Metabonomic Analysis Reveals Mechanisms for Both Renoprotection of Exendin-4 in Rats with Diabetic Kidney Disease and Adaptation of Microbacterium YLB-01 to High Pressure and Low Temperature

基于核磁共振（NMR）的代谢组学是一门新兴的“组学”学科，它将1H-NMR波谱检测技术和模式识别分析技术相结合，被广泛应用于疾病的早期诊断、病理机制、药物的药效评估、微生物环境胁迫适应性等研究。本论文应用基于NMR技术的代谢组学方法，研究艾塞那肽Exendin-4（胰高血糖素样肽-1（GPL-1）类药物）对糖尿病肾病（DKD）大鼠的肾功能保护机制以及深海沉积微杆菌YLB-01耐受高压低温的分子机制。 糖尿病肾病(DKD)发病机制尚不完全明确。最近的研究表明GLP-1类药物（如Exendin-4）可能通过改善代谢来抑制DKD的发生发展，但其作用机制并不明确。为了揭示Exendin-4保护DKD...Nuclear magnetic resonance (NMR)-based metabonomics approach is a newly emerging “omic” discipline with the integration of NMR technique and pattern recognition analysis. It can been widely used in the early diagnosis and pathological mechanism of disease, efficacy evaluatio of drugs, mechanism of extremophiles adapation to environmental stress. In this work, we applied NMR-based metabonomics anal...学位：理学硕士院系专业：化学化工学院_化学生物学学号：2052013115166

关于“经济发展方式转变进程中的财税政策”的探讨(笔谈)

转变经济发展方式是当前中国的热门话题,而上海在城市发展中又肩负着率先转变的重要任务,在这一意义和背景下,2010年4月24日由上海金融学院学院主办、上海金融学院公共经济管理学院承办的“《中国城市财政发展报告2009/2010:促进‘两个中心’建设的上海城市财政》首发式暨‘经济发展方式转变进程中的财税政策’论坛“在我校举行。与会专家围绕经济发展方式转变进程中的财税政策的“趋势与目标“、“机遇和挑战“、“实施方略“和“地方实践“等四个专题进行研讨,各抒己见,智慧交锋。现将其真知灼见整理摘要与读者分享,以期待更多学者共同关注当前经济发展方式转变进程中的财税政策

Genomic Insights into the Formation of Human Populations in East Asia

厦门大学人类学研究所、厦门大学生命科学学院细胞应激生物学国家重点实验室王传超教授课题组与哈佛医学院David Reich教授团队合作，联合全球43个单位的85位共同作者组成的国际合作团队通过古DNA精细解析东亚人群形成历史。研究人员利用古DNA数据检验了东亚地区农业和语言共扩散理论，综合考古学、语言学等证据，该研究系统性地重构了东亚人群的形成、迁徙和混合历史。这是目前国内开展的东亚地区最大规模的考古基因组学研究，此次所报道的东亚地区古人基因组样本量是以往国内研究机构所发表的样本量总和的两倍，改变了东亚地区尤其是中国境内考古基因组学研究长期滞后的局面。 该研究是由王传超教授团队与哈佛医学院（David Reich教授）、德国马普人类历史科学研究所（Johannes Krause教授）、复旦大学现代人类学教育部重点实验室（李辉教授和金力院士）、维也纳大学进化人类学系（Ron Pinhasi副教授）、南洋理工大学人文学院（Hui-Yuan Yeh助理教授）、俄罗斯远东联邦大学科学博物馆（Alexander N Popov研究员）、西安交通大学（张虎勤教授）、蒙古国国家博物馆研究中心、乌兰巴托国立大学考古系、华盛顿大学人类学系、台湾成功大学考古所、加州大学人类学系等全球43个单位的85位共同作者组成的国际合作团队联合完成的。厦门大学人类学研究所、厦门大学生命科学学院细胞应激生物学国家重点实验室为论文第一完成单位。厦门大学人类学研究所韦兰海副教授、胡荣助理教授、郭健新博士后、何光林博士后和杨晓敏硕士参与了研究工作。The deep population history of East Asia remains poorly understood due to a lack of ancient DNA data and sparse sampling of present-day people1,2. We report genome-wide data from 166 East Asians dating to 6000 BCE-1000 CE and 46 present-day groups. Hunter-gatherers from Japan, the Amur River Basin, and people of Neolithic and Iron Age Taiwan and the Tibetan plateau are linked by a deeply-splitting lineage likely reflecting a Late Pleistocene coastal migration. We follow Holocene expansions from four regions. First, hunter-gatherers of Mongolia and the Amur River Basin have ancestry shared by Mongolic and Tungusic language speakers but do not carry West Liao River farmer ancestry contradicting theories that their expansion spread these proto-languages. Second, Yellow River Basin farmers at ～3000 BCE likely spread Sino-Tibetan languages as their ancestry dispersed both to Tibet where it forms up ～84% to some groups and to the Central Plain where it contributed ～59-84% to Han Chinese. Third, people from Taiwan ～1300 BCE to 800 CE derived ～75% ancestry from a lineage also common in modern Austronesian, Tai-Kadai and Austroasiatic speakers likely deriving from Yangtze River Valley farmers; ancient Taiwan people also derived ～25% ancestry from a northern lineage related to but different from Yellow River farmers implying an additional north-to-south expansion. Fourth, Yamnaya Steppe pastoralist ancestry arrived in western Mongolia after ～3000 BCE but was displaced by previously established lineages even while it persisted in western China as expected if it spread the ancestor of Tocharian Indo-European languages. Two later gene flows affected western Mongolia: after ～2000 BCE migrants with Yamnaya and European farmer ancestry, and episodic impacts of later groups with ancestry from Turan.We thank David Anthony, Ofer Bar-Yosef, Katherine Brunson, Rowan Flad, Pavel Flegontov,Qiaomei Fu, Wolfgang Haak, Iosif Lazaridis, Mark Lipson, Iain Mathieson, Richard Meadow,Inigo Olalde, Nick Patterson, Pontus Skoglund, Dan Xu, and the four reviewers for valuable comments. We thank Naruya Saitou and the Asian DNA Repository Consortium for sharing genotype data from present-day Japanese groups. We thank Toyohiro Nishimoto and Takashi Fujisawa from the Rebun Town Board of Education for sharing the Funadomari Jomon samples, and Hideyo Tanaka and Watru Nagahara from the Archeological Center of Chiba City who are excavators of the Rokutsu Jomon site. The excavations at Boisman-2 site (Boisman culture), the Pospelovo-1 site (Yankovsky culture), and the Roshino-4 site (Heishui Mohe culture) were funded by the Far Eastern Federal University and the Institute of History,Archaeology and Ethnology Far Eastern Branch of the Russian Academy of Sciences; research on Pospelovo-1 is funded by RFBR project number 18-09-40101. C.C.W was funded by the Max Planck Society, the National Natural Science Foundation of China (NSFC 31801040), the Nanqiang Outstanding Young Talents Program of Xiamen University (X2123302), the Major project of National Social Science Foundation of China (20&ZD248), a European Research Council (ERC) grant to Dan Xu (ERC-2019-ADG-883700-TRAM) and Fundamental Research Funds for the Central Universities (ZK1144). O.B. and Y.B. were funded by Russian Scientific Foundation grant 17-14-01345. H.M. was supported by the grant JSPS 16H02527. M.R. and C.C.W received funding from the ERC under the European Union’s Horizon 2020 research and innovation program (grant No 646612) to M.R. The research of C.S. is supported 30 by the Calleva Foundation and the Human Origins Research Fund. H.L was funded NSFC (91731303, 31671297), B&R International Joint Laboratory of Eurasian Anthropology (18490750300). J.K. was funded by DFG grant KR 4015/1-1, the Baden Württemberg Foundation, and the Max Planck Institute. Accelerator Mass Spectrometry radiocarbon dating work was supported by the National Science Foundation (NSF) (BCS-1460369) to D.J.K. and B.J.C. D.R. was funded by NSF grant BCS-1032255, NIH (NIGMS) grant GM100233, the Paul M. Allen Frontiers Group, John Templeton Foundation grant 61220, a gift from Jean-Francois Clin, and the Howard Hughes Medical Institute. 该研究得到了国家自然科学基金“中国东南各族群的遗传混合”、国家社科基金重大项目“多学科视角下的南岛语族的起源和形成研究”、厦门大学南强青年拔尖人才支持计划A类、中央高校基本科研业务费等资助

道路防风沙设施专利技术综述

论文对中国和其他国家的道路防风沙设施（IPC分类号E01F7）2018年以前的专利进行了统计分析。结果表明，中国和日本是最重要的专利申请国。在技术分支上，线网型防风沙设施和孔板型防风沙设施是目前申请量最多的两大分支，其发展相比其他技术主题也更具连续性。进一步通过对不同时期的重点专利进行分析，梳理了中国和日本不同类型防风沙设施的专利技术发展路线。</jats:p

无意识种族信息知觉加工

目的：在种族信息加工领域，前人通过持续闪现抑制（CFS）范式在社会评价层面发现了无意识的本族效应（Yuan et al., 2017），即被试对无意识呈现的异族面孔存在偏见。但是，无意识呈现的种族面孔能否在知觉水平得到加工还尚无定论，且研究甚少，本研究采用bCFS（突破CFS）考察无意识呈现的本族面孔在知觉水平是否具有优势。 方法：本研究包含两个实验。实验1的目标刺激为标准化的中国人与白人黑白面孔，通过红蓝眼镜呈现在中国被试的非优势眼；高对比度、彩色、快速闪现的蒙德里安（Mondrian）色块作为掩蔽刺激呈现在被试的优势眼。面孔刺激的对比度在1秒内从0增加到100%并保持不变，直至被试按键；因此，在开始阶段，面孔是被抑制的，实现了无意识的效果。面孔随机出现在中央注视点两侧的两条弧形轨迹上，被试的任务是判断面孔出现在注视点左侧或右侧。此外，实验1还包含一个对照实验，实验中蒙德里安色块和面孔刺激同时呈现在被试的双眼。实验2为了排除种族面孔所存在的熟悉性差异，采用两种几何图形，与种族概念进行联结学习。除了刺激为联结后的图形，实验2与实验1基本相同。 结果：实验1发现与异族面孔相比，本族面孔能更快突破抑制进入意识；而对照实验未发现差异，排除了面孔低水平物理属性的影响。实验2发现被试在本族的联结学习中表现更好，反应时更快，正确率更高。同时，代表本族的图形在突破抑制上也存在优势，而对照实验则未发现差异。实验2重复了实验1的结果，排除了面孔熟悉性的影响。 结论：本研究通过两个实验，发现种族信息可以在无意识下得到加工，无意识呈现的本族面孔与代表本族的图形在知觉水平上存在优势。</p

Postscript of Two Study Guiding Polymer Books

[中文文摘]在编写了《高分子物理学习指导》(科学出版社,2005) 和《高分子化学学习指导》(科学出版,2007) 两本高分子教学参考书之后,作者总结了书中的例题和思考题的编写感想。对高分子习题中题型的分类和搭配、题数的分布规律、出题技巧、难题释疑以及名词辨析等方面提出一些思考。[英文文摘]After writing two teaching reference books“Study Guiding of Polymer Physics”(Science Press ,2005) and“Study Guiding of Polymer Chemistry”(Science Press , 2007) , authors summarize the writing impressions of examples and exercises of the books , and ponder over the classification and collocation of the exercises, the distribution rule of the exercise number, the skill of writing exercises, clear up doubts of difficult exercises, and the comparison and explanation of terminology in the polymeric exercises