82 research outputs found
Digital Contents Education in Universities
We cannot emphasize the importance of nurturing professional
human resources in digital contents who can lead the era of the 21th
century digital culture too much. Professional human resources in
digital contents indicate those who hold cultural insight, creativity,
expertise in state of the art IT and CT technology, and at the same
time the content business ability, all together. This study examines
the present state of the prototype educational systems in universities
that aim to foster these professional experts via analyzing the
outstanding cases of the US, Japan, and Korea. More specifically, this
study analyzed the digital content related educational systems of
Annenberg School for Communication at University of Southern
California, USA, the Content Creation Science Program of Interfaculty
Initiative in Information Studies (IIIS) at Tokyo University, Japan, and
the Graduate School of Culture Technology at KAIST, Korea. These
cases reveal quite some differences in terms of the purposes,
histories, and operational systems of institutions. Considering these
differences, this study tries to induce the implications of each cases
and discusses the desirable instructional model of nurturing
professional human resources in digital contents
Improving undergraduate education of media major in digital age
이 글은 미디어 환경 변화에 대응하여 지속가능한 가치를 지닌 미디어 전공 교육의 방향을 모색하는 데 목적이 있다. 이를 위해 미디어 전공 교육에 관한 종래의 연구들을 살펴본 후 목표, 내용, 방법의 차원에서 학부 미디어 교육과정의 개선 방향을 제시하였다. 또한 서울대학교 언론정보학과 학부의 사례를 통해 현실에 적용 가능한 구체적인 개선 방안을 제안하였다. 논의를 통해 목표, 내용, 방법의 차원에서 다음과 같은 결론이 도출되었다. 첫째, 미디어 전공 교육의 목표는 미디어에 대한 이론 및 실무 지식의 전수가 아니라 사회적 소통 전문가의 양성에 두어야 한다. 둘째, 교육의 내용 면에서 세분화되고 체계적인 교과과정을 구축함으로써 심층적이고 전문화된 교육을 제공해야 한다. 셋째, 교수 개개인의 차원에서, 그리고 교과과정 운영 차원에서 미디어 전공 교육 방법에 획기적인 개선이 필요하다. 이러한 변화를 위해서는 교수자의 혁신 노력과 더불어 교육을 둘러싼 이해관계자들 간의 합의, 제도적인 지원이 뒷받침 되어야 한다.
The revolution of the digital media has rapidly weakened the status of traditional media, leaving the prospect of new media unclear and generating confusion in the education of media major at universities. This paper aims to explore the directions in media major education seeking sustainable values in response to changes in the media environment. In order to accomplish this goal, we examine the preceding studies on media major education and suggest the directions to improve the undergraduate curriculum for media education in terms of goals, content, and methods. In addition, through the case study of the Department of Communication at Seoul National University several specific improvement plans are suggested. This study results in the following conclusions in terms of goals, content, and methods. First, the goal of media major education should aim at fostering social communication experts instead of transferring theory and practical knowledge of media. Second, it is necessary to provide in-depth and specialized education by building a detailed and systematic curriculum in terms of contents of education. Third, enormous improvement in educational methods for media major is required in terms of individual professors as well as curriculum management. These changes must be accompanied by the instructors efforts along with institutional support.OAIID:RECH_ACHV_DSTSH_NO:T201738727RECH_ACHV_FG:RR00200001ADJUST_YN:EMP_ID:A074943CITE_RATE:0DEPT_NM:언론정보학과EMAIL:[email protected]_YN:NN
Synthesis of Nanomaterials Based on Small Organic Molecules via Vaporization-Condensation-Recrystallization (VCR) Process and Their Physico-chemical Propertie
Docto
폐쇄성 수면 무호흡 환자에서 변형 양악전진술이 상기도의 삼차원적 변화에 미치는 영향
학위논문(석사) -- 서울대학교대학원 : 치과대학 치의과학과, 2024. 2. 최진영.Purpose: This study aimed to compare three-dimensional (3D) changes, particularly in upper airway volume, between modified maxillomandibular advancement (m-MMA) and conventional MMA (c-MMA) in patients with obstructive sleep apnea (OSA). Methods: The sample comprised 18 adult Korean patients diagnosed with severe OSA who underwent c-MMA or m-MMA (n=9/group) performed by a single operator at Seoul National University Dental Hospital between January 2010 and September 2023. The c-MMA group had a mean age of 33.1 years, mean body mass index (BMI) of 22.7 kg/m2, and mean Apnea-Hypopnea Index (AHI) of 33.98 events/h. The m-MMA group had a mean age of 31.3 years, mean BMI of 22.7 kg/m2, and mean AHI of 49.14 events/h. Three-dimensional cone-beam computed tomography (CBCT) scans were obtained within 1 month pre- and at least 2 months postoperative. Linear, planar, and volumetric analyses of the upper airway were performed by comparison of pre-and postoperative CBCT images. The Wilcoxon signed- rank test was used to analyze the statistical significance of the pre- and postoperative results. Results: Postoperative polysomnography results, available for some patients, showed an AHI improvement of 17.52 events/h in the c-MMA group (p>0.05) versus 13.9 events/h in the m-MMA group (p0.05), m-MMA 그룹은 13.9회/시간(p<0.05)의 AHI 개선 효과를 보였다. c-MMA그룹은 하악전진(오른쪽, 8.79mm, 왼쪽 8.66mm)과 상악 전진(5.00mm)이 있었다. 두명의 환자에서 이설근 전진술을 받았다. m-MMA 그룹에서 환자들은 하악 전진(오른쪽, 9.12mm; 왼쪽, 9.16mm) 및 상악전진(2.11mm)을 받았다. 상기도에 대한 선형 분석 결과, 두 그룹 모두에서 경구개(HP) 및 연구개(SP) 수준에서 평균 전후방 거리가 유의하게 증가(p<0.05)한 것으로 나타났다.(c-MMA,p<0.05; m-MMA,p<0.01). 측면(LAT) 거리는 c-MMA 그룹에서는 SP 수준에서만 증가했고(p<0.01), m-MMA 그룹에서는 HP 수준에서 증가했다(p<0.05). 총 기도 높이는 두 그룹 모두에서 감소했다(c-MMA, p<0.01; m- MMA, p<0.05). 상기도 최소 단면적의 평면 분석 결과, 구개 쪽에서 유의미한 증가를 보였다(c-MMA, p<0.05; m-MMA, p<0.01). 총 상기도 용적은 두 군 모두에서 증가하였으며(p<0.05), c-MMA군에서 후구개 용적(p<0.05)과 m-MMA군에서 후구개 용적(p<0.05)에 유의한 변화가 있었다. 결론: c-MMA와 m-MMA는 하악의 전진량은 비슷했으나 상악의 전진량은 차이가 있었다. 기존 문헌에서 폐쇄성 수면 무호흡의 치료를 위한 c-MMA는 백인 환자에서 시행된 반면, 아시아 국적의 환자는 미용상의 이유로 m-MMA를 시행할 수 있다. 수술 후 변화는 두 그룹 모두 선형(HP 및 SP 위치에서 전후방 길이 증가, 기도 길이 감소), 평면(구개측 증가) 및 체적(총 부피 증가)변화에 대해 유사한 효과를 보였고 두 그룹 간에 유사한 결과가 나왔다. 이 연구는 중등도에서 중증의 폐쇄성 수면 무호흡 환자를 치료하는데 있어 m-MMA의 효과가 c-MMA와 유사한 개선 정도를 보임을 입증하였다. 주요어 :수면 무호흡, 상기도 부피, 양악전진술, 변형 양악전진술 학 번 :2021-23850Chapter 1. INTRODUCTION 4
Chapter 2. MATERIAL AND METHODS 5
Chapter 3. RESULTS 8
Chapter 4. DISCUSSION 10
References . 14
Tables 18
Figures . 23
Abstract in Korean 28석
Key issues & confusion surrounding the debate over the reformation of broadcasting and telecommunication policy organizations in Korea in early 2008
This paper aims to evaluate a debate on the reformation of Korea's
broadcasting and telecommunication policy organizations in the wake
of media convergence. Recently, the Presidential Transition Committee
ended this ongoing debate, proposing to establish one single
government agency that integrates broadcasting policy implemented by
the Korean Broadcasting Commission and telecommunication policy
implemented by the Ministry of Information and Communication. The
author argues that the basic directions of the Committee's decision is
valid, still its hasty, closed and undemocratic decision making
procedure leaves large room for political backfire. The major reason
why its decision is valid despite the procedural problems is because it
overcomes the limitations of so-called mechanical administrative
approach pervasive among the past debates on the reformation of
broadcasting and telecommunication policy organizations. From a
microscopic and shortsighted perspective, existing debates have focused
mainly on re-engineering of broadcasting and communication regulation
without recognizing the true meaning of social communication policy
with few references to the fundamental meaning of social communication
policy. The status, role, and function of a new communication policy
entity should come from a macroscopic and long-term standpoint.
First, as for its status, a new entity should act as a comprehensive
communication policy organization encompassing media and communication policies at all levels. Institutional separation of a
governmental ministry in charge of industrial policies and a commission
in charge of socio-cultural regulation policies is hard to realize this
macroscopic vision. The Presidential Transition Committee's proposal
comes closer at building an integrated media and communication policy
organization. Second, the vital role of the new communication policy
organization in the media convergence era is to accomplish balance and
harmony between media's public goals and market efficiency at the
same time. The separation of industrial policy and socio-cultural
regulation is an anachronistic approach to follow existing communication
policy mechanism that differentiates broadcasting policy (social and cultural
policy paradigm) and telecommunication policy (industrial policy paradigm).
The Presidential Transition Committee's proposal for a single
broadcasting and telecommunication organization that accomplishes its
policy goal of improving public value and market efficiency within one
organization appears valid in this vein. The Presidential Transition
Committee's approach, however, lacks procedural rationality. Not a few
people see its hasty, closed and undemocratic decision making procedure
as a new government's attempt to control media and communication
polices and even as a threat to the very roots of a democratic civil
society. Procedural problems can not only fuel people's suspicion or
mistrust of a new government's media policy but also cause a
problem of well-directed plausible policies to drift away. In media
policy, the new Korean government needs to take more cautious
consideration of procedural rationality as well as the substance of
policy itself
Isolation of tick-borne encephalitis virus and in vivo virulence analysis of TBEV isolates
의과학과/석사[한글]
진드기매개뇌염바이러스 (tick-borne encephalitis virus, TBEV)는 Flaviviridae family, Flavivirus genus에 속하는 바이러스로서 심각한 신경질환의 원인이 되는 주요 절지동물매개바이러스 (arboviruses)중 하나이다. 이 바이러스에 의한 진드기매개뇌염 (tick-borne encephalitis, TBE)은 유럽, 러시아 및 아시아 등지에서 유행하며, 이 지역들에서 중요한 공중보건학상의 문제가 되고 있는 질병이다. 아직까지 국내에TBEV에 의한 뇌염환자 발생사례는 없지만, 불명뇌염환자의 증가를 비롯한 우리나라와 인접한 아시아 국가들에서의 바이러스 분리 및 환자보고 사례, 국내 TBEV 매개체 서식 등으로 미루어 볼 때 국내에서도 TBE 발생가능성은 높다고 할 수 있다. 하지만 아직까지 관련연구가 수행되고 있지 않은 실정이다. 본 연구에서는 국내에서 확보한 임상, 숙주 및 매개체 검체를 이용하여 TBEV 감염여부를 조사하였다. TBEV 유전자가 검출된 검체를 대상으로 감수성 세포 및 ICR 마우스를 이용한 바이러스 분리를 시도하여 야생쥐 폐조직 검체로부터 5주의 TBEV를 분리하였다. TBEV 국내분리주의 분자유전학적 특성을 분석하고자 세포배양액으로부터 RT-PCR으로 전체 envelope (E) 유전자를 증폭한 후, 클로닝하여 염기서열을 분석하였다. 이를 기존에 보고된 TBEV 분리주와의 계통유연관계 및 연역된 아미노산 서열을 비교 분석한 결과 국내분리주 5주는 모두 Western 아형에 속했으며 (97%이상의 상동성), Western 아형에서만 특징적으로 나타나는 아미노산 서열이 잘 보존된 것을 확인하였다. 이와 같은 결과를 통해 국내분리주는 TBEV 중 Western 아형의 특징을 가짐을 확인하였고, Sofjin-HO나 Neudoerfl 주와 비교해 E 단백의 domain Ⅰ,Ⅱ,Ⅲ에서 특정아미노산이 치환됨을 확인하였다.
국내분리주의 E 단백을 구성하는 3가지 domain의 특정 아미노산 치환이 병원성에 영향을 주는지 알아보기 위해 6주령 ICR 마우스를 이용하여 병원성을 표준주와 비교하였다. 그 결과 국내분리주 5주는 표준주인 Sofjin-HO나 Neudoerfl 주에 비하여 neuroinvasiveness와 neurovirulence가 낮았다.
본 연구를 통해서 국내 최초로 야생숙주동물 (야생쥐 폐조직)로부터 TBEV를 분리하였으며, 국내분리주의 낮은 병원성은 E 단백의 특정아미노산 치환과 관련이 있는 것으로 사료된다. 특정아미노산 치환과 병원성의 관련성에 대하여는 향후 추가연구가 요구되며, 본 연구에서 분리된 TBEV 국내분리주의 E 단백 유전자 및 병원성 분석은 TBEV 진단법 개선 및 백신개발을 위한 유용한 정보를 제공할 것이다.
[영문]
Tick-borne encephalitis virus (TBEV) is an arthropod-borne virus belonging to the genus flavivirus within the family Flaviviridae. It is endemic in central Europe, Russia and parts of Asia and represents a significant public health problem in these areas. Although tick-borne encephalitis (TBE) has not been reported in Korea, it seems quite probable that tick-borne encephalitis by TBEV occurred in Korea since an increase of the number of unknown encephalitis patients, distribution of the main vectors of TBEV in Korea and TBEVs have been isolated near the countries including Japan, China and Russia. But TBEV has never been investigated so far in Korea. To investigate whether TBEV is present in Korea, Human, vector ticks and animal hosts were tested to detect and isolate TBEV using RT-nested PCR, cell culture and inoculation into ICR mices. As a result, TBEV were isolated from wild rodents (lung tissue) in Korea. We determined the complete envelope (E) protein genes of five Korean isolates and analyzed the genetic variability within five Korean isolates or with 13 other TBEV strains. Five isolates had high identity with Western subtype (97~99%identity) in nucleotide and deduced amino acid. The phylogenetic analysis showed TBEV isolates from Korea were clustered with Western subtype. Results of deduced amino acid alignment of five isolates conserved unique amino acids as Western subtype strains. It was found from the result that provide the first evidence of the presence of TBEV in Korea and five isolates was characterized by Western subtype.
To identify whether the amino acid substitutions of three domains in E protein associated with neuroinvasiveness and/or neurovirulence, in vivo virulence assay in 6-week-old ICR mice were performed. The results showed both neuroinvasiveness level by subcutaneous inoculation and neurovirulence level by intracerebral inoculation, five Korean isolates were lower than Sofjin-HO and Neudoerfl strains. The amino acid substitution of domain Ⅰ,Ⅱ,Ⅲ in E protein between five Korean isolates and 2 other TBEV strains (Sofjin-HO and Neudoerfl strain) were identified.
From these studies the precise mutation sites were unable to identify involved in attenuation of neuroinvasiveness and/or neurovirulence of five Korean isolates. However, one or more of the amino acid substitutions in domain Ⅰ,Ⅱ,Ⅲ may be assumed to the contribute to attenuation of neuroinvasiveness and/or neurovirulence of five Korean isolates. The results of this study will provide a valuable information for the development of an effective vaccine and diagnosis of TBEV.ope
A Study on sentence-final moods in modern Korean
학위논문(박사)--서울大學校 大學院 :國語國文學科 國語學專攻,1996.Docto
Synthesis of Helical m-Aminobenzoic acid Nanobelts via Vaporization-Condensation-Recrystallization method
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