121 research outputs found
Mahan’s Theory of Sea Power with Modern China
本文力图通过对马汉海权论在近代中国的传播史的回顾,以史鉴今,回答“什么是海权”、“当代中国应当树立怎样的海权观”的问题,希望对中国当代海权战略的推进有所裨益。 阿尔弗雷德•塞耶•马汉(AlfredThayerMahan,1840年-1914年),是美国杰出的军事学家、历史学家和战略家,他提出的现代海权理论被命名为“马汉海权论”,受到世界各国政治家和军事家的高度推崇,并被用以指导各国实践。 马汉海权论产生后二十年间(1890年-1910年)在世界范围迅速传播开来,美国和日本推行海权战略取得了巨大的成功。马汉海权论于清末传入中国,正处于甲午战败后的悲痛反思中的中国人从中...This article tries to review the history of communication in modern China on Mahan's theory of Sea Power, in order to answer "what is the Sea Power" and "contemporary China should set up the right view of the Sea Power", which is helpful to the promotion of China's contemporary Sea Power strategy. Alfred Thayer Mahan (1840 - 1914) is an outstanding American military scientist, historian and strat...学位:历史学博士院系专业:人文学院_海洋史学学号:1032011015386
An empirical study of conduction mechanism about the monetary policies in Chinese real estate market
在我国城镇化和工业化不断推进的过程中,房地产业在国民经济中发挥着越来越重要的作用,成为政府和民众关注的焦点。近年来,货币政策对房市的影响慢慢显现,房市则通过不同的传导路径影响实体经济,成为推动经济增长和拉动内需的关键力量。 面对房价年年上涨,房市投资过猛的态势,政府出台了相应的调控手段,希望运用货币政策,稳定房价,抑制房地产投资过快增长,促进房市可持续健康发展。因此制定合适的货币政策,一方面要对过高的房价实施适度的宏观调控,另一方面使货币政策通过房市这一平台对整个宏观经济起到积极的作用。这些货币政策的有效性,关键在于其传导机制是否通畅,畅通的传导机制能实现预期的目标,起到稳定房价,抑制投资过...In the process of urbanization and Industrialization,real estate plays important role on the economy and becomes the focus of the government and people.Recently,monetary policy affects the real estate more and more notably.Real estate affects the economy in several different ways and becomes the key factor of promoting the economy. Confronting the situation of rising real estate price and ex...学位:经济学硕士院系专业:经济学院_政治经济学学号:1532010115204
The Strategy Study on Haitian Container Terminal
本文所研究的厦门港务集团海天集装箱有限公司(文中简称海天公司或海天)是厦门港最大、最现代化的集装箱码头。我国的集装箱码头业正处于其高速增长期,与此同时,随着厦门市“以港兴市”战略的逐步推进,厦门港得到了地方政府越来越多的重视与支持,海天公司正面临着难得的发展机遇。然而,海天公司也存在着诸多问题,制约了它的进一步发展。此时的海天公司迫切需要科学适用的发展战略。本文即就此问题做出研究和分析。本文遵循制定公司战略的一般思路,全文结构为企业简介――战略环境分析――SWOT分析及结论――企业战略应是什么――针对这样的战略企业应进行怎样的内部管理改革?――全文总结。基于以上思路,全文分为以下8个部分:第一...Xiamen Haitian Container Terminal (XHCT), which is studied in this paper, is the biggest and most modern one of Xiamen container terminal. The container terminal industry of China keeps growing at a high speed. In the same time, due to the “Develop Xiamen City Depending on the harbour” policy, the government of Xiamen City has pay more and more attention to the Xiamen harbour. So, XHCT is matching...学位:工商管理硕士院系专业:管理学院工商管理教育中心_工商管理硕士(MBA)学号:20011504
Mechanism Study of the Promoting Action of Elongated Needle Acupuncture on Functional Repair in Rats with Acute Spinal Cord Injury
目的 观察芒针对急性脊髓损伤炎症反应和神经细胞凋亡的影响,研究PI3K/Akt和MAPK/ERK信号转导途径是否参与芒针的神经保护作用,探讨芒针促脊髓损伤修复的具体作用机制.方法 将150只成年雄性SD大鼠随机分为A组、B组、C组、D组和E组,每组30只.采用改良Allen's法制作大鼠脊髓中度损伤模型,A组为假手术组,不予以损伤脊髓及芒针治疗;B组造模后不予以芒针治疗;C组造模后采用芒针治疗;D组造模前0.5 h鞘内注射LY294002,造模后采用芒针治疗;E组造模前0.5 h鞘内注射PD98059,造模后采用芒针治疗.分别采用BBB评分检测大鼠的自发活动;ELISA检测炎性因子TNF-α 、IL-6、IL-1β、NF-κB的含量;TUNEL检测细胞凋亡的程度;免疫组化检测Bcl-2和Bax阳性细胞水平;Western印迹分析p-Akt和p-ERK在脊髓组织的表达,RT-PCR分析Cyt-C和Caspase-3在体内的表达.相对的下行Akt和ERK信号通路通过LY294002和PD98059特异性抑制剂处理分析在体内的抑制作用.结果 炎症反应和PI3K/Akt和MAPK/ERK信号通路抑制的神经元凋亡参与了脊髓损伤大鼠模型的损害,芒针介导的神经保护作用与Bax蛋白阳性神经元数目的减少及Bcl-2蛋白阳性神经元数量的增加有关.芒针治疗能改善大鼠的运动功能,PI3K/Akt和MAPK/ERK信号通路中p-Akt和p-ERK的激活,通过下调Bax蛋白和Bcl-2表达上调,抑制了线粒体凋亡途径关键因子Cyt-C的表达.TUNEL法检测并抑制激活神经元凋亡的Caspase-3的级联.PI3K/Akt和MAPK/ERK信号通路特异性抑制剂LY294002和PD98059的应用抑制了p-Akt和p-ERK的表达.结论 芒针促脊髓损伤修复的神经保护作用可能与炎症反应和PI3K/Akt和MAPK/ERK信号通路的激活、通过下调Bax蛋白和Bcl-2表达上调以及抑制线粒体途径诱导的凋亡有关.Objective To observe the effect of elongated needle acupuncture on inflammatory reactions and apoptosis in acute spinal cord injury, investigate if PI3K/Akt and MAPK/ERK signal transduction pathways are involved in the neuroprotective effect of elongated needle acupuncture and explore the promoting action of elongated needle acupuncture on spinal cord injury repair.Method One hundred and fifty adult male SD rats were randomized into groups A, B, C, D and E, 30 each. A model of moderate spinal cord injury was made by modified Allen's method. Group A received a sham operation without spinal cord injury and no elongated needle acupuncture. Group B did not receive elongated needle acupuncture after model making. Group C received elongated needle acupuncture after model making. Group D received an intrathecal injection of LY294002 at 0.5 hour before model making and elongated needle acupuncture after model making. Group E received an intrathecal injection of PD98059 at 0.5 hour before model making and elongated needle acupuncture after model making. Rat spontaneous activity was examined using the BBB rating. Inflammatory cytokines TNF-α, IL-6, IL-1β and NF-κB contents were measured by ELISA. The degree of apoptosis was determined by TUNEL. Bcl-2- and Bax-positive cell levels were measured by an immunohistochemical method. Spinal p-Akt and p-ERK expressions were determined by Western blot. In vivo expressions of Cyt-C and Caspase-3 were determined by RT-PCR. The in vivo inhibitory effect on downstream Akt and ERK signaling pathways was investigated using specific inhibitors LY294002 and PD98059.Result Inflammatory reactions and neuronal apoptosis due to the inhibition of PI3K/Akt and MAPK/ERK signal pathways were involved in the damage in a rat model of spinal cord injury. The neuroprotective effect of elongated needle acupuncture was related to a decrease in the number of Bax protein-positive neurons and an increase in the number of Bcl-2 protein-positive neurons. Elongated needle acupuncture treatment improved r浙江省中医药科研计划项目(2008CB067
cis-(1R,2S)-2-ベンズアミドシクロヘキサンカルボン酸から誘導した1,3-アミノアルコールを用いた芳香族アルデヒドへのジエチル亜鉛の不斉付加における置換基による不斉制御
A series of novel optically active 1,3-aminoalcohols based on cis-(1R,2S)-2-benzamido- cyclohexanecarboxylic acid and trans-(1R,2R)-2-benzamidocyclohexanecarboxylic acid were synthesized and used in the asymmetric diethylzinc addition to aromatic aldehydes. Not only the enantioselectivity but also the stereochemistry of the product were
controlled by the N-substituents and the substituents on the vicinity carbon to hydroxyl group of the cis-derivatives.textapplication/pdfdepartmental bulletin pape
Effects of electro-acupuncture on neuronal apoptosis and associative function in rats with spinal cord injury
目的 :探讨电针对大鼠急性脊髓损伤后膀胱功能改善的影响及作用机制。方法 :取健康成年雄性SPf级Sd大鼠60只,体重220~250 g,适应性饲养1周后,将大鼠按照随机数字表法随机分为假手术组、模型组、电针组和电针对照组,各15只。假手术组不予任何刺激,模型组、电针组和电针对照组大鼠采用改良AllEnS法制作脊髓损伤中度损伤Sd大鼠模型,模型组不予治疗,电针组给予秩边与水道穴电针治疗,电针对照组给予秩边与水道穴旁开0.5寸电针治疗,频率2/100 Hz,电流1 M A,刺激15 MIn,电针左右隔次交替,每日1次,共7次;分别于术后1、7 d观察大鼠残余尿量、排尿量的变化;术后7 d处死大鼠取伤段脊髓观察各组大鼠凋亡情况,检测bCl-2、bAX、bAd含量的变化。结果:造模后3组大鼠均出现不同程度的膀胱功能障碍。术后7 d,电针组、电针对照组残余尿量较术后1 d明显降低(P<0.001),且电针组与电针对照组比较差异有统计学意义(P<0.01);电针组、电针对照组较模型组在术后7 d排尿量增加,且电针组与电针对照组比较差异有统计学意义(P<0.001);TunEl发现电针可以抑制脊髓神经细胞的凋亡,电针组、电针对照组与模型组相比在术后7 d脊髓神经细胞凋亡率显著增加(P<0.01,P<0.05),且电针组与电针对照组比较差异有统计学意义(P<0.05);与模型组相比,电针组、电针对照组bAX、bAd的阳性表达率降低(P<0.01,P<0.05),而bCl-2的阳性表达率升高(P<0.01);且电针组与电针对照组比较差异有统计学意义(P<0.05)。结论 :电针能明显促进急性脊髓损伤的修复,其机制可能为通过增加bCl-2、抑制bAX、bAd的表达,从而抑制脊髓神经元细胞的凋亡发生作用的。Objective:To explore the effect of electro acupuncture to improve the bladder function after acute spinal cord injury in rats and its possible mechanism.Methods:Sixty healthy adult male SD rats of SPF grade,with body weight of 220 to250 g,one week after feeding adaptation,were randomly divided into sham operation group,model group,electro acupuncture group,electro acupuncture control group with 15 rats in each group.Sham operation group underwent no stimulation,and the moderate damage model of spinal cord injury were made in other three groups according to modified Allens method.The model group were not treated,electro acupuncture group were treated with electro acupuncture on Zhibianxue and Shuidaoxue,and electro acupuncture control group were treated with electro acupuncture on 0.5 inch next to Zhibianxue and Shuidaoxue.The frequency of 2 / 100 Hz,current of 1 m A,stimulation time of 15 min,once a day,left and right alternately stimulate every time,for a total of 7 times.The changes of residual urine volume and urine output in rats at the 1st and the 7th days after operation were observed.And 7 d later,the rats were sacrificed and the injured spinal cord were taken out to observe the apoptosis,and to detect the changes of Bcl-2,Bax,Bad content.Results:After modeling,the rats of three groups showed different bladder dysfunction.In electro acupuncture group and electro acupuncture control group,the residual urine volume of the 7th day after operation was significant lower than the 1st day after operation(P<0.001),and there was statistically significant difference on the 7th day after operation between two groups(P<0.001).Compared with model group,the urine output of electro acupuncture group and electro acupuncture control group was significantly increased on the 7th day after operation,and there was significant difference between electro acupuncture group and electro acupuncture control group(P<0.001).Electro acupuncture can inhibit apoptosis of spinal cord neurons by TUNEL detection.Postoperative at 7 d,the rate of nerve cell apoptosis in electro acupuncture group and electro acupuncture control group was significant increased than model group(P<0.01,P<0.05),and there was significant difference between electro acupuncture group and electro acupuncture control group(P<0.005).Compared with model group,the positive expression rate of Bax,Bad decreased(P<0.01,P<0.05),and Bcl-2 increased(P<0.01)in electro acupuncture group and electro acupuncture control group,there was significant difference between electro acupuncture group and electro acupuncture control group(P<0.01).Conclusion:Electro acupuncture can obviously promote the repair of acute spinal cord injury,its mechanism may be through increasing Bcl-2,inhibiting the expression of Bax,Bad,which inhibits the apoptosis of spinal cord neurons.浙江省中医药科研计划项目(编号:2008CB067)~
cis-(1R,2S)-2-ベンズアミドシクロヘキサンカルボン酸から誘導した1,3-アミノアルコールを用いた芳香族アルデヒドへの立体選択的アリール化反応における置換基による不斉制御
A series of chiral 1,3-aminoalcohols derived from cis-(1R,2S)-2-benzamidocyclohexanecarboxylic acid were synthesized and applied in the enantioselective arylation of aromatic aldehydes. The reactions exhibited good yields (up to 90%) and moderate to high enantioselectivities (up to 99%). Not only the enantioselectivity but also the stereochemistry of the product was controlled by the substituent effect of the chiral ligands.textapplication/pdfdepartmental bulletin pape
空気渦流を利用するバイオマスと石油の異種燃料燃焼器の評価
In order to carry out heat use of the agricultural abandonment biomasses, such as chaff, simple, it inquired for the purpose of development of a compact metal burner at the low cost which can perform automatic operation. The equipment which combustion as assumed at the beginning can be realized as a result of some improvement, and combustion of oil and chaff can be performed.
As the biomass such as chaff could be supplied in the direction of a tangent of the end of combustion of a cylinder furnace form was made to generate the primary revolution style of air, and it formed so that this revolution style might be reversed at other ends and might be discharged from an exhaust port. Equipment adopted the system which considers as a length type, prepares an oil burner in the upper part, goes up, supplying the biomass and burning from the lower part, and is discharged below with a reversal revolution style.
Although it became clear that the target it not only can completely reduce smoke, but set up at the
beginning was mostly satisfied at the time of the start of chaff combustion and fire extinguishing as a result of
investigating the fundamental characteristic, an improvement of the further combustion conditions is also
needed.textapplication/pdfdepartmental bulletin pape
Effect of Simultaneous Dual-Task Training on Regional Cerebral Blood Flow in Older Adults with Amnestic Mild Cognitive Impairment
東京都立大学Tokyo Metropolitan University博士(理学療法学)doctoral thesi
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