就学前教育機関における多動児の実態 : 幼稚園・保育所に対する質問紙調査から

Departmental Bulletin Paperパイデイア : 教育実践研究指導センター紀要, 第9巻, pp.109-120departmental bulletin pape

天南星提取物及其用於創傷-癒合作用的用途

本发明提供天南星的水和醇提取物、从天南星分离的化合物(比如3‑O‑(9,12‑十八碳二烯酰基)‑甘油基‑β‑D‑吡喃半乳糖苷、N‑(β‑D‑呋喃核糖‑1‑基)‑苯丙氨酸、和腺苷)、包含前述成分的药物组合物、以及其用于促进创伤愈合的用途。在一个实施方案中，所述药物组合物为局部剂型，比如乳膏剂、软膏剂、泡沫剂、洗剂、硬膏剂、凝胶剂和乳剂。 The present invention provides Rhizoma extract of water and alcohol, from the compound (such as 3-O- (9,12- octadecadienoyl) Araceae isolated - glycero -β-D- galactopyranoside, N- (β-D- ribofuranosyl-l-yl) - phenylalanine, and adenosine), comprising the ingredients of the pharmaceutical compositions, and their use for promoting wound healing. In one embodiment, the pharmaceutical composition is topical dosage forms, such as creams, ointments, foams, lotions, plasters, gels, and emulsions

CDK5抑制剂及其治疗用途

本发明涉及细胞周期蛋白依赖性激酶5(Cdk5)的天然来源的抑制剂，其分离自玫瑰红景天根，并且其结构与已知的Cdk抑制剂不同。它们对不同的Cdks显示出选择性，并且通过混合类型的抑制模式而表现出抑制Cdk的效力，这使得其毒性和副作用较小。它们可用于预防和治疗与异常Cdk5活性相关的疾病或病症，例如，急性和/或慢性疼痛、神经性疼痛、糖尿病、癌症、神经退行性疾病和神经病理紊乱等

一叶萩生物碱类成分研究

目的 对一叶荻的生物碱类成分进行研究.方法 采用各种色谱技术对一叶蔌的总生物碱部位进行分离,应用理化常数和波谱技术(NMR、MS等)鉴定化合物的结构.结果 自一叶蔌枝叶的总碱部位中分离得到2个新的生物碱类化合物,分别命名为叶下珠碱B(phyllanthidine B,4α-methoxy-phyllanthidine,Ⅰ)和一叶蔌醇D(securinol D,14β-hydroxyviroallosecurinine,Ⅱ).结论 化合物Ⅰ和Ⅱ均为新化合物. Objective: To investigate the total alkaloids in chemical constituents from the tender leaves and twigs of Securinega suffruticosa. Methods: Column chromatographies were used to separate the total alkaloids in the tender leaves and twigs of S. suffruticosa whose structures were elucidated by means of physicochemical properties and spectral data. Results: Two new alkaloids named as phyllanthidine B, 4α-methoxy- phyllanthidine (I) and securinol D, 14β-hydroxyviroallosecurinine (II) were isolated and identified. Conclusion: The two alkaloids, compounds I and II, are new ones