The expression of USP39 in non-small cell lung cancer and its function in A549 cells

肺癌是最常见的肺部原发性恶性肿瘤，由于其中大部分起源于支气管粘膜上皮，所以又称支气管肺癌。其中非小细胞肺癌（non-smallcelllungcancer，NSCLC）占到85%。如今肺癌已成为全世界范围内癌症死亡的首要原因，其患病率和死亡率均居各大恶性肿瘤之首。在中国，随着人口基数的快速增长以及环境污染的恶化，肺癌的死亡率在急剧上升。可见，肺癌已经成为全人类健康的重要威胁。虽然近年来各种化疗药物和手术治疗的联合应用，在一定程度上提高了治疗效果，但是由于肺癌的发病隐匿，早期诊出率低，临床症状多出现在中晚期，导致治疗效果差。随着对肺癌的分子机制的不断认识，以及无数临床实践，以减少对正常细胞的毒副...Lung cancer is the most common primary pulmonary malignant tumor, because most of them originated in bronchial epithelium, also called bronchial lung cancer. Non - small cell lung cancer (NSCLC) accounted for 85%. Nowadays, lung cancer has become the leading cause of cancer-related mortality worldwide, and its incidence and mortality rates are on the top of those major malignant tumors. In China, ...学位：医学硕士院系专业：医学院_肿瘤学学号：2452013115354

柯里拉京对宫颈癌Hela细胞增殖与凋亡的影响

为了探讨柯里拉京对宫颈癌Hela细胞增殖与凋亡的影响,不同浓度柯里拉京作用Hela细胞后,利用MTT法和克隆形成实验检测柯里拉京对Hela细胞的增殖抑制作用,用倒置显微镜观察Hela细胞的形态变化,用流式细胞仪分析细胞周期与细胞死亡率,用Western blot法检测细胞PCNA、Caspase-3、Caspase-8、Caspase-9、PARP蛋白的表达。结果:柯里拉京能显著抑制宫颈癌Hela细胞增殖,并呈浓度依赖效应;流式细胞仪测定结果表明柯里拉京能使Hela细胞发生S期周期阻滞;Western blot结果显示加药组细胞中与增殖有关蛋白PCNA的表达量显著下调,与凋亡有关蛋白Caspase-3、Caspase-8、Caspase-9、PARP被剪切激活。结论:柯里拉京对宫颈癌Hela细胞有明显的抑制作用,其抑制作用与柯里拉京诱导细胞周期阻滞及凋亡有关。福建省高校产学合作重大项目(2016Y4011

Corrosion inhibitor of the different consiting phosphate pigments

以铬酸锌为参照物,考察了45#钢在不同pH值3.5%NaCl的磷酸盐颜料提取液腐蚀体系下的电化学行为,讨论了传统和新型复合掺杂磷酸盐颜料的腐蚀抑制特性。结果表明,AlZnPO4MoO4.4H2O和AlZn2P3O10-(MoO4)2.2H2O两种新型复合掺杂磷酸盐颜料在不同酸碱度条件下均展现出较为理想的效果,尤其是很好的改善了传统磷酸盐在中性体系中的防腐性能,甚至超过了性能优异的铬酸锌颜料,同时,进一步提升了酸性环境下磷酸盐颜料所具有的优越性。The behaviors of 45# carbon steel in different pH values of pigment-doped water extracts with 3.5% NaCl were observed by a reference of zinc chromate.The corrosion inhibitions of the traditional and two new co-doped phosphate pigments were also discussed.The results show that： perfect results were indicated with the two co-doped phosphate of both AlZnPO4MoO4·4H2O and AlZn2P3O10（MoO4）2·2H2O in different pH values.Especially good for improving the traditional phosphate in neutral system of corrosion resistance,even more than the excellent performance of zinc chrome.At the same time,superiorities were further enhanced in the acidic environments of phosphate pigment.家自然科学基金项目(20566003);广西民族大学重大项目(2008ZD012);广西科学研究与技术开发计划应用基础研究专项项目(桂科基0991005

黑颈鹤在新疆罗布泊和昆仑山分布及种群状况/Distribution and Population State of Black-necked Crane Grus nigricollis in Lop Nur and Kunlun Mts.,Southern Xinjiang[J]

黑颈鹤(Grus nigricollis)俗称"吐尔那",在新疆罕见,主要分布在与西藏和青海接壤的阿尔金山、昆仑山、喀喇昆仑山区.作者1985～2010年间在若羌(祁曼塔格、东昆仑山、阿尔金山)、且末(吐拉牧场、车尔臣河流域)、和田(阿克赛钦湖)、墨玉、皮山(喀拉喀什河流域)、叶城(叶尔羌河流域)等地记录到黑颈鹤.采用直接计数法和问卷调查法,2003年秋季在阿尔金山保护区统计到约137只的迁徙集群,全疆种群数量估计180～220只.2010年5月18日,在罗布泊洼地(N 40°19′,E 9°158′,海拔790 m)首次记录到黑颈鹤栖息,这可能是目前黑颈鹤分布的最北端,也是海拔最低和极端干旱区域的一个纪录.历史上是否有分布,尚不得而知.这意味着,对这一青藏高原特有物种生存领地的认识向北扩展了2～3个纬度.本文对以往的记录提出质疑

Determination of the number of ψ(3686) events taken at BESIII

The number of ψ(3686) events collected by the BESIII detector during the 2021 run period is determined to be (2259.3±11.1)×106 by counting inclusive ψ(3686) hadronic events. The uncertainty is systematic and the statistical uncertainty is negligible. Meanwhile, the numbers of ψ(3686) events collected during the 2009 and 2012 run periods are updated to be (107.7±0.6)×106 and (345.4±2.6)×106, respectively. Both numbers are consistent with the previous measurements within one standard deviation. The total number of ψ(3686) events in the three data samples is (2712.4±14.3)×10^