Correlation analysis between bone metabolism and blood stasis in perimenopausal women

目的探讨围绝经期女性骨代谢状况与"血瘀"的关联性。方法 132例符合纳入标准的围绝经期女性按年龄每5岁为一组,分为4组,采用电化学发光法检测不同阶段Ⅰ型胶原氨基端前肽(PINP)、Ⅰ型胶原羧基端肽β特殊序列(β-CTX)、骨钙素N-端中分子片段(N-MID)等骨代谢指标,同时检测血液流变学指标,并对其进行"血瘀"量化评分、甲襞微循环评分,相关数据采用多元回归等统计学进行分析。结果 PINP与全血中切粘度、血瘀量化评分、甲襞微循环评分存在显著的正相关(P<0.01);β-CTX与血瘀量化评分、甲襞微循环评分存在显著的正相关(P<0.01),与红细胞电泳时间存在显著负相关(P<0.01),与全血低切粘度、红细胞刚性指数存在正相关(P<0.05);N-MID与全血中切粘度、血瘀量化评分、甲襞微循环评分存在显著正相关(P<0.01)与全血低切粘度存在正相关(P<0.05)。结论围绝经女性骨代谢状况与"血瘀"关系密切,血瘀是导致围绝经女性骨代谢状况发生变化而发生骨质疏松的重要因素之一。Objective To discuss the correlation between bone metabolism and blood stasis in perimenopausal women. Me thods132 cases of perimenopausal women meeting the inclusion criteria were divided into 4 groups by every 5-year age. Type I collagen amino-terminal propeptide( PINP),carboxy-terminal peptide β special sequence( β-CTX),and molecular osteocalcin N- terminal fragment( N-MID) were detected with electrochemical luminescence at different stages. Blood rheology,blood stasis quantitative score,and microcirculation score were simultaneously detected. Data were analyzed using multiple regression method. Re sults PINP was positively correlated with shear viscosity of whole blood,blood stasis quantitative score,and microcirculation score( P <0. 01). β-CTX was positively correlated with blood stasis quantitative score,microcirculation score,lowshear whole blood viscosity,and erythrocyte rigidity index( P < 0. 01),but was negatively correlated with erythrocyte electrophoresis time( P <0. 01). N-MID was positively correlated with whole blood viscosity,blood stasis quantitative score,microcirculation score( P <0. 01),and lowshear whole blood viscosity( P < 0. 05). Conclusion Bone metabolism and blood stasis are closely related in perimenopausal women. Blood stasis is one of the important factors leading to osteoporosis and change of bone metabolism in perimenopausal women.福建省医学创新课题(2012-CXB-26);; 福建省中医药课题(WST201205

Study of Underwater Target Recognition for Torpedo Electromagnetic Fuse with High Detecting Precision

鱼雷武器系统的主动电磁引信回波信号中蕴含着雷目交会过程重要特征信息。针对回波信号能量比较法受到直达场耦合成分和噪声影响的问题,提出了基于数字信号处理技术的目标特征提取算法。对接收天线的回波信号进行全相位二次补偿处理;采用短时傅里叶变换对目标回波信号进行包络解调;再利用改进的三次多项式最小二乘拟合方法,以抑制数据波动影响并提高计算效率;提出一种基于钟型脉冲的参数识别算法对回波包络极大值点进行估计。仿真和试验数据验证表明所提出方法具有一定的工程实用性。Characteristic information is hidden in the received signal of active torpedo electromagnetic fuse.The conventional burst controlling strategies based on energy-comparison are affected by ambient and electromechanical noises.The improved algorithms based on digital signal processing techniques are proposed.The received signals are first processed by all-phase compensation method to eliminate the direct coupling component,and then the residual signal is demodulated using STFT.An improved polynomial least mean square approximation method,which reduces the computation time,is presented for eliminating the side-effects brought by noise.A parametric estimation model base on bell-shape impulse is used to estimate the maximum of echo envelope.Simulation and trial data show that the proposed algorithm is effective and practical.国家自然科学基金项目(51275384、51275382); 国家科技重大专项(2010ZX04014-016

南海中深层动力格局与演变机制研究进展

南海是连接印度洋-太平洋的最大边缘海,在季风、海峡水交换以及复杂地形影响下,南海环流呈现出独特的三层结构以及远强于大洋的混合特征.理论与观测表明,南海内潮、内孤立波以及强风等过程是强混合的动力来源.在南海强混合作用下,南海发育了活跃的中深层动力系统,一方面促进了南海与大洋之间的水体交换,另一方面调控上层风生环流,使得南海环流显著区别于其他热带与副热带海盆.南海活跃的中深层环流所具有的物质搬运能力又显著影响着南海的地质沉积、生物地球化学循环等过程.中国对深海研究持续投入,在南海中深层环流动力学研究方面取得了显著的成果,文章就该方面进行总结,并对南海深海环流未来研究设想进行初步探讨

Observation of inhomogeneous plasmonic field distribution in a nanocavity

等离激元材料和器件中电场的强度分布是等离激元技术及其应用的重要基础。虽然针尖增强光谱成像技术的发展已经实现了亚纳米的横向空间分辨率，并发现了亚纳米级电场的不均匀性，但是迄今人们对电场的纵向场强分布仍然知之甚少。李剑锋教授课题组设计了一种具有~2Å空间分辨率的分子尺，利用金单晶基底和壳层隔绝金纳米粒子来构筑等离激元纳米腔，并通过分子尺的拉曼信号强度，精准地直接表征纳米腔中的纵轴方向上高度不均匀的场强分布。中国科学技术大学罗毅教授课题组利用基于量子场论的局域场光谱理论，精确地模拟得到了与实验相符的等离激元纳腔中的场分布，并发现了因分子自聚焦作用而引起的“等离激元梳”。该工作提供了一种通用有效的定量表征纳腔中场强分布的方法，完善了对等离激元学基础的理解，为超高空间分辨的拉曼光谱成像、光学力调控分子组装、单分子反应操控提供指导。 该工作是在李剑锋教授和中国科学技术大学罗毅教授共同指导下完成的。实验部分主要由李超禹（论文第一作者，已毕业博士）、温宝英（在读博士）、李松波（已毕业硕士）完成，复旦大学段赛研究员（论文共同第一作者）和陈舒（已毕业博士）进行了局域场光谱理论计算。谢立强（已毕业博士）和毛秉伟教授帮助完成了扫描探针显微镜实验。浙江师范大学周小顺教授和王亚浩老师提供了自组装膜表征方面的重要帮助。印度的Kathiresan、叶龙武教授课题组和浙江大学陆展教授课题组在分子合成方面提供了重要帮助。瑞士伯尔尼大学Wandlowski教授和田中群教授为该工作提供了指导。【Abstract】The progress of plasmon-based technologies relies on an understanding of the properties of the enhanced electromagnetic fields generated by the coupling nanostrucutres.Plasmon-enhanced applications include advanced spectroscopies, optomechanics, optomagnetics and biosensing. However, precise determination of plasmon field intensity distribution within a nanogap remains challenging. Here, we demonstrate a molecular ruler made from a set of viologen-based, self-assembly monolayers with which we precisely measures field distribution within a plasmon nanocavity with ~2-Å spatial resolution. We observed an unusually large plasmon field intensity inhomogeneity that we attribute to the formation of a plasmonic comb in the nanocavity. As a consequence, we posit that the generally adopted continuous media approximation for molecular monolayers should be used carefully.The progress of plasmon-based technologies relies on an understanding of the properties of the enhanced electromagnetic fields generated by the coupling nanostrucutres1,2,3,4,5,6. Plasmon-enhanced applications include advanced spectroscopies7,8,9,10, optomechanics11, optomagnetics12 and biosensing13,14,15,16,17. However, precise determination of plasmon field intensity distribution within a nanogap remains challenging. Here, we demonstrate a molecular ruler made from a set of viologen-based, self-assembly monolayers with which we precisely measures field distribution within a plasmon nanocavity with ~2-Å spatial resolution. We observed an unusually large plasmon field intensity inhomogeneity that we attribute to the formation of a plasmonic comb in the nanocavity. As a consequence, we posit that the generally adopted continuous media approximation for molecular monolayers should be used carefully.The Swedish National Infrastructure for Computing is acknowledged for computer time. S.D. is sponsored by Shanghai Pujiang Programme (grant no. 19PJ1400600). 该研究工作得到国家自然科学基金、国家重点研发计划、安徽省量子信息技术引导专项等的资助和支持

塔里木河流域下游植被生态风险遥感定量评估

近年来,生态风险评估已被人们所重视,但到目前为止,生态风险评估还没有一套完整的方法体系。以我国最大的内陆河——塔里木河下游为研究区,将遥感、地理信息系统等技术手段与模糊数学方法相结合,根据ERA框架和层次分析思想建立塔里木河下游植被的生态风险评估指标,运用模糊综合评判的方法进行塔里木河下游植被生态风险的遥感定量评估,并在评估结果的基础上进行可视化分析。结果表明:在流域生态风险评估缺乏有效的定量评估方法的情况下,Fuzzy集合论与AHP方法结合的模糊综合评判方法是可行的,具有较高的科学性;运用遥感、地理信息系统(GIS)等技术手段,实现了评估结果的定性、定量和可视化

RS和GIS支持下的生态风险评估——以塔里木河下游为例

目前为止,生态风险评估还没有一套完整的方法体系。本文以我国最大的内陆河-塔里木河下游区段为研究区域,将遥感、地理信息系统等先进技术手段与模糊数学方法相结合,根据ERA框架和层次分析思想建立塔河下游植被的生态风险评估指标,运用模糊综合评判的方法进行塔河下游植被生态风险的遥感定量评估;在评估结果的基础上进行可视化分析。结果表明:在流域生态风险评估缺乏有效的定量评估方法的情况下,Fuzzy集合论与AH P方法结合的模糊综合评判方法是可行的,具有较高的科学性;运用遥感、地理信息系统等先进的技术手段,实现了评估结果的定性、定量和可视化