Co3（HCOO）6@rGO作为锂离子电池负极材料的研究

MOFs材料作为一类新型的锂离子电池电极材料而受到广泛关注和研究.作者通过溶液扩散法将Co3（HCOO）6原位负载在rGO（还原氧化石墨烯）上制备出Co3（HCOO）6@rGO复合材料.将Co3（HCOO）6@rGO作为锂离子电池负极材料,以500 mA·g-1的电流密度恒电流充放电循环100周后,仍然保持有926 mAh·g-1的比容量,亦表现出很好的倍率性能.循环伏安和X-射线光电子能谱测试表明,Co3（HCOO）6@rGO材料上的Co2+和甲酸根在充放电过程中均发生可逆的电化学反应.对比同样采用溶液扩散法合成的Co3（HCOO）6的测试结果发现,rGO起到活化甲酸根的电化学反应的作用,同时也改善了Co3（HCOO）6的倍率性能.将MOFs材料与rGO复合为优化MOFs材料的电池性能提供了一个新思路.973项目(No.2015CB251102);;国家自然科学基金项目(No.U1305246,No.21673196,No.21621091)资

Tunable narrow linewidth fiber laser with two FBG-FPs

基于游标原理,利用一对自由谱宽(fSr)略有不同的光纤布喇格光栅法布里-珀罗腔(fbg-fP)作为模式选择器件,设计了一种新颖的环形腔光纤激光器。从理论和实验上研究了该激光器的特性。通过对可调谐fbg-fP应力调谐,在1552.240~1552.912 nM范围内,以96 PM为平均间距,获得了8个由固定fbg-fP的透射谱所确定的窄线宽稳定激光输出。8个输出波长的平均功率为-17.66 dbM,波动在0.7 db范围内。当泵浦光的功率为95 MW的时候,输出信号的信噪比均大于50 db。实验上每隔1 MIn用光谱分析仪(OSA)对输出光波长自动扫描,记录的输出光波长漂移在数皮米范围内,且功率的波动小于0.1 db。这种可调谐的窄线宽光纤激光器在光纤通信和光纤传感方面有潜在的应用价值。Using a pair of Fiber Bragg grating Fabry-Pérots(FBG-FP)with a little different FSR as its wavelength-selective components,a novel ring laser based on the vernier effect is proposed.We have studied the characteristics of this kind of tunable fiber laser both theoretically and experimentally,and obtained 8 discretely tunable laser wavelengths ranging from 1552.240 nm to 1552.912 nm with an average 96 pm span by pulling the tunable FBG-FP.The output spectrum peak is uniform among different wavelength at-17.66 dBm with a fluctuation of 0.7 dB.When the pump power is 95 mW,the signal-to-noise ratio is better than 50 dB.The output spectrum of the laser is recorded automatically by an optical spectrum analyzer(OSA)once a minute.It is found that the output wavelength drift within a few pico-meter and the fluctuation of the output power is less than 0.1 dB.This kind of fiber ring laser may have potential applications in optical communications and sensors.国家自然科学基金项目(No.61077031/F050208); 福建省教育厅B类科技研究项目(No.JB11097)资

射频消融双上肺静脉口治疗心房颤动一例

采用射频消融电学隔离双上肺静脉口成功治疗心房颤动 (简称房颤 ) 1例。电学隔离法有如下几个优点 :①以环型肺静脉 (PV)标测电极导管精确地显示整个环型管壁的电活动及靶点位置 ,引导靶肺静脉的电学隔离。②消融终点不仅要求自发或诱发的房性早搏 /房颤消失 ,而且要求消除靶肺静脉口所有的PV电位 ,它在窦性心律下或起搏冠状窦远端下即可消融和判断终点 (靶肺静脉电学隔离 ) ,不仅节省了大量的时间 ,而且提高了手术的成功率。③在肺静脉开口部 (或近端 )消融 ,较少出现PV狭

巨噬细胞移动抑制因子在原发性肝癌中的临床意义

【目的】探讨肝癌患者血清巨噬细胞移动抑制因子（macrophage migration inhibitory factor,MIF）水平与其临床特征及预后的关系。【方法】用酶联免疫吸附法检测2004年1月至2006年5月60例确诊初治的原发性肝癌患者的血清MIF水平,并与30例健康人相比较,分析其与临床特征及预后的关系。【结果】原发性肝癌患者血清MIF水平较健康对照组显著升高（中位值,34.1ng/mL与15.9ng/mL,P〈0.001）。血清MIF水平与血管侵犯（P=0.014）、进展的临床TMN分期（P=0.037）及转移（P=0.026）密切相关。血清MIF高（〉34.1ng/mL）的患者2年生存率较血清MIF低的患者（≤34.1ng/mL）明显降低（59%与28%,LogRank为6.02,P=0.014）。多因素分析表明MIF水平是影响患者生存的独立预后因素。【结论】MIF可能参与了原发性肝癌的疾病进展过程,提示MIF在原发性肝癌患者中可作为反应肿瘤侵袭及预后的一个有用的生物标记物

B细胞淋巴瘤SHP-1基因甲基化状态及其意义

【目的】探讨JAK/STAT信号转导途径负调控子SHP-1基因启动子区域CpG岛异常甲基化在B细胞淋巴瘤中的意义。【方法】收集存档石蜡包埋组织标本61例(52例B细胞非霍奇金淋巴瘤标本,9例良性增生淋巴结标本),健康人外周血单个核细胞DNA标本15例,用甲基化特异性PCR(methylation-specific PCR,MSP)和非甲基化特异性PCR(unmethylation-specific PCR,un-MSP)检测SHP-1启动子区域CpG岛甲基化状态,MSP、un-MSP和RT-PCR方法分别检测接受或未接受去甲基化处理的Burkitt淋巴瘤细胞系Raji的甲基化状态及mRNA的表达,MTT法检测接受去甲基化干预后细胞生长受抑情况。【结果】SHP-1基因启动子区域在弥漫性大B细胞淋巴瘤和滤泡性淋巴瘤甲基化频率分别为94%及97%,对照组9例淋巴结良性增生标本和15例正常人外周血单个核细胞标本中SHP-1基因启动子区域甲基化频率为0。经去甲基化干预后,Raji细胞SHP-1基因启动子区域呈去甲基化状态,基因恢复表达,细胞生长受到抑制。【结论】SHP-1基因启动子区域启动子区域CpG岛在B细胞淋巴瘤中存在高度甲基化，由其所致的SHP-1基因沉默可能是B细胞淋巴瘤发生的一个重要因素，SHP-1基因的甲基化可作为一个良好的分子诊断标记及可能的治疗靶点

The Application of Metabolomics for Gestational Diabetes Mellitus

妊娠期糖尿病(gdM)易造成子痫前期、羊水过多、巨大儿等多种并发症。目前在妊娠中晚期检测血糖筛查gdM,确诊患者接受治疗的时间短,母婴健康存在严重隐患。代谢组学(METAbOlOMICS)是一种定量考察生命系统受内外界刺激或基因修饰后的代谢应答规律的学科。将代谢组学的方法应用于gdM研究,有望实现gdM的早期诊断,理解gdM的致病机制,对gdM的防治和母婴预后都有重要的意义。综述代谢组学方法在gdM及相关疾病研究中的应用。Gestational diabetes mellitus(GDM) easily lead to some complications,such as preeclampsia,polyhydramnios,macrosomia,and so on.The traditional diagnostic protocols for GDM mainly rely on detecting elevated glucose levels in blood,often late in the second trimester.Therefore the treatment time for the patients is not enough and the serious risk to maternal and child health raise.Metabolomics is an approach that investigates the metabolic responses of living systems to internal or external stimuli or genetic modification.The application of metabolomics to GDM research will help to interpret the pathogenesis of GDM.In addition,it can also provide the theoretical and experimental support for prevention and treatment of GDM as well as the prognosis of mothers and their infants.The characteristics of the common detection methods and the metabolomics studies of GDM were analyzed and compared in detail in this paper,and the metabolomic studies in GDM was further reviewed.国家自然科学基金(81201143;81371639); 中央高校基本科研业务费(2013121007

Specific Release of Bacteriochlorophylls B800 of LH2 from Rhodobacter azotoformans Induced by Sodium Dodecyl Sulfate

采用吸收光谱法研究了十二烷基硫酸钠(SdS)诱导rHOdObACTEr AzOTOfOrMAnS外周捕光复合体lH2细菌叶绿素(bACTErIOCHlOrOPHyllS,bCHlS)的解离行为和规律.结果表明:室温下,在10MMOl？l-1TrIS-HCl(PH8.0)缓冲液中,低浓度SdS只诱导lH2中b800细菌叶绿素解离生成游离bCHlS,而b850不受影响;当浓度达到0.08%(W/V)时,能特异性地诱导b800缺失,其缺失过程和游离bCHlS的生成过程均符合单指数模型,且二者的速率常数近似相等.高浓度SdS能同时诱导b800和b850解离生成游离bCHlS,其中b800可发生缺失,而b850则不完全解离,解离过程均符合单指数模型;b800对SdS更敏感,其解离速率常数约是b850的4倍,游离bCHlS生成速率常数明显低于b800解离速率常数,而与b850解离速率常数相接近.The release behaviors of bacteriochlorophylls of peripheral light-harvesting complex LH2 from Rhodobacter azotoformans induced by sodium dodecyl sulfate (SDS) were investigated using absorption spectroscopy.The results indicated that bacteriochlorophylls of B800 band are released from their binding sites and transformed into free bacteriochlorophylls by incubating LH2 sample in 10 mmol?L-1 Tris-HCl (pH 8.0) buffer containing SDS of low concentration at room temperature.However, the bacteriochlorophylls of B850 band are not released.The dynamics of B800 release and free BChl formation induced by 0.08% (w/V) SDS can be well fitted by the monoexponential model.The rate constant of B800 release is nearly equal to that of free BChls formation.The release of both B800 and B850 of LH2 can be induced by high concentration SDS, simultaneously.The bacteriochlorophylls of B800 band can be completely transformed into free BChls, but not for B850.Although both of their release processes show monoexponential models in 1% SDS solution, the release rate constant of B850 is remarkably lower than that of B800 and close to that of free BChls formation.国家自然科学基金(No.30970068);国家科技基础条件平台建设(No.2005DKA21209);厦门大学近海海洋环境科学国家重点实验室高级访问学者基金(No.MELRS0907);山西省回国留学人员科研(No.200713)资助项

超声心动图监测45例法布雷病患者心脏早期受累的特征分析

目的分析45例临床确诊的法布雷病（AFD）患者的临床特征，同时应用超声心动图二维斑点追踪技术（2D-STE）评估法布雷病患者应变图像，以期探索法布雷患者心脏早期受累在超声心动图（UCG）上的表现。方法本研究为观察性研究。共纳入确诊为AFD的患者45例，根据UCG测量左室壁有无肥厚，分为左室壁肥厚组（17例，室间隔或左室后壁厚度≥12 mm）和无左室壁肥厚组（28例）。收集患者基线资料，并对所有患者进行常规UCG检查及二维斑点追踪超声心动图分析。应用TomTec工作站分析超声心动图图像，比较两组的临床基线资料、UCG常规参数及心肌应变特征。结果本研究共纳入45例AFD患者，年龄（32.33±16.11）岁，其中男性27例（60.00%）。左室壁肥厚组17例（37.78%），无左室壁肥厚组28例（62.22%）。45例患者的左室射血分数（LVEF）均正常（＞50%）。与无左室壁肥厚组相比，左室壁肥厚组患者的靶器官受累比例明显增加。与无左室壁肥厚组相比，左室壁肥厚组患者的E/A，平均E/E'明显升高（P＜0.05）；左室壁肥厚组的整体、心肌层、心内膜以及各节段的纵向应变（LS），周向应变（CS）及径向应变（RS）的差异均无统计学意义（P 值均＞0.05）。AFD患者心肌层的整体和各节段LS、CS的绝对值均低于心内膜的对应值（P 值均＜0.05）。AFD患者的中间段的LS、RS绝对值较基底段和心尖段高（P 值均＜0.05）。结论早期收缩功能障碍与左室壁厚度无明显关系。2D-STE心肌应变可以早期监测AFD室壁肌层受累较心内膜严重，而中间段受累较心尖段和基底段轻