdS/CdTe could be as high as 15.8% [7] . Here we report the fabrication and UV_Vis absorption spectra of CdS、CdSe and Cd xZn 1-x S nanowire arrays deposited into the template matrix of porous alumina. The diameters of these nanowires were varied from 10 nm to 50 nm in our experiments.作者联系地址：南京师范大学化学系!江苏南京210097,南京师范大学化学系!江苏南京210097,南京师范大学化学系!江苏南京210097,南京师范大学化学系!江苏南京210097,南京师范大学化学系!江苏南京210097,南京师范大学化学系!江苏南京210097,南京大学固体微结构国家重点实验室!江苏南京21009