多盘式磁流变液传动装置设计与仿真

介绍了磁流变液传动装置的工作原理,基于磁流变液Bingham模型设计了多盘式磁流变液传动装置的机械结构和散热系统,并利用有限元分析软件Ansoft Maxwell进行了磁路设计和磁场仿真,得到了不同励磁电流下磁场的分布云图,为磁流变液传动装置的优化设计提供了参考和依据

Inhibitory effect of mitomycin C-loaded controlled release collagen implant on the growth of hepatocellular carcinoma in nude mice

目的研究植入式丝裂霉素(mitomycin C-loaded collagen,MMC)控释膜剂对人肝癌裸鼠移植瘤的抑瘤作用。方法:将0．06、0．12、0．18 mg三种不同剂量的MMC控释膜剂植入荷人肝癌裸小鼠皮下移植瘤内,并与用相同剂量的瘤内注射、腹腔注射及对照组比较,观察其抑瘤作用。结果:0．18 mg MMC瘤内植入组抑瘤率明显高于对照组(P＜0．01)及0．06 nag MMC瘤内植入组(P＜0．05);0．18 mg MMC控释膜剂瘤内植入组抑瘤率也明显高于0．18 mg MMC腹腔注射组(P＜0．01)。结论:植入式MMC控释膜剂可能是一种有效治疗原发性肝癌的药物新剂型。 【英文摘要】 Objective:To study the inhibitory effect of controlled release mitomycin C(MMC)-loaded collagen implant on the growth of hepatocellular carcinoma in nude mice.Methods:Three different doses(0.06.0.12,and 0.18 mg)of controlled release mitomycin C-loaded collagen implant were implanted into the transplanted human hepatocellular carcinoma(LCI-D20)in nude mice.The inhibitory effect on tumor growth was observed and compared with intratumoral injection,intraperitoneal injec- tion.and control group at the same dosa...厦门市科技计划资助项目(编号:3502720055007

The chiral shift mechanism of α-alanine molecule in SWCNT (9, 9) of armchair(α-丙氨酸分子在扶手椅型SWCNT(9，9)内的手性转变机制)

采用组合的量子化学ONIOM(B3LYP/6-31 + + G(d，p)：UFF）方法，研究了限域在SWCNT(9，9)内α-丙氨酸的分子结构和手性转变机制.为得到相对高水平的体系能量和反应势能面，在ONIOM(B3LYP/6-311 + + G(3 df, 3 pd):UFF)水平上计算了各个包结物的单点能.分子结构分析表明：与单体α-丙氨酸相比，受限在SWCNT (9, 9)碳纳米管内时，键长均略缩短，骨架原子的二面角基本不变.反应路径研究发现，α-丙氨酸分子在SWCNT(9，9)内的手性转变路径有2条与单体情况大致相同.不存在单体情况的有羰基H和甲基H协同转移过程的反应通道.对手性转变反应过程势能面的计算发现，S型α-丙氨酸在SWCNT(9，9)内向R型转变与单体α-丙氨酸手性转变反应过程的主要能垒相比较，路径1的最高能垒同样是由在纸外面的氢从手性碳直接到羰基氧的过渡态产生的，能垒基本不变；路径2是氢先在羧基内转移，此过程的能垒由194.5降到137.6 kJ • mol-1.而后纸外面的氢从手性碳转移到羰基，此过程的能垒由317.1降到302.9 kJ • mol-l.研究结果表明，SWCNT(9，9)对α-丙氨酸的限域影响使手性转变反应过程的某些能垒降低，改变或部分改变了反应路径

Formation of breath figure arrays in methanol vapor assisted by surface active agents

Breath figure (BF) process is a promising technique for fabricating honeycomb polymer films. It is usually conducted in water vapor. While, in organic vapors only unique polymer can be used to prepare BF arrays as reported in our previous article (Breath Figure in Nonaqueous Vapor. Soft Matter, 2013, 506-514), although new structure features are induced in the film. In this paper, a universal modified BF processing is devised for preparing porous films in methanol vapor with conventional polymers, by adding a small amount of surface active agent into the casting solution, such as siloxane- and fluorine-containing block copolymers. The pores in the PS films prepared with this method are of cylindrical shape with large depth-diameter aspect ratio, and the diameter and depth of pores can be well controlled by the experiment conditions. Based on these results, the formation mechanism of honeycomb structure in methanol vapor is discussed. ? 2014 American Chemical Society