A Cross-Platform Personalized Recommender System for Connecting E-Commerce and Social Network

In this paper, we build a recommender system for a new study area: social commerce, which combines rich information about social network users and products on an e-commerce platform. The idea behind this recommender system is that a social network contains abundant information about its users which could be exploited to create profiles of the users. For social commerce, the quality of the profiles of potential consumers determines whether the recommender system is a success or a failure. In our work, not only the user’s textual information but also the tags and the relationships between users have been considered in the process of building user profiling model. A topic model has been adopted in our system, and a feedback mechanism also been design in this paper. Then, we apply a collative filtering method and a clustering algorithm in order to obtain a high recommendation accuracy. We do an empirical analysis based on real data collected on a social network and an e-commerce platform. We find that the social network has an impact on e-commerce, so social commerce could be realized. Simulations show that our topic model has a better performance in topic finding, meaning that our profile-building model is suitable for a social commerce recommender system

A Cross-Platform Personalized Recommender System for Connecting E-Commerce and Social Network

In this paper, we build a recommender system for a new study area: social commerce, which combines rich information about social network users and products on an e-commerce platform. The idea behind this recommender system is that a social network contains abundant information about its users which could be exploited to create profiles of the users. For social commerce, the quality of the profiles of potential consumers determines whether the recommender system is a success or a failure. In our work, not only the user’s textual information but also the tags and the relationships between users have been considered in the process of building user profiling model. A topic model has been adopted in our system, and a feedback mechanism also been design in this paper. Then, we apply a collative filtering method and a clustering algorithm in order to obtain a high recommendation accuracy. We do an empirical analysis based on real data collected on a social network and an e-commerce platform. We find that the social network has an impact on e-commerce, so social commerce could be realized. Simulations show that our topic model has a better performance in topic finding, meaning that our profile-building model is suitable for a social commerce recommender system.</jats:p

Longitudinal 18F-VUIIS1008 PET imaging in a rat model of rheumatoid arthritis

Macrophages have crucial roles in the pathogenesis of rheumatoid arthritis (RA). We aimed to elucidate the temporal profile of macrophage infiltration in synovitis in RA rat models using PET (positron emission tomography) imaging based a new generation of TSPO (Translocator protein, 18 kDa)-PET ligand, 18F-VUIIS1008 {2-[5,7-Diethyl-2-{4-[2-(18F)fluoroethoxy]phenyl}pyrazolo(1,5-a)pyri-midin-3-yl]-N, N-diethylacetamide}. In vitro and in vivo studies were conducted using RAW264.7 macrophage cells and a rat model of RA induced by Complete Freund’s Adjuvant (CFA). Our results showed 18F-VUIIS1008 showed excellent stability in vitro and binding specificity to RAW264.7 cells, and rapid accumulation in the left inflammatory ankles. PET studies revealed that 18F-VUIIS1008 could clearly identify the left inflammatory ankles with good contrast at 30–120 min post-injection. The uptake of 18F-VUIIS1008 of left inflammatory ankles was a wiggle trace with two peaks on day 7 and 29, and then, the highest peak uptake was seen on day 29 (3.00% ± 0.08%ID/g) at 60 min after injection. Tracer uptakes could be inhibited by PK11195 or VUIIS1008. Immunohistochemistry and immunofluorescence tests showed that elevated TSPO expression and infiltrated macrophages were found in the left inflammation ankles. 18F-VUIIS1008 as a novel PET imaging agent showed great potential to identify temporal profile of macrophage infiltration in synovitis in RA, and deliver accurate non-invasive diagnosis and real-time monitoring of RA development.</jats:p

Dy³⁺ and Mn⁴⁺ Ions Co-Doped Stannate Phosphors for Applications in Dual-Mode Optical Thermometry

In order to break through the limitations of the application of traditional temperature measurement technology, non-contact optical temperature sensing material with good sensitivity is one of the current research hotspots. Herein, a series of Dy3+ and Mn4+ co-doping Mg3Ga2SnO8 fluorescent materials were prepared successfully, and the crystal structure, phase purity, and morphology of the synthesized phosphors were comprehensively investigated, as well as their photoluminescence properties, energy transfer, and high-temperature thermal stability. The two pairs of independent thermally coupled energy levels of Dy3+ ions and Mn4+ ions in Mg3Ga2SnO8 are utilized to realize the dual-mode optical temperature detection with excellent performance. On the one hand, based on the different ionic energy level transitions of 4F9/2→6H13/2 and 2Eg→4A2g responding differently to temperature, two emission bands of 577 nm and 668 nm were chosen to construct the fluorescence intensity ratio thermometry, and the maximum sensitivity of 1.82 %K−1 was achieved at 473 K. On the other hand, based on the strong temperature dependence of the lifetime of Mn4+ in Mg3Ga2SnO8:0.06Dy3+,0.009Mn4+, fluorescence lifetime thermometry was constructed and a maximum sensitivity of 2.75 %K−1 was achieved at 473 K. Finally, the Mg3Ga2SnO8: 0.06Dy3+,0.009Mn4+ sample realizes dual-mode optical temperature measurement with high sensitivity and a wide temperature detection range, indicating that the sample has promising applications in optical temperature measurement

99mTc-labeled TSPO ligand CB86 targeting macrophages for rheumatoid arthritis SPECT imaging and preliminary evaluation of anti-inflammatory effect

Abstract Background and Objective TSPO (translocator protein, 18 kDa) is up-regulated in activated macrophages, and serves as an attractive target for macrophages molecular imaging. Previous studies showed that TSPO radiotracer can visualize arthritis via positron emission tomography (PET). Compared with PET, single photon emission computed tomography (SPECT) has several advantages, such as lower cost and commercial availability. The aim of the present study is to develop the 99mTc-labeled TSPO ligand CB86 as a novel SPECT probe for imaging of rheumatoid arthritis and preliminary evaluating the effectiveness of steroid anti-inflammatory therapy. Methods A novel TSPO ligand CB86 was linked to DTPAA and then labeled with 99mTc to obtain 99mTc-DTPA-CB86. The labeling efficiency, radiochemical purity, and stability were determined in vitro. In vitro cellular uptake, efflux and binding affinity of 99mTc-DTPA-CB86 to TSPO were performed on RAW264.7 macrophage cells. The distribution and SPECT studies were conducted on Freund’s Adjuvant-Induced Left Arthritis in rats after the injection of 99mTc-DTPA-CB86 with or without co-injection of unlabeled DTPA-CB86. Result The radiosynthesis of 99mTc-DTPA-CB86 was completed successfully with the labeling yields and radiochemical purity of 95.86 ± 2.45 % and 97.45 ± 0.69 %, respectively. 99mTc-DTPA-CB86 displayed good stability, which the radiochemical purity was more than &gt; 90%, in the saline or mouse serum at 4 h. It also exhibited high specific TSPO binging in RAW264.7 macrophage cells in vitro. The highest uptake ratio was (36.45 ± 2.18) % at 3 h after incubation, and decreased significantly after adding excessive unlabeled DTPA-CB86. 99mTc-DTPA-CB86 bound to TSPO with low nanomolar affinity (IC50 =0.49 nM) in RAW264.7 cells. The cell efflux study showed that 99mTc-DTPA-CB86 has good cell retention by RAW264.7 cells, with only about 13.99 % (decreased from (33.31 ± 2.34) % to (19.32 ± 2.01) % of total input radioactivity) of 99mTc-DTPA-CB86 efflux observed during 4.5 h to 8 h incubation. Biodistribution studies showed the left inflammatory ankle uptake was 2.35±0.10 %ID/g, and the inflammatory ankle to muscle ratio was 3.01 ± 0.09 at 180 min after injection. Small animal SPET imaging studies revealed that 99mTc-DTPA-CB86 could clearly identify left inflammatory ankle with good contrast at 30-180 min after injection. Uptake of 99mTc-DTPA-CB86 in the inflammatory ankles could be largely blocked by an excess of unlabled DTPA-CB86. Furthermore, 99mTc-DTPA-CB86 accumulation in the left inflammatory ankles significantly decreased in RA rats treated with dexamethasone. Conclusion 99mTc-DTPA-CB86 can be readily synthesized, clearly visualized arthritis with low background and monitor therapy response of anti-inflammatory therapy, suggesting its potential as a novel promising molecular probe targeting TSPO for arthritic SPECT imaging. Key words TSPO (translocator protein, 18 kDa); Technetium radioisotope; SPECT imaging; Rheumatoid arthritis; Macrophages; Glucocorticoids.</jats:p