Study the Heavy Molecular States in Quark Model with Meson Exchange Interaction

Some charmonium-like resonances such as X(3872) can be interpreted as possible $D^{(*)}D^{(*)}$ molecular states. Within the quark model, we study the structure of such molecular states and the similar $B^{(*)}B^{(*)}$ molecular states by taking into account of the light meson exchange ($\pi$, $\eta$, $\rho$, $\omega$ and $\sigma$) between two light quarks from different mesons

Dynamical study of the possible molecular state X(3872) with the s-channel one gluon exchange interaction

The recently observed X(3872) resonance, which is difficult to be assigned a conventional $c\bar{c}$ charmonium state in the quark model, may be interpreted as a molecular state. Such a molecular state is a hidden flavor four quark state because of its charmonium-like quantum numbers. The s-channel one gluon exchange is an interaction which only acts in the hidden flavor multi-quark system. In this paper, we will study the X(3872) and other similiar hidden flavor molecular states in a quark model by taking into account of the s-channel one gluon exchange interaction

Modulating Linker Composition of Haptens Resulted in Improved Immunoassay for Histamine.

Histamine (HA) is an important food contaminant generated during food fermentation or spoilage. However, an immunoassay for direct (derivatization free) determination of HA has rarely been reported due to its small size to induce the desired antibodies by its current hapten-protein conjugates. In this work, despite violating the classical hapten design criteria which recommend introducing a linear aliphatic (phenyl free) linker into the immunizing hapten, a novel haptens, HA-245 designed and synthesized with a phenyl-contained linker, exhibited significantly enhanced immunological properties. Thus, a quality-improved monoclonal antibody (Mab) against HA was elicited by its hapten-carrier conjugates. Then, as the linear aliphatic linker contained haptens, Hapten B was used as linker-heterologous coating haptens to eliminate the recognition of linker antibodies. Indirect competitive ELISA (ic-ELISA) was developed with a 50% inhibition concentration (IC50) of 0.21 mg/L and a limit of detection (LOD) of 0.06 mg/L in buffer solution. The average recoveries of HA from spiked food samples for this ic-ELISA ranged from 84.1% and 108.5%, and the analysis results agreed well with those of referenced LC-MS/MS. This investigation not only realized derivatization-free immunoassay for HA, but also provided a valuable guidance for hapten design and development of immunoassay for small molecules