The cultural implication of YingzhiCi poems in the Tang and Song Dynasty

本文以唐宋两朝六百多年间的应制词为研究对象，按照发展轨迹将之分为唐五代、北宋、南宋三个阶段，尝试从文化的角度分别讨论其发展过程中所折射出来的文化意义。 全文分绪论、正文和结语三部分。 绪论：明确本文研究对象和范围，通过分析与回顾应制词以及其相关的学术研究情况，展现应制词的研究现状，进而讨论本论题的研究价值，并简要概括论文基本思路和研究意义。 第一章：论述唐五代应制词的文化意蕴。本章以安史之乱为界，将应制词分前后两期论述。盛唐、中唐时期，重点阐述应制词和燕乐文化的联系；晚唐五代时期，研究应制词在畸形时代下特殊的文化意蕴。 第二章：论述北宋应制词的文化意蕴。本章从朝廷的复雅政策、经...Based on the existing research results, this thesis makes a further study on the cultural implication of Yingzhi Ci poems during the six hundred years of the Tang and Song Dynasties. The development of Yingzhi Ci poems is divided into three significant periods: the Tang Dynasty, the North Song Dynasty, and the South Song Dynasty. The cultural significance of Yingzhi Ci poems in each period is disc...学位：文学硕士院系专业：人文学院中文系_中国语言文学学号：1022008115242

高密度脂蛋白在心肌炎中的作用机制研究

心肌炎为心肌细胞及间质的局限性或弥漫性病变,可由多种因素如感染、物理和化学引起,可发展为扩张性心肌病。众多细胞因子参与到炎症反应中,临床及实验中均发现血脂代谢和炎症的关系密切,血脂代谢中的脂蛋白包括高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、极低密度脂蛋白、乳糜微粒等,其中HDL是由多种蛋白和脂质组成的异质性脂蛋白复合物,是抗动脉粥样硬化的主要物质。HDL的保护作

Primary Identification of Triterpene Compounds in Chizhi (Ganoderma lucidum) by HPLC-APCI-MS

采用反相高效液相色谱-二极管阵列检测器(RP-HPLC-DAD)和大气压化学电离质谱(APCI-MS)联用技术,分析赤芝中含有的三萜类化合物。使用反相C18色谱柱,以乙腈和水(含2%冰醋酸)为流动相梯度洗脱,流速为0.8ml/min,室温下,色谱检测波长253nm;用DAD检测器记录各个色谱峰的紫外吸收光谱,采用APCI-MS进行在线同步分析,记录TIC总离子流色谱图和各个色谱峰的质谱图,通过紫外光谱及质谱分析并与文献对照初步鉴定了赤芝中的32个三萜类成分。High performance liquid chromatography (HPLC)-atmospheric pressure chemical ionization-mass spectrometry (APCI-MS) was applied to analyze the triterpenoids in extracts of Ganoderma lucidum. The extraction conditions are: Hypersil C4 (4.6 mm × 150 mm) column with gradient elution with acetonitrile and water (2.0% acetic acid) as mobile phase, flow-rate 0.8 ml/min, and room temperature about 25 ℃. The detection wavelength is 253 nm and the UV spectra of peaks are obtainedwith a photodiode array detector (DAD). On-line APCI-MS in positive and negative mode was used to get the mass spectrum of the analyte. Thirty-two components of Ganoderma lucidum are primarily identified by comparison of the UV spectra and mass spectrum according to published literatures.青岛“2004将才计划”项目(04-3-JJ-11);; 共建生物医药研发测试中心资助项目(LS-05-KJZX-76

Study on the Elements and Element Speciation in the Extract of Taizishen

目的对太子参水提液中3种金属元素Cu,Mn,Zn进行形态研究。方法采用电感耦合等离子体质谱(ICP-MS)测定太子参及太子参水提液中3种金属元素的含量,并用反相高效色谱(RP-HPLC)-电感耦合等离子体质谱(ICP-MS)联用技术对太子参水提液中的Cu,Mn,Zn元素进行形态分析。结果太子参水提液中金属元素Cu,Mn,Zn含量较高,其中Cu,Mn,Zn均主要以结合态形式存在。结论该实验所建立的HPLC-ICP-MS分析方法是太子参水提液中金属元素形态分析的良好方法。ObjectiveTo develop a modern analysis method for speciation of metal elements(Cu,Mn,Zn) in Taizishen.MethodsThe contents of three elements in Taizishen and the extract of Taizishen were determined by ICP-MS,and the coupling of high performance liquid chromatography(HPLC) with inductively coupled plasma mass spectrometry(ICP-MS) was applied for elemental speciation.ResultsIn the extract of Taizishen,the contents of Cu,Mn,Zn were high,and the organic speciation of Cu,Mn,Zn were the main speciation.ConclusionThe HPLC-ICP-MS method is efficient to separate inorganic speciation and organic speciation of the metal elements in Taizishen.国家自然科学基金资助项目(No.20235020

Comparison on Pseudostellarin B(Cyclic peptide) Content in Different Kinds/Harvest Time of Pseudostellaria heterophylla(Miq.) Pax

目的分析比较不同品种不同采收期太子参环肽Pseudostellarin B的含量,为合理开发利用太子参的植物资源提供参考。方法不同品种不同采收期太子参经提取制备后,采用高效液相色谱测定太子参环肽Pseudostellarin B的含量。结果一号品种不同采收期太子参中Pseudostellarin B的平均含量为198.1μg/g,二号品种不同采收期太子参中Pseudostella-rin B的平均含量为105.8μg/g。结论不同品种不同采收期太子参中Pseudostellarin B的含量有差异。Objective To compare the Pseudostellarin B content in different kinds and harvest time of pseudostellana heterophyua and provide reference for rational exploiting and utilizing the plant.Methods After extraction,Pseudostellarin B(cyclic peptide) in different kinds/harvest time of Pseudostellaria heterophylla(Miq.) Pax were determined by Agilent 1100 HPLC.Results The average contents of Pseudostellarin B in No.1 and No.2 Pseudostellaria heterophylla(Miq.) Pax were 198.1μg/g,105.8 μg/g,respectively.Conclusion There are differences among the contents of Pseudostellarin B in different kinds of Pseudostellaria heterophylla(Miq.) Pax.福建省科委创新药物与中药现代化项目(No.2001BA701A61-13);; 国家科技部攻关项目(No.2003BA759C

Study on the Preparation of Salvianolic Acid B of High Purity

目的:建立高纯度丹酚酸B的最佳制备工艺流程。方法:通过比较几种不同大孔吸附树脂对丹酚酸B的吸附及洗脱性能,筛选出最佳树脂并对该树脂分离纯化丹酚酸B的工艺参数进行优化。结果:在本文所确定的最佳工艺条件下,丹酚酸B回收率为90.6%,纯度高达91.8%,稳定性良好,可作为丹参制剂的原料药应用。结论:该工艺操作简便,适用于工业化生产,有利于促进丹酚酸B的开发利用。Objective:The best technology of the preparation of salvianolic acid B was established.Methods:A series of macroporous adsorption resins were compared on their adsorption and desorption properties for salvianolic acid B and the optimal type resin had been selected. The technical parameters for purification of salvianolic acid B with the selected type resin were studied. Results:Under this condition, the recovery is 90.6% and the purity of salvianolic acid B is 91.8%. The product has a good stability and could be used for preparation directly.Conclusion:This method is simple and could be used for industrial production, promoting the exploitation and utilization of salvianolic acid B.国家自然科学基金重点项目(No.20235020);; 青岛市重点实验室建设项目(No.04-2-JS-135

基于颗粒阻尼的矿用自卸车振动舒适性

采用颗粒阻尼技术对驾驶室座椅进行减振,提高其振动舒适性;选择与驾驶室底板和座椅连接的基座作为颗粒阻尼器,建立了基座阻尼器的离散元模型;模拟整车在发动机最高转速下的振动环境,针对不同阻尼器方案（颗粒材质、阻尼器分层数、颗粒粒径和颗粒填充率）,通过离散元仿真计算逐一进行耗能分析,得到了最优方案;对实物模型进行试验,对比原结构与增加阻尼颗粒后基座的加速度均方根,确认减振效果,将试验与仿真计算结果进行趋势对比,验证了离散元模型的可行性;在实际样车试验中应用最优方案,采集了座椅在发动机不同转速下的响应,进行了数据分析;针对最高转速的工况,进行了人体振动暴露的舒适性分析。研究结果表明:从频域图的单峰最大值来看,减振前座椅最大加速度响应出现在425 Hz处的0.643 4 m·s-2,安装颗粒阻尼器后最大值为25 Hz处的0.087 5 m·s-2;从时域图来看,当发动机转速分别为750、1 110、1 470、1 830、2 200 r·min-1时,安装颗粒阻尼器后座椅加速度均方根综合减幅分别达到24.2%、29.6%、34.7%、39.2%、46.0%,发动机转速越高,颗粒阻尼器的减振效果越好;安装颗粒阻尼器后各频段舒适性界限时长均有大幅度增加,频段为3.1和4.0 Hz时,安装颗粒阻尼器后舒适性界限时长均提升了1.50倍,为20 Hz时,安装颗粒阻尼器后舒适性界限时长提升了1.57倍。国家自然科学基金项目(51875490)厦门市科技计划项目(3202Z20173021)厦门市交通基础设施智能管养工程技术研究中心开放基金项目(TCIMI201813)中央高校基本科研业务费专项资金项目(20720180063

Preparative Separation of Salvianolic Acid B from Salvia miltiorrhiza by High Speed Counter-Current Chromatorgraphy

采用高速逆流色谱法分离纯化丹参水溶性成分丹酚酸类物质,制备丹酚酸B化学对照品。分离采用的溶剂系统为正己烷-乙酸乙酯-水-甲醇(1.5:5:5:1.5),上相做固定相,下相做流动相,流速为1.7 mL/min,仪器转速850 rpm,进样量80 mg,纯度用HPLC方法测定。结果表明:一次分离可制备63.4 mg丹酚酸B,其纯度为98.6%。该方法操作简单,可作为高纯度丹酚酸B化学对照品的制备分离方法。Salvianolic acid B,a major bioactive component in Danshen(Salvia miltiorrhiza Bge.),was isolated and purified by high-speed counter-current chromatography(HSCCC) in semi-preparative scale from the crude extract of Danshen.Separation was performed with a two-phase solvent system composed of hexane-ethyl acetate-water-methanol(1.5:5:5:1.5,v/v) by eluting the lower aqueous phase at a flow-rate of 1.7 mL/min and a revolution speed of 850 rpm with injection volume of 80 mg.After the proceeding of separation,63.4 mg salvianolic acid B was obtained,and analyzed by normalization method according to HPLC areas giving a purity of 98.6%.HSCCC is a recommendable method to prepare and purify the active constituents from Salvia miltiorrhiza.国家自然科学基金重点项目(20235020);; 厦门市科技创新重点项目(3502Z20031096