A Teratogenicity Study on Dimethyl Dimethoxy Biphenylate Derivative (DDB-S) in Rats

A teratogenic study of dimethyl dimethoxy biphenylate derivative (DDB-S) was carriedout on Sprague-Dawley rats. DDB-S dissolved in saline was administered to male and female rats byintravenously injection at daily doses of 50 mg/kg, 75 mg/kg, and 100 mg/kg. A half of dams weresacrificed at 20th day of gestation to scrutinize the pregnant performances and fetal development.And the remaining dams were allowed to deliver. The growth, reflex, behaviour and reproductive func-tion of F1 offsprings were examined. There was no treatment-related diference in body weight, foodconsumption and necropsy findings of dams. No gross, skeletal and visceral abnormalities wasobserved in F1 fetuses from dams treated with DDB-S. F1 offsprings did not show any treatment-related diference in growth, reflex, behaviour and reproductive performance. At caesarean section ofF1 dams, no growth retardation and gross abnormality was observed in F2 fetuses. In conclusion,DDB-S did not show any potential teratogenic effect in rats.N