Cancer stem cell theory and update in oral squamous cell carcinoma

학위논문 (석사)-- 서울대학교 대학원 : 치의학과, 2011.2. 명훈.Maste

3차원 영상 데이터베이스 검색을 위한 형상 기술자에 관한 연구

학위논문(석사)--서울대학교 대학원 :전기공학부,2000.Maste

DISCONTINUOUS GALERKIN SPECTRAL ELEMENT METHOD FOR ELLIPTIC PROBLEMS BASED ON FIRST-ORDER HYPERBOLIC SYSTEM

A new implicit discontinuous Galerkin spectral element method (DGSEM) based on the first order hyperbolic system(FOHS) is presented for solving elliptic type partial different equations, such as the Poisson problems. By utilizing the idea of hyperbolic formulation of Nishikawa[1], the original Poisson equation was reformulated in the first-order hyperbolic system. Such hyperbolic system is solved implicitly by the collocation type DGSEM. The steady state solution in pseudo- time, which is the solution of the original Poisson problem, was obtained by the implicit solution of the global linear system. The optimal polynomial orders of ??(????+1)) are obtained for both the solution and gradient variables from the test cases in 1D and 2D regular grids. Spectral accuracy of the solution and gradient variables are confirmed from all test cases of using the uniform grids in 2D

지각적 3차원 형상 기술자를 이용한 3차원 물체 검색 시스템에 관한 연구

Thesis(doctoral)--서울대학교 대학원 :전기·컴퓨터공학부, 2005.Docto

A study on the ductile / brittle fracture behavior of crystalline solids

학위논문(박사) - 한국과학기술원 : 재료공학과, 1992.2, [ [ix], 114 p. ]한국과학기술원 : 재료공학과

Cancer stem cell theory and update in oral squamous cell carcinoma

Cancer stem cells have stem cell-like features, such as the ability for self-renewal and differentiation but show unlimited growth because they have the lost normal regulation of cell growth. Cancer stem cells and normal stem cells have similar features. They show high motility, diversity of progeny,robust proliferative potential, association with blood vessels, immature expression profiles, nestin expression, epidermal growth factor (EGF)-receptor expression, phosphatase and tensin homolog (PTEN) expression, hedgehog pathway activity, telomerase activity, and Wnt pathway activity. On the other hand, with cancer cells, some of these signaling pathways are abnormally modified. In 1875, Cohnheim suggested the concept of cancer stem cells. Recently, evidence for the existence of cancer stem cells was identified. In 1994, the cancer stem cellsspecific cell surface marker for leukemia was identified. Since then, other specific cell surface markers for cancer stem cells in solid tumors (e.g. breast and colon cancer) have been identified. In oral cancer, studies on cancer stem cells have been performed mainly with squamous cell carcinomas. Oral cancer specific cell surface markers,which are genes strongly expressed in oral cancer and cancer stem cell specific side populations, have been identified. Cancer stem cells are resistant to radiotherapy and chemotherapy. Therefore, to eliminate malignant tumors efficiently and reduce the recurrence rate, therapy targeting cancer stem cells needs to be performed. Currently, studies targeting the cancer stem cellsspecific signaling pathways, telomerase and tumor vasculatures are being done.N

Exploring the resistance mechanisms of second-line osimertinib and their prognostic implications using next-generation sequencing in patients with non-small-cell lung cancer

Introduction: Although osimertinib overcomes the T790M mutation acquired after traditional epidermal growth factor receptor (EGFR) gene tyrosine kinase inhibitor (TKI) treatment, resistance to osimertinib eventually occurs. We explored resistance mechanisms of second-line osimertinib and their clinical implications by comparing next-generation sequencing (NGS) results before and after resistance acquisition. Methods: We enrolled 34 patients with advanced EGFR-mutant adenocarcinoma whose biopsied tumour tissues were subjected to targeted NGS at the time of progression on osimertinib. For comparison, NGS was also performed on archived tumour tissues from each patient excised before osimertinib initiation. Results: The tumours of three patients? were observed to have transformed to small-cell carcinoma and those of two patients to squamous cell carcinoma. Among the remaining 29 patients, T790M mutations were maintained in seven patients (24.1%), including four patients (13.8%) acquiring C797S mutations and one with MET amplification. Among the 22 patients (75.9%) with T790M loss, a variety of novel mutations were identified, including KRAS mutations, PIK3CA mutations, and RET fusion, but MET amplifications (n Z 4, 18.2%) wer

Mitochondrial DNA Haplogroup Related to the Prevalence of Helicobacter pylori

Mitochondria are essential organelles that are not only responsible for energy production but are also involved in cell metabolism, calcium homeostasis, and apoptosis. Targeting mitochondria is a key strategy for bacteria to subvert host cells’ physiology and promote infection. Helicobacter (H.) pylori targets mitochondria directly. However, mitochondrial genome (mtDNA) polymorphism (haplogroup) is not yet considered an important factor for H. pylori infection. Here, we clarified the association of mitochondrial haplogroups with H. pylori prevalence and the ability to perform damage. Seven mtDNA haplogroups were identified among 28 H. pylori-positive subjects. Haplogroup B was present at a higher frequency and haplotype D at a lower one in the H. pylori population than in that of the H. pylori-negative one. The fibroblasts carrying high-frequency haplogroup displayed a higher apoptotic rate and diminished mitochondrial respiration following H. pylori infection. mtDNA mutations were accumulated more in the H. pylori-positive population than in that of the H. pylorinegative one in old age. Among the mutations, 57% were located in RNA genes or nonsynonymous protein-coding regions in the H. pylori-positive population, while 35% were in the H. pylori-negative one. We concluded that gastric disease caused by Helicobacter virulence could be associated with haplogroups and mtDNA mutatio