Influence of cardiovascular related disease on periodontitis

Objcetives: The aim of this study was to evaluate the influence of cardiovascular related diseas(CVD-R) on periodontitis. Methods: The nested case-control study was performed among 550 male workess, who submitted written consent, out or 2002 Workes' Health Cohort(N=1,800). CVD-R such as metabolic syndrome(MS), hypertension, body mass index(BMI). low HCL-cholesterol(HDL-C), fasting blood sugar(FBS) were evaluated in 2002 and periodontitis(probing pocket depth>4mm) was determined in 2004. Age, education, monthly income, parental medical history, smokingm drinkin, physical excerise and past periodontal status were used as confounders. For obtaining odd ratos(OR). bivariate and multivariate logistic regression analysis were applied. Results: MS increased periodontitis, which was not statisically significant (p=0.495). Hypertension might increase periocontitis(p=0.056), showed OR or 1.4(95% Confidence Interval(CI)=0.90-2.29)adjusted for age, education, monthly income and past periodontal status, parental medical history, smoking, drinking and physicl excercise. Conclusions: Hypertension showed a possibility to increase periodontitis. CVD-R such as MS, hypertension, BMI, HDL-C, FBS were not associated with periodontitis.서울대학교 발전기구 신임교수연구비(850-20030095

The Effect of Adjusted Water Fluoridation on Bone Mineral Density

Adjusted water fluoridation has been disputed because of its various effects on human health. Previous studies have been concerned with the difference in bone mineral density (BMD) between water fluoridated (WF) and none water fluoridated (NWF) districts. The aim of this study is to examine whether water fluoridation affects BMD. BMD was measured by dual energy X-ray absorptiometry (DXA). 386 adults(174 males and 212 females) in Ansan (WF) district and 399 adults (176 males and 223 females) in Sihwa (NWF) district, participated in this study. The Ansan and Sihwa districts are similar in residential environment and living class. The relationship between serum fluoride concentration and BMD was also examined by analysis of the serum fluoride concentrations from 402 inhabitants of the Ansan district. In females, the BMD of subjects living in Ansan () was a little higher than that of Sihwa subjects (), although it is not significant, after adjusting for BMI, physical activity level, educational achievement, smoking volume, menopause status, and number of births. However, the BMD of Ansan subjects () in their forties was statistically higher than that of Sihwa (0.498{\pm}0.019). No relationship was found in males. In residential periods, there was significant difference (Ansan , Sihwa , p=0.0125) in the BMD between females of two districts, particularly in the group of over 6 year long-term inhabitants. On the contrary, there was no remarkable difference in males from the two districts. Serum fluoride concentrations in females were associated with BMD, especially in the age group of forties (p=0.0457). No relationship was observed in the male group. Analysis of adult BMD over the age of 20 in a water fluoridated and a none water fluoridated district, confirms more or less a higher BMD in the water fluoridated (WF) district, especially for females. It is assumed that the difference between two districts came somewhat from the effect of water fluoridation

Early snapshot on exposure to environmental chemicals among Korean adults-results of the first Korean National Environmental Health Survey (2009-2011)

Background: Chemical exposure may cause serious adverse health effects. Under the Environmental Health Act in Korea, the first national survey, Korean National Environmental Health Survey (KoNHES), was conducted, and dozens of major environmental chemicals were measured among Korean adults between 2009 and 2011. Objectives: To understand the levels of exposure to environmental chemicals among general Korean adults population, and to identify factors that may influence the levels of exposure. Methods: The blood and urine samples were collected from Korean adults with 19 years of age and older (n = 6311), and were analyzed for a number of environmental chemicals including metals, bisphenol A (BPA), and metabolites of polycyclic aromatic hydrocarbons (PAHs), phthalates, a pyrethroid insecticide (3-PBA) and several volatile organic carbons (VOCs). Demographic and other behavioral factors were asked through questionnaire. Results: Among general Korean adults, mercury, arsenic, cadmium, and metabolite of DBP (MnBP) were higher than those reported in other nationwide surveys of Canada, Germany, and USA. Most target chemicals except for MEOHP and 3-PBA showed significant differences on the exposure levels by sex Conclusion: This is the first nationwide reconnaissance on exposure to environmental chemicals among general Korean population. Chemicals with high occurrence level will be further investigated to identify exposure sources and possible health outcomes, and eventually to develop measures to mitigate exposure. (C) 2016 Published by Elsevier GmbH.OAIID:RECH_ACHV_DSTSH_NO:T201635601RECH_ACHV_FG:RR00200001ADJUST_YN:EMP_ID:A002120CITE_RATE:4.643DEPT_NM:환경보건학과EMAIL:[email protected]_YN:YN

Nationwide study of fumidifier disinfectant lung injury in South Korea, 1994-2011 incidence and dose-response relationships

Rationale: Humidifier disinfectant lung injury is an acute lung disease attributed to recurrent inhalation of certain disinfectant aerosols emitted from room humidifiers. An outbreak of this toxic lung injury occurred in South Korea from 1995 until all humidifier disinfectant products were recalled from the consumer market by the government in 2011. Objectives: A nationwide study was conducted to ascertain and classify all potential cases of humidifier disinfectant lung injury in Korea and to assess dose-response relationships. Methods: By several mechanisms, clinicians and the general public were invited to report all suspected cases of humidifier disinfectant lung injury to public health officials in South Korea. A committee was convened to define diagnostic criteria based on pathologic, radiologic, and clinical findings for index cases, combined with assessment of environmental exposure to humidifier disinfectants. Clinical review and environmental assessments were performed and later combined to determine overall likelihood of disease for each study participant, classified as definite, probable, possible, or unlikely. Survival time from exposure to onset of symptoms was analyzed to assess dose-response relationships. Three broad categories of risk factors were examined: (1) biological susceptibility, (2) temporal cycle of exposure and recovery, and (3) spatial conditions and density of disinfectant. Measurements and Main Results: Of 374 possible cases identified and reviewed, 329 were unanimously classified by the diagnostic committee, as follows: 117 definite, 34 probable, 38 possible and 140 unlikely cases. A total of 62 individuals with definite or probable disease died. Risk factors examined for polyhexamethyleneguanidine phosphate exposure that were found to be significant in shortening survival included age 4 years or younger at onset, use of disinfectant for 7 days per week, airborne density of 800 mg/m(3) or more of disinfectant, and daily exposure 11 or more hours in duration. Conclusions: Dose-response analysis indicated that development of humidifier disinfectant lung injury and death were associated strongly with recurrent, intense, acute exposure without sufficient recovery time between exposures, more so than longterm cumulative exposure. These findings may explain some reversible or clinically unapparent cases among coexposed family members.OAIID:RECH_ACHV_DSTSH_NO:T201511786RECH_ACHV_FG:RR00200001ADJUST_YN:EMP_ID:A002120CITE_RATE:0DEPT_NM:환경보건학과EMAIL:[email protected]_YN:YN