노화된 생쥐에서 지방줄기세포와 지방이식의 항피부노화 상승효과

학위논문 (박사)-- 서울대학교 대학원 : 의과대학 의학과, 2018. 8. 김석화.Background: We investigated the beneficial effects of adipose-derived stem cells (ADSCs) and fat graft on skin wrinkles in a nude mouse model of chronological aging. Methods: With 50 weeks of chronological aging, 44 female BALB/c-nude mice were classified into 4 groups, i.e., a negative control group and groups injected subcutaneously with ADSCs (1 × 105 cells in 0.5 ml) on the back, injected with fat tissue (0.5 ml), or injected with both fat tissue (0.5 ml) and ADSCs (1 × 105 cells in 0.5ml). The degree of wrinkling was evaluated by a replica analysis and skin biopsies were performed after 4 weeks. The dermal thickness and density of collagen were determined. The levels of type 1 collagen and MMP were determined by western blot and type 1 procollagen mRNA levels were evaluated by RT-PCR. Tropoelastin, fibrillin-1, and CD31 were evaluated by immunohistochemistry. Results: Based on the total wrinkle area, there was significant wrinkle reduction in the fat group and the ADSC with fat group. Collagen expression and type I procollagen mRNA levels were significantly higher in the ADSC with fat group than in the ADSC group and in the fat group. In addition, the ADSC with fat group exhibited significantly higher CD31 expression levels than those in the ADSC group and in the fat group. Conclusions: ADSCs and fat could both play important roles in wrinkle reduction and have synergic effects on collagen synthesis and neovascularization.CONTENTS Abstract ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ і List of figures ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ iii Ⅰ. Introduction ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ 1 Ⅱ. Materials and Methods ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ 3 Ⅲ. Results ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ 9 Ⅳ. Discussion ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ 27 Ⅴ. Conclusion ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ 32 References ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ 33 Abstract in Korean ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ ∙ 40 Docto

Facial Form after Facial Bone Contouring Surgery

학위논문(석사) --서울대학교 대학원 :의학과 성형외과 전공,2007.Maste

평면3 관절 여유 자유도 로보트의 역 기구학 해석및 최적설계

학위논문(박사) - 한국과학기술원 : 기계공학과, 1992.2, [ xiii, 123 p. ]In this study, the moving acceleration radius (MAR) is proposed as a local performance index quantifying the dynamic uniformity of a redundant robot, which has no assumption of zero angular velocity such as in Yoshikawa``s dynamic manipulability. MAR can be calculated by a simple sequential algorithm and the resolution of the redundant joint angles are obtained by maximizing MAR locally. In addition, the reduction of the joint torques are achieved by maximizing the acceleration bound in the direction of work path for short motion. Also a new differentiation algorithm for angular acceleration is suggested for numerical efficiency as well as accuracy using a null space operator. For the real time calculation of the joint angles maximizing Yoshikawa``s manipulability and moving acceleration radius, a neural network approach is employed to find the joint angles corresponding to redundancy and then the remaining joint angles are found exactly by using the analytic inverse kinematic equations. A three degrees of freedom planar robot with one degree of redundancy is simulated using these algorithms for various situations and showed a marked improvement in dynamic characteristics. And the results from the modified neural network approach were favorable compared with those from conventional inverse kinematic method, neural network approach, and resolved motion rate control. For a planar three degrees of freedom redundant manipulator, an optimal design of the determination of manipulator parameters is carried out. Here IOABO, which can treat discrete continuous and discrete variable easily, is newly proposed and used for improvement of four performance indices: manipulability index, condition number of Jacobian matrix, moving acceleration radius, and isotropy index of moving acceleration polygon. From the results, it is found that the larger distal link case is more profitable for velocity and acceleration capability, and the smaller distal link case is more profitable f...한국과학기술원 : 기계공학과

Study on the data reduction technique for the human motion analysis

학위논문(석사) - 한국과학기술원 : 기계공학과, 1986.2, [ viii, 60 p. ]한국과학기술원 : 기계공학과